1.Multiple primary malignant neoplasms.
Journal of the Korean Cancer Association 1993;25(1):92-96
No abstract available.
2.A clinico-pathological comparative study of gastric cancer in the young and the aged.
Kyoung Ho SEO ; Chung Han LEE ; Sung Do LEE ; Jae Kwan SEO ; Young Hoon PARK ; Bang HUH ; Man Ha HUH
Journal of the Korean Surgical Society 1991;41(2):168-180
No abstract available.
Stomach Neoplasms*
4.Prognostic Significance of Histologic Features, DNA Content, Expression of Proliferating Cell Nuclear Antigen (PCNA), c-fos Protein and Transforming Growth Factor (TGF)-alpha and -beta in Giant Cell Tumor of Bone.
Hee Kyung CHANG ; Sung Hun YOON ; Jae Do KIM ; Man Ha HUH
Journal of the Korean Cancer Association 1997;29(2):266-279
PURPOSE: This study was attempted to investigate the prevalence of the expression of c-fos protein, TGF-alpha and -beta, PCNA , DNA ploidy pattern and histopathological parameters of giant cell tumor (GCT) of bone and to correlate with prognosis and to extend our understanding on tumorigenesis of GCT. MATERIALS AND METHODS: Twenty eight cases of paraffin-embedded tissue were studied, classified as recurrent (5 cases) and non-recurrent group (12cases) within the limits of the cases which afforded surgical material on first operation. RESULTS: No significant difference was observed in cellularity of stromal cells, atypia of stromal and giant cells, presence of hemorrhage and necrosis between recurrent and non-recurrent group. However, presence of more than 10 mitotic figures in 10 high power fields in recurrent group was significantly higher than non-recurrent group (p<0.05). The immunoreactivity for PCNA was seen only in nuclei of stromal cells, whereas nuclei of giant cells showed negative staining. The positivity of PCNA revealed no significant difference between non-recurrent (mean; 40.9%) and recurrent group (34.4%). The expression of c-fos oncogene was seen in 5 cases (100%) in recurrent group, and 8 cases (66.7%) in non-recurrent group, and no significant difference was seen. No significant difference of expression of TGF-alpha was seen in 5 cases (100%) in recurrent group and in 11 cases (91.7%) in non-recurrent group. The expression of TGF-beta in stromal cells was significantly higher in non-recurrent group (80%) compared to recurrent group (100%) (p<0.05). In DNA analysis out of 18 cases, 4 cases (22.2%) were aneuploidy and 14 cases (77.8%) were diploidy. Among 4 aneuploidy cases, 3 cases (75%) had no recurrence, and 1 case (25%) had metastasis to lung and expired. No significant difference of DNA ploidy pattern was seen between the recurrent and non-recurrent group. CONCLUSION: Presence of more than 10 mitotic figures in 10 high power fields and less expression of TGF-beta are related to higher possibility of recurrence and it is suggested that the number of mitotic figure (more than 10/10HPF) and expression of TGF-beta could be helpful parameters in predicting recurrence of GCT.
Aneuploidy
;
Carcinogenesis
;
Diploidy
;
DNA*
;
Giant Cell Tumor of Bone*
;
Giant Cell Tumors*
;
Giant Cells*
;
Hemorrhage
;
Lung
;
Necrosis
;
Negative Staining
;
Neoplasm Metastasis
;
Oncogenes
;
Ploidies
;
Prevalence
;
Prognosis
;
Proliferating Cell Nuclear Antigen*
;
Recurrence
;
Stromal Cells
;
Transforming Growth Factor alpha
;
Transforming Growth Factor beta
;
Transforming Growth Factors*
5.Enzooticity of the dogs, the reservoir host of Thelazia callipaeda, in Korea.
Min SEO ; Jae Ran YU ; Hyun Young PARK ; Sun HUH ; Sang Kun KIM ; Sung Tae HONG
The Korean Journal of Parasitology 2002;40(2):101-103
The reservoir hosts of Thelazia callipaeda were examined. The eyes of the 76 dogs raised at farm, 78 military dogs (shepherds), 96 cattle, and 105 pigs were investigated for the presence of eyeworm. Among them, six worms of T. callipaeda were collected from two dogs raised at farm (2.7%), and 188 worms from 26 shepherds (33.5%). No worms were recovered from the cattle or pigs. These results suggest that the dogs, especially the military dogs are serving as a reservoir host of T. callipaeda. in Korea.
Animals
;
Cattle
;
Disease Reservoirs/*veterinary
;
Dog Diseases/epidemiology/*parasitology
;
Dogs
;
Eye/parasitology
;
Female
;
*Host-Parasite Interactions
;
Korea/epidemiology
;
Male
;
Prevalence
;
Spirurida Infections/epidemiology/parasitology/*veterinary
;
Swine
;
Thelazioidea/*isolation & purification
6.Primary squamous cell carcinoma of the liver.
