No abstract available.
Anemia, Aplastic* ; Child* ; Granulocyte Colony-Stimulating Factor* ; Granulocytes* ; Humans ; Sweet Syndrome*

No abstract available.
Benzalkonium Compounds* ; Dermatitis, Contact*

Dihydropyridine (DHP) calcium channel blockers (CCBs) have been widely used to treat of several cardiovascular diseases. An excessive shortening of action potential duration (APD) due to the reduction of Ca2+ channel current (I(Ca)) might increase the risk of arrhythmia. In this study we investigated the electrophysiological effects of nicardipine (NIC), isradipine (ISR), and amlodipine (AML) on the cardiac APD in rabbit Purkinje fibers, voltage-gated K+ channel currents (I(Kr), I(Ks)) and voltage-gated Na+ channel current (I(Na)). The concentration-dependent inhibition of Ca2+ channel currents (I(Ca)) was examined in rat cardiomyocytes; these CCBs have similar potency on I(Ca) channel blocking with IC50 (the half-maximum inhibiting concentration) values of 0.142, 0.229, and 0.227 nM on NIC, ISR, and AML, respectively. However, ISR shortened both APD50 and APD90 already at 1 microM whereas NIC and AML shortened APD50 but not APD90 up to 30 microM. According to ion channel studies, NIC and AML concentration-dependently inhibited I(Kr) and I(Ks) while ISR had only partial inhibitory effects (<50% at 30 microM). Inhibition of I(Na) was similarly observed in the three CCBs. Since the I(Kr) and I(Ks) mainly contribute to cardiac repolarization, their inhibition by NIC and AML could compensate for the AP shortening effects due to the block of I(Ca).
Action Potentials ; Amlodipine ; Animals ; Antihypertensive Agents ; Arrhythmias, Cardiac ; Calcium Channel Blockers* ; Calcium Channels* ; Calcium* ; Cardiovascular Diseases ; Inhibitory Concentration 50 ; Ion Channels ; Isradipine ; Myocytes, Cardiac ; Nicardipine ; Purkinje Fibers ; Rats

Phthisis bulbi, resulting from repeated ocular inflammation and infection or ocular trauma, causes various degeneration of ocular tissue as well as changes in ocular external shape. It shows the impression of scleral thickening with calcification of ocular tissue and an unusual ossification as well. Having observed 31-year-old patients of phthisis bulbi and band keratopathy caused by repeated operation after ocular trauma years ago, we extracted the tan brown colored shell-like firm tissue in posterior segment and report sclerotic impression of some of ocular tissue and histopathologic finding of the typical ossificationof ocular tissue during the course evisceration.
Adult ; Humans ; Inflammation ; Triacetoneamine-N-Oxyl

Secondary eyeball injury can be caused by head injury as well as direct injury of the eyeball or the orbit. Authors of this report have researched on 117 patients who were applied for ophthalmic examination which in care of the neurosurgical department and have researched frequency of secondary eyeball injury, association between the eyeball injury and the head injury, and favourable frequency of the eyeball injury which were developed without direct injury of the eyeball. There were 21 eyes(9.0%) with external ocular abnormality in 18 patients which included lagophthalmos, ptosis, paralytic strabismus, and there were 14 eyes(6.0 %) with posterior segment abnormality which were vitreoretinal hemorrhage, option. injury and papilledema in 11 patients. In association between the head injury and the eyeball injury, there were many external paralytic injury in basal skull injury and many posterior segment injury in cerebral parenchymal injury. After their injury, follow-up was executed in 3 month interval for 12 month. 15 eyes with external ocular abnormality and 8 eyes with posterior segment abnormality showed favourable progression. Posterior segment abnormality improved statistically significant at 3 month after injury(p<0.05). Secondary ophthalmic injury can be caused by various head injuries. Based on periodic observation, external ocular abnormality improved frequently at more than 9 months after injury. In cases of posterior segment abnormality, there was statistically significant improvement at 3 month after injury(p<0.05). Thus careful observation and treatment should be made in its early stage.
Craniocerebral Trauma* ; Follow-Up Studies ; Head* ; Hemorrhage ; Humans ; Orbit ; Papilledema ; Skull ; Strabismus

Anaphylactic reaction during the perioperative period typically exhibits rapid onset, varying clinical manifestations, and an expected mortality rate of 1.5-9%. Neuromuscular blocking agents are the leading cause of perioperative anaphylaxis. Here, we report a severe case of anaphylaxis that developed in a 66-year-old man due to cisatracurium administration. And he was successfully managed by extracorporeal membrane oxygenation. Cardiopulmonary resuscitation was performed by extracorporeal membrane oxygenation, and the patient was successfully weaned off 24 hours later.
Aged ; Anaphylaxis* ; Cardiopulmonary Resuscitation ; Extracorporeal Membrane Oxygenation* ; Heart Arrest* ; Humans ; Mortality ; Neuromuscular Blocking Agents ; Perioperative Period

The proliferative vitreoretinopathy was a complication followed by operation of rhegmatogenous retinal detachment. It was the mot, comon cause of a failure of retinal detachment surgery. It was characterized by the growth of cellular fibrous membrance in detached both retinal side and vitreous and also developed by giant retinal dialysis, posterior segmental trauma, excessive cryotherapy, endophthalmitis, retianl vascular disease. In order to prevent and treat of proliferative vitreoretinopathy, various methods of operation and drugs have been researched. We executed the experiment using the rabbit to observe the effect of retinoic acid that is known by inhibition of migration and proliferation of retinal pigment epithelial cell and fibroblast in vitro. With 121 eyes of rabbit, we induced the proliferative vitreoretinopathy by injecting of human retinal pigment epithelial cell, human fibroblast, and rabbit fibroblast into eyeball of rabbits. The extent of proliferative vitreoretinopathy was compaired by injecting those cells with the group that was injected by retinoic acid and control. The result was that in those cell groups, the extent of proliferative vitreoretinopathy was significantly higher in the rabbit fibroblast group than the other two groups(P<0.05). And in the groups that were injected retinoic acid, when subconjuctivaly injected(0.3mg/0.3ml), proliferative vitreoretinopathy was effectively suppressed and when intravitrealy injected (0.05mg/0.1ml), vitreoretinopathy was more increased than the control group. This result was probably caused by high concentration of retinoic acid in vitreous and further evaluation with various concentration of retinoic acid is needed. In conclusion, we recommend a rabbit fibroblast and subconjunctival injection of retinoic acid for the study on the suppressive effect of proliferative vitreoretinopathy.
Cryotherapy ; Dialysis ; Endophthalmitis ; Epithelial Cells ; Fibroblasts ; Humans ; Rabbits ; Retinal Detachment ; Retinaldehyde ; Tretinoin* ; Vascular Diseases ; Vitreoretinopathy, Proliferative*

No abstract available.
Cicatrix* ; Hepatitis C, Chronic* ; Hepatitis, Chronic* ; Humans ; Interferons ; Ribavirin*