Neonatal bacterial meningitis remains as one of the significant causes of death and neurological sequellae. Twenty four cases of neonatal meningitis who were admitted to pediatric department, National Medical Center from Jan. 1970 to Dec. 1978 were reviewed clinically and the following results were obtained. 1. Age of onset was chiefly in the lst week of life(57.4%) followed by the 2nd week of life(25%). 2. Sex ratio showed predominance of male(83.3%). Seasonal distribution was non remarkable. 3. Among 24 cases, there noted 11 cases of positive cultrues for the etiologic agents, 5 of Gram positive and 6 of Gram negative. 4. Mean duration of days between the onset and the diagnosis was 2.5 days. The most common presenting symptoms and signs were poor sucking, irritability and lethargy. 5. On cerebrospinal fluid examination there noted increased cell count and protein and decreased sugar content in all cases 6. Case fatality rate was 25%. Subdural effusion was complicated in 20% of the cases but no hydrocephalus was noted.
Age of Onset ; Cause of Death ; Cell Count ; Cerebrospinal Fluid ; Diagnosis ; Hydrocephalus ; Lethargy ; Meningitis ; Meningitis, Bacterial* ; Mortality ; Seasons ; Sex Ratio ; Subdural Effusion

A double-blind trial of the efficacy of propranolol hydrochloride a new beta adrenergic blocking agent, in the prophylactic treatment of angina pectoris was conducted in 9 patients. Through the trial period of 8 weeks to more than 26 weeks, the patients received propranolol and placebo for equal period. Following are the results. 1. The effective dose of propranolol hydrochloride in the prophylactic treatment of angina pectoris was 80 mg to 120 mg per day. 2. The effectiveness of propranolol hydrochloride was manifested by a reduction in frequency of pain to 40.7%, in nitroglycerin comsumption to 38.8% and by an increase in exercise tolerance. 3. Obseved side effects were transient nausea, vomiting and bradycardia, which were improved with reduction in drug dosage. 4. Further clinical and experimental information may be necessary in order to assess the long-term effects of propranolol hydrochloride.
Angina Pectoris* ; Bradycardia ; Exercise Tolerance ; Humans ; Nausea ; Nitroglycerin ; Propranolol* ; Vomiting

No abstract available.
Necrosis* ; Typhoid Fever*

No abstract available.
Humans ; Nephritis, Hereditary* ; Siblings*

Carcinoma ex pleomorphic adenoma is a very rare malignant tumor arising in the salivary gland and mainly in the parotid gland. It is highly malignant but asymptomatic, painless and has space occupying lesion sometimes. The metastasis is common(70%) and the prognosis is relatively poor. Although there is no definite treatment modality, the combined surgical intervention and the postoperative radiation therapy has been recommended. We treated a case of carcinoma ex pleomorphic adenoma of the palate with local excision, skin graft and postoperative radiation therapy
Adenoma, Pleomorphic* ; Neoplasm Metastasis ; Palate* ; Parotid Gland ; Prognosis ; Salivary Glands ; Skin ; Transplants

The prediction of possibility which patient will develop vasospasm constitutes a further advance in the management of this complication. So the possible clinical risk factors predicting ischemic complication of subarachnoid hemorrhage were retrospectively investigated in patients with ruptured intracranial aneurysm. A comparative analysis of risk factors contributing to symptomatic vasospasm was carried out between 40 patients with symptomatic vasospasm as DID(Delayed Ischemic Neurologic Deficit) group and 52 patients without symptomatic vasospasm as Non-DID group, those who were selected among 349 cases of ruptured intracranial aneurysm admitted to department of neurosurgery at Presbyterian Medical Center, Jeon Ju for 6 years from August, 1982 to July, 1988. Peripheral WBC count, clinical grade, hematocrit, blood glucose level, EKG findings, age, sex and aneurysm location of admission failed to show a prognostic value as a factor developing delayed ischemic neurologic deficit in the patients. However a statistically significant rise in peripheral WBC count was observed at the beginning of clinical deterioration and also systolic blood pressure at admission were significantly higher in DID than Non-DID group. The results suggest that the increase of peripheral WBC count observed at the time of neurological deterioration of delayed onset and high systolic blood pressure at admission might be a risk factor for developing vasospasm.
Aneurysm* ; Blood Glucose ; Blood Pressure ; Electrocardiography ; Hematocrit ; Humans ; Intracranial Aneurysm ; Jeollabuk-do ; Neurologic Manifestations ; Neurosurgery ; Protestantism ; Retrospective Studies ; Risk Factors* ; Subarachnoid Hemorrhage*

