1.Immunohistochemical Expression of Placental Nitric Oxide Synthase in Preeclampsia and Normal Pregnancy.
Jong In KIM ; Sung Do YOON ; Duk Man KIM
Korean Journal of Obstetrics and Gynecology 1998;41(12):2957-2961
OBJECTIVE: Our purpose was to compare the expression of endothelial nitric oxide synthase in the placenta and umbilical cord of preeclamptic placenta with that of the normotensive placenta. METHOD: We compared placental endothelial nitric oxide synthase expression in preeclamptic (n=5) with in normal (n=5) pregnancies. Frozen sections of umbilical cords, chorionic plate vessels, and terminal villi were immunostained with a monoclonal endothelial nitric oxide synthase antibody. RESULTS: The age revaled no difference between control (28.1+4.2 years). and study group (26.1+4.7 years). The gestational age was statistically different between control (38.9+1.7 weeks) and study group (34.9+3.5 weeks). The neonatal body weight and placental weight were also statistically different between control (3060+528 g) and study group (2160 417 g). No difference in endothelial nitric oxide synthase immunostaining in the endothelium of the umbilical vessels and stem villous vessels was found between preeclamptic and normotensive pregnancies. In contrast, in the preeclamptic placental endothelial nitric oxide synthase immunostaining was seen in the terminal villous vessels. In the syncytiotrophoblast endothelial niric oxide synthase immunostaining appeared primary basal in location and diffuse in distribution in the preeclamptic placentas but primary apical in the normotensive placentas. CONCLUSION: Differences in endothelial nitric oxide synthase expression in terminal villous vessels and syncytiotrophblast may be a result of vascular alterations or damage that take place in the placenta in preeclampsia.
Body Weight
;
Chorion
;
Endothelium
;
Frozen Sections
;
Gestational Age
;
Nitric Oxide Synthase Type III
;
Nitric Oxide Synthase*
;
Nitric Oxide*
;
Placenta
;
Pre-Eclampsia*
;
Pregnancy*
;
Trophoblasts
;
Umbilical Cord
2.Sex Hormone Binding Globulin Levels in Children with Insulin Dependent Diabetes Mellitus.
Duk Hi KIM ; Mi Jung PARK ; Ho Sung KIM
Journal of the Korean Pediatric Society 1995;38(7):963-969
No abstract available.
Child*
;
Diabetes Mellitus*
;
Humans
;
Insulin*
;
Sex Hormone-Binding Globulin*
3.Prevalence of Insulin Resistance and Impaired Glucose Tolerance among Children and Adolescents with Obesity.
Duk Hee KIM ; In Kyong CHOI ; Ho Sung KIM
Journal of Korean Society of Pediatric Endocrinology 2003;8(2):139-148
Pupose:Recently childhood obesity is increasing and has been accompanied by an increase in the prevalence of type 2 diabetes mellitus(DM) among children and adolescents. We evaluated insulin resistance and impaired glucose tolerance(IGT) in 48 obese children and adolescents. METHODS:All subjects underwent a two-hour oral glucose tolerance test(1.75 g of glucose per kg of body weight) and then glucose and insulin levels were measured. Insulin resistance was estimated by homeostatic model assessment, and betacell function was estimated by calculating the ratio between the changes in the insulin level and glucose level during the first 30 minutes after the ingestion of glucose. RESULTS:IGT was detected in 4.2% of the 24 obese children(4-10 years of age) and 20.8% of the 24 obese adolescents(11 to 18 years of age). Type 2 DM was identified in 8.3% in children and 29.2% in adolescent obesity. Insulin levels were markedly elevated after the glucose tolerance test in subjects with IGT but a little decreased in cases with DM. Those changes of insulin levels were not significant statistically. The insulinogenic index was decreased in IGT and DM group of childhood and adolescent obesity compared to normal glucose tolerance(NGT) but it was not significant statistically. Insulin resistance, which was evaluated with fasting insulin, QUICKI and HOMA-IR, was increased in childhood obesity compared with adolescent obesity and the HOMA-IR of adolescent IGT group was significantly higher compared with NGT group(P<0.05). CONCLUSION: IGT is highly prevalent among children and adolescents with obesity. IGT was associated with insulin resistance and hyperinsulinemia, while beta-cell function was still relatively preserved. Overt type 2 diabetes was linked to insulin resistance and to beta cell failure.
Adolescent*
;
Child*
;
Eating
;
Fasting
;
Glucose Tolerance Test
;
Glucose*
;
Humans
;
Hyperinsulinism
;
Insulin Resistance*
;
Insulin*
;
Obesity*
;
Pediatric Obesity
;
Prevalence*
4.Prevalence of Insulin Resistance and Impaired Glucose Tolerance among Children and Adolescents with Obesity.
