1.A Case of Rotor Syndrome.
Chan Kyu KANG ; Joung Sun KANG ; Hyoung Woo LEE ; Moon Kwan CHUNG ; Bong Sup SHIM ; Hyun Woo LEE
Yeungnam University Journal of Medicine 1989;6(2):257-263
Rotor syndrome is a rare disease of hereditary hyperbilirubinemia transmitted with autosomal recessive trait. In general, Rotor syndrome shows direct hyperbilirubinemia and there has been several reports since Sons's report in 1966, in Korea. A 34-year-old female was admitted with the chief complaint of intermittent icteric sclera for 24 years. There was no family history of jaundice. Rotor syndrome was diagnosed by oral cholecystogram, BSP retention test, 99mTc-DISIDA scan, liver biopsy and electron microscopy study of liver biopsy specimen. We report this case with brief review of the literature.
Adult
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Biopsy
;
Female
;
Humans
;
Hyperbilirubinemia
;
Hyperbilirubinemia, Hereditary*
;
Jaundice
;
Korea
;
Liver
;
Microscopy, Electron
;
Rare Diseases
;
Sclera
;
Technetium Tc 99m Disofenin
2.Effect of Ascorbic Acid Against the Oxidative Stress-Induced Cellular Senescence in Trabecular Meshwork Cells.
Jae Woo KIM ; Sun Hee KANG ; Keun Woo LEE
Journal of the Korean Ophthalmological Society 2013;54(3):490-495
PURPOSE: To investigate the effect of L-ascorbic acid (LAA) on oxidative-stress-induced cellular senescence in trabecular meshwork (TM) cells. METHODS: Primarily cultured human TM cells were exposed to 0, 10, or 100 microM hydrogen peroxide for 7 days with or without co-exposure of LAA. Cellular survival and nitrite production were assessed with MTT and Griess assays, respectively. SA-beta-gal staining was performed to quantify cellular senescence. RESULTS: Hydrogen peroxide decreased cellular survival, accompanied by decreased nitric oxide (NO) production. These decreases of cellular survival and NO production were abolished by co-exposure of 100 microM LAA. Analysis of SA-beta-gal staining revealed that LAA inhibited hydrogen peroxide-induced cellular senescence by 6.8% (p < 0.05). CONCLUSIONS: LAA may have a protective effect against the oxidative-stress-induced cellular senescence in TM cells.
Aging
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Ascorbic Acid
;
Cell Aging
;
Humans
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Hydrogen
;
Hydrogen Peroxide
;
Nitric Oxide
;
Oxidative Stress
;
Trabecular Meshwork
3.Clinical Evaluation of Unilateral Open-Angle Glaucoma: A Two-Year Follow-Up Study
Jeoung Woo NAM ; Yeon Soo KANG ; Mi Sun SUNG ; Sang Woo PARK
Chonnam Medical Journal 2021;57(2):144-151
To evaluate the clinical characteristics of unilateral open-angle glaucoma, patients diagnosed with unilateral open-angle glaucoma from January 2017 to October 2018 were divided into primary open-angle glaucoma and normal-tension glaucoma groups according to the type of glaucoma diagnosed. The glaucoma and the contralateral eyes were compared, and the contralateral eye was analyzed for conversion to glaucoma and its risk factors were assessed during the 2-year follow-up period. Among 99 patients, 36 were diagnosed with primary open-angle glaucoma and 63 with normal-tension glaucoma. When comparing the glaucoma eye with the contralateral eye, the visual field mean deviation value (all p<0.001), peripapillary retinal nerve fiber layer thickness (all p<0.001), macular ganglion cell layer-inner plexiform layer thickness (p< 0.001, p=0.003), and optic nerve cup-disc ratio (p=0.005, p<0.001) were significantly different in both the primary open-angle glaucoma and normal-tension glaucoma groups. In normal-tension glaucoma, peripapillary retinal nerve fiber layer thickness was significantly thinner in the glaucoma conversion group than in the glaucoma non-conversion group (p=0.008). It was significantly associated with glaucoma conversion (odds ratio=0.97, p=0.023). In conclusion, in patients with unilateral open-angle glaucoma, the contralateral eye may develop glaucoma. In particular, if the peripapillary retinal nerve fiber layer thickness is decreased in normal-tension glaucoma, the possibility of glaucoma conversion is high; hence, careful examination is required.
