To observe the effect of serious illness, surgical trauma, body weight, and clofibrate on serum lipids, the serum levels of cholesterol and triglyceride with lipoprotein patterns by electrophoresis on cellulose acetate membrane were studied in 30 normal persons, 18 patients with coronary heart disease, 26 patients with cerebral thrombosis, and 7 surgical patients. The results obtained were as follows; 1. The values of serum cholesterol and triglyceride in cerebral thrombosis and coronary heart disease were markedly higher than those of control, and the optic dinsities of each serum lipoprotein fractions were also increased significantly. 2. Serum lipoprotein type IIa and IIb were more frequently observed than type IV in cerebral thrombosis and coronary heart disease. 3. The change of serum cholesterol and triglyceride related moderately to relative body weight in normal persons. 4. The decrease in serum cholesterol occured on the 1st day following surgery, and recovered to 97.8% of the preoperation level on the 7th day. The serum triglyceride started to increase on the 3rd day following surgery, and reached to 115.1% of the preoperation level on the 7th day. 5. After attack of cerebrovascular accident the serum cholesterol and triglyceride level increased slowly to the 122.1% and 133.1% of the each lst day level on the 7th day. 6. The serum lipid lowering effect of clofibrate was most conspicuous in the hypertriglyceridemic patients, especially during lst and 2nd week after medication, and mixed hyperlipidemic patients responded moderately. But pure hypercholesterolemic patients resisted completely. The optic densities of each serum lipoprotein fraction were also decreased in drug responded groups.
Body Weight ; Cellulose ; Cholesterol ; Clofibrate ; Coronary Disease ; Electrophoresis ; Humans ; Intracranial Thrombosis ; Lipoproteins ; Membranes ; Stroke ; Triglycerides

One hundred and seven cases of coronary heart disease were clinically studied at Seoul National University Hospital from September 1967 to August 1971 and following results were obtained. 1. The total cases were composed with 70 cases of myocardial infarction (46 cases of acute type and 24 cases of old type), 26 cases of angina pectoris and 11 cases of coronary insufficiency. 2. The ratio of male to female was 3.5:1, and over two-thirds of patients were sixth and seventh decade in ages. 3. As the underlying diseases, hypertension was found in 38.3% of the cases, and diabetes mellitus in 10.3%. 4. Among the various symptoms, precordial pain was a most common and characteristic, which was noted in 81.1% of the cases. Pain was radiated to the left arm and/or left shoulder in 45.2% of the cases. 5. In 57.2% of the cases, serum cholesterol was more than 200mg%. 6. The ratio between anterior and posterior wall infarction on electrocardiogram was about 3.5:1. 7. Left ventricular hypertrophy was the most frequently noted finding, and sinus tachycardia, low voltage, ventricular premature beat, myocardial ischemia, and others were also observed in some cases. 8. Mortality rate was 8.4%, and the major causes of death were cardiogenic shock and ventricular fibrillation.
Angina Pectoris ; Arm ; Cardiac Complexes, Premature ; Cause of Death ; Cholesterol ; Coronary Disease* ; Diabetes Mellitus ; Electrocardiography ; Female ; Humans ; Hypertension ; Hypertrophy, Left Ventricular ; Infarction ; Male ; Mortality ; Myocardial Infarction ; Myocardial Ischemia ; Seoul ; Shock, Cardiogenic ; Shoulder ; Tachycardia, Sinus ; Ventricular Fibrillation

