No abstract available.
Finite Element Analysis*

No abstract available.
Finite Element Analysis*

The present study was carried out to evaluate the postoperative results of Millard rotation-advancement repair (MR) and lip adhesion followed by Millard rotation-advancement repair (LAMR) in unilateral complete cleft lip. Twenty patients with unilateral complete cleft lip underwent MR or LAMR at the Department of Oral and Maxillofacial Surgery of Chonnam University Hospital over a period of 6 years (January 1994 to December 1999) were analyzed. The surgical results following the operation were assessed on the basis of scoring, vertical lip length, and scar hypertrophy. The mean score was better in LAMR group (74.74+/-1.09, n=13) than in MR group (66.50+/-1.14, n=7) for both lip and nose segments. Scar hypertrophy developed in MR group with 28.6% and in LAMR group with 23.1%. No significant difference was noted in the ratio of lip length between LAMR and MR groups (0.84+/-0.08 and 0.73+/-0.10). These results suggest that LAMR is better than MR in repairing the unilateral complete cleft lip.
Cicatrix ; Cleft Lip* ; Humans ; Hypertrophy ; Jeollanam-do ; Lip* ; Nose ; Surgery, Oral

Treacher Collins syndrome is inherited as an autosomal dominant trait with variable penetrance. It shows a marked variability even in the same family. This syndrome is developmental defect affecting the branchial arches. It is not usually associated with acute respiratory distress, but has symptoms of microtia, hypoplastic zygomatic bones, hypoplastic mandibular rami, and bilateral coloboma. It usually requires an emergency operation immediately after the birth. We experienced an infant with Treacher Collins syndrome who showed retrognathia, glossoptosis, microtia, and cleft palate. Intermittent cyanosis, depression of the chest, respiratory difficulty associated with airway obstruction, and swallowing difficulty were also observed. To relieve severe upper airway obstruction caused by retrognathia and glossoptosis, we simultaneously performed tongue-lip adhesion and subperiosteal release of the floor of the mouth. The respiratory and swallowing difficulties were relieved and the tongue repositioned anteriorly. We report the present case with a review of the literature.
Airway Obstruction* ; Branchial Region ; Cleft Palate ; Coloboma ; Cyanosis ; Deglutition ; Depression ; Emergencies ; Humans ; Infant* ; Mandibulofacial Dysostosis* ; Mouth ; Parturition ; Penetrance ; Retrognathia ; Thorax ; Tongue

No abstract available.
Mesothelioma* ; Pleura*

The deformities of micrognathia and glossoptosis in the newborn are frequently associated with a cleft palate, which is known as Pierre Robin sequence. Upper airway obstruction is the most serious problem in these patients. Treatment of Pierre Robin sequence includes either positional or surgical intervention. Mild cases are often managed in the prone position. However, when the patient fails to thrive due to chronic upper airway obstruction, or severe respiratory distress ensures despite positional treatment, surgical intervention is mandatory to relieve the obstruction. We experienced three infants with Pierre Robin sequence who showed a symptom triad of micrognathia, glossoptosis, and cleft palate. Intermittent cyanosis, depression of the chest, respiratory difficulty and feeding problems were also observed. To relieve severe upper airway obstruction caused by micrognathia and glossoptosis, we simultaneously performed modified tongue lip adhesion (TLA) and a subperiosteal release of the floor of the mouth (SRFM). Respiratory and feeding difficulties were relieved, the tongue positioned anteriorly, body weight increased, and mandibular growth improved. Simultaneous TLA and SRFM may constitute a simple and reliable method for surgical treatment of airway obstruction in patients with Pierre Robin sequence.
Airway Obstruction* ; Body Weight ; Cleft Palate ; Congenital Abnormalities ; Cyanosis ; Depression ; Humans ; Infant* ; Infant, Newborn ; Lip ; Mouth ; Pierre Robin Syndrome* ; Prone Position ; Thorax ; Tongue

