A total of 40 adult black-mice was used and divided into two groups for expeiment. Group A was irradiated by UVB only and Group B had SPF 15 sunscreen a.pplied to the back followed by irradiation by UVB. Each group was divided again into 5 subgroups according to the days of UVB irradiation frcm 2 to 10 days. A Waldmann combination UVA+UVB Radiation Treatment Cabin 8001 was used as the light source and the UVB dosage was 50 mJ/cm2 daily. Skin specimens were taken 24 hours after the last irradiation. Histologic changes in epidermis were reviewed by the light microscope. In group A, the characteristic sunburn cells(SBC) were observed with 100 mJ/ cm2. SBC number was maximum with 400 mJ/cm2. The other epidermal changes were parakerat.osis, crusts, atypical cells, and mitoses of basal cells, which showed graded responses to the UVB doses. Pretreatment with the sunscreen completely prevented these changes.
Adult ; Epidermis ; Humans ; Keratinocytes* ; Mitosis ; Skin ; Sunburn

This study was done to study the effect of UVA radiation upon sunburn cell formation by UVB. In this study a total of 67 ICR male albino haired mice were used. The results were as follows: 1. UVA radiation produce a little or no sunburn cell in doses 5 J/cm(2), 10 J/cm(2), and 15 J/cm(2). 2. Preirradiation of UVA 5 J/cm, 10 J/cm(2), 15 J/cm(2) had no effect on the sunburn cell formation by UVB 20 mJ/cm(2), 80 mj/cm(2)
Animals ; Hair ; Humans ; Male ; Mice ; Sunburn*

A 26-year-old woman who had myasthenia gravis (MG) experienced several instances of sunburns. A phototest was performed by ultraviolet (UV) A, UVB and visible light irradiation to the back surface of the sunburns. Numerous erythematous papules developed at the 20, 25, 30 J/cm2 UVA irradiated site. The phototest induced lesions were compatible with polymorphic light eruption (PMLE) with action spectrum in the UVA range. After immunosuppresant treatment, the MG and PMLE were in a well-controlled state. We report MG associated with PMLE followed with a literature review.
Adult ; Female ; Humans ; Light ; Myasthenia Gravis* ; Sunburn

This study was undertaken to investigate the quantitative change of sunburn cell(FiBC)production and ear swelling reaction(ESR)aecording to the UVA radiation dose and time course sfter PUVA treatment. A total of 75 ICR male albino haired mice were used as subjects. The results were as follows : 1. At 24 hours after PUVA treatment, the mean SBC numbers per cm length of epidermis were 29.1+13.6 with 1J/cm, 48.8+19.5 with 5J/cm, and 51.6+14. 8 with 10J/cm of UVA irradiation. SBC production was dose related with respect to radiation dose, but the increment was not so remarkable with more than 5J /cm of UVA irradiation. 2. [n PUVA treatment using 5J/cm of UVA, the mean SBC numbers per cm length of epiderrnis were 48.8+19.5 after 24 hours, 63.8+18.3 after 48 hours. SBC numbers rose to a maximum at 48 hours, but epidermal damage precludecl SBC counting after this. 3. At, 24 hours after PUVA treatment, no significant ESR was observed with 1 an3 5J/cm of UVA. In PUVA treatment using lOJ/cm of UVA, the mean ear thickness was 20.6+1.7( x 10mm) before treatment and 30.1+3.3( x 10mm') at 2h: hours after treatment, which showed significa.nt change(p<0.05). 4. In PUVA treatment using 5J(cm of UVA, ESR showed significant change at 43hours reaching a maximum at 72 hours. After 7 days, ESR was not measurable due to ear necrosis.
Animals ; Ear* ; Epidermis ; Hair ; Humans ; Male ; Mice* ; Necrosis ; Skin* ; Sunburn*

index (%) in unirradiated mouse skin was 11.0+/-4.3. LI was significantly increased by tape stripping to 22.1+/-4.6. 2. The number of SBC in 1cm epidermis after 50mJ/cm UVB exposure was 28.2+/-4.1. The number of SBC was increased by tape stripping to 57.4+Cell proliferation, by evaluating sunburn cell (SBC) formation, was studied in mouse skin following tape stripping and ultraviolet light B (UVB) exposun.. 1-radiation was achieved using high pressure mercury are UVB. The results are summarized as follows. 1. Labeling 19.2. These results suggest that proliferating cells are more sensitive to UVB exposure.
Animals ; Cell Proliferation* ; Epidermis ; Mice ; Skin ; Sunburn* ; Ultraviolet Rays

