1.Comparison of the E-test with agar dilution susceptibility test by using bacteroides fragilis.
Hee Sun KIM ; Sung Kwang KIM ; Hwa Sun CHA
Yeungnam University Journal of Medicine 1993;10(1):135-143
The susceptibilities of 45 clinical isolates of bacteroidis fragilis to cefaclor, ciproflxacin and imipenem were determined by new method, E-test (AB Bidisk, Solna, Sweden) and were compared with those from conventional agar dilution method by using brain heart infusion, Mueller-Hinton and Wilk:..s Chalgren agar plates. And the susceptibility of 60 clinical isolates of bacteroides fragilis group (B. fragilis 45 strains, B. distasonis 6 strains, B. ovatus 5 strains, B. thetaiotaomicron 4 strains) to 5 quinolones (ciprofloxacin, enoxacin, norfloxacin, ofloxacin, pefloxacin) were determined by in vitro agar dilution method. Compared with agar dilution MICs for B. fragilis 45 strains, 90.3% of E-test MICs were within +/- 1 dilution of the agar dilutions, and 98.4% were within 2 dilutions. And there were little effect of different medium bases to determine MICs except Mueller-Hinton agar. On Mueller-Hinton agar, B. fragilis showed have or no growth activity. In vitro susceptibility of B. fragilis group to quinolones, most of the test strains showed resistant patterns to quinolones except ofloxacin and there was little difference of susceptibility patterns between species of B. fragilis group.
Agar*
;
Bacteroides fragilis*
;
Bacteroides*
;
Brain
;
Cefaclor
;
Enoxacin
;
Heart
;
Imipenem
;
Norfloxacin
;
Ofloxacin
;
Quinolones
2.Correlation between Chromosome Abnormalities and Genomic Imprinting in Developing Human 2) Independent Expression of Imprinted Genes, H19 and Insulin-like growth factor II (IGF2), in Androgenetic Hydatidiform Moles.
Sung Ik CHANG ; Bo Hwa CHOI ; Tae Sung LEE ; Dae Kwang KIM ; In Hwan LEE
Korean Journal of Anatomy 1998;31(4):611-617
Human uniparental gestations such as androgenetic hydatidiform moles provide a model to evaluate the integrity of parent-specific gene expression,-i.e, genomic imprinting,- in the absence of a complementary parental genetic contribution. Several imprinted genes are characterized so far including the insulin-like growth factor-2 gene (IGF2) coding for a fetal growth factor and the Hl9 gene whose normal function is unknown but which is likely to act as an untranslated mRNA for its tumor-suppressing function. IGF2 is expressed exclusively from the paternal allele while Hl9 from the maternal allele. Such an alternate expression is quite interesting because both Hl9 and IGF2 genes are located close to each other on chromosome 11p15.5. An in situ hybridization analysis has shown strong expression of Hl9 and IGF2 alleles in nine hydatidiform moles. Especially, a prominent expression of Hl9 and IGF2 was detected in cytotrophoblast and the cellular localization was almost paralleled in Hl9 and IGF2 transcripts . Hl9 and IGF2 genes could be expressed either biallelically or monoallelically in the moles. However, IGF2 biallelic expression did not affect allele-specificity of Hl9 expression.. These results suggest that both H19 and IGF2 transcripts are expressed in the same cells and that the functional imprinting of H19 and IGF2 genes in hydatidiform moles can be controlled individually and independently of each other.
Alleles
;
Chromosome Aberrations*
;
Clinical Coding
;
Female
;
Fetal Development
;
Genomic Imprinting*
;
Humans*
;
Hydatidiform Mole*
;
In Situ Hybridization
;
Insulin-Like Growth Factor II*
;
Parents
;
Pregnancy
;
RNA, Messenger
;
Trophoblasts
3.A Case of Corrosive Gastritis Caused by Hydrochloric Acid.
Hyung Gil KIM ; Kwang Hyub HAN ; Sang In LEE ; Heung Jai CHOI ; Sung Hoon NOH ; Kwang Hwa PARK ; Yoo Bock LEE
Korean Journal of Gastrointestinal Endoscopy 1988;8(1):19-23
Recently the use of hydrochloric acid as a toilet disinfectant has become more common, and the risk of its ingestion is though to be increasing. We experienced a case of 67 year-old man who accidentally ingested hydrochloric acid and as a result developed a postprandial epigastric fullness end pain 3 weeks thereafter, The patient underwent an UGI series, fiberoptic gastroscope and abdominal ultrasonography and was found to have a gastric midbody stricture. A total gastreetomy and Roux-en- Y esophagojejunostomy was performed. We report this case with brief review of the literature.
Aged
;
Constriction, Pathologic
;
Eating
;
Gastritis*
;
Gastroscopes
;
Humans
;
Hydrochloric Acid*
;
Ultrasonography
4.A case of Endobronchial Metastatic Malignant Melanoma.
Sang Hee KIM ; Young Kyoo SHIN ; Kwang Chul LEE ; Chang Sung SON ; Pyung Hwa CHOE
Journal of the Korean Pediatric Society 1990;33(4):573-578
No abstract available.
Melanoma*
5.A Case of Toxic Epidermal Necrolysis.
Eun Hwa SHIN ; Youn Hong CHOI ; Ju Hong CHA ; Kwang Jun KI ; Kyung Je SUNG
Journal of the Korean Pediatric Society 1988;31(8):1079-1084
No abstract available.
Stevens-Johnson Syndrome*
6.Case of Follicular Bronchiolitis in Rheumatoid Arthritis.
