1.Clinical and Angiographic Findings in Patients with Toxoplasmic Retinochroiditis.
In Taek KIM ; Sung Dong JANG ; Sung Bin PARK
Journal of the Korean Ophthalmological Society 2000;41(12):2741-2749
No Abstract Available.
Humans
2.Effects of synthetic estrogen on the biosynthesis of testosterone, LH, and prolactin.
Sung Dong LEE ; Hyuck JUNG ; Ha Jong JANG
Korean Journal of Obstetrics and Gynecology 1991;34(12):1691-1699
No abstract available.
Estrogens*
;
Prolactin*
;
Testosterone*
3.Carcinosarcoma in Recurrent Lesion of Serous Cystadenocarcinoma of the Ovary: A case report.
Kyu Yun JANG ; Woo Sung MOON ; Dong Geun LEE
Korean Journal of Pathology 1999;33(3):221-224
Neoplasms showing both carcinomatous and sarcomatous features are well established, and have been reported in practically every organ where carcinoma can occur. But the difference in terminology and difficulties in histopathologic interpretation have hampered adequate understanding of these neoplasms. We report a case of carcinosarcoma in the recurrent form of serous cystadenocarcinoma of the ovary. The patient was a 64-year-old female who underwent total hysterectomy and bilateral salpingoophorectomy three years ago, due to perforated papillary serous cysta denocarcinoma of the right ovary. Recurrent pelvic masses contained both carcinomatous and sarcomatous components. Morphological transition between carcinomatous and sarcomatous components, and epithelial characteristics in the sarcomatous component by immunohistochemistry were recognized. We postulate the histopathogenetic mechanism based on the phenotypic conversion of carcinoma into sarcoma in the carcinosarcoma.
Carcinosarcoma*
;
Cystadenocarcinoma, Serous*
;
Female
;
Humans
;
Hysterectomy
;
Immunohistochemistry
;
Middle Aged
;
Ovary*
;
Sarcoma
4.Ovarian Mucinous Cystadenocarcinoma with Mural Nodules of Anaplastic Carcinoma: A case report.
Kyu Yun JANG ; Woo Sung MOON ; Dong Geun LEE
Korean Journal of Pathology 1999;33(3):217-220
A case of an ovarian mucinous cystadenocarcinoma with mural nodules of anaplastic carcinoma is reported. The patient was a 46-year-old female with a right ovarian cystic mass and underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy. The patient died of the disease in five months. Macroscopically, the right ovarian cyst wall contained numerous well-demarcated mural nodules. Histologically, the cysts were mucinous cystadenocarcinoma, and the nodules were composed of sarcoma-like spindle and polygonal cells with atypia and numerous mitoses. Spindle cells in the mural nodule showed epithelial characteristics by electron microscopy and immunohistochemistry. This case supports an epithelial origin of the mural nodule of anaplastic carcinoma in ovarian mucinous tumors.
Carcinoma*
;
Cystadenocarcinoma, Mucinous*
;
Female
;
Humans
;
Hysterectomy
;
Immunohistochemistry
;
Microscopy, Electron
;
Middle Aged
;
Mitosis
;
Mucins*
;
Ovarian Cysts
;
Ovary
5.Pulmonary aspergiloma associated pulmonary tuberculosis.
Sung Bo SIM ; Oug Jin KIM ; Byung Seok KIM ; Dong Cheol JANG ; Bum Shik KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 1991;24(10):1011-1018
No abstract available.
Tuberculosis, Pulmonary*
6.Relationship between HPV Infection and bcl-2 Protein Expression and Apoptosis in Invasive and In Situ Squamous Cell Carcinoma of the Uterine Cervix.