BACKGROUND: Indomethacin is a potent inhibitor of prostaglandins biosysnthesis. Sunburn erythema is mainly mediated by prostaglandins. OBJECTIVE: Our purpose was to compare objectively the effectiveness of topical indomethacin with topical corticosteroid on the suppression of UVB erythema METHODS: Sixteen male medical students who had not exposed their back skin during the last year were included in this study. According to the individual´s MED, 1,2, and 3 MED of UVB were irradiated on each back in triplicate lines. Immediately after UVB irradiation, 2.5% indomethacin solution and 0.25% desoximethasone were applied to each row with one row left for control. 24 hours after the initial application the intensity of each erythema was measured by the naked eye and by colorimeter. RESULTS: The suppressive effectiveness of 2.5% indomethacin solution on UVB induced erythema was superior to that of 0.25% desoximethasone. The L* and a* value of colorimeter were significantly correlated to the differencies of UVB induced erythema among the experimental and control groups is a useful and rapid method to evaluate the UVB induced erythema, and can give a numerical expression to eye perception. CONCLUSION: Our data confirm that topical indomethacin has a stronger suggestive effect on UVB erythema than that of topical corticosteroid.. We suggest that the suppressive effect of indomethacin is mainly due to the inhibition of prostaglandins biosynthesis. The colorimeter CR-200(MINOLTA) is well correlated with the naked eye score and is a useful instrument for objective measurement of the degree of erythema.
Erythema* ; Humans ; Indomethacin* ; Male ; Methods ; Prostaglandins ; Skin ; Students, Medical ; Sunburn

In this study, a total of 115 ICR male albino haired mice were used and divided into two groups(A & B) for experiment. In group A(65 mice), quantiatation of sunburn cell(SBC) production and its distribution according to the time course after ultraviolet irradiation was measured. In group B(50mice), quantitation of dose-response experiments for SBC production after ultraviolet irradiation was measured. The results were as follows: ]. SBCs were recognized by 2 hours after irradiation. There was a tendency to increase from 2 hours to 24 hours and decrease from then to l week after irradiation, 2. The increase of SBCs in lower epidermis 2 hours io 8 hours after exposure and in upper epidermis 24 hours after irradiation were statistically significant (p<0. 05). SBG number in all layers declined from 36 hours to 1 week after exposure. 3. The linear relationship which observed(y=8.09+0.85x, R=0.87) suggests a dose-response relationship between UVB dose and SBC number.
Animals ; Epidermis ; Hair ; Humans ; Male ; Mice* ; Skin* ; Sunburn*

Rhabdomyolysis is a potentially life-threatening syndrome resulting from the breakdown of skeletal muscle fibers with leakage of muscle content into the circulation. The most common causes are crush injuries, overexertion, alcohol abuse and certain medications and toxic substances, burns, infections, and several inherited genetic disorders. There is no report of sunburn-induced rhabdomyolysis. We are reporting a case of rhabdomyolysis after sunburn. A 51-year-old male patient presented with confused mental state and sunburn on his body. He was treated with intravenous hydration and urine alkalinization. He recovered fully without complications. This case highlights the need for a high index of the suspicion for rhabdomyolysis in case of sunburn.
Alcoholism ; Burns ; Humans ; Male ; Middle Aged ; Muscle Fibers, Skeletal ; Rhabdomyolysis* ; Sunburn*

Granuloma annulare (GA) is a benign granulomatous disease. Although its etiology is not well understood, there are some reports about GA occurring after specific conditions such as sunburn, a tuberculin test, insect bites, viral diseases and trauma. Especially, in case of the auricular region which is vulnerable to trauma, it seems that GA has some relation with trauma. In 1992, Mills and Chetty proposed that repetitive minor trauma may be an important cause of auricular GA. Among the 5 cases of auricular GA that have been reported in the English literatures, 3 cases are assumed to be associated with repetitive minor trauma. Herein, we report on two cases of auricular GA that were thought to be associated with repetitive minor trauma.
Granuloma ; Granuloma Annulare ; Insect Bites and Stings ; Sunburn ; Tuberculin Test ; Virus Diseases

Increased pigmentation of skin after sun exposure is a normal response to solar radiation. Like sunburn, suntan can also be produced by natural solar radiation and by artificial, narrow-spectrum ultraviolet B and ultraviolet A sources. The tanning response is a sign of ultraviolet damage. The western search for the suntan has led to an increased incidence of photoaging and skin cancer of light-skinned individuals. Photoaging is characterized by wrinkling, coarseness, dryness, mottled pigmentation, loss of elasticity, easy bruising, telangiectasias, and benign, premalignant and malignant growths on sun-exposed areas. Photoagings is a slow process, taking decades to become clinically apparent and even longer for all the manifestations to occur. Development of photoagings is determined both by genetic skin type and by the total lifetime radiation dose. Photoaging is more apparent in light-skinned Caucasians than in dark-skinned people. Although it is not possible to state what proportion is due to chronologic aging and what is due to photoaging, it has been estimated that photodamage may account for greater than 90 percent of the age- associated cosmetic problems of the skin. The proliferation of natural tanning and tanning salons should be discouraged by physicians. There is no safe tan.
Aging ; Elasticity ; Incidence ; Pigmentation ; Skin ; Skin Neoplasms ; Solar System ; Sunburn ; Suntan* ; Tanning ; Telangiectasis ; Triacetoneamine-N-Oxyl