1.Clinicopathologic Analysis of the Liver Explant with Severe Hepatitis A Virus Infection.
Joo Young KIM ; Sung Gyu LEE ; Shin HWANG ; Ji Hoon KIM ; Se Jin JANG ; Eunsil YU
Korean Journal of Pathology 2011;45(Suppl 1):S48-S52
The incidence of severe hepatitis A virus (HAV) infection has been increasing. However, clinicopathologic features of severe HAV infection that lead to liver transplantation (LT) have not been reported in Korea. We retrieved 16 LT cases with HAV infection during the last 3 years at Asan Medical Center, Seoul, Korea. Fifteen cases progressed to hepatic encephalopathy. Thirteen cases survived with or without complications, and three patients died of sepsis. The explanted liver showed massive or zonal necrosis with moderate to severe cholestasis. The zonal distribution of necrosis was frequently associated with endothelialitis of portal and/or central veins. Degenerative changes of hepatocytes were various in degree and distribution. Viral inclusions were suspected in two cases. Although HAV infection is usually confirmed by serological tests, significant venulitis of central and/or portal veins and viral inclusions, which are rarely observed, can suggest an HAV infection as a cause of massive hepatic necrosis of unknown mechanism.
Cholestasis
;
Fluconazole
;
Hepatic Encephalopathy
;
Hepatitis
;
Hepatitis A
;
Hepatitis A virus
;
Hepatocytes
;
Humans
;
Incidence
;
Korea
;
Liver
;
Liver Transplantation
;
Massive Hepatic Necrosis
;
Necrosis
;
Portal Vein
;
Sepsis
;
Serologic Tests
;
Veins
2.Activity of quinolones and virulence to isolated aerobic bacteria from the intraabdominal abscess.
Chan Hoon YU ; Hee Sun KIM ; Tai Il JEON ; Sung Kwang KIM
Journal of the Korean Society for Microbiology 1991;26(3):233-240
No abstract available.
Abscess*
;
Bacteria, Aerobic*
;
Quinolones*
;
Virulence*
3.Management of Gestational Diabetes Mellitus.
Hanyang Medical Reviews 2017;37(1):30-33
Gestational diabetes mellitus (GDM) is a frequent medical problem during pregnancy. It is associated with an increased risk of complications for GDM mother and the offspring. There is increasing evidence that GDM may increase the risk of future type 2 diabetes and cardiovascular disease in mothers, and may also increase the risk of obesity and diabetes in children. Therefore GDM affects health for a lifetime. The International Association of Diabetes and Pregnancy Study Groups (IADPSG) proposed a new screening approach for pre-diagnosed diabetes at the first prenatal visit and diagnostic criteria for GDM in accordance with perinatal outcomes. Nonetheless, controversies still exist about these issues. There is a positive linear association between increasing maternal glucose at oral glucose tolerance testing and risk of important perinatal outcomes. In managing the GDM patients, an individualized medical approach is essential. If maternal glucose levels have increased, insulin can be used to achieve glycemic targets. Postpartum screening for diagnosing of diabetes is essential for women with previous GDM.
Cardiovascular Diseases
;
Child
;
Diabetes, Gestational*
;
Diagnosis
;
Female
;
Glucose
;
Glucose Tolerance Test
;
Humans
;
Insulin
;
Mass Screening
;
Mothers
;
Obesity
;
Postpartum Period
;
Pregnancy
4.Screening tests in early detection of proximal deep venous thrombosis(DVT): prospective study.
Duk Yun CHO ; Jae Gon SEO ; Byung Yong YU ; Sung Churl LEE ; Tae Hoon KIM
The Journal of the Korean Orthopaedic Association 1992;27(5):1273-1283
No abstract available.
Mass Screening*
;
Prospective Studies*
5.Management of Cardiovascular Risk Factors in Elderly Diabetes Mellitus Patients
Journal of Korean Diabetes 2019;20(4):233-238
Tight control of dyslipidemia and hypertension in elderly diabetic patients aged 65 years or older are considered to be very important for the secondary prevention of cardiovascular disease and control of severe diseases associated with macrovascular complications. In addition, in elderly diabetes with risk factors for cardiovascular disease, it is important to control all of the accompanying risk factors together to accomplish the primary prevention of cardiovascular disease. In elderly diabetic patients, thorough control of blood glucose level by itself prevents macrovascular complications. However, it is recommended to perform tight blood glucose control along with other risk factors in consideration of the function and life of the patient. In particular, insulin resistance progresses before the onset of diabetes mellitus and other risk factors for cardiovascular disease. It is important to suppress and prevent the progression of macrovascular complications.
Aged
;
Blood Glucose
;
Cardiovascular Diseases
;
Diabetes Mellitus
;
Dyslipidemias
;
Humans
;
Hypertension
;
Insulin Resistance
;
Primary Prevention
;
Risk Factors
;
Secondary Prevention
6.Ketamine-induced generalized convulsive seizure during procedural sedation
Ji Hoon KIM ; Chong Kun LEE ; Sung Hoon YU ; Byung Duk MIN ; Chang Eun CHUNG ; Dong Chul KIM
Archives of Craniofacial Surgery 2021;22(2):119-121
Ketamine is used widely in emergency departments for a variety of purposes, including procedural sedation for facial laceration in pediatric patients. The major benefits are its rapid onset of effects, relatively short half-life, and lack of respiratory depression. The known side effects of ketamine are hallucinations, dizziness, nausea, and vomiting. Seizure is not a known side effect of ketamine in patients without a seizure history. Here, we present the case of a patient in whom ketamine likely induced a generalized tonic-clonic seizure when used as a single agent in procedural sedation for facial laceration repair. The aim of this article is to report a rare and unexpected side effect of ketamine used at the regular dose for procedural sedation. This novel case should be of interest to not only emergency physicians but also plastic surgeons.
