No abstract available.
Chromosome Aberrations* ; Oncogenes*

No abstract available.
Brain Injuries* ; Brain* ; Disability Evaluation* ; Humans ; Perfusion* ; Technetium Tc 99m Exametazime* ; Tomography, Emission-Computed, Single-Photon*

We have compared the computed tomographic(C. T.) findings with those of conventional roentgenogram(simple AP and lateral radiograms) in 18 cases of osteochondritis dissecans of the capitellum humeri available for review. Among the 18 cases, 2 cases of them had a lesion of osteochondritis dissecans on C. T. which, however, had not been found on conventional rentgenograms. Fro the 5 cases, which had not clearly found on conventional rentgenograms, 2 loose body on conventional view, 3 cases had different numbers and locations of loose body on C. T. films. On the bases of our findings, we recommend that C. T. is necessary in early detection and the determination of anatomical location and status of osteochondritis dissecans of capitellum.
Osteochondritis Dissecans ; Osteochondritis

No abstract available.
Debridement* ; Knee* ; Osteoarthritis*

PURPOSE: We evaluated restoration of range of motion(ROM) after manipulation under intravenous anesthesia in patients whose maximum flexion was less than 90 degrees at 2 weeks after total knee arthroplasty(TKA). MATERIALS AND METHODS: 136 knees of 108 patients who received TKA between January 1996 and December 2000 and followed up for more than 2 years were analyzed. The forceful manipulation underwent for 16 knees because whose maximum flexion was less than 90 degrees after 2 weeks of TKA. Manipulation were done for 12 of 16 cases at 2 weeks after TKA and 4 cases after more than 3 months. RESULTS: 12 knees which were manipulated 2 weeks after TKA had a mean flexion 103+/-10.2 degrees , 111+/-9.6 degrees and 116+/-11.4 degrees at immediate post-operation, 3 months and 2 years after TKA. In 4 knees manipulated more than 3 months after TKA, a mean flexion was 100+/-10.4 degrees , 102+/-11.5 degrees and 96+/-11.4 degrees at immediate post-operation, 3 months after manipulation and 2 years after TKA. 120 knees with no manipulation had a mean flexion 115+/-13.7 degrees at last follow-up. There was no difference of a mean flexion at last follow-up between group manipulation within 2weeks after TKA and group with no manipulation. CONCLUSION: Manipulation under intravenous anesthesia performed 2 weeks after TKA if patients had less than 90 degrees of flexion increased flexion of the operated knee without any serious complication.
Anesthesia, Intravenous ; Arthroplasty* ; Follow-Up Studies ; Humans ; Knee*

Plasma renin activity (ORA) was determined by radioimmunoassay in 55 normal controls and 121 hypertensive patients in basal state and after double stimulation with furosemide administration and upright posture of 4 hrs. The results were obtained as follows, 1) Mean value of PRA of normal control was 2.2+/-1.41ng/ml/hr in basal state and 2.9+/-1.39ng/ml/hr after double stimulation, respectively. The latter was elevated significantly as compaired to the former. 2) PRA in males was significantly higher than in females, and PRA tend to be decreased as age become old. 3) Normal value of PRA after double stimulation was ranged from 1.0 to 5.0 ng/ml/hr. Of total 121 hypertensive patients(55 males and 66 females), PRA was low in 33 cases(27.3%), normal in 77 cases (63.6%), and high in 11 cases(9.1%). 4) Of 55 male hypertensive patients, PRA was low in 13 cases(23.6%), normal in 35 cases (63.7%), and high in 7 cases(12.7%). Of 66 female hypertensive patients,, PRA was low in 20 cases (30.3%), normal in 42 cases(63.6%), and high in 4 cases(6.1%). High renin group was observed more frequently in male hypertensive patients than in female hypertensive patients, while low renin group more frequently in famale than in male patients. 5) Low renin group was observed more frequently in older age group than in younger age group, while high renin group more frequently in younger age than in older age group.
Female ; Furosemide ; Humans ; Hypertension* ; Korea* ; Male ; Plasma* ; Posture ; Radioimmunoassay ; Reference Values ; Renin*

This is a cross-sectional observational study undertaken to explore the current prescription pattern of non-steroidal anti-inflammatory drugs (NSAIDs) and the prevalence of NSAID-induced gastrointestinal (GI) risk factors of orthopaedic patients in real clinical practice in Korea. Study cohort included 3,140 orthopaedic outpatients at 131 hospitals and clinics between January 2008 and August 2008. A self-administered questionnaire was completed by each patient and physician. A simplified risk scoring scale (the Standardized Calculator of Risk for Events; SCORE) was used to measure patients' risk for GI complications. The pattern of NSAIDs prescription was identified from medical recordings. Forty-five percents of the patients belonged to high risk or very high risk groups for GI complications. The cyclooxygenase-2 enzyme (COX-2) selective NSAID showed a propensity to be prescribed more commonly for high/very high GI risk groups, but the rate was still as low as 51%. In conclusion, physician's considerate prescription of NSAIDs with well-understanding of each patient's GI risk factors is strongly encouraged in order to maximize cost effectiveness and to prevent serious GI complications in Korea. Other strategic efforts such as medical association-led education programs and application of Korean electronic SCORE system to hospital order communication system (OCS) should also be accompanied in a way to promote physician's attention.
Adult ; Aged ; Aged, 80 and over ; Anti-Inflammatory Agents, Non-Steroidal/*adverse effects ; Cohort Studies ; Cross-Sectional Studies ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2 Inhibitors/adverse effects ; Drug Prescriptions ; Female ; Gastrointestinal Diseases/chemically induced/complications/*epidemiology ; Humans ; Male ; Middle Aged ; Musculoskeletal Diseases/complications/*drug therapy ; Prevalence ; Questionnaires ; Republic of Korea ; Risk Factors