Myoung Ja CHUNG ; Kyu Yun JANG ; Woo Sung MOON ; Myoung Jae KANG ; Dong Geun LEE
Korean Journal of Pathology 1999;33(9):702-708
Human papillomavirus (HPV) 16/18 is a causative agent of uterine cervical carcinoma. HPV 16/18 can alter cell cycle regulation through apoptosis. Bcl-2 is an important regulatory gene of apoptosis. A study was done to evaluate the relation between HPV 16/18 and bcl-2 and apoptosis in 21 cases of carcinoma in-situ (CIS), 5 cases of microinvasive carcinoma and 23 cases of invasive squamous cell carcinoma. HPV 16/18 was detected by hybrid capture system (HCS), bcl-2 protein by immunohistochemical method and apoptosis by using the hematoxylin-eosin stained slide. The results were as follows: Expression of the bcl-2 protein was 43% (9/21) in CIS and 26% (6/23) in invasive carcinoma. Expression of the bcl-2 protein was 42% (5/12) in CIS with HPV 16/18 infection, 44% in CIS without HPV 16/18 infection, 20% (2/10) in invasive carcinoma with HPV 16/18 infection and 31% (4/13) in invasive carcinoma without HPV 16/18 infection. Mean apoptotic index (mAI) was 3.36 in CIS, 5.23 in microinvasive and 6.25 in invasive carcinoma. mAI was 3.66 in CIS with HPV 16/18 infection, 2.86 in CIS without HPV 16/18 infection, 6.18 in invasive carcinoma with HPV 16/18 infection and 6.30 in invasive carcinoma without HPV 16/18 infection. Based on these results, we conclude that there are no correlation between HPV infection and bcl-2, and between HPV infection and apoptosis in invasive and in situ carcinoma of the uterine cervix, and apoptosis is increased according to tumor progression.
Apoptosis*
;
Carcinoma, Squamous Cell*
;
Cell Cycle
;
Cervix Uteri*
;
Female
;
Genes, Regulator
;
Humans
7.Correlation between Magnetic Resonance Image Signal Changes and Electromyographic Findings after Sciatic Nerve Transection in the Rat.
Joo Hwan LEE ; Jang Chul LEE ; Dong Won KIM ; Ki Young PARK ; Sung Moon LEE
Journal of Korean Neurosurgical Society 2000;29(1):101-107
No abstract available.
Animals
;
Rats*
;
Sciatic Nerve*
8.Clinical Observation of Neonatal Sepsis according to Onset of Disease.
Young Chul JANG ; Soon Kyung BAIK ; Chang Sung LIM ; Dong Jin LEE
Journal of the Korean Pediatric Society 1994;37(12):1676-1686
We have experienced 113 cases of neonatal sepsis comfirmed by clinical manifestations and blood cultures from Jan. 1988 to Dec. 1992 at the Neonatal Intensive Care Unit of Ulsan Dong-Kang Hospital and observed the incidence, predisposing perinatal factors, clinical manifestations, associated illnesses, laboratory findings, isolated microorganisms, antibiotics sensitivity test and mortality rate of neonatal sepsis according to onset of disease. The result were as follows: 1) The incidence of neonatal sepsis was 1.39% and male to female ration was 1.38:1. The incidence and sex difference between early onset and late onset disease were not significant. 2) Neonatal sepsis was more prevalent in premature infants (2.47%) than in fullterm infants (1.28%) and nore prevalent in low birth weight infants(3.01%) than in normal birth weight infants (1.25%). In premature infants, neonatal sepsis was more prevalent in early onset (63.2%) than in late onset diease (36.8%). In low birth weight infants, neonatal sepsis was more prevalent in early onset (64.8%) than in late onset dieases (35.7%P). 3) Predisposing perinatal factors, such as meconium staining, birth asphyxia, difficult delivery, premature rupture of membrane, maternal infection, toxemia and postpartum bleeding were slightly frequent in early onset disease. 4) Among the clinical manifestations, jaundice, respiratory symptoms, pallor, lethargy, poor feeding and hepatosplenonegaly were slightly frequent in early onset disease, but temperature instability and gastrointestinal symptoms were slightly frequent in late onset disease. 5) Among the associated illness, pneumonia, disseminated intravascular coagulopathy, amnionitis, hyaline membrane disease and osteomyelits were more common in early onset disease, but gastroenteritis, urinary tract infection, necrotizing enterocolitis, wound infection and meningitis were mors common in late onset disease. 6) The difference of laboratory findings between early onset and late onset disease was not significant. 7) Causative organisms were gram positive organisms in 87 cases(77.0%), gram negative organisms in 22 cases (18.6%) and mixed infections in 5 cases (4.4%). Among them, coagulase negative staphylococcus was the most common one and staphylococcus aureus was the second. The incidence of infections caused by coagulase negative staphylococcus and staphylococcus aureus, between early onset and late onset disease, was not significantly different. Streptococcal infection was more prevalent in early onset disease, especially all group B streptococcus caused early onset disease. 8) Gram positive organisms ware sensitive to Cephalothin (92.9%), Chloramphenicol (90.0%) and Ceftriaxone (88.9%). Gram negative organisms were sensitive to Amikacin (91.3%) and Colistin (82.6%). The difference of antibiotics sensitivity for organisms causing early onset and late onset diease were not significant. Gram negative organisms causing early onset disease were resistant to gentamicin and terramycin, but those organisms causing late onset disease were more sensitive to gentamicin (88.9%) and tobramycin (77.8%). 9) The mortality rate was 7.96%. It was higher in gram negative infections (23.8%) than in gram positive infections (4.6%). No significant difference of mortality rate between early onset and late onset disease was found.
