Dysregulation of TGF-beta that is a modulator of cell growth and differentiation can result in uncontrolled growth and tumor formation. Monitoring these pattern of genes and protein expression during tumor development will provide a basis for understanding normal growth and distortion of osteochondrogenesis. Our comparative studies on the experssion of TGF-beta protein indicate that TGF-beta may primarily be a regulator of epithelial differentiation during tooth development (between 4 weeks and 40 gestational weeks) and tumorigenesis of odontogenic neoplasm (ameloblastoma). In early human tooth germ (cap/early bell stage) TGF-beta protein was found in the epithelial dentallamina and enamel orgen. TGF-beta experessions were seen in inner and outer dental epithelium during bell stage. During enamel and cementum appositional stage, TGF-beta expression shifted from the ameloblast to the odontoblast. In eruption stage, TGF-beta expressions look like moderate positive pattern in odontoblast and rare pattern in enamel, dentin and cementum. TGF-beta expressions of follicular and plexiform amelobalstoma are moderate positive reaction in ectodermal tumor components and mild positive in vessels of stroma tissue. In acanthomatous type, TGF-beta expression was shown severely positive finding in stellate reticulum cell. TGF-beta expressions were noted moderate reaction in margin of tumor epithelium and stellate reticulum cell of granular ameloblastoma. In unicystic ameloblastoma, TGF-beta expression was rare feature in cystic luminal epithelium. With these result, I should be suggested that TGF-beta may play an important role in epithelial-mesenchymal interactions in human tooth morphogenesis and development of odontogenic epithelial tumors.
Ameloblastoma* ; Ameloblasts ; Carcinogenesis ; Dental Cementum ; Dental Enamel ; Dentin ; Ectoderm ; Embryonic Structures* ; Epithelium ; Fetus* ; Humans* ; Morphogenesis ; Odontoblasts ; Phenobarbital ; Reticulum ; Tooth Germ* ; Tooth* ; Transforming Growth Factor beta*

Brodie's abscess is a primary subacute pyogenic osteomyelitis that has a thin wall of fibrous tissue and sclerotic bone. The authors have encountered a case of a Brodie's abscess that was developed in the same place of both tibia at the same time and treated the case with surgery and continuous closed irrigation.
Abscess ; Osteomyelitis ; Tibia

PURPOSE: RFCA has been proven to be an effective and safe tool for treating different kinds of tachycardia in adults. This study was designed to analyze the efficacy of this method in children and adolescents. METHODS: Seventy-eight patients referred to Gachon Medical School, Gil Hospital for ablation of supraventricular(SVT) and ventricular tachycardia(VT) between January 1997 and February 1999 were included in this study. An electrophysiologic study was performed in the same session to assure the diagnosis, and meet the appropriate criteria for ablation. All patients had regular follow-up at our center. RESULTS: Mean age of the patients was 9.9 years. Thirty-seven patients had Wolff-Parkinson- White syndrome, atrioventricular nodal reentrant tachycardiain in 12 patients, atrial flutter in 11 patients, atrial tachycardia in 9 patients, Mahaim tachycardia in 2 patients, nodoventricular tachycardia in one patients and VT in 6 patients was found. Seventy-seven patients were treated successfully(98.7%), 75 patients were treated in a single procedure, but 2 patients needed a second attempt. RFCA treatment failed in only one patient with nodoventricular tachycardia. In three of the 77 successfully treated patients(3.9%), tachycardia recurred after 1-3 months but could be treated by a further intervention. The duration of follow up after RFCA was from 2 to 27 months. CONCLUSION: RFCA is a highly effective method in the treatment of SVT and VT in children and adolescents. The major benefit of this technique is its potential as a cure for a chronic disease. RFCA can be used as the primary treatment for SVT and VT.
Adolescent* ; Adult ; Atrial Flutter ; Catheter Ablation* ; Child* ; Chronic Disease ; Diagnosis ; Follow-Up Studies ; Humans ; Schools, Medical ; Tachycardia*

No abstract available.
Colon*

No abstract available.
Peptic Ulcer*

No abstract available.
Electric Stimulation* ; Tendons*

No abstract available.
Meconium* ; Peritonitis*

No abstract available.
Ear Cartilage ; Rabbits ; Transplants

No abstract available.
Cartilage ; Rabbits ; Temporomandibular Joint Disc ; Temporomandibular Joint ; Transplants

Transurethral resection syndrome are caused by the sudden intravascular absorption of large volumes of the irrigating solution which are used during transurethral surgery. It relates to many determining conditions of the patient postoperatively. We studied changes in serum electrolyte following transurethral resection of prostate in 61 patients used 5% Dextrose-Water solution as the irrigant and 46 patients used 1.5% glycine as the irrigant of benign prostatic hypertrophy. We divided the patients into group I and II. group I : those were given 5% Dextrose-Water solution as the irrigant. group II : those were given 1.5% glycine as the irrigant. Change in serum ammonia was obtained in 19 patients of group II. Following results were obtained. 1. Operation time, resected weight and amount of irrigant between group I and II showed no difference, statistically. 2. Serum sodium concentration was decreased in 42 cases of group I (range : 1-20mEq/L, mean : 5.0mEq/L). 3. Serum sodium concentration was decreased in 31 cases of group II (range : 1-18mEq/L, mean : 6.0mEq/L). These changes in serum concentration between group I and group II showed no significant difference, statistically. 4. Change in serum sodium concentration in the group I showed no significant correlation with operation time, resected weight and amount of irrigation. 5. Change in serum sodium concentration in the group II showed no significant correlation with operation time, resected weight and amount of irrigation. 6. Serum ammonia concentration was increased in 10 patients of 19 patients in group II (range : 5-100ug/dl, mean : 42ug/dl).
Absorption ; Ammonia ; Glycine* ; Humans ; Prostate* ; Prostatic Hyperplasia ; Sodium ; Transurethral Resection of Prostate