Jong Hwa LEE ; MyungWoo CHOI ; Sung Sik OH ; Mi Rim CHOI ; Hyun Ju YANG ; Kwang Min LEE ; Kyoung Hwa CHOI
Journal of Rheumatic Diseases 2016;23(6):392-395
Follicular bronchiolitis is an uncommon bronchiolar disorder that is characterized by the presence of hyperplastic lymphoid follicles with reactive germinal centers. The condition is associated with connective tissue diseases such as rheumatoid arthritis, Sjögren’s syndrome, and immunodeficiency disorders. A 56-year-old man with rheumatoid arthritis was admitted to hospital with a progressively enlarging pulmonary nodule in the left upper lobe. A follow-up contrast tomography scan showed that the nodule had increased in size from 4.2 mm to 6.3 mm over a 3 month period. An open lung biopsy was performed to establish a definite pathologic diagnosis of the pulmonary nodule, which was suspected to be a lung malignancy. The nodule was diagnosed as follicular bronchiolitis based on the histopathology findings. We describe a patient with follicular bronchiolitis that was confirmed by an open lung biopsy, and is believed to have had rheumatoid involvement.
Arthritis, Rheumatoid*
;
Biopsy
;
Bronchiolitis*
;
Connective Tissue Diseases
;
Diagnosis
;
Follow-Up Studies
;
Germinal Center
;
Humans
;
Lung
;
Middle Aged
;
Solitary Pulmonary Nodule
7.A case of Distal Renal Tubular Acidosis.
Seong Gyoo PARK ; Gyung Min ANN ; Sang Hee PARK ; Kwang Chul LEE ; Chang Sung SON ; Pyung Hwa CHOI
Journal of the Korean Pediatric Society 1990;33(4):539-543
No abstract available.
Acidosis, Renal Tubular*
8.The Effects of a Small dose of Scopolamine on the Heart Rate in the Halothane Anesthetized and Comstose Patient.
Hwa Young MOON ; Woong Mo IM ; Sung Su JUNG
Korean Journal of Anesthesiology 1985;18(2):145-149
It is well known that small dose of belladonna alkaloid(atropine, scopolarnine) has the effect of decreasing the heart rate in normal conscious subjects, but the mechanism involved in it remains still unanswered. Based on various lines of evidence, the most likely mechanism seems to be the blockade of sympathetic ganglion caused by the alkaloids and it is possible that the effect on the slower heart rate may differ in the depressed state of the sympathetic ganglion when under halothane anesthesia. The present study was undertaken, therefore, on comatose patients and halothane anesthetized patients with and without atropine premedication about 1 hour before anesthesia to observe the effect of a small dose of scopolamine(0.1 mg) which affects the heart rate more significantly than atropine in conscious subjects. The results were as follows: 1) In the comatose patients, scopolamine(0.1 mg) produced a significant decrease in heart rate. 2) During halothane anesthesia without atropine premedication, scopolamine produced a slight decrease in heart rate. 3) During halothane anesthesia with atropine premedication, scopolamine produced a significant increase in the heart rate. These results indicate that scopolamine can further affect the sympathetic ganglion already depressed by halothane, and it is suggested that scopolamine is more effective in blocking the sympathetic ganglion than halothane.
Alkaloids
;
Anesthesia
;
Atropa belladonna
;
Atropine
;
Coma
;
Ganglia, Sympathetic
;
Halothane*
;
Heart Rate*
;
Heart*
;
Humans
;
Premedication
;
Scopolamine Hydrobromide*
9.Effect of Liver Transplantation in Children with Fulminant Hepatitis .
Young Mee SEO ; Bo Hwa CHOI ; Kyung Mo KIM ; Kwang Min PARK ; Young Joo LEE ; Sung Gyu LEE
Journal of the Korean Pediatric Society 2000;43(4):535-542
PURPOSE: Liver transplantation (LT) is regarded as an important management option for fulminant hepatitis (FH), which is associated with considerable mortality under conservative management. The aim of this study was to evaluate the outcome of children with FH according to management. METHODS: We reviewed medical records of patients presented with FH from January 1994 until April 1999. The children were grouped according to the treatment. Group A was classified for supportive treatment only and group B for supportive treatment plus LT. Children were considered as candidates for LT if the level of factor V decreased to below 20% of normal or the patient's condition deteriorated despite intensive care during the initial 48 hours. Underlying disease, duration after jaundice, grade of encephalopathy, laboratory findings, treatment and outcomes were analyzed. RESULTS: The study group comprised 7 females and 8 males aged from 8 months to 15 years old (median age of 4 years). The causes of FH were Wilson disease (4 cases), Epstein-Barr virus infection (1 case), drug (1 case) and idiopathic (9 cases). There were 5 children in group A and 10 in group B, and there were no significant differences in age, sex ratio, underlying diseases, grade of hepatic encephalopathy and laboratory findings between the two groups. One out of 5 in group A and 9 out of 10 in group B survived. But all the children in group A who met the criteria for LT and received only supportive care died. One out of 10 in group B died because of grade IVa hepatic encephalopathy which advanced to brainstem herniation. CONCLUSION: This study showed that patients who were managed with supportive care only, although LT was indicated, died and that 9 out of 10 who received LT survived. Therefore, we suggest LT should be considered in the management of FH.
Adolescent
;
Brain Stem
;
Child*
;
Factor V
;
Female
;
Hepatic Encephalopathy
;
Hepatitis*
;
Hepatolenticular Degeneration
;
Herpesvirus 4, Human
;
Humans
;
Critical Care
;
Jaundice
;
Liver Transplantation*
;
Liver*
;
Male
;
Medical Records
;
Mortality
;
Sex Ratio
10.A Case of Methylmalonic Acidemia.
Jong Hoon PARK ; Si Houn HAHN ; Kee Hwan YOO ; Kwang Chul LEE ; Chang Sung SOHN ; Pyung Hwa CHOE
Journal of the Korean Pediatric Society 1989;32(7):984-989
No abstract available.