1.An Unusual Case of Transepidermal Elimination of Calcinosis Cutis.
Annals of Dermatology 1989;1(2):80-82
A 45 year-old Korean woman presented with multiple pruritic umbilicated papules on both ankles of 3 months duration. Histopathologic findings showed calcium deposits in the upper dermis and the transepidermal elimination of calcium. This is a very rare presentation of calcinosis cutis.
Ankle
;
Calcinosis*
;
Calcium
;
Dermis
;
Female
;
Humans
2.Perforating Folliculitis in Association with Hemodialysis.
Korean Journal of Dermatology 1988;26(5):774-778
A 37-year-old man was diagnosed as having chronic renal failure received hemodialysis, Five months after starting hemodialysis developed rice to pea sized erythematous follicular papvles on the posterior neck and trunk which was accompanied by mild pruritus. Histopathologically the lesion showed typical finding of perforating folliculitis and Pickers nodule like changes in the adjacent epidermis.
Adult
;
Epidermis
;
Folliculitis*
;
Humans
;
Kidney Failure, Chronic
;
Neck
;
Peas
;
Pruritus
;
Renal Dialysis*
3.Differentiation Related Gene (Drg-1) as a Molecular Marker during the Treatment of in vitro Intermittent Androgen Deprivation in prostate Cancer.
Il Mo KANG ; Kwang Sung AHN ; Han Yong CHOI
Korean Journal of Urology 2001;42(1):51-58
PURPOSE: recent studies have reported that the expression of Drg-1 is up-regulated by androgen. It has been suggested that Drg-1 gene be used as a molecular marker for prostate cancer therapies like PSA. To de termine the role of Drg-1 gene as a molecular marker during intermittent androgen deprivation(IAD) therapy, we investigated the expression of Drg-1 and compared it with PSA expression in human prostate cancer cell lines treated with dihydrotestosterone (DHT) continuously or intermittently. MATERIALS AND METHODS: Two prostate cancer cells having different status of androgen receptor [LNCaP (androgen dependent) and PC-3 (androgen independent)] were used in this study. To know the change in PSA and Drg-1 expression after DHT treatment the cells were cultured in steroid-free RPMI media for 24 hours. 10(-7) and 10(-8)M of DHT and 10(-7)M bicalutimide was added into the cells and then cultured for 72 hours. And we established in vitro IAD model using LNCaP cells. Northern analyses were performed to determine the expression level of both PSA and Drg-1genes. Also, western analyses were performed to determine the protein level of proliferating cellular nuclear antigen and androgen receptor. RESULTS: Transcripts of Drg-1 were detected in both LNCaP and PC-3 cells but PSA was not expressed in PC-3 cells. The expression of Drg-1gene in LNCaP cells was up-regulated by 10(-8)M of DHT like PSA gene and down-regulated by 10(-7)M bicalutamide. In the treatment of intermittent androgen deprivation, the expression pattern of Drg-1was similar to that of PSA. However, up-regulation of PSA was detected earlier than of Drg-1. CONCLUSIONS: Based on observation, Drg-1 was up-regulated by androgen and down-regulated by anti-androgen. This suggests that Drg-1gene is useful for determining the androgen independency of prostate cancer during IAD.
Cell Line
;
Dihydrotestosterone
;
Humans
;
Prostate*
;
Prostatic Neoplasms*
;
Receptors, Androgen
;
Up-Regulation
4.Comparison of Two-Dimensional Doppler Echocardiography and Fick Method with Cardiac Catheterization of Qp, Qs and Qp/Qs Ratio in Ventricular Septal Defect in Children.
Sung Ho CHA ; Chang Il AHN ; Jong Hoa BAE
Korean Circulation Journal 1987;17(1):103-112
This study was performed to compare the amount of blood flow from left and right side heart using Doppler echocardiography and Fick method. The pulmonary blood flow (Qp), aortic blood flow (Qs) and Qp/Qs ratio were noninvasively evaluated by two dimensional Doppler echocardiography in 10 patients with ventricular septal defect in children, aged 2 years to 15 years (mean+/-SD=7.1+/-4.9 years). Cardiac catheterization was performed within 2 days after examination of Doppler echocardiography in all patients. Systemic and pulmonary blood flow was calculated by using Fick principle, based on measured oxygen consumption and measured blood oxygen saturation. The Doppler frequency shift was analyzed by computer system combined with Meridian Echocardiography System. Comparison of Qp, Qs and Qp/Qs ratio obtained by invasive methods and by two-dimensional pulsed wave Doppler echocardiography showed a correlation of 0.679 in Qp, 0.710 in Qs and 0.639 in Qp/Qs ratio (p<0.05).
Cardiac Catheterization*
;
Cardiac Catheters*
;
Child*
;
Computer Systems
;
Echocardiography
;
Echocardiography, Doppler*
;
Heart
;
Heart Septal Defects, Ventricular*
;
Humans
;
Oxygen
;
Oxygen Consumption
5.Clinical Observation of Rheumatic Fever and Rheumatic Heart Disease in Children.
Soon Don HONG ; Sung Ho CHA ; Chang Il AHN
Journal of the Korean Pediatric Society 1986;29(6):14-21
No abstract available.