A 6 year 6month-old boy was admitted with complains of severe spontaneou epistaxis and easy brusability. He was one of five siblings, and two of them died of recurred severe epistaxis at their age of six years. There was no history of bleeding tendency to his antecedents and parents, whose marriage was unrelated. Platelet count and partial thromboplastin time were noraml with prolonged bleeding time, but clot retraction was poor. Platelet adhesion(Salzman method) was decreased and platelet aggregation test showed flat curve with no response to epinephrine and ADP. These tests of other were normal. Diagnosis of thrombasthenia was made with the above history and laboratory results.
Adenosine Diphosphate ; Bleeding Time ; Blood Platelets ; Clot Retraction ; Diagnosis ; Epinephrine ; Epistaxis ; Hemorrhage ; Humans ; Male ; Marriage ; Parents ; Partial Thromboplastin Time ; Platelet Aggregation ; Platelet Count ; Siblings ; Thrombasthenia*

A 6 year 6month-old boy was admitted with complains of severe spontaneou epistaxis and easy brusability. He was one of five siblings, and two of them died of recurred severe epistaxis at their age of six years. There was no history of bleeding tendency to his antecedents and parents, whose marriage was unrelated. Platelet count and partial thromboplastin time were noraml with prolonged bleeding time, but clot retraction was poor. Platelet adhesion(Salzman method) was decreased and platelet aggregation test showed flat curve with no response to epinephrine and ADP. These tests of other were normal. Diagnosis of thrombasthenia was made with the above history and laboratory results.
Adenosine Diphosphate ; Bleeding Time ; Blood Platelets ; Clot Retraction ; Diagnosis ; Epinephrine ; Epistaxis ; Hemorrhage ; Humans ; Male ; Marriage ; Parents ; Partial Thromboplastin Time ; Platelet Aggregation ; Platelet Count ; Siblings ; Thrombasthenia*

The results of a retrospective study on 197 cases of malignant skin tumors, which were operated from July 1991 to June 1996 were presented. 1. Primary malignant skin tumors in our series included basal cell carcinoma (42%), squamous cell carcinoma (39%), melanoma (7%). Eighty five percentage of them were developed after 5th decade. There was a slight male preponderance (male to female ratio; 1.2:1). 2. seventy five percentage of malignant skin tumors were occurred in the head and neck. However 34% of squamous cell carcinoma occurred in the extremities. 3. Overall recurrence rate was 7.1% and overall metastasis rate was 7.6%. Seven cases (8.5%) of basal cell carcinoma were recurred without metastasis and seven cases (53.8%) of melanoma were meatastasized without recurrence. 4. Overall recurrence occurred at average 27 months after primary resection and 79% of them occurred in the head and neck. Among 14 recurred tumors, one recurred secondarily and three were metastasized elsewhere. 5.Two thirds of metastasis occurred within one year of resection. Mortality rate in the patients with metastasis was 40%. Metastases involved multiple organs and involved lymph nodes most frequently. 6.Fifteen patients with metastasis were treated with surgery alone (2 cases), surgery and adjuvant therapy (3 cases), radiation and/or chemolherapy without surgery (6 cases), and no therapy(4 cases).
Carcinoma, Basal Cell ; Carcinoma, Squamous Cell ; Extremities ; Female ; Head ; Humans ; Lymph Nodes ; Male ; Melanoma ; Mortality ; Neck ; Neoplasm Metastasis* ; Recurrence ; Retrospective Studies* ; Skin*

Thirty-four patients with various intracranial lesions underwent the stereotatic surgery using the Pelorus system, which consists of integrated skull set, phantom and Arc adaptor, between September, 1987 and October, 1988.10 of 12 biopsies(83%) were diagnosed as 4 metastatic tumors, 3 glioblastoma multiforme, 1 cerebral infarction and 1 calcification. Fifteen patients with the spontaneous intracerebral hematoma and 2 with the abscess were treated successfully. Two patients with the malignant tumors underwent the stereotatic isotope implantation with I125. Only one case of transient hemiparesis among 34 procedures developed. From the results, the use of a simple interlocking plate system, rather than a bulky frame produce benifits evident during application with capabilities and accuracy of most other stereotactic system. It has offered the advantages of stereotaxis to a currently possible wide range of patients, which it can be used to diagnose and treat.
Abscess ; Cerebral Infarction ; Glioblastoma ; Hematoma ; Humans ; Paresis ; Skull