A role of nitric oxide (NO) in the regulation of sodium transporters and water channels in the salivary gland was investigated. Male Sprague-Dawley rats were treated with NG-nitro-L-arginine methyl ester (L- NAME, 100 mg/L drinking water) for 1 week. The control group was supplied with normal tap water. The expression of Na+,K+-ATPase, type 2 Na+/K+/2Cl- cotransporter (NKCC2), type 1 Na+/H+ exchanger (NHE1), alpha-subunit of epithelial sodium transporter (ENaC), and aquaporin-5 (AQP5) and aquaporin-1 (AQP1) proteins were determined in the submandibular gland by Western blot analysis. Following the treatment with L-NAME, the expression of Na+,K+-ATPase alpha1-subunit, NKCC2, NHE1, and ENaC alpha- subunit increased significantly. On the contrary, the expression of AQP5 was significantly decreased, while that of AQP1 was not significantly altered. These findings indicate that the sodium transporters and water channels may be under a tonic regulatory influence of NO in the salivary gland.
Animals ; Aquaporin 5 ; Aquaporins ; Blotting, Western ; Drinking ; Humans ; Male ; NG-Nitroarginine Methyl Ester ; Nitric Oxide ; Proteins ; Rats ; Rats, Sprague-Dawley ; Salivary Glands ; Sodium ; Submandibular Gland ; Water

The present study was carried out to evaluate the correlation of metastasis and prognostic factors in squamous cell carcinoma of head and neck. Examination was performed on a series of thirty-seven patients who were confirmed to squamous cell carcinoma and its lymphatic metastasis by pathologist. Correlations of metastasis and other factors such as angiogenesis, histologic grading, and p53 expression and ras oncogene were studied. The depth of tumors was around 1 to 27mm. Twenty cases were more than 10mm deep, of which seventeen cases were shown lymphatic metastasis. Total score of histologic grading including keratinization, nuclear atypia, growth pattern and intensity of inflammation was ranged from 5 to 10 points. Of these factors, nuclear atypia with intensity of inflammation, and nuclear atypia with growth pattern was correlated with nuclear atypia each. For angiogenesis, number of new-formed vessels were counted 13 to 58 each. Twenty-eight cases were shown to lymphatic metastasis. No correlation with histologic grading and lymphatic metastasis was found. The results of immunohistochemical staining for p53 and ras oncogene revealed that positive cases were 16 and 22, negative for 21 and 15 each. However, both were not correlated with histologic grading and lymphatic metastasis. These results were revealed that angiogenesis was not correlated with lymphatic metastasis of squamous cell carcinoma arising in head and neck. Nuclear atypia with intensity of inflammation and dysplasia with growth pattern were correlated with histologic grading, which suggested that more careful and adequate advice is needed for effective treatment.
Carcinoma, Squamous Cell* ; Genes, ras ; Head* ; Humans ; Inflammation ; Lymphatic Metastasis ; Neck* ; Neoplasm Metastasis*

Age Distribution ; Ampicillin ; Anti-Bacterial Agents ; Bacteria ; Cefotaxime ; Clindamycin ; Erythromycin ; Humans ; Incidence ; Jeollanam-do ; Lacerations ; Maxillofacial Injuries ; Motor Vehicles ; Mouth ; Oxacillin ; Penicillins ; Skin ; Staphylococcus ; Streptococcus ; Surgery, Oral ; Wound Infection ; Wounds and Injuries

Age Distribution ; Ampicillin ; Anti-Bacterial Agents ; Bacteria ; Cefotaxime ; Clindamycin ; Erythromycin ; Humans ; Incidence ; Jeollanam-do ; Lacerations ; Maxillofacial Injuries ; Motor Vehicles ; Mouth ; Oxacillin ; Penicillins ; Skin ; Staphylococcus ; Streptococcus ; Surgery, Oral ; Wound Infection ; Wounds and Injuries