4.Clinical Evaluation of Unilateral Open-Angle Glaucoma: A Two-Year Follow-Up Study
Jeoung Woo NAM ; Yeon Soo KANG ; Mi Sun SUNG ; Sang Woo PARK
Chonnam Medical Journal 2021;57(2):144-151
To evaluate the clinical characteristics of unilateral open-angle glaucoma, patients diagnosed with unilateral open-angle glaucoma from January 2017 to October 2018 were divided into primary open-angle glaucoma and normal-tension glaucoma groups according to the type of glaucoma diagnosed. The glaucoma and the contralateral eyes were compared, and the contralateral eye was analyzed for conversion to glaucoma and its risk factors were assessed during the 2-year follow-up period. Among 99 patients, 36 were diagnosed with primary open-angle glaucoma and 63 with normal-tension glaucoma. When comparing the glaucoma eye with the contralateral eye, the visual field mean deviation value (all p<0.001), peripapillary retinal nerve fiber layer thickness (all p<0.001), macular ganglion cell layer-inner plexiform layer thickness (p< 0.001, p=0.003), and optic nerve cup-disc ratio (p=0.005, p<0.001) were significantly different in both the primary open-angle glaucoma and normal-tension glaucoma groups. In normal-tension glaucoma, peripapillary retinal nerve fiber layer thickness was significantly thinner in the glaucoma conversion group than in the glaucoma non-conversion group (p=0.008). It was significantly associated with glaucoma conversion (odds ratio=0.97, p=0.023). In conclusion, in patients with unilateral open-angle glaucoma, the contralateral eye may develop glaucoma. In particular, if the peripapillary retinal nerve fiber layer thickness is decreased in normal-tension glaucoma, the possibility of glaucoma conversion is high; hence, careful examination is required.
5.Morphological studies on recombinant virus(recB-8) selected by coinfection of the baculoviruses bombyx mori and autographa californica nuclear palyhedrosis viruses.
Ji Hyun] PARK ; Soo Dong WOO ; Beom Seok PKR ; Kang Sun PYU ; Jai Myung YANG ; In Shik CHUNG ; Seok Kwon KANG
Journal of the Korean Society of Virology 1993;23(1):95-104
No abstract available.
Baculoviridae*
;
Bombyx*
;
Coinfection*
6.Erratum: Author Correction.
So Mi CHOI ; Min Youp CHOI ; Woo Dae KANG ; Ho Sun CHOI ; Seok Mo KIM
Obstetrics & Gynecology Science 2014;57(5):424-424
The author list should be corrected.
7.Adrenergic Genetic Mechanisms in Hypertension and Hypertensive Kidney Disease.
Electrolytes & Blood Pressure 2013;11(1):24-28
Catecholamine secretory traits were significantly heritable, as were stress-induced blood pressure changes. Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis. In the tyrosine hyroxylase promoter, significant associations were found for urinary catecholamine excretion and for blood pressure response to stress. TH promoter haplotype 2 (TGGG) showed pleiotropy, increasing both norepinephrine excretion and blood pressure during stress. In hypertension, 2 independent case-control studies (1,266 subjects with 53% women and 927 subjects with 24% women) replicated the effect of C-824T in the determination of blood pressure. Chromogranin A (CHGA) plays a fundamental role in the biogenesis of catecholamine secretory granules. Changes in the storage and release of CHGA in clinical and experimental hypertension prompted us to study whether genetic variation at the CHGA locus might contribute to alterations in autonomic function, and hence hypertension and its target organ consequences such as hypertensive kidney disease (nephrosclerosis). Systematic polymorphism discovery across the human CHGA locus revealed such regulatory regions as the proximal promoter and 3'-UTR. In chromaffin cell-transfected CHGA 3'-UTR and promoter/luciferase reporter plasmids, the functional consequences of the regulatory/non-coding allelic variants were documented. Variants in both the proximal promoter and the 3'-UTR displayed statistical associations with hypertension and hypertensive end stage renal disease. Therefore, I would like to review the common genetic variation in TH and CHGA as a cause of inter-individual variation in sympathetic activity, and ultimately blood pressure and hypertensive kidney disease.
