To study the relationship between the bone mineral density measured by DEXA and QCT methods and to study the factors influencing on the value, bone mineral density in 208 patients with low back pain were measured by the two methods and compared statistically. Ages were varied between 17 to 79(Av. 46.7) years and male and female were 86 and 122. The results of this are as follows; 1. The values of DEXA and QCT showed statistically significant relationship(γ=0.58) as a whole. And bone mineral density in L2, L3 and L4 showed no difference in both groups. 2. Bone loss by aging(per year) in male and female was 0.99% and 1.06% by DEXA, 0,99% and 1.41% by QCT. 3. Body height and weight showed no significant influence of the value in two methods. 4. In body mass index over 27.5, the value measured by QCT was influenced to be diminished while that of DEXA was not influenced. 5. The value by QCT was influenced to be diminished by the increase of age especially over 50 years old in both sex. While the value by DEXA was influenced to be lowered than expected in female over 50 years old. It is concluded that the methods of measurement of bone mineral density have their limitation depend on the age, sex and mass index.
Body Height ; Body Mass Index ; Bone Density ; Female ; Humans ; Low Back Pain ; Male ; Spine

This is a retrospective clinical analysis of 27 cases of pancreatic pseudocysts that were treated at the Department of Surgery, Chung Goo Sung Sim Hospital, from 1988 to 1996. The results are as follows:1) The ratio of males to females was 12.5 :1, and the highest incidence was in the 4th decade. 2) Acute & Chronic Pancreatitis was most frequently associated with pancreatic pseudocysts (72.4%). 3) The most frequent symptom of patients with a pancreatic pseudocyst was abdominal pain (92.5%), and the most common site of the pancreatic pseudocyst was the tail of the pancreas (55.6%). 4) Of the 7 cases involving pseudocysts of less than 5 cm, 6 cases were managed conservatively and 1 case surgically . In the 15 cases with sizes from 5 cm to 10 cm, percutaneous catheter drainage was performed in 7 cases, with sizes larger conservative management in 5 cases and surgical management in 4 cases. In the 5 cases with sizes larger than 10 cm, percutaneous catheter drainage was performed in 3 cases and surgical management in 1 case. 5) Cases involving conservative management and percutaneous drainage (average:31 & 34 days), respectively had shorter hospital stays than surgical menagement (42 days). 6) Complications of pancreatic pseudocysts, such as intra-abdominal abscesses, cutaneous fistulas, pulmonary complications, wound infection, leakage or rupture, etc, were relatively common after surgery. In conclusion, we propose that conservative management and percutaneous catheter drainage are first-line treatment modalities for pancreatic pseudocysts if the clinical conditions of the patient can tolerate them.
Abdominal Abscess ; Abdominal Pain ; Catheters ; Cutaneous Fistula ; Drainage ; Female ; Humans ; Incidence ; Length of Stay ; Male ; Pancreas ; Pancreatic Pseudocyst* ; Pancreatitis, Chronic ; Retrospective Studies ; Rupture ; Wound Infection

The present study evaluated the effects of guided tissue regeneration using biodegradable membrane, with and without calcium-phosphate thin film coated deproteinated bone powder in beagle dogs. Contralateral fenestration defects(6 x 4 mm) were created 4 mm apical to the buccal alveolar crest on maxillary canine teeth in 5 beagle dogs. Ca-P thin film coated deproteinated bone powder was implanted into one randomly selected fenestration defect(experimental group). Biodegradable membranes were used to provide bilateral GTR. Tissue blocks including defects with overlying membranes and soft tissues were harvested following a four- & eight-week healing interval and prepared for histologic analysis. The results of this study were as follows. 1. The regeneration of new bone, new periodontal ligament, and new cementum was occurred in experimental group more than control group. 2. The collapse of biodegradable membranes into defects were showed in control group and the space for regeneration was diminished. In experimental group, the space was maintained without collapse by graft materials. 3. In experimental group, the graft materials were resorbed at 4 weeks after surgery and regeneration of bone surrounding graft materials was occurred at 8 weeks after surgery. 4. Biodegradable membranes were not resorbed at 4 weeks and partial resorption was occurred at 8 weeks but the framework and the shape of membranes were maintained. No inflammation was showed at resorption. In conclusion, the results of the present study suggest that Ca-P thin film coated deproteinated bone powder has adjunctive effect to GTR in periodontal fenestration defects. Because it has osteoconductive property and prohibit collapse of membrane into defect, can promote regeneration of much new attachment apparatus.
Animals ; Cuspid ; Dental Cementum ; Dogs* ; Guided Tissue Regeneration* ; Inflammation ; Membranes* ; Periodontal Ligament ; Regeneration ; Transplants

