Among the skeletal tuberculous spondylitis is high incidence and curable disease, if early diagnosis and treatment are possible. We reviewed clinical manifestations and radiologic analysis of 30 cases tuberculous spondylitis from May 1983 to Sept. 1986, at Yeungnam medical center, Yeungnam University. The results were follows: 1. The frequent involve sites were thoracolumbar vertebra. 2. The continuous lesion is 86.7% of the all cases. 3. The most common type was intervertebral type, and lytic and sclerotic lesion were same incidence. 4. Paravertebral abscess, kyphosis and disc space narrowing were demonstrated more than 80.0% of the cases. 5. Computed tomography was more accurate diagnostic method rather than conventional plain study to evaluation of extent of lesion, involvement of spinal canal and cord, and size and location of paravertebral abscess. And CT guided abscess drainage procedure was helpful to diagnosis and treatment. 6. Ultrasonography was helpful to differential diagnosis between paravertebral abscess and other solid mass, and useful to follow up study of paravertebral abscess after treatment.
Abscess ; Diagnosis ; Diagnosis, Differential ; Drainage ; Early Diagnosis ; Follow-Up Studies ; Incidence ; Kyphosis ; Methods ; Spinal Canal ; Spine ; Spondylitis* ; Ultrasonography

No abstract available.
Female ; Obstetric Labor, Premature* ; Pregnancy ; Ritodrine* ; Tocolytic Agents*

No abstract available.
Animals ; Brain* ; Cats* ; Magnetic Resonance Spectroscopy*

BACKGROUND: The central physiological derangement of hemorrhagic fever with renal syndrome (HFRS) caused by hantaan virus (HTNV) is a vascular dysfunction, manifested by hemorrhage, impaired vascular tone and increased vascular permeability. Platelet activating factor (PAF), whose actions are mediated through a specific receptor, is a potent bioactive lipid. PAF has diverse biological functions in the vascular system, such as increasing vascular permeability, adhesion of leukocytes to the endothelium and reduction of cardiac output, which result in hypotension and shock. The goal of the present study was to investigate whether PAF is involved in the pathogenesis of HFRS. For this purpose, we evaluated the effect of HTNV on the expression of PAF receptor (PAF-R) and on the activity of PAF-acetylhydrolase (PAF-AH) instead of PAF because PAF is rapidly degraded by PAF-AH in vivo. MATERIALS AND METHODS: To evaluate the expression of PAF-R, we performed reverse-transcription PCR, western blot and FACS analyses using HTNV-infected human umbilical vein endothelial cells (HUVECs) and non-infected (control) HUVECs. In addition, we measured the activity of plasma PAF-AH in HFRS patients and normal healthy persons. RESULTS: The mRNA and protein expression of PAF-R was increased in HTNV-infected HUVECs compared with control HUVECs at 2 and 3 days post-infection (d.p.i.). FACS analysis showed that HTNV induced the surface expression of PAF-R in HUVECs from 2 d.p.i. The activity of plasma PAF-AH was 2.5-fold lower in HFRS patients than in normal healthy persons. CONCLUSION: Increased PAF-R expression by HTNV might increase the responsiveness to PAF in endothelial cells. Reduced PAF-AH activity in the blood of HFRS patients might delay PAF degradation. These results suggest that changes in PAF-R and PAF-AH by HTNV might influence to PAF activity and might be involved in the vascular dysfunction of HFRS.
Blood Platelets ; Blotting, Western ; Capillary Permeability ; Cardiac Output ; Endothelial Cells ; Endothelium ; Hantaan virus ; Hemorrhage ; Hemorrhagic Fever with Renal Syndrome ; Human Umbilical Vein Endothelial Cells ; Humans ; Hypotension ; Leukocytes ; Plasma ; Platelet Activating Factor ; Platelet Membrane Glycoproteins ; Polymerase Chain Reaction ; Receptors, G-Protein-Coupled ; RNA, Messenger ; Shock

No abstract available.
Female ; Obstetric Labor, Premature* ; Pregnancy ; Ritodrine*

PURPOSE: Cerebrovascular disease in children is more common than was once recognized and the etiology and prognosis of the disease in children are quite different from those of adults. Recently according to medical reports and clinical experiences, the incidence of childhood cerebrovascular disease is increasing in Korea. To clarify the clinical features of childhood cerebrovascular disease and to analyze its prognostic factors, retrospective study was perinatal problem, trauma or hypoxia. METHODS: We reviewed clinical records of the patients who had admitted to Seoul National University Children's Hospital during 5 years from Jan. 1989 to Dec. 1993. RESULTS: There were 82 cases(66.8%) of ischemic cerebrovascular disease as well as 41cases(33.3%) of hemorrhagic cerebrovascular disease. Various predisposing causes were known in 108 cases(87.8%); vasculopathy was frequent in ischemic group while hemato-oncologic disease was frequent in hemorrhagic group. The presenting symptoms and signs of childhood cerebrovascular disease were seizure, motor paralysis, headache, altered consciousness, etc. Transient ischemic attack and bulbar palsy were relatively common in ischemic group while ltered consciousness was more frequent in hemorrhagic group. The overall mortality of childhood cerebrovascular disease in this study was 11.4%, and deaths were frequent in hemorrhagic group(24.4%) than in ischemic group(4.9%) (p<0.005). Patients with a hemato-oncologic disease as a predisposing cause, and with an alteration of consciousness as a presenting sign were at increased risk for death (p<0.0005). Only 37 cases(33.9%) of the 109 patients surviving stroke were recovered completely while 72 cases(66.1%) had one or more residual deficits. Residual deficits occurred more often following ischemic stroke(71.8%), than after hemorrhagic stroke (51.6%), and complete recovery vice versa. Motor deficit was the commonest of the residual deficits. But the majority of motor deficits were mild and disability in fine motor control is common. Unlike in adults, seizure, mental retardation and learning disability were common as residual deficits in children. CONCLUSIONS: Considering above results childhood cerebrovascular disease is not so rare in Korea. And the clinical features and prognosis of cerebrovascular disease in children were somewhat different from those in adults. Since the outcome of childhood cerebrovascular disease is not so good, further exact and inclusive studies on this subject are required for early diagnosis and treatment which are important in decreasing mortality and morbidity of the disease.
Adult ; Anoxia ; Bulbar Palsy, Progressive ; Child ; Consciousness ; Early Diagnosis ; Headache ; Humans ; Incidence ; Intellectual Disability ; Ischemic Attack, Transient ; Korea ; Learning Disorders ; Mortality ; Paralysis ; Prognosis ; Retrospective Studies ; Seizures ; Seoul ; Stroke

No abstract available.

No abstract available.
Animals ; Cell Line* ; Guinea Pigs* ; Guinea* ; Hantaan virus* ; Humans*

No abstract available.
Syringomyelia*

No abstract available.
Intellectual Disability ; Muscle Weakness ; Muscular Dystrophy, Duchenne*