BACKGROUND AND OBJECTIVES: Psychological distress may develop from tinnitus, or that recognition of tinnitus may even be greater during exposure to environmental stress. So, patients with tinnitus need to consider the psychologic aspect in their diagnosis and treatment. The aim of this study is to evaluate the degree and characteristics of the psychologic factors associated in patients undergoing tinnitus retraining therapy. MATERIALS AND METHOD: 119 patients with tinnitus who received the Symptom Check List-90-Revision (SCL-90-R) and a control group without tinnitus were compared first; and then 92 out of 119 patients performed the follow up study after three months of tinnitus retraining therapy. RESULTS: The results were as follows. 1. The tinnitus group scored higher than the control group in somatization, anxiety, phobic anxiety (p<0.05). 2. The gender difference, age, duration, position, hearing, and Feldmann masking curve of tinnitus were not related to the psychologic status of patients with tinnitus (p>0.05). 3. The psychologic aspect of patients with tinnitus were related to loudness, pitch, annoyance (p<0.05). 4. The follow-up study of 3 months on patients who underwent tinnitus retraining therapy showed diminished score in all components of SCL-90-R, except phobic anxiety, and paranoid (p<0.05). CONCLUSION: This study indicated that the compliant behaviour of tinnitus is related closely with intrinsic psychodynamic mechanism.
Anxiety ; Diagnosis ; Follow-Up Studies ; Hearing ; Humans ; Masks ; Psychology ; Surveys and Questionnaires ; Tinnitus*

BACKGROUND AND OBJECTIVES: It has been recognized that salicylate induces ototoxicity in animals and humans. Many studies have been done to identify the mechanisms of ototoxicity of salicylate with histopathological, biochemical and electrophysiological methods. Among these methods, the electrophysiological method is useful for clinical diagnosis and evaluation of therapeutic effect. The studies reported here were aimed at performing electrophysiological effects of salicylate by using Auditory Brainstem Response (ABR) and Electrocochleography (EcoG) through non-invasive approach. MATERIAL AND METHODS: Auditory brainstem response and electrocochleogram were observed by non-invasive approaching method after the intraperitoneal injection of 450 mg/kg of lysine salicylate on 10 ears of 5 guinea pigs. RESULTS: The threshold shifting of ABR and ECoG were less than 10 dB. The latency of ABR waves and Summating Potential were increased after salicylate was administered especially at low intensity sound stimulation. CONCLUSION: The latency of ABR wave and SP would be useful in diagnosing ototoxicity and evaluating the therapeutic effect in ototoxic patients.
Animals ; Audiometry, Evoked Response ; Diagnosis ; Ear ; Evoked Potentials, Auditory, Brain Stem ; Guinea Pigs* ; Guinea* ; Humans ; Injections, Intraperitoneal ; Lysine

PURPOSE: This study evaluated the minimum 3 year follow-up results of cementless bipolar hemiarthroplasty in elderly patients more than 80 years of age with a femoral neck fracture. MATERIALS AND METHODS: 57 cementless bipolar hemiarthroplasties for femoral neck fractures were performed in elderly patients more than 80 years of age between January 1996 and December 2000. The clinical, radiological results and bone mineral density of 38 hips in 35 patients who could be followed up for at least 3 years were analyzed. The mean age of the patients was 82.5 years (80 to 100 years). 29 patients were women and 6 were men. For all cases, an identical prosthesis (VerSys(R) fiber metal midcoat collarless stem, Zimmer, Warsaw, Indiana, USA) was implanted. RESULTS: The average follow-up period was 41 months (36 to 62 months). The average Harris Hip Score was 76.4+/-14.1 points at the time of the most recent follow-up. An excellent score (90-100 points) was recorded in 2 hips (5%), good (80-89 points) in 10 hips (26%), fair (70-79 points) in 21 hips (55%) and poor (60-69) in 5 hips (13%). The radiological assessment showed that all stems were biological stable, with 20 stems (53%) showing bony ingrowth and 18 stems (47%) having stable fibrous fixation. No cup migration, osteolysis, vertical subsidence, pedestal reaction and varus deposition of the stem etc. were observed. The mean T value of the bone mineral density (BMD) was -3.75+/-0.75 and was not related to the clinical and radiological results. CONCLUSION: Cementless bipolar hemiarthroplasty for elderly patients more than 80 years of age with a femoral neck fracture showed satisfactory short-term results with no relationship to the severity of osteoporosis.
Aged ; Bone Density ; Female ; Femoral Neck Fractures* ; Femur Neck* ; Follow-Up Studies ; Hemiarthroplasty* ; Hip ; Humans ; Indiana ; Male ; Osteolysis ; Osteoporosis ; Prostheses and Implants