Statistical observation was made on the 1949 patients with cardiovascular diseases who had been treated in Dept. of Internal Medicine, Seoul national University Hospital during the period of four years, from jan. 1972 to Dec. 1975. 1) The patients wth cardiovascular diseases accounted for 20.2% out of total 9,638 medical inpatients. The incidence for the consecutive years was not apparently variable. 2) The diseases occured most frequently in the sixth decades and the incidence decreased in the order of fifth and seventh decades. 3) The disease was more prevalent in male than female with ratio of 1.3 of 1. 4) The hypertension was the most common disease among cardiovascular diseases, accounting for 67.5% of patients with cardiovascular diseases and 13.6% of total medical inpatients. The disease occurred most frequently in the sixth decades and the incidence decreased in the order of fifth and seventh decades with male preponderance. 81.8% of patients with hypertension was essential hypertension and 18.2% was secondary hypertension. Secondary hypertension was caused by parenchylmal renal diseases in most patients and there were only several patients with renovascular and endocrine hypertension. 40.2% of patients with essential hypertension had no complications, 38.6% had cerebral vascular accidents, 12.1% had uremia and 9.1% had congestive heart failure. The patients with malignant hypertension was 9.6% of total patients with hypertension. 5) Rheumatic heart disease was 14% of patients with cardiovascular diseases, being second in incidence. It was more prevalent in female than male with ratio of 1 male to 1.3 female and affected the mitral valve in most of the cases, whereas involvement of aortic valve was rare. 6) The coronary heart disease was 5.3% of patients with cardiovascular diseases, being third in incidence. It occured most frequently in seventh and sixth decades and affected male two times more frquently than female. 7) The congenital heart disease was 2.9% of patients with cardiovascular diseases, of which atrial septal defect was highest in incidence. 8) The cor-pulmonale was 1.4%, pericarditis 1.4%, endocarditis 0.9%, postpartum heart disease 1.2%, myxedematous heart disease 0.2%, arrhythmia 2.1%, peripheral vascular disease 1.1% and miscellaneous 0.6% of patients with cardiovascular diseases. 9) Postpartum heart failure and endocarditis was remarkably decreased in incidence recently and there were one patients with beriberi heart disease and one patient with syphilitic heart disease during those years of this study.
Aortic Valve ; Arrhythmias, Cardiac ; Beriberi ; Cardiovascular Diseases* ; Coronary Disease ; Endocarditis ; Female ; Heart Defects, Congenital ; Heart Diseases ; Heart Failure ; Heart Septal Defects, Atrial ; Humans ; Hypertension ; Hypertension, Malignant ; Incidence ; Inpatients ; Internal Medicine ; Korea* ; Male ; Mitral Valve ; Pericarditis ; Peripheral Vascular Diseases ; Postpartum Period ; Rheumatic Heart Disease ; Seoul ; Uremia

The serum cholesterol and triglyceride levels were measured and the lipoprotein patterns by electrophoresis on cellulose acetate membrane were observed in 30 normal Koreans, 26 patients with cerebrovascular accident, and 18 patients with coronary heart disease. Similar measurements and observations were made in normal Koreas, surgical patients, the patients with cerebrovascular accident and hyperlipidemia in an attempt to examine the effects of body weight, surgical operations, cerebrovascular accident and the administration of clofibrate on serum lipids. The results obtained were as follows. 1. The mean values of serum cholesterol and triglyceride, which shows moderately significant correlation to the body weight in normal Koreans, were markedly higher in the patients with cerebrovascular accident and coronary heart disease than those of control. 2. Serum pre-beta- and beta-lipoprotein patterns in the densitometry of the serum lipoprotein electropherogram of the patients with coronary heart disease were larger than those of control, but the densitometric patterns of the patients with cerebrovascular accident were similar to those of control. Serum pre-beta- and beta-lipoprotein-cholesterol levels of the patients with cerebrovascular accident and coronary heart disease were higher than those of control. 3. Serum hyperlipoproteinemic type IIa and IIb were more frequently observed than type IV in the patients with cerebrovascular accident and coronary heart disease. 4. Serum cholesterol levels decreased to 74.9% of preoperation levels on the 1st postoperative day and recovered to 97.8% of preoperation levels on the 7th day. Serum triglyceride levels started to increase on the 3rd postoperative day, and reached to 115.3% of preoperation levels on the 7th day. After attack of cerebrovascular accident, serum cholesterol and triglyceride levels increased slowly to 121.7% and 133.7% of the each 1st day levels on the 7th day. 5. Serum lipid lowering effect of clofibrate was most conspicuous in the hypertriglyceridemic patients, especially during the 1st and 2nd weeks after initiation of medication, and moderately in the mixed hyperlipidemic patients. Serum pre-beta- and beta-lipoprotein-cholesterol levels were decreased after 8 weeks of clofibrate therapy, but alpha-lipoprotein-cholesterol levels did not change significantly.
Body Weight ; Cellulose ; Cholesterol* ; Clofibrate ; Coronary Disease ; Densitometry ; Electrophoresis ; Humans ; Hyperlipidemias ; Korea ; Lipoproteins* ; Membranes ; Stroke ; Triglycerides*