PURPOSE: Feminizing genitoplasty is the surgical management after female gender assignment for intersex patients. The surgical outcome and complications of 20 cases of feminizing genitoplasty were analyzed. MATERIALS AND METHODS: Between January 1988 and December 2003, 20 patients surgically treated by feminizing genitoplasty, were retrospectively reviewed. The mean ages at the time of diagnosis and surgical treatment were 6.25 and 7.35 years, respectively. The preoperative evaluations included history taking, physical examination, and chromosomal, hormonal, and radiological studies. All patients underwent feminizing genitoplasty, including at least one of clitoral reconstruction, vaginoplasty or labial reconstruction. The 20 patients were analyzed according to their karyotype, phenotype, gender of rearing, ages at diagnosis and operation, surgical procedures, complications and follow up. RESULTS: Of the 20 cases, there were 10 female pseudohermaphroditism, 6 male pseudo- hermaphroditism, 3 gonadal dysgenesis, and 1 Mayer- Rokitanski-Kuster syndrome. Within these cases, 14, 10 and 9 clitoral reconstructions, vaginoplasties and labial reconstructions were performed. The streak gonad was removed in all patients with gonadal dysgenesis. Postoperative cosmetic and functional effects were successful, with few complications. CONCLUSIONS: Considering our surgical outcomes, feminizing genitoplasty for intersex patients, who are determined to a female gender assignment, is a good surgical procedure.
46, XX Disorders of Sex Development ; Diagnosis ; Disorders of Sex Development ; Female ; Follow-Up Studies ; Gonadal Dysgenesis ; Gonads ; Humans ; Karyotype ; Male ; Phenotype ; Physical Examination ; Retrospective Studies ; Surgery, Plastic

The purpose of this study was to evaluate the effects of periodontal curet and various rotating instruments on the root surfaces. Thirty-five extracted teeth with advanced periodontal disease were used. They was root planed with periodontal curet, periodontal Perio-Clean bur, periodontal Roto-Perio bur, resin polishing ET bur, and resin polishing diamond fissure bur. To find dentinal tubule orifices on the root surface, tetracycline HC1 solution was applied to the one tooth of treated each group. Then, root surfaces were investigated using scanning electron microscope. Amount of loss of cementum was evaluated by loss of tooth substance index. The results were as follows. 1. Groups treated with periodontal curet and Perio-Clean bur showed irregular surface and concavities. Concavities seemed to be lacunae of cementocyte. Other groups treated with Roto-Perio bur, resin polishing ET bur, and resin polishing diamond fissure bur showed partially opened dentinal tubule orifice. 2. Groups treated with periodontal curet and Perio-Clean bur and tetracycline HC1 showed irregular surface. No dentinal tubule orifice was seen. Other groups treated with Roto-Perio bur, resin polishing ET bur, and resin polishing diamond fissure bur and tetracycline HCI showed dentinal tubule orifice with various shape and size. 3. Loss of tooth substance indices were compared between groups. There was no statistically difference between periodontal curet and Perio-Clean bur groups. There were statistically differences between periodontal curet and Roto-Perio bur, ET bur, and diamond fissure bur groups. As a result of this study, groups treated with Roto-Perio bur, resin polishing ET bur, and resin polishmg diamond fissure bur showed more cementum removed than groups treated with periodontal curet and Perio-Clean bur. Therefore, in a conventional treatment for periodontal disease, it was recommended that periodontal curet or Perio-Clean bur should he used. In a treatment for regeneration of periodontal tissue, it was recommended that Roto-Perio bur, resin polishing ET bur, or resin polishing diamond fissure bur should be used
Dental Cementum ; Dentin ; Diamond ; Periodontal Diseases ; Regeneration ; Root Planing* ; Tetracycline ; Tooth

