An unruptured sinus of Valsalva aneurysm is rare and is usually asymptomatic until a symptom associated with its complication develops. Hence, an unruptured sinus of Valsalva aneurysm is not infrequently missed unless echocardiogram is performed with other indications. An unruptured sinus of Valsalva aneurysm rarely protrudes into the right ventricular outflow tract, causing the right ventricular outflow tract obstruction. In this report, I describe a rare case of unruptured sinus of Valsalva aneurysm producing the right ventricular outflow tract obstruction, which was incidentally detected by echocardiography.
Aneurysm ; Echocardiography ; Sinus of Valsalva ; Ventricular Outflow Obstruction

Reduction in the extremity length of more than three to four centimeters has significant effect on both gait disturbance and aesthetic change. The method of Anderson has been one of the most successful procedures of surgical leg elongation but requires long period of bed rest and immobilization. Also. the lengthening occurs the tibia, although shortening occurs twice as frequently in the femur as in the tibia. Wagner in 1971 reported his experience with the technique that allows correction in both the femur and tibia yet does not require prolonged immobilizaton. This involves a two stage procedure with rigid external fixation and lengthening of 1.5mm per day. The second stage is for osteosynthesis and may be suppleniented by bone graft. We began using the Wagner's technique of leg lengthening at Chonju Presbyterian Medical Center about 18 months age. Two patients are presented with 7 and 9 month follow-ups after femoral lengthening of 5 cm each. Both femurs united well and the leg length discrepancy was corrected. These cases indicate that this method is a good addition to the armamentarium of treating leg length discrepancy. A subsequent review of more cases and their follow-up using this tretment program shall be forthcoming.
Bed Rest ; Extremities ; Femur ; Follow-Up Studies ; Gait ; Humans ; Immobilization ; Jeollabuk-do ; Leg ; Methods ; Protestantism ; Tibia ; Transplants

The skeleton is a frequent site of bone tumor metastasis. Radiographic examination Is not sufficiently reliable in early detection since an abnormality is unlikely to be observed until more than 50% of the bone material has been lost. Therefore there was much effort to discover radiographic materials for use in scanning. At the present tirne, 99m Tc-labeled diphosphonate is the best available material for bone scanning. We applied whole body scanning with 99m Tc-to 40 patients who had bone tumors (primary or secondary), infection and other cases. The results obtained are as follow: 1. The scan can detect the extensiveness of the tumor better than plain X-ray in the early stage. 2. In metastatic disease, 60% of all patients were positive in the scan and all of there were negative in X-ray. 3. In cases of cancer, definitive treatment planning can be facilitated by the information obtained from whole body scanning. 4. In inflammatory disease, we can differentiate osteomyelltis from cellulitis or pyogenic arthritis in the early stage. 5. In fibrous dysplasia, it was possible to differentiate monostatic from polyostotic disease. 6. In nonunion of bone, scan was positive but X-ray was eouivocal.
Arthritis ; Cellulitis ; Humans ; Neoplasm Metastasis ; Skeleton ; Whole Body Imaging

No abstract available.
Acute Disease ; *Gene Rearrangement ; Genome, Human ; Humans ; Leukemia/*diagnosis/genetics ; Polymerase Chain Reaction/*methods ; Translocation, Genetic

No abstract available.
Child ; Chromosome Banding ; *Chromosome Deletion ; Chromosomes, Human, Pair 4/*genetics ; Comparative Genomic Hybridization ; Developmental Disabilities/diagnosis/*genetics ; Humans ; Male ; Sequence Deletion

No abstract available.
Leukemia, Promyelocytic, Acute ; Translocation, Genetic

In this review, we provide a brief synopsis of the connections between adipose tissue and metabolic health and highlight some recent developments in understanding and exploiting adipocyte biology. Adipose tissue plays critical roles in the regulation of systemic glucose and lipid metabolism and secretes bioactive molecules possessing endocrine, paracrine, and autocrine functions. Dysfunctional adipose tissue has a detrimental impact on metabolic health and is intimately involved in key aspects of metabolic diseases such as insulin resistance, lipid overload, inflammation, and organelle stress. Differences in the distribution of fat depots and adipose characteristics relate to divergent degrees of metabolic dysfunction found in metabolically healthy and unhealthy obese individuals. Thermogenic adipocytes increase energy expenditure via mitochondrial uncoupling or adenosine triphosphate-consuming futile substrate cycles, while functioning as a metabolic sink and participating in crosstalk with other metabolic organs. Manipulation of adipose tissue provides a wealth of opportunities to intervene and combat the progression of associated metabolic diseases. We discuss current treatment modalities for obesity including incretin hormone analogs and touch upon emerging strategies with therapeutic potential including exosome-based therapy, pharmacological activation of brown and beige adipocyte thermogenesis, and administration or inhibition of adipocyte-derived factors.

Floating thrombi in the aortic arch are very rare, and often go under-diagnosed. Herein, a case of an 8-cm long thrombus in the aortic arch is reported. It was a floating, highly mobile thrombus attached to the atherosclerotic plaque in the proximal aortic arch. The patient was a 59-year-old woman with a history of hypertension. The thrombus was operatively removed, with a favorable outcome.
Aorta, Thoracic* ; Arteriosclerosis ; Female ; Humans ; Hypertension ; Middle Aged ; Plaque, Atherosclerotic ; Thrombosis*

Background: The coronavirus disease 2019 (COVID-19) pandemic has caused significant changes. This study aimed to investigate the impact of COVID-19 on patients with chronic pain. Methods: Patients with chronic pain from 23 university hospitals in South Korea participated in this study. The anonymous survey questionnaire consisted of 25 questions regarding the following: demographic data, diagnosis, hospital visit frequency, exercise duration, time outside, sleep duration, weight change, nervousness and anxiety, depression, interest or pleasure, fatigue, daily life difficulties, and self-harm thoughts. Depression severity was evaluated using the Patient Health Questionnaire-9 (PHQ-9). Logistic regression analysis was used to investigate the relationship between increased pain and patient factors. Results: A total of 914 patients completed the survey, 35.9% of whom had decreased their number of visits to the hospital, mostly due to COVID-19. The pain level of 200 patients has worsened since the COVID-19 outbreak, which was more prominent in complex regional pain syndrome (CRPS). Noticeable post-COVID-19 changes such as exercise duration, time spent outside, sleep patterns, mood, and weight affected patients with chronic pain. Depression severity was more significant in patients with CRPS. The total PHQ-9 average score of patients with CRPS was 15.5, corresponding to major depressive orders. The patients’ decreased exercise duration, decreased sleep duration, and increased depression were significantly associated with increased pain. Conclusions COVID-19 has caused several changes in patients with chronic pain.During the pandemic, decreased exercise and sleep duration and increased depression were associated with patients’ increasing pain.

No abstract available.
Aged ; Bone Marrow/pathology ; Genome, Human ; Humans ; Isochromosomes/*genetics ; Karyotyping ; Leukemia, Myeloid, Acute/complications/*diagnosis/genetics ; *Loss of Heterozygosity ; Male ; Oligonucleotide Array Sequence Analysis ; Thrombocytosis/*etiology