Duk Hee KIM ; In Kyong CHOI ; Ho Sung KIM
Journal of Korean Society of Pediatric Endocrinology 2003;8(2):139-148
Pupose:Recently childhood obesity is increasing and has been accompanied by an increase in the prevalence of type 2 diabetes mellitus(DM) among children and adolescents. We evaluated insulin resistance and impaired glucose tolerance(IGT) in 48 obese children and adolescents. METHODS:All subjects underwent a two-hour oral glucose tolerance test(1.75 g of glucose per kg of body weight) and then glucose and insulin levels were measured. Insulin resistance was estimated by homeostatic model assessment, and betacell function was estimated by calculating the ratio between the changes in the insulin level and glucose level during the first 30 minutes after the ingestion of glucose. RESULTS:IGT was detected in 4.2% of the 24 obese children(4-10 years of age) and 20.8% of the 24 obese adolescents(11 to 18 years of age). Type 2 DM was identified in 8.3% in children and 29.2% in adolescent obesity. Insulin levels were markedly elevated after the glucose tolerance test in subjects with IGT but a little decreased in cases with DM. Those changes of insulin levels were not significant statistically. The insulinogenic index was decreased in IGT and DM group of childhood and adolescent obesity compared to normal glucose tolerance(NGT) but it was not significant statistically. Insulin resistance, which was evaluated with fasting insulin, QUICKI and HOMA-IR, was increased in childhood obesity compared with adolescent obesity and the HOMA-IR of adolescent IGT group was significantly higher compared with NGT group(P<0.05). CONCLUSION: IGT is highly prevalent among children and adolescents with obesity. IGT was associated with insulin resistance and hyperinsulinemia, while beta-cell function was still relatively preserved. Overt type 2 diabetes was linked to insulin resistance and to beta cell failure.
Adolescent*
;
Child*
;
Eating
;
Fasting
;
Glucose Tolerance Test
;
Glucose*
;
Humans
;
Hyperinsulinism
;
Insulin Resistance*
;
Insulin*
;
Obesity*
;
Pediatric Obesity
;
Prevalence*
5.Immunoelectrophoretic Analysis of Blister Fluids.
Won Suk KIM ; Soo Duk LIM ; Sung Hwan KIM
Korean Journal of Dermatology 1970;8(1):25-29
The proteins, especially the 19S globulin (IgM) and 7S globulin (IgA) in the CO2 snow-induced blister fluids of 10 male healty volunteers were analyzed immunoelectrophoretically. The fnllawing results were obtained. 1) Compared with autologous serum, all blister fluids tested lacked some protein fraction lines. 2) The 19S globulin (lgM) line was absent in all of the blister fluids except one which was contaminated with blood. 3) The 7S globulin (IgA) line was present in all of the blister fluids when undiluted. In 1 : 2 dilution, however, it was absent, or of trace amount in a few cases.
Blister*
;
Humans
;
Male
;
Volunteers
6.Quantitative Changes of Immunoglobun Levels in the Serum of Allergic Dermatoses Patients.
Chung Ju LEE ; Soo Duk LIM ; Sung Hwan KIM
Korean Journal of Dermatology 1969;7(1):1-7
With development of immunochemical methods for anlysis of serum proteins, quantitative determination of serum immunoglobulin levels and purification of them have been made possible in recent years. There are numerous reports about immunoglobulin levels in various diseases. A search of the literature reveals very few reports of quantitative immunoglobulin determinations in allergic dermatoses. The present study was conducted to find quantitative changes of serum immunoglobulins in a few allergic dermatoses. To quantify the IgG, IgA and IgM, one hundred and two sera were analysed form 30 normal control group, 30 contact dermatitis patients, 12 stopic dermatitis patients and 30 urticaria patients by modified Oudin's capillary tube method. The results are as follows. 1.In contact dermatitis the IgG was significantly increased to compare with control group(p<0.01) 2.In atopic dermatitis the IgA was significantly increased to compare with control group(p<0.01) 3.In urticaria the IgG was increased (p<0.05) 4.The IgM has no differences between allergic dermatoses and control group.
Blood Proteins
;
Capillaries
;
Dermatitis
;
Dermatitis, Atopic
;
Dermatitis, Contact
;
Humans
;
Immunoglobulin A
;
Immunoglobulin G
;
Immunoglobulin M
;
Immunoglobulins
;
Skin Diseases*
;
Urticaria
7.Comparison of the depression and anxiety between the elderly in the home for the aged and those in the community.