Hee Duck KIM ; Sung Do LEE ; Jae Kwan SEO ; Man Ha HUH
Journal of the Korean Surgical Society 1992;42(5):709-716
No abstract available.
Carcinoma, Squamous Cell*
;
Liver*
7.A study on the applicability of polymer(polyglactin)for the artificial dermis.
Sung Pyo HONG ; Jae Kyung PARK ; Seung Ho HUH ; Hong Seok KIM
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1998;25(4):547-556
The result of artificial skins made with collagen is poor after grafting over the full thickness wounds due to their rapid degradation by enzymatic cleavage. This study is an in vivo study of an artificial skin made with a biodegradable polymer, which can better address the problem of the collagenous artificial dermis. To investigate the availability of a biodegradable polymer for an artificial dermis and to get an information about the optimal degradation rate of a polymer for an artificial dermis, we made an artificial dermis by seeding of fibroblasts within the vicryl mesh and made a bilayer artificial skin by covering the artificial dermis with cultured keratinocytes. And these artificial dermis and artificial skin were evaluated in a full thickness wound model. The results are as followings: 1. The artificial dermis was available for grafting for 1 week culture of vicryl mesh-fibroblast. 2. The artificial dermis retarded the contraction of full thickness wounds. 3. The artificial dermis generated the granulation tissue and accepted the STSG completely. 4. The generated tissue from the artificial dermis had incorporated into the surrounding tissue by 4 weeks postgrafting. 5. Vicryl in the artificial dermis became to biodegrade from the culture period and absorbed completely by 5 weeks. 6. The epidermal portion was poorly differntiated during in vitro culture period. In conclusion, the polymer-fibroblast graft can retard the wound contraction and generate a new tissue permitting a useful dermal replacement. And to get more optimal results, another polymer which has slower biodegradation rate than vicryl should be used for the artificial dermis and the epidermal portion should be differentiated after in vivo grafting.
Collagen
;
Dermis*
;
Fibroblasts
;
Granulation Tissue
;
Keratinocytes
;
Polyglactin 910
;
Polymers
;
Skin, Artificial
;
Transplants
;
Wounds and Injuries
8.Clinical study on acute pylonephritis during pregnancy and puerperium.
Hae Sung CHO ; Seun Kyung LEE ; Chu Yeop HUH ; Byung Hee SUH ; Jae Hyun LEE
Korean Journal of Perinatology 1991;2(1):48-57
No abstract available.
Postpartum Period*
;
Pregnancy*
9.Enhancement of Short-Term Memory by Methyl-6-(Phenylethynyl)-Pyridine in the BTBR T+tf/J Mouse Model of Autism Spectrum Disorder.
Haijie YANG ; Sung Oh HUH ; Jae Seung HONG
Endocrinology and Metabolism 2015;30(1):98-104
BACKGROUND: Autism spectrum disorder (ASD) encompasses a range of disorders that are characterized by social and communication deficits and repetitive behaviors. This study evaluated the effect of methyl-6-(phenylethynyl)-pyridine (MPEP), an antagonist of the mGluR5 metabotropic glutamate receptor, on memory enhancement in the BTBR T+tf/J (BTBR) mouse strain, which has been recognized as a model of ASD. METHODS: The pharmacological effects of MPEP on memory and motor coordination were assessed using the Morris water maze and rotarod tests in BTBR and C57BL/6J (B6) mice. Furthermore, we performed morphological analyses of cerebellar foliation in BTBR and B6 mice using hematoxylin and eosin staining. RESULTS: MPEP-treated BTBR mice exhibited improved learning and memory in the Morris water maze test. MPEP administration also improved motor coordination in the rotarod test. However, no significant difference was observed regarding the numbers of Purkinje cells in the cerebella of BTBR versus normal B6 mice. CONCLUSION: This study suggests that the mGluR5 antagonist MPEP has the potential to ameliorate learning and memory dysfunction and impaired motor coordination in BTBR mice. These results further suggest that the BTBR mouse model may be useful in pharmacological studies investigating drugs that could potentially alleviate cognitive dysfunction in ASD.
Animals
;
Child
;
Autism Spectrum Disorder*
;
Eosine Yellowish-(YS)
;
Hematoxylin
;
Learning
;
Maze Learning
;
Memory
;
Memory, Short-Term*
;
Mice*
;
Purkinje Cells
;
Receptors, Metabotropic Glutamate
;
Rotarod Performance Test
10.Clinical analysis of Paget's disease of the breast.
Joon Young HUH ; Kyung Hyun CHOI ; Sung Do LEE ; Jae Kwan SEO
Journal of the Korean Cancer Association 1992;24(4):612-617
No abstract available.
Paget's Disease, Mammary*