Child*
;
Humans
;
Rheumatic Fever*
;
Rheumatic Heart Disease*
6.A Study on the Intertrochanteric Fracture
Se Il SUK ; Jea Whan AHN ; Sung Kee KIM
The Journal of the Korean Orthopaedic Association 1976;11(2):180-186
As trochanteric fractures frequently occur in the elderly patients and complications such as pneumonia, thrombo-embolic disease, decubitus ulcer, and urinary tract infection are common, early mobilization after open reduction and internal fixation with hip nail are the standard treatment. Since 1931 when Smith-Peterson first introduced a tri-flanged nail, further more, since 1941 when Jewett pioneered the one-piece nail by adding a solid plate to a Smith-Peterson nail, numorous implants including threaded pins, screws, nails, and plates have been modified and desiged for fractured hips till now to achieve early ambulation and to maintain stable reduction. In 1955 Pugh and Ken introduced a sliding nail-plate and Schumpelick described the use of sliding screw-plate, which was modified further by Callender and Holt pioneered the concept of heavy nail in 1963. Recently compression sliding screw-plate is popular. Also many surgeons such as Evans, Dimon and Hughston, Sarmiento, and Boyd and Anderson have attempted to provide stable fixation of fracture by altering the position of fracture fragments to improve the mechanical resistances of bone to disruptive forces of weight-bearing. The surgical procedures of open reduction and internal fixation were carried out and followed for more than 6 months on 45 intertrochanteric fractures at Department of Orthopedic Surgery, Seoul National University Hospital, from Jan. 1968 to June. 1975 and the results were observed as follows. 1. Of 45 cases of inter-trochanteric fractures 28 cases occurred in man, 17 cases in woman and each mean age was 54 years in man, 74 years in woman. 2. Of fixation devices, Smith-Peterson nail-plates were used in 19 cases, Jewett nails in 15 cases, compression sliding screw-plates in 9 cases, Smith-Peterson nail in 1 case, and Ken sliding nail-plate in 1 case. 3. Stable fractures occurred in 10 cases were fixed internaly after anatomical reduction. 4. Dimon-Hughston reductions and Jewett Nailing were achieved in 11 cases of 12 unstabIe fractures and had disadvantages such as some limitation of R.O.M. of the affected hip, shortening, and valgus deformity. 5. Of 9 unstable fractures treated by compression sliding screw-plate 7 cases were reduced as anatomicaly as possible and 2 cases were reduced non-anatomicaly because of impossible anatomical reduction but good results were obtained except one failed nailing. 6. Of 7 failures, 6 cases resuIted from failures of nailing during operation and only 1 failure resulted in varus defermity after Dimen-Hughston reduction with Jewett nail.
Aged
;
Congenital Abnormalities
;
Early Ambulation
;
Female
;
Hip
;
Hip Fractures
;
Humans
;
Orthopedics
;
Pneumonia
;
Pressure Ulcer
;
Seoul
;
Surgeons
;
Urinary Tract Infections
;
Weight-Bearing
7.Follow
Bong Kun KIM ; Yong Sung AHN ; Il Hyung CHO
The Journal of the Korean Orthopaedic Association 1984;19(4):649-658
From May, 1971 to June, 1984, we performed extensive saucerization on the chronic osteomyelitis of long bones eradicating all pathologic foci; not only sequestra but sclerotic involocurum and necrotic original cortex embeded by new bone, which was different from the conventional methods such as sequestrectomy or guttering in its extensiveness. Clinical analysis on the base of radiologic evaluation after saucerization was done on the 16 patients; for average 5 years of follow-up. The results obtained were as follows; 1. The angulatory deformity of the long bones after pathologic fracture complicated by the chronic osteomyelitis was not corrected satisfactorily due to the bony sclerosis or hyperostosis at the fracture site, especially in cases of posterior or medial angulation. 2. The recurrence was closely related to the persisting non-sequestered original cortical lesion after incomplete saucerization, which was embeded by the new bone. So to prevent the recurrence the non-sequestered original cortical lesion must be removed completely. 3. The cortical defect after saucerization was restored completely in patients under the age of 14, but which was not the way in patients over the age of 16.
Congenital Abnormalities
;
Follow-Up Studies
;
Fractures, Spontaneous
;
Humans
;
Hyperostosis
;
Osteomyelitis
;
Recurrence
;
Sclerosis
8.A case of seronegative enthesopathy and arthropathy syndrome (SEA syndrome).
Il Su KIM ; Jae Yoon KIM ; Byung Su CHO ; Sung Ho CHA ; Chang Il AHN
Journal of the Korean Pediatric Society 1992;35(10):1459-1462
No abstract available.
Rheumatic Diseases*
;
Spondylarthropathies
9.A Clinical Study of Kawasaki Disease Complicating Coronary Aneurysm.
Chong Sung CHUNG ; Byung Yul LIM ; Sung Ho CHA ; Yong Mook CHOI ; Chang Il AHN
Journal of the Korean Pediatric Society 1989;32(9):1240-1247
No abstract available.
Coronary Aneurysm*
;
Mucocutaneous Lymph Node Syndrome*
10.A Comparative Study of Therapeutic Effect of Intravenous Gammaglobulin plus Aspirin Versus Aspirin Alone in Kawasaki Syndrome.
Boung Yul LEEM ; Chong Sung CHUNG ; Sung Ho CHA ; Yong Mook CHOI ; Chang Il AHN
Journal of the Korean Pediatric Society 1989;32(10):1408-1415
No abstract available.
Aspirin*
;
Mucocutaneous Lymph Node Syndrome*