No abstract available.
Free Tissue Flaps* ; Head* ; Neck*

No abstract available.
Skull Base* ; Skull*

No abstract available.
Rabbits* ; Transplants* ; Zygoma*

No abstract available.
Gyeongsangbuk-do* ; Humans ; Retrospective Studies*

The term 'orbital pseudotumor' has been used to describe inflammatory lesions of the orbital tissues of unknown etiology simulating in their clinical picture a neoplasm of the orbit. The term inflammatory pseudotumor of the orbit has a clinical rather than a pathological connotation. The clinical picture presented by inflammatory pseudotumor may resemble that of a true neoplasm in every way-there is proptosis which is irreducible, chemosis, swelling of the lid, limitation of mobility and frequently a discrete palpable mass. Usually recurrence has been Tare and several methods of treatment has been reported. A 48 year old Korean woman was found to have pseudotumor of her right orbit which was confirmed histopathologically on biopsy.
Biopsy ; Exophthalmos ; Female ; Granuloma, Plasma Cell ; Humans ; Middle Aged ; Orbit* ; Orbital Pseudotumor* ; Recurrence

Interferons(IFNs) exhibit an antiproliferative effect on many normal and transformed cells and have in vivo antitumor activity in a variety of cancers. Recent clinical studies have suggested major activity with IFNs, especially in advanced squamous cell carcinoma of the skin and cervix. With the objective of exploring how the IFNs might work in squamous carcinoma cell line, we studied the effect of IFN-a on cervical cancer cell lines. The effect of IFNs on apoptosis and cell cycle of cervical cancer cell lines(C33A, CaSki, SiHa, HeLa, ME-180) was analysed by flow cytometry in time dependent manner. Results were as follows: (1) According to cell count of studied cancer cell lines treated with 2,000 IU/ml IFN-a for 7 days exposure, IFN-a had the antiproliferative effect on all five tested cervical cancer cell lines. Also this antiproliferative effect was confirmed by WST-1 assay. (2) The effect of IFN-a on apoptosis of each cultute was analysed by flow cytometry after 3 days and 7 days exposure with 2,000 IU/ml IFN-a, Apoptosis was not induced by IFN-a treatment. (3) The effect of IFN-a on the cell cycle of each culture was analysed by flow cytometry after 3 days exposure with 2,000 IU/ml IFN-a. As compared to control cells, treatment with IFN-a resulted in a higher proportion of cells in S phase with lower portion of cells with G2/M phase. (4) Time course of IFN-a effect on HPV 16 and HPV 18 E6 mRNA levels was evaluated by northern blot analysis. In CaSki cell line, HPV 16 E6 mRNA expression induced by IFN-a was not inhibited. But in HeLa cell line, HPV 18 E6 inRNA expression was inhibited. IFN-a appears to have the antiproliferative effect on all five tested cervical cancer cell lines and the antiproliferative effect of IFN-a seemed to be induced not by apoptosis but by disruption on specific cell cycle. Also regulation of HPV E6 mRNA expression induced by IFN-a is not directly related to the mechanisms of the antiproliferative effect of IFN-a in cancer cell lines.
Apoptosis ; Blotting, Northern ; Carcinoma, Squamous Cell ; Cell Count ; Cell Cycle ; Cell Line* ; Cervix Uteri ; Female ; Flow Cytometry ; HeLa Cells ; Human papillomavirus 16 ; Human papillomavirus 18 ; Humans ; RNA, Messenger ; S Phase ; Skin ; Uterine Cervical Neoplasms*

Fifty patients with mild essential hypertension were studied to evaluate the efficacy of once-daily regimen of nitrendipine, 10~20mg daily for 12 weeks. 1) Thirty-Seven patients completed the study and showed -9% change in mean arterial headache etc. 2) Eight patients were dropped out because of side reaction, namely flushing, palpitation, headache etc. 3) Ambulatory blood pressure monitoring before and after treatment in 3 patients confirmed the drug efficacy revealing 9% decrement in mean blood pressure and 46% decrease in % elevated BP. 4) Twenty patients who were controlled with other hypotensive drugs were well controlled & maintained the blood pressure in normal range after switching to nitrendpine 10~20mg daily. In conclusion, citrendipine is a safe and good antihypertensive calcium antagonist in the treatment of mild hypertensives with 10~20mg of once-daily dosage.
Blood Pressure Monitoring, Ambulatory ; Blood Pressure* ; Calcium ; Flushing ; Headache ; Humans ; Hypertension ; Nitrendipine* ; Reference Values

The purpose of a static visual field examination is primarily to establish the contrast sensitivity for a large number of retinal points at a defined background luminance, spot size and exposure duration. The light threshold is defined as the value at which the probability for a stimulus to be detected is 50%. This implies that scatter of the threshold value determined by quantitative perimetry is always present. When the visual threshold is measured several times at a location, the result is not always identical. The variability of the threshold value obtained has been termed "fluctuation". The amount of fluctuation is influenced by the visual sensitivity at the location, by whether the location is normal or defective, by the frequency of the patient's false positive and false negative responses in catch trials, and by the refractive errors, and by the size of target. The mean fluctuation of normal subjects was 2.69 +/- 1.60 dB, the mean fluctuation of glaucomatous patients was 4.32 +/- 1.56 dB. Using the independent t-test to compare groups individually, the difference between the patients with glaucoma and the normals was significant for all components(p<0.05). This study also shows that the fluctuation of peripheral visual field is greater than that of central visual field, and that in eyes with poor cooperation, the fluctuation is greater than in eyes with better cooperation(p<0.05). Using the dependent t-test to compare groups individually, the difference between the subjects with refractive correction and inaccurate refractive correction was not significant for all components(p>0.05). Using the dependent t-test to compare groups individually, the difference between the subjects with using target III and target IV was not signifficant for all components(p>0.05).
Contrast Sensitivity ; Glaucoma ; Humans ; Refractive Errors ; Retinaldehyde ; Visual Field Tests ; Visual Fields

The authers investigated the effct of liposome encapsulation on the pharmacokinetics of tobramycin after subconjuctival in jnjection in rabbits. Tobramycin was encapsulated into neutral liposomes of phosphatidylcholine and cholesterol. The final liposomal suspension contained tobramycin, 5mg/ml. One of the each rabbit received a subconjunctival injection(2.5mg/0.5ml) of liposome-encapsulated tobramycin or tobramycin alone. Tobramycin levels in the sclera measured 3 and 24 hours after injection were marked higher with the liposome-encapsulated drug than with the another preperation. The difference between liposomeencapsulated drug and the another preperation was not significant for cornea.
Cholesterol ; Cornea* ; Liposomes ; Pharmacokinetics ; Phosphatidylcholines ; Rabbits* ; Sclera* ; Tobramycin*

No abstract available.
Adolescent* ; Child* ; Humans ; Obesity*