Myxofibrosarcomas (MFSs), which consist of multiple nodules with a variable cellular population in a myxoid matrix, are primarily located in subcutaneous tissue. Pleomorphic hyalinizing angiectatic tumors (PHATs) are rare soft-tissue tumors characterized by a proliferation of highly pleomorphic spindle or polygonal cells and abundant ectatic blood vessels in cellular or myxoid stroma. We present here an unusual case of a high-grade MFS with a PHAT-like appearance. A 67-year-old man presented with an asymptomatic subcutaneous mass in the right forearm. The tumor had myxoid, hypo-, and hypercellular areas with highly pleomorphic spindle or polygonal tumor cells that showed frequent mitoses and nuclear pseudoinclusions. Foci of punctuate necrosis and inflammatory infiltration were present throughout the tumor, and abundant ectatic, thick-walled vessels containing blood clots were noted. The tumor cells were immunohistochemically positive for vimentin but negative for CD34, S-100 protein, smooth muscle actin, desmin, and bcl-2.
Actins ; Aged ; Blood Vessels ; Desmin ; Forearm ; Humans ; Hyalin ; Mitosis ; Muscle, Smooth ; Necrosis ; S100 Proteins ; Sarcoma ; Subcutaneous Tissue ; Vimentin

We reviewed the clinical features and the skin biopsy slides of 27 patients who were diagnosed as PLEVA clinically or histapathologically in order to evaluate the clinical characteristics and the specific histopathological findings of PLEVA. The results were as follows : l. 13 of these 27 cases(48%) were confirmed as PLEVA. 2. PLEVA was more frequent in males(85% ), most of whom were young adults. 3. In most cases of PLEVA, the predilection site was on the trunk and extremities, and mild pruritus was a characteristic complaint. 4. Most cases of PLEVA were treated with tetracycline or PUVA therapy with temporary remission, but this therapy did not decrease the rate of recurrence. 5. Some histopathological findings previously described as typical in PLEVA(eg, trapped RBC in the epidermis, exocytosis of lymphocyte, dermal hernorrhage and lymphocytic perivasculitis) seemed not to be specific and were often seen in a variety of other dermatoses. 6. The histopathological findings of linear parakeratosis(85%) and dyskeratotic cells in the middle and upper epidermis(92% ) seemed to be significant findings for PLEUA. 7. The above mentioned histopat,hological findings for PLEVA were frequently found from the vesicular lesions or necrotic hemorrhagic papules.
Biopsy ; Epidermis ; Exocytosis ; Extremities ; Humans ; Lymphocytes ; Pityriasis Lichenoides* ; Pityriasis* ; Pruritus ; PUVA Therapy ; Recurrence ; Skin ; Skin Diseases ; Tetracycline ; Young Adult

Obesity has been implicated as a significant risk factor for multiple medical condition including hypertention, glucose intolerance, hyperlipidemia, hyperinsulinemia and fatty liver. Furthermore, obesity in childhood is believed to be a reliable predictor of a similar condition in adulthood. During the recent years, there has been a rapid rise in the incidence of childhood obesity in Korea due to increased dietary intake rich in caloric content. This study was undertaken to investigate the epidemiology and potential health complications of obesity observed in elmentary school students. A total of 3,103 children (1630 boys and 1,473 girls), ages ranging from 6 to 12, were studied with personal interview, physical examination, and laboratory evaluation. The results were as follows: 1) The prevalence of obesity was 13.44% with approximately equal distribution among boys (14.42%) and girls (12.36%). 2) The prevalence of childhood obesity in Seoul was significantly higher (18.62%) than that in Suwon (7.85%) and in Hongchon (6.02%). 3) A higher incidence of hypertension was dectected in obese subjects and this was more obvious in girls. 4) Hyperlipidemia and elevated Atherogenic Index were more frequently observed in obese group. 5) although fasting blood glucose levels were similar in both groups. AST and ALT abnormalities were much more prevalent in obese group. It is concluded that hypertension and other metabolic abnormalities are much more frequently observed in obese children and that our effects should be focused on the earliest dection, prevention and management of childhood obesity.
Blood Glucose ; Child* ; Epidemiology ; Fasting ; Fatty Liver ; Female ; Glucose Intolerance ; Gyeonggi-do ; Humans ; Hyperinsulinism ; Hyperlipidemias ; Hypertension ; Incidence ; Korea ; Obesity* ; Pediatric Obesity ; Physical Examination ; Prevalence ; Risk Factors ; Seoul

