The methods of management for condylar fractures have been investigated and improved. The methods which have been used up to date are classified broadly into conservative and surgical treatment. Conservative treatment is chosen usually in the cases of children's or growing adolescent's fracture and non-displaced high leveled condylar fracture. But in the cases of displaced fracture, surgical reduction is to fit. The aim of surgical treatment is restore preexisting anatomical relationships by means of functionally stable rigid fixation. And rigid fixation will avoid uncomfortable IMF. Most miniplate fixations are accomplished through extraoral approaches. Extraoral approaches have the advantage of accurate reduction and fixation under a good visual field, but they have several disadvantages of facial nerve injury, facial scarring, and the possibility of necrotic bone change of fragment. Thus trocar assisted intraoral approach was introduced. But this method have disadvantage of uncertain fixation, because of visual field limitation and unaccurate reduction. To overcome this, we design a bended iron stick scale. The iron stick scale has 2 holes, 5 mm and 7 mm. apart from bending point for drilling. This hole was used for accuracy drilling. We treated 16 cases of displaced subcondylar fracture, using this method.
Cicatrix ; Facial Nerve Injuries ; Iron* ; Surgical Instruments ; Visual Fields

BACKGROUND: Overt hypothyroidism is a well-known cause of secondary hyperlipidemia and atherosclerosis. However, there have been some dissenting report of abnormalities and in serum lipid concentration in patients with subclinical hypothyroidism. We have attempted to analyze serum lipid concentrations to investigate whether they are increased in patients with subclinical hypothyroidism and to see if there is a correlation between serum LDL-C and TSH concentrations. METHODS: Serum lipid profiles(total cholesterol, triglycerides, LDL-C, HDL-C) of patients with subclinical hypothyroidism (M/F=7/119) compared with age, sex and body mass index matched control subjects(M/F=14/239) from Jan. 1 . 1996. to Dec. 30. 1997. RESULTS: There were no significant differences of serum total cholesterol, LDL cholesterol, TG, and HDL concentrations in 126 patients with subclinical hypothyroidism and 253 control subjects(178.47+/-35.76mg/dL vs. 173.05+/-35.93mg/dL ; 113.33+/-52.89mg/dL vs 117.64+/-68.70mg/dL ; 112.89+/-33.26mg.dL vs 109.65+/-29.02mg/dL ; 48.60+/-11.34mg/dL vs 46.51+/-11.73mg/dL). There was no correlation between LDL cholesterol and TSH concentrations in subclinical hypothyroidism(r=0.29, p<0.05). CONCLUSION: Serum lipid concentration (total cholesterol, LDL cholesterol, and TG, HDL) was not increased in patients with subclinical hypothyroidism. There was no correltion between serum LDL and TSH levels in patients with subclinical hypothyroidism.
Atherosclerosis ; Body Mass Index ; Cholesterol ; Cholesterol, LDL ; Dissent and Disputes ; Humans ; Hyperlipidemias ; Hypothyroidism* ; Lipoproteins* ; Triglycerides

Granuloma pyogenicum (GP) has been reported to be associated with hemangioma and hamartomas, including port-wine stains. GP may rarely occur in association with port-wine stains, either de novo or following trauma such as laser therapy. It has been suggested that the development of GP in a port-wine stain following trauma might be associated with microscopic arteriovenous anastomosis in the port-wine stain. We report a 48 year-old woman with GP arising within port-wine stain following trauma.
Arteriovenous Anastomosis ; Female ; Granuloma* ; Granuloma, Pyogenic* ; Hamartoma ; Hemangioma ; Humans ; Laser Therapy ; Middle Aged ; Port-Wine Stain*