Amikacin
;
Amnion
;
Anti-Bacterial Agents
;
Asphyxia
;
Birth Weight
;
Ceftriaxone
;
Cephalothin
;
Chloramphenicol
;
Chorioamnionitis
;
Coagulase
;
Coinfection
;
Colistin
;
Enterocolitis, Necrotizing
;
Female
;
Gastroenteritis
;
Gentamicins
;
Hemorrhage
;
Humans
;
Hyaline Membrane Disease
;
Incidence
;
Infant
;
Infant, Low Birth Weight
;
Infant, Newborn
;
Infant, Premature
;
Intensive Care, Neonatal
;
Jaundice
;
Lethargy
;
Male
;
Meconium
;
Membranes
;
Meningitis
;
Mortality
;
Oxytetracycline
;
Pallor
;
Parturition
;
Pneumonia
;
Postpartum Period
;
Pregnancy
;
Rupture
;
Sepsis*
;
Sex Characteristics
;
Staphylococcus
;
Staphylococcus aureus
;
Streptococcal Infections
;
Streptococcus
;
Tobramycin
;
Toxemia
;
Ulsan
;
Urinary Tract Infections
;
Wound Infection
9.A Case of Hobnail Hemangioma.
Shin Taek OH ; Seung Dong LEE ; Sung Wook KIM ; In Gang JANG ; Baik Kee CHO
Annals of Dermatology 2002;14(1):45-47
Hobnail hemangioma(HH) is a benign acquired vascular tumor of endothelial origin which should be differentiated from other malignant vascular neoplasm such as Kaposi's sarcoma or angiosarcoma. We report a case of hobnail hemangioma in a 21-year-old woman who had a dusky-red patch on her left shin. Histologically, ectatic vascular channels with a single layer of plumped endothelial cells were seen and the vascular channels seemed to dissect the collagen bundles. She underwent treatment with surgical excision with primary closure.
Collagen
;
Endothelial Cells
;
Female
;
Hemangioma*
;
Hemangiosarcoma
;
Humans
;
Sarcoma, Kaposi
;
Vascular Neoplasms
;
Young Adult
10.Unilateral Idiopathic Maculopathy.
Journal of the Korean Ophthalmological Society 1999;40(5):1260-1268
This is a report of five patients who experienced slow, severe, unilateral central vision loss without a history of any other systemic illness. All patients were female and the age of the patients ranged from 21 to 33 years, with a mean age of 27 years. The follow-up period was 1 to 3 years. Each patient had a small yellowish spot in the fovea, which was associated with subretinal or retinal hemorrhage. No inflammatory cells were found in the vitreous or anterior chamber. Most patients presented with a visual acuity of 0.3 to 0.6. In one patient, the presenting visual acuity was 1. 0. Each patient described a central scotoma which was confirmed by Amsler`s grid test. The presenting manifestations of the disorder did not progress or recur in any of these patients during the period of follow-up. Visual acuity recovered to the visual acuity of the initial visit in three of five patients. The fluorescein angiogram revealed the early hyperfluorescence in the spot of the fovea which remained the same through the late phase. Three of five patients demonstrated a neurosensory detachment of the macula usually with irregular margins. The spot of the fovea showed hypofluorescence on the indocyanine green angiography. No hyperfluorescence in the center of the macula was found on the ICG-A. To the best of our knowledge, this unique clinical entity does not seem to be consistent with any previously described maculopathies in its clinical, angiographic features, and its natural course.
Angiography
;
Anterior Chamber
;
Female
;
Fluorescein
;
Fluorescein Angiography
;
Follow-Up Studies
;
Humans
;
Indocyanine Green
;
Retinal Hemorrhage
;
Scotoma
;
Visual Acuity