BACKGROUND: Epidermal cyst is a common disease. The clinical and histo pathologic findings in patients with epidermal cysts are described. OBJECTIVE: Our purpose is to identify the clinical and histopathologic feastures of epidermal cysts. MEHTODS: We ealuated the clinical and histopathologie features of 11 cases which were diagnosed with epidermal cysts at the department of dermatology in Wonju Chist.an Hospital and Jeju Severance Dermatologic clinic for 13 years, from January 1980 to June 1992. RESULTS: The ratio of males to females was 1.9: 1 with male predominance. Age distribution at first visit was variable, ranging from to 85 years old. The mean age was 3.5 years old. The Duration of lesions was variable, ranging from a 3 days to 20 years, with the mean duration of 2.4 years. The most common site of lesions was the face(36%), followed by the trunk(18%), neck(13%), leg(13%), arm (8%), scalp(3%), scrotum(3%), vagina(3%), palm(1%) and fingers(1%). Histopathologically, 46 cases(41%) were ruptured. The most common stromal change was fibrosi followed by granulation tissue formation, giant cell, calcifiration, pilomatricoma like change, pigment, squamous eddy, bone formation and vessel proliferation. The most common cystic content was keiatinous material followed by parakeratotic cell, bacterial colony, calcification, cholesterol cleft, pigment and RBC. The most common cystic wall change was acanthosis followed by atrophy, hyperplasia, hyergranulosis, basalioma like change, parakeratosis and reticulation. CONCLUSION: Epidermal cysts are slowly growing tumors. They occur nost commonly on the face, trunk, neck, legs and arms. Histopathologically, they have a wall compose 1 of true epidermis. When an epidermal cyst ruptures, a foreignbody reaction with numerous multinu leated giant cells occurs.
Age Distribution ; Aged, 80 and over ; Arm ; Atrophy ; Cholesterol ; Dermatology ; Epidermal Cyst* ; Epidermis ; Female ; Gangwon-do ; Giant Cells ; Granulation Tissue ; Humans ; Hyperplasia ; Leg ; Male ; Neck ; Osteogenesis ; Parakeratosis ; Pilomatrixoma ; Rupture

No abstract available.
Anti-Bacterial Agents* ; Arthroplasty* ; Knee* ; Replantation*

Growth hormone (GH) is crucial for childhood growth and body composition. In pediatric GH deficiency (pGHD), the pituitary gland fails to produce sufficient GH, which affects linear growth in childhood. pGHD is conventionally treated with daily recombinant human GH (rhGH); however, because GH therapy lasts throughout childhood, adherence to daily rhGH treatment can be low, resulting in suboptimal effectiveness. Somatrogon is a long-acting GH analog designed to address the challenges associated with daily GH therapy for pGHD. Somatrogon administered once per week is a potential alternative to daily GH therapy. The use of somatrogon is supported by phase II and III clinical trials demonstrating that once-weekly injections are noninferior to once-daily somatropin injections in terms of efficacy, safety, and tolerability and have the advantage of reduced treatment burden. This review summarizes the clinical trials of somatrogon and discusses the therapeutic profile and effects of treating pGHD with reduced injection frequency.

Growth hormone (GH) is crucial for childhood growth and body composition. In pediatric GH deficiency (pGHD), the pituitary gland fails to produce sufficient GH, which affects linear growth in childhood. pGHD is conventionally treated with daily recombinant human GH (rhGH); however, because GH therapy lasts throughout childhood, adherence to daily rhGH treatment can be low, resulting in suboptimal effectiveness. Somatrogon is a long-acting GH analog designed to address the challenges associated with daily GH therapy for pGHD. Somatrogon administered once per week is a potential alternative to daily GH therapy. The use of somatrogon is supported by phase II and III clinical trials demonstrating that once-weekly injections are noninferior to once-daily somatropin injections in terms of efficacy, safety, and tolerability and have the advantage of reduced treatment burden. This review summarizes the clinical trials of somatrogon and discusses the therapeutic profile and effects of treating pGHD with reduced injection frequency.

Growth hormone (GH) is crucial for childhood growth and body composition. In pediatric GH deficiency (pGHD), the pituitary gland fails to produce sufficient GH, which affects linear growth in childhood. pGHD is conventionally treated with daily recombinant human GH (rhGH); however, because GH therapy lasts throughout childhood, adherence to daily rhGH treatment can be low, resulting in suboptimal effectiveness. Somatrogon is a long-acting GH analog designed to address the challenges associated with daily GH therapy for pGHD. Somatrogon administered once per week is a potential alternative to daily GH therapy. The use of somatrogon is supported by phase II and III clinical trials demonstrating that once-weekly injections are noninferior to once-daily somatropin injections in terms of efficacy, safety, and tolerability and have the advantage of reduced treatment burden. This review summarizes the clinical trials of somatrogon and discusses the therapeutic profile and effects of treating pGHD with reduced injection frequency.