Hyo Seok SEO ; Sung Duk JUNG ; Chang Su KIM
Yeungnam University Journal of Medicine 1992;9(2):256-268
This survey was conducted from January 1991 to May 1991. Two hundred and eight residents in 4 government supported homes for the aged and hundred and eleven living in the community in Taegu, Korea, were examined to evaluate the depression and the anxiety of the aged with combined anxiety and depression scale (CADS) and somatization symptom check list (SCL). There are no significant differences between residents in the home for the aged and those living in the community on the total scores of CADS and SCL. However, in the case of the total score of CADS of the female subjects in the home for the aged were significantly higher than those of the community residents. The elderly in the home for the aged tended to have pure depression, while community residents were likely to have anxiety and depression. Fifty-two subjects of home for the aged and sixty-nine of the community scored over 50 points of CADS, which indicates considerable depression or anxiety. In psychosocial factors, the subjects who in the following situations had statistically significant higher scores than others. The results were as follow. Poor health, unhappiness, unsatisfaction to the past occupation, pessimistic thought in future view for both group and unsatisfaction of the relationship with familiar people for the elderly in the community. The SCL scores of two groups subgrouped by under 49 and 50 on CADS showed significant differences between each subgroup on all of the SCL items. It could be suggested that somatic symptoms for the aged is a sign of depression.
Aged*
;
Anxiety*
;
Daegu
;
Depression*
;
Female
;
Homes for the Aged
;
Humans
;
Korea
;
Occupations
;
Psychology
8.Refraction in School Children.
Soon Kak HONG ; Sung Duk KIM ; Jong Woo LEE
Journal of the Korean Ophthalmological Society 1967;8(2):8-11
611 children (297 boys and 314 girls) of a primary school were determined under 2% cyclogyl. (1) Among 611 children, refractive error was 70.46 % and emmetropia. 29.54 %. (2) As to the distribution of refractive errors, 72.47 % were hyperopic and 27.53 % myopic Hyperopia was more common than myopia. (3) Hyperopic refractive error was increased until 7 years of age. Since then it has been decreased 8.74 % yearly. Myopic refractive error has been increased 8.14 % yearly since 8 years of age. (4) The refractive errors were more frequent in women (37.81) than men (32.65 %) (5) Refractive errors were numerous around the age of 11. (24.77 %). (6) The degree of refractive errors varied, but in the great majority was less than 3 diopters. (7) As to the type of astigmatism; 59.42 % were with the rule and 39.94 % were against the rule.
Astigmatism
;
Child*
;
Cyclopentolate
;
Emmetropia
;
Female
;
Humans
;
Hyperopia
;
Male
;
Myopia
;
Refractive Errors
9.Automatic quantitative analysis of EMG interference pattern in the neuropathy and myopathy.
Jin Ho KIM ; Tai Ryoon HAN ; Duk Hyun SUNG
Journal of the Korean Academy of Rehabilitation Medicine 1991;15(1):22-33
No abstract available.
Muscular Diseases*
10.CT Appearance of Internal Hernia:Whorling Sign of Mesentery and Mesenteric Vessels.
Tae Hun KIM ; Won Ho KIM ; Geun Seok YANG ; Sung Woo KIM ; Duk Sik KANG
Journal of the Korean Radiological Society 1995;32(2):297-302
PURPOSE: To evaluate CT findings of internal hernia. MATERIALS AND METHODS: Three patients with internal hernia had abdominal CT scans and two of them had small bowel follow through examinations. The CT features of two patients with retroanastomotic and one patient with left paraduodenal hernia were evaluated and correlated with small bowel follow through examinations, and surgical findings. Two patients with retroanastomotic hernia had a history of subtotal gastrectomy with antecolic gastrojejunostomy. The diagnosis of internal hernia was made on the basis of surgical find ings in two patients of retroanastomotic hernia, and characteristic barium study findings in one patient of left paraduodenal hernia. RESULTS: The small bowel follow through examination showed small bowel loops gathered in a circumscribed mass in the left mid abdomen, and delay in passage through these loops. In case of left paraduodenal hernia, abrupt narrowing of the distal duodenum could be identified. The characteristic CT findings of all three patients were whorling of the mesentery and mesenteric vessels in the left mid-abdomen. In the patient with left paraduodenal hernia, after resolution of the gastrointestinal symptoms, a follow-up CT scan showed spontaneous disappearance of whorling of the mesentery and mesenteric vessels suggesting spontaneous resolution of the hernia. In the other two cases, upon exploration of the abdomen, dilatation of afferent duodenum caused by adhesion between ligament of Treitz and adjacent bowel walls, and retro- anastomotic herniation of the efferent loops were found. CONCLUSION: The usual diagnosis of internal hernia is based on the appearance of the small bowel follow through examination. However, we consider that the whorling appearance(we call it whorling sign) of the mesentery and mesenteric vessels on CT scan is also suggestive of internal hernia in patients under clinical suspicion.
Abdomen
;
Barium
;
Diagnosis
;
Dilatation
;
Duodenum
;
Follow-Up Studies
;
Gastrectomy
;
Gastric Bypass
;
Hernia
;
Humans
;
Ligaments
;
Mesentery*
;
Tomography, X-Ray Computed