7.Ketamine-induced generalized convulsive seizure during procedural sedation
Ji Hoon KIM ; Chong Kun LEE ; Sung Hoon YU ; Byung Duk MIN ; Chang Eun CHUNG ; Dong Chul KIM
Archives of Craniofacial Surgery 2021;22(2):119-121
Ketamine is used widely in emergency departments for a variety of purposes, including procedural sedation for facial laceration in pediatric patients. The major benefits are its rapid onset of effects, relatively short half-life, and lack of respiratory depression. The known side effects of ketamine are hallucinations, dizziness, nausea, and vomiting. Seizure is not a known side effect of ketamine in patients without a seizure history. Here, we present the case of a patient in whom ketamine likely induced a generalized tonic-clonic seizure when used as a single agent in procedural sedation for facial laceration repair. The aim of this article is to report a rare and unexpected side effect of ketamine used at the regular dose for procedural sedation. This novel case should be of interest to not only emergency physicians but also plastic surgeons.
8.Rhombus Subcutaneous Pedicle Skin Flap for Reconstruction of Linear Depressed Postburn Scar Band
Dong Chul KIM ; Ji Hoon KIM ; Sung Hoon YU ; Chi Ho SHIN ; Chong Kun LEE
Journal of Korean Burn Society 2020;23(1):25-29
This paper presents our clinical experiences for reconstruction of the linear depressed postburn scar band by rhombus subcutaneous pedicle skin flap (RSPF). We report new RSPF, it’s versatility, and effectiveness for correction of the mild to moderate linear depressed postburn scar band. To correct the postburn scar band, we have newly designed the Rhombus Subcutaneous Pedicle Skin Flap (RSPF), which is made as rhombus-shaped skin flap on the inside of scar band. After excision of burn scar band, the each vertex of RSPF flap is advanced into the skin defects at apex of extended skin incision, which is starting from the upper and lower portion of the removed burn scar band at a near right angle. This flap can add more extra skin to adjacent superior and inferior area of excised scar band. We have experienced 2 cases of RSPF for reconstruction of linear depressed postburn scar band deformities in lower extremity. After 3 weeks to 3 months postoperative follow ups, relatively satisfactory results were obtained in all cases. We had successfully reconstructed the linear depressed postburn scar postburn band of lower extremity using the rhombus subcutaneous pedicle skin flap. For the correction of mild to moderate sized linear depressed postburn scar band deformities in extremity, the RSPF is simple, and very effective without donor morbidity.
9.A Clinical Study on Recent Causing Agents of Chemical Burns
Chi Ho SHIN ; Sung Hoon YU ; Ji Hoon KIM ; Dong Chul KIM
Journal of Korean Burn Society 2020;23(1):7-12
Purpose:
Due to rapid changes in the industrial structure in last decade, the wider various types of chemical agents were introduced. Burn surgeons should be well-informed with rapid changes of chemical burns. We present the recent incidence trends of causing agents of chemical burns.
Methods:
From 2010 to 2019, 92 chemical burn victims were included in this study. A retrospective study was made about the type, distribution and incidence of the causing agents of chemical burns. Initial treatments of most chemical burn wounds are copious saline irrigation by tap water, except hydrofluoric acid burn cases managed by 10% calcium gluconate injection. In alkali chemical burns on extremity, if thin eschars appear in postburn 2∼3 days, acute early surgical escharectomy and split thickness skin graft were done.
Results:
More than 9 types of major chemicals causing chemical burns were surveyed, and the most common causing agent of chemical burns was Hydrofluoric acid (23.9%) followed by Acetic acid (19.6%) and Sodium hydroxide (8.7%).
Conclusion
From 2010 to 2019, changes in the causing agent of chemical burns are that the types of major causing agents of chemical burns have increased and the distribution and incidence of causing agents have changed compared to previous reports. According to this study, more than 9 types of major chemicals causing chemical burns were surveyed, and the most common causing agent of chemical burns was Hydrofluoric acid (23.9%) followed by Acetic acid, Sodium hydroxide.
10.A modified Atkin’s diet for an infant with pyruvate dehydrogenase complex deficiency confirmed by PDHA1 gene mutation
Jeong A Kim ; Rita Yu ; Wonha Jo ; Youn Hee Ko ; Jin-Sung Lee ; Heung Dong Kim ; Hoon-Chul Kang
Neurology Asia 2014;19(3):327-329
Pyruvate dehydrogenase complex deficiency (PDCD) is one of the most common neurodegenerative
disorders associated with abnormal mitochondrial metabolism. Pyruvate dehydrogenase complex
plays an important role in glucose metabolism and generation of energy from carbohydrates. Potential
therapies for PDCD, include thiamine and ketogenic diet (KD), have been used with varying degrees
of success. However, the KD is too restrictive, and its serious complications, particularly in early
age of neonate or infancy are important drawbacks. Recently, the modified Atkins diet (MAD) for
intractable epilepsy has provided balanced nutrients. The complications can be expected to be less
frequent and well controlled. In this report, we describe an infant with PDCD confirmed by PDHA1
gene mutation through high-throughput sequencing technique of whole exome sequencing, who failed
to continue the KD, but made good progress on MAD.