Debonding of cement-femoral stem interface has been suggested as a initial focus of loosening mechanism in many previous studies of cemented total hip replacement. The purpose of this study was to investigate the effect of debonding of cement-femoral stem interface to the cement-bone inter- face by using three-dimensional non-linear finite element analysis. Three cases of partial debonded, full debonded, and full bonded cement-bone interface were modelled with partial bonding of distal 70mm from the tip of femoral stem. Each situation was studied under loading simulating one-leg stanced gait of 68kg patient. The results showed that under partial and full debonded cement-stem interface conditions the peak von Mises stress (3.1 MPa) were observed at the cement of cement-bone interface just under the calcar of proximal medial of femur, and sudden high peak stresses (3.5 MPa) were developed at the distal tip of femoral stem at the lateral bone-cement interface in all 3 cases of bonding. The stresses were transfered very little to the cement of upper lateral bone-cement interface in partial and full debonded cases. Once partial or full debonded cement-femoral stem interface occured, 3 times higher stress concentration were developed on the cement of proximal medial cement-bone interface than full bonded interface, and these could cause loosening of cemented total hip replacement. Clinically, preservation of more rigid cement-femoral stem interface may be important factor to prevent loosening of femoral stem.
Arthroplasty, Replacement, Hip ; Femur ; Finite Element Analysis* ; Gait ; Humans

Mandibular prognathism was defined by Johe Hunter as follows : 'The lower jaw projecting too far forwards so that the foreteeth pass before those of upper jaw, therefore disfigurement and malocclusion are the two of facial main characteristics.' Mandibular ramus osteotomy by vertical osteotomy or sagittal splitting osteotomy recently has come into more common use. Although preoperative and postoperative orthdontic management is indispensable in surgery of this type, we occasionally encounter patients who are intolerant to a long duration of orthodontic treatment and intermaxillary fixation. We describe surgical refinement accomplishing mandibular anterior segmental osteotomy, recession genioplasty by horizontal osteotomies and decortication of the anterior portion of the bony bar for a minor degree of mandibular prognathism. In results, the amount of setback is limited to 4 to 5mm, no intermaxillary fixation is required and no orthodontic treatment, in this operation, is needed. This procedure can obtain a rapid aesthetic improvement. We used this preocedure in 8 patients (3 males and 5 females) with a mild mandibular prognathism. No major complications occurred throughout the follow-up period except transient paresthesia of the mental nerves, otherwise all patients were satisfied with the result.
Follow-Up Studies ; Genioplasty* ; Humans ; Jaw ; Male ; Malocclusion ; Osteotomy* ; Paresthesia ; Prognathism*

No abstract available.
Fasting* ; Female ; Humans

No abstract available.

BACKGROUND: For the evaluation of pulmonary nrtery branches after operation of right ventricular outflow obstructive disease, we reviewed the usefulness of both simple X-ray and lung perfusion scan with 99mTc-macroaggregated albumin compared with cardiac angiography. METHODS: From March, 1986 to July, 1993, at Seoul National University Children;s Hospital, we chose 23 cases who underwent both simple X-ray and cardiac angiography among the patients who had distinct difference between right and left pulmonary blood flow in lung perfusion scan after operation of right ventricular outflow obstructive disease. So we calculated the ratio of right and left pulmonary blood flow and Spearman correlation coefficient. RESULTS: Of the 23 cases, 17 cases were tetralogy of Fallot, 4 cases pulmonary atresia, 1 case double outlet right ventricle, and 1 case truncus arteriosus. The mean age at poeration was 27 months, and the mean postoperative follow-up period was for 68 months. The correlation coefficient between cardiac angiography and simple X-ray was 0.86(p<0.01), and that beteen cardiac angiography and lung perfusion scan was 0.80(p<0.01). CONCLUSION: The cardiac angiography has been known as the best diagnostic tool for the evaluation of pulmonary artery branches after operation of right ventricular outflow obstructive ddisease, but we proposed that the lung perfusion scan should be widely used because its results were similar with those of cardiac angiography.
Angiography ; Double Outlet Right Ventricle ; Follow-Up Studies ; Humans ; Lung* ; Perfusion* ; Pulmonary Artery* ; Pulmonary Atresia ; Seoul ; Tetralogy of Fallot ; Truncus Arteriosus

No abstract available.
Ductus Arteriosus, Patent*