Blood Pressure
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Case-Control Studies
;
Chromogranin A
;
Female
;
Genetic Variation
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Genomics
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Haplotypes
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Humans
;
Hypertension
;
Kidney
;
Kidney Diseases
;
Kidney Failure, Chronic
;
Norepinephrine
;
Plasmids
;
Regulatory Sequences, Nucleic Acid
;
Secretory Vesicles
;
Tyrosine
;
Tyrosine 3-Monooxygenase
;
Organelle Biogenesis
8.The Effects of Steroid and Lidocaine on Inflammatory Responses in the Rabbit Lung of Induced Endotoxemia.
Yong Gul LIM ; Yoo Jin KANG ; Dae Woo KIM ; Won Sun CHO
Korean Journal of Anesthesiology 1998;35(5):846-851
Background: It has been reported that steroid and lidocaine reduce inflammatory responses to endotoxin. The aim of this study is to compare the effects of lidocaine with those of steroid on inflammatory responses to Escherichia coli endotoxemia in the rabbit lung. Methods: Twenty four animals were randomly assigned to one of four groups. Group I (endotoxemic group; control, n=6): They were received E. coli endotoxin (500 microg/kg) intravenously through the ear vein and followed by saline infusion at 20 ml/kg/hr for 4 hours. Group II (steroid treated group, n=6): They were treated with steroid (30 mg/kg) intravenously just after endotoxin injection and then saline was given at 20 ml/kg/hr for 4 hours. Group III (lidocaine treated group, n=6): They were received same as the endotoxemic group and lidocaine (3 mg/kg IV bolus, then continuous infusion at the rate of 2 mg/kg/hr) was administered with saline at 20 ml/kg/hr for 4 hours. Group IV (steroid & lidocaine treated group, n=6): They were received same as the endotoxemic group and after endotoxin infusion, steroid (30 mg/kg) and lidocaine (3 mg/kg IV bolus, then continuous infusion at the rate of 2 mg/kg/hr) was administered intravenously with saline. Numbers of neutrophils and monocytes in the samples of peripheral blood and lung tissue were counted and compared to evaluate the anti-inflammatory effect of drugs. Results: The group II, III, and IV showed significant attenuation of inflammatory responses compared to group I in the rabbit lung(P<0.05). But there were no significant differences among group II, III, and IV. There was no additive effect between steroid and lidocaine. Conclusion: These results suggest that lidocaine could be used as an alternative drug to steroid for its anti-inflammatory effects and cost-effectiveness.
Animals
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Ear
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Endotoxemia*
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Escherichia coli
;
Lidocaine*
;
Lung*
;
Monocytes
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Neutrophils
;
Veins
9.The Role of Tc-99m HMPAO Brain Perfusion SPECT in the Psychiatric Disability Evaluation of Patients with Chronic Traumatic Brain Injury.
Young SO ; Kang Wook LEE ; Sun Woo LEE ; Ick Sung GHI ; Chang June SONG
Korean Journal of Nuclear Medicine 2002;36(4):232-243
No abstract available.
Brain Injuries*
;
Brain*
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Disability Evaluation*
;
Humans
;
Perfusion*
;
Technetium Tc 99m Exametazime*
;
Tomography, Emission-Computed, Single-Photon*
10.The Pathomorphologic Study of Spinal Stenosis as Seen on CT - Myelography of the Lumbar.
Woo Seog LEE ; Byung Gyu AHN ; Sun Kil CHOI ; Seung Koo KANG
Journal of Korean Neurosurgical Society 1987;16(2):439-446
This study has been examined different morphologic measurements in the evaluation of patients with lumbar spinal stenosis. Preoperative CT-Myelography from 30 patients who underwent surgery for central lumbar stenosis were analyzed. Based on this, we concluded as follows : 1) Bony measurement alone did not reliably identify patients with spinal stenosis. 2) Measurement of the transverse area of the dural sac on CT-Myelography was the most accurate method for identifying stenosis. 3) Lumbar myelography was still considered to have an important role in the valuation of a patient with stenosis because of correlation between the cross-sectional area of the dural sac and the anteroposterior diameter of the dural sac was excellent. 4) We identified soft-tissue problems as the main cause of stenosis. 5) The most common level of maximum stenosis was L4-5.
Constriction, Pathologic
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Humans
;
Myelography*
;
Spinal Stenosis*