No abstract available.
Blood Flow Velocity* ; Humans ; Infant, Newborn*

No abstract available.
Animals ; Bone and Bones* ; Dogs* ; Titanium*

PURPOSE: The aim of the present study was to investigate the effect of single dose imipramine on nocturnal urine output in patients with nocturnal enuresis. METHODS:A total of 6 monosymptomatic enuretic patients of more than 5 years of age were enrolled in this study. We measured nocturnal urine output, urine osrnolality, creatinine clearance, osmolal clearance, excretion rate of solutes, fractional excretion of sodium and potassium, and plasma vasopressin with and without a single oral dose of imipramine(lmg/kg of body weight) at 8 p.m. RESULTS: The administration of imipramine was followed by a significant decrease in noctumal urine output(P=0.02). Urine osmolality was not significantly increased(P>0.05), but osmolal clearance was significantly decreased during imipramine medication(P=0.03). Urinary excretion rate of sodium and potassium showed a statistically insignificant trend toward lower values during imipramine administration in nocturnal enuretics. Fractional urinary excretion of sodium and potassium was significantly decreased during imipramine medication(P<0.05). There was no significant difference in plasma vasopressin level and creatinine clearance in nocturnal enuretics after imipramine. CONCLUSION: Imipramine has a vasopressin independent antidiuretic effect in patients with nocturnal enuresis. The antidiuretic effect of imipramine can be attributed prirnarily to increased a-adrenergic stimulation in the proximal tubules with secondary increased urea and water reabsorption more distally in the nephron. (J Korean Pediatr Soc 2000;43:792 - 797)
Antidiuretic Agents ; Creatinine ; Enuresis ; Humans ; Imipramine* ; Nephrons ; Nocturnal Enuresis* ; Osmolar Concentration ; Plasma ; Potassium ; Sodium ; Urea ; Vasopressins

The purpose of this study was to determine biochemical parameters related to protein and immunity. Subjects were 125 preschool children(M:69, F:56) residing in low income area of Seoul. Mean serum total protein of the children aged 6 was 7.3g/dl which was significantly higher than 6.6g/dl of the group aged 3. The mean serum albumin was 4.7g/dl for 3, 4, 5 age group, and 4.9g/dl for 6 age group and there was no significant difference. Serum retinol binding protein(RBP) is used as a sensitive indicatior of protein, becase it tends to fall rapidly in response to protein status and respond to quickly dietary treatment. Mean RBP for each group(3, 4, 5 and 6 age group) were 2.5 microgram/dl was 15.9%, 19.2%, 24.3% and 16.7%, respectively. The 24-hour urinary excretion of hydroxyproline was 7.9 mg, 14.6 mg, 11.7 mg and 11.8 mg for each group and the mean excretion of all children was 12.2 mg/day. Children aged 3 were excreting significantly lower amount of hydroxprolinc per day than the children aged 4. The mean hydroxyproline index were 2.18, 2.39, 2.52, 2.80 for each age group and the mean of a group aged 6 was significantly higher than that of the group aged 3. The proportion of children assessed as malnourished and impaired growth(hydroxyproline index<2.0) was 18.8%, 4.9%, 2.5% and 4.3%, respectively. The nutrients which showed significant relationship with protein and immunity parameters were niacin, vitamin C and calcium. Vitamin C showed significant positive relationship(p<0.05-p<0.01) with serum RBP, total protein and globulin. The triceps skinfold thickness was significantly and positively correlated with serum globulin. Serum IgG showed significant positive relationship with height, weight, girth of chest and midarm circumference(p<0.05-p<0.01).
Ascorbic Acid ; Calcium ; Child ; Child, Preschool* ; Complement C3 ; Humans ; Hydroxyproline ; Immunoglobulin A ; Immunoglobulin G ; Niacin ; Nutritional Status* ; Seoul ; Serum Albumin ; Skinfold Thickness ; Thorax ; Vitamin A

The nutritional status of 125 preschool chidren(Female : 56, Male : 69) residing in low income area of Seoul was surveyed. The mean family size was 4.3 and the mean monthly income was 921,000 won which was below the poverty level. Average heights of boys aged 3, 4, 5 and 6 were 98.6 cm, 106.1 cm, 111.9 cm and 116.0 cm and those for girls were 99.4 cm, 106.4 cm, 110.9 cm, and 116.0 cm, respectively. There was no significant difference between the height of boys and girls. The proportion of children showing stunted growth(<90% of Korean standard of height) was 3.2%. The mean weight of boys for each age group(3, 4, 5, 6) were not significantly differient from that of girls. The proposetion of children assessed as moderately underweight (<80-90% of Korean Standard of weight) was 10.4% and 3.2% of children was underweight(<80% of weight standard). The group of children aged 3 were taking adequate energy, whereas the mean energy intake of children aged 4.5 and 6 were wirthin 77.3-78.6% of RDA. The proportion of energy derived from carbohydrate, fat and protein was 60.1%, 24.6% and 15.3%. The high proportion of energy derived from fat seems partly due to high energy intake from fat in the snack. The nutrients which did not meet 75% of the RDA were vitamin A and calcium for children aged 5, and iron for children aged 3 to 5. Carbohydrate intake was positively correlated with the height, weight and girth of chest(P<0.05-P<0.001). There was positive correlation between protein intake and weight, girth of chest and BMI, respectively(P<0.05). Iron intake showed positive relationship with height, weight and BMI(P<0.05).
Anthropometry* ; Calcium ; Child ; Child, Preschool* ; Energy Intake ; Family Characteristics ; Female ; Humans ; Iron ; Male ; Nutritional Status* ; Poverty ; Seoul ; Snacks ; Thinness ; Thorax ; Vitamin A

No abstract available.
Alprostadil* ; Ductus Arteriosus ; Heart Defects, Congenital* ; Humans ; Infant, Newborn*

We reported a case of cutaneous focal mucinosis in a 19 year-old male, which occured by multiple nodules on the both dorsa of hands, extensor surface of elbows, intergluteal folds and shins, and responded well to intralesional injection of triamcinolon acetonide. Histopathologically, most of the collagen in the dermis is replaced to homogeneous mucinous material which was confirmed as hyaluronic acid.
Collagen ; Dermis ; Elbow ; Hand ; Humans ; Hyaluronic Acid ; Injections, Intralesional ; Male ; Mucinoses* ; Mucins ; Young Adult