BACKGROUND/AIMS: Oxidative stress results in protein oxidation and is implicated in carcinogenesis. Sulfiredoxin (Srx) is responsible for the enzymatic reversal of inactivated peroxiredoxin (Prx). Nuclear factor E2-related factor 2 (Nrf2) binds to antioxidant responsive elements and upregulates the expression of Srx and Prx during oxidative stress. We aimed to elucidate the biological functions and potential roles of Srx in lung cancer. METHODS: To study the roles of Srx and Prx III in lung cancer, we compared the protein levels of Nrf2, Prxs, thioredoxin, and Srx in 40 surgically resected human lung cancer tissues using immunoblot and immunohistochemical analyses. Transforming growth factor-beta1, tumor necrosis factor-alpha, and camptothecin treatment were used to examine Prx III inactivation in Mv1Lu mink lung epithelial cells and A549 lung cancer cells. RESULTS: Prx I and Prx III proteins were markedly overexpressed in lung cancer tissues. A significant increase in the oxidized form of a cysteine sulfhydryl at the catalytic site of Prxs was found in carcinogenic lung tissue compared to normal lung tissue. Densitometric analyses of immunoblot data revealed significant Srx expression, which was higher in squamous cell carcinoma tissue (60%, 12/20) than in adenocarcinoma (20%, 4/20). Also, Nrf2 was present in the nuclear compartment of cancer cells. CONCLUSIONS: Srx and Prx III proteins were markedly overexpressed in human squamous cell carcinoma, suggesting that these proteins may play a protective role against oxidative injury and compensate for the high rate of mitochondrial metabolism in lung cancer.
Adenocarcinoma/*enzymology/genetics/mortality/pathology ; Animals ; Antineoplastic Agents, Phytogenic/pharmacology ; Blotting, Western ; Camptothecin/pharmacology ; Carcinoma, Squamous Cell/*enzymology/genetics/mortality/pathology ; Cell Line, Tumor ; Humans ; Immunohistochemistry ; Lung Neoplasms/*enzymology/genetics/mortality/pathology ; Mink ; NF-E2-Related Factor 2/*metabolism ; Oxidoreductases Acting on Sulfur Group Donors/genetics/*metabolism ; Peroxiredoxin III/*metabolism ; Peroxiredoxins/metabolism ; Prognosis ; RNA Interference ; Reactive Oxygen Species/metabolism ; Transfection ; Transforming Growth Factor beta1/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Up-Regulation

BACKGROUND/AIMS: Peroxiredoxin (Prx) belongs to a ubiquitous family of antioxidant enzymes that regulates many cellular processes through intracellular oxidative signal transduction pathways. Silica-induced lung damage involves reactive oxygen species (ROS) that trigger subsequent toxic effects and inflammatory responses in alveolar epithelial cells resulting in fibrosis. Therefore, we investigated the role of Prx in the development of lung oxidant injury caused by silicosis, and determined the implication of ROS in that process. METHODS: Lung epithelial cell lines A549 and WI26 were treated with 1% silica for 0, 24, or 48 hours, following pretreatment of the A549 cells with N-acetyl-L-cysteine and diphenylene iodonium and no pretreatment of the WI26 cells. We transfected an HA-ubiquitin construct into the A549 cell line and then analyzed the cells via Western blotting and co-immunoprecipitation. RESULTS: Silica treatment induced cell death in the A549 lung epithelial cell line and selectively degraded Prx I without impairing protein synthesis in the A549 cells, even when the ROS effect was blocked chemically by N-acetyl-L-cysteine. A co-immunoprecipitation study revealed that Prx I did not undergo ubiquitination. CONCLUSIONS: Silica treatment induces a decrease of Prx I expression in lung epithelial cell lines regardless of the presence of ROS. The silica-induced degradation of Prx does not involve the ubiquitin-proteasomal pathway.
Cell Line ; Epithelial Cells/drug effects/metabolism ; Humans ; Lung/chemistry/*drug effects/metabolism ; Peroxiredoxins/analysis/*physiology ; Protein Isoforms ; Reactive Oxygen Species/metabolism ; Silicon Dioxide/*toxicity ; Ubiquitin/metabolism

The point prevalence of atopic dermatitis (AD) among Korean adults visiting the Health Service Center for health check-ups was assessed. AD was diagnosed based on the questionnaires filled by patients and through physical examination by dermatologists. A total of 3,563 persons completed the questionnaires, and 2,032 persons were examined by the dermatologists. According to the questionnaires, the prevalence of AD was 7.1%, and from the dermatologists' examination, it was 2.6% overall, which decreased with age significantly. The prevalence in men was higher than that of women. Grading the severity of AD according to their eczema area and severity index scores, 70.6% were classified as being mild, 25.5% moderate, and 3.9% severe. Interestingly, concomitance of psoriasis and AD was found in 0.5% of those examined by the dermatologists. Our results suggest that AD is one of the most common skin diseases not only in children but also in adults in Korea.
Adult ; Age Factors ; Aged ; Dermatitis, Atopic/complications/diagnosis/*epidemiology ; Female ; Hospitals, University ; Humans ; Male ; Middle Aged ; Prevalence ; Psoriasis/complications ; Questionnaires ; Republic of Korea/epidemiology ; Severity of Illness Index ; Sex Factors