No abstract available.
Rabbits* ; Transplants* ; Zygoma*

No abstract available.
Free Tissue Flaps* ; Head* ; Neck*

No abstract available.
Skull Base* ; Skull*

No abstract available.
Gyeongsangbuk-do* ; Humans ; Retrospective Studies*

BACKGROUND: The common histopathology of Behget's disease is vasculitis associated with activation of neutrophils. The level of plasma elastase a 1 proteinase inhibitor (E a 1 PI), which represents the activation of neutrophils, may be a marker of Behcet's disease. OBJECTIVE: We examined the level of plasma elastase al proteinase inhibitor to evaluate the degree of neutrophil activation in Behcet's disease. METHOD: We measured plasma elastase a 1 proteinase inhibitor in 34 cases of untreated Behcet's disease patients and 30 cases of normal individuals by an enzyme immunoassay. We also studied the differences between the levels in two clinical types of Behcet's disease, the complete and incomplete type. RESULTS: The plasma level of elastase a 1 proteinase inhibitor was significantly higher in untreated Behcet's disease patients than in healthy controls. However, there was no significant difference between the levels in the two clinical types. CONCLUSION: These data suggest that the elevated level of plasma elastase a 1 proteinase inhibitor may reflect a state of chronic activation of neutrophils in Behcet's disease immunologically and further studies will be needed to evaluate the clinical status of Behcet's disease patients by measuring levels of plasma elastase a 1 proteinase inhibitor.
Humans ; Immunoenzyme Techniques ; Methods ; Neutrophil Activation ; Neutrophils ; Pancreatic Elastase ; Plasma* ; Vasculitis

One consistent finding in the aging human RPE is the intracellular accumulation of lipofuscin Lipofuscin was applied to the cell culture technique to clarify the relationship between age related macular degeneration and lipofuscin accumulation in the human RPE. The results obtained in this study are as follows: 1. The initial suspensions of dissociated RPE cells consisted of densely pigmented and hexagonal cells. Rapid cell proliferation and confluency of a culture occured from 2 weeks after seeding. No pigment granule was observed in subcultured cells of 3rd passage. 2. When RPE cultures were subcultured the cells gradually de pigmented due to a redistribution of pigment granules. Quantitative analysis demonstrated that intensity of fluorescence for a certain number of cells reduced proportionally as the cell division proceeded. 3. Cultured human retinal pigment epithelial cells readily ingested lipofuscin isolated from human RPE cells. The amount of lipofuscin phagocytized by cultured RPE cells were greater than that phagocytized by aged cells. Accumulation and/or saturation of lipofuscin in the RPE cells at least in cell culture did not necessarily affect RPE cell survival.
Aging ; Cell Culture Techniques ; Cell Division ; Cell Proliferation ; Cell Survival ; Epithelial Cells ; Fluorescence ; Humans* ; Lipofuscin* ; Macular Degeneration ; Retinal Pigment Epithelium* ; Retinaldehyde* ; Suspensions

The authers investigated the effct of liposome encapsulation on the pharmacokinetics of tobramycin after subconjuctival in jnjection in rabbits. Tobramycin was encapsulated into neutral liposomes of phosphatidylcholine and cholesterol. The final liposomal suspension contained tobramycin, 5mg/ml. One of the each rabbit received a subconjunctival injection(2.5mg/0.5ml) of liposome-encapsulated tobramycin or tobramycin alone. Tobramycin levels in the sclera measured 3 and 24 hours after injection were marked higher with the liposome-encapsulated drug than with the another preperation. The difference between liposomeencapsulated drug and the another preperation was not significant for cornea.
Cholesterol ; Cornea* ; Liposomes ; Pharmacokinetics ; Phosphatidylcholines ; Rabbits* ; Sclera* ; Tobramycin*

No abstract available.
Adolescent* ; Child* ; Humans ; Obesity*

Fifty patients with mild essential hypertension were studied to evaluate the efficacy of once-daily regimen of nitrendipine, 10~20mg daily for 12 weeks. 1) Thirty-Seven patients completed the study and showed -9% change in mean arterial headache etc. 2) Eight patients were dropped out because of side reaction, namely flushing, palpitation, headache etc. 3) Ambulatory blood pressure monitoring before and after treatment in 3 patients confirmed the drug efficacy revealing 9% decrement in mean blood pressure and 46% decrease in % elevated BP. 4) Twenty patients who were controlled with other hypotensive drugs were well controlled & maintained the blood pressure in normal range after switching to nitrendpine 10~20mg daily. In conclusion, citrendipine is a safe and good antihypertensive calcium antagonist in the treatment of mild hypertensives with 10~20mg of once-daily dosage.
Blood Pressure Monitoring, Ambulatory ; Blood Pressure* ; Calcium ; Flushing ; Headache ; Humans ; Hypertension ; Nitrendipine* ; Reference Values

The purpose of a static visual field examination is primarily to establish the contrast sensitivity for a large number of retinal points at a defined background luminance, spot size and exposure duration. The light threshold is defined as the value at which the probability for a stimulus to be detected is 50%. This implies that scatter of the threshold value determined by quantitative perimetry is always present. When the visual threshold is measured several times at a location, the result is not always identical. The variability of the threshold value obtained has been termed "fluctuation". The amount of fluctuation is influenced by the visual sensitivity at the location, by whether the location is normal or defective, by the frequency of the patient's false positive and false negative responses in catch trials, and by the refractive errors, and by the size of target. The mean fluctuation of normal subjects was 2.69 +/- 1.60 dB, the mean fluctuation of glaucomatous patients was 4.32 +/- 1.56 dB. Using the independent t-test to compare groups individually, the difference between the patients with glaucoma and the normals was significant for all components(p<0.05). This study also shows that the fluctuation of peripheral visual field is greater than that of central visual field, and that in eyes with poor cooperation, the fluctuation is greater than in eyes with better cooperation(p<0.05). Using the dependent t-test to compare groups individually, the difference between the subjects with refractive correction and inaccurate refractive correction was not significant for all components(p>0.05). Using the dependent t-test to compare groups individually, the difference between the subjects with using target III and target IV was not signifficant for all components(p>0.05).
Contrast Sensitivity ; Glaucoma ; Humans ; Refractive Errors ; Retinaldehyde ; Visual Field Tests ; Visual Fields