1.Epidemiology of liver cancer in Korea
Journal of the Korean Medical Association 2019;62(8):416-423
The incidence rate of primary liver cancer in Korea, the majority of which is hepatocellular carcinoma, has been decreasing steadily since 1999. However, Korea still has one of the highest incidence rates of liver cancer worldwide. Currently, liver cancer is the fifth most common cancer type in men and sixth in women. A total of 15,771 cases (11,774 men and 3,997 women) were identified, with an age-standardized incidence rate of 18.0 persons per 100,000 (29.2 in men and 7.9 in women) in 2016. Mortality from liver cancer has also decreased since 2002 in both sexes, although it is still the second most common cause of cancer deaths with 10,721 deaths (7,982 in men and 2,739 in women) in 2017. The 5-year relative survival rate was 13.2% in those diagnosed in 1996–2000, and it increased to 34.3% in those diagnosed in 2012–2016. Hepatitis B (HBV) and C (HCV) viruses are the most important causes of liver cancer, accounting for approximately 70% and 10% of liver cancer cases, respectively. Recently, the seroprevalence of HBV has markedly decreased to less than 3%, and the HCV antibody positivity rate has been estimated as about 0.7% in a nationwide survey. The participation rate of patients with hepatitis in liver cancer screening, a part of the National Cancer Screening Program, was still low at about 60% in 2018. Recent advances in the treatment of HBV and HCV could further reduce the burden of liver cancer despite its limited accessibility.
Carcinoma, Hepatocellular
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Early Detection of Cancer
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Epidemiology
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Female
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Hepatitis
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Hepatitis B
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Humans
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Incidence
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Korea
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Liver Neoplasms
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Liver
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Male
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Mass Screening
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Mortality
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Seroepidemiologic Studies
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Survival Rate
2.Updates on Cancer Epidemiology in Korea, 2018.
Chonnam Medical Journal 2018;54(2):90-100
Cancer is a major cause of morbidity and the most common cause of death in Korea. There are currently approximately 200,000 incident cancer cases and 78,000 individuals die from cancer every year. The factors directly related to cancer incidence, including aging, smoking, obesity, and Westernized dietary habits, have been increasing during the past several decades. Since 1999, trends toward increased incidence have been observed for thyroid, breast (in women), colorectal, and prostate cancer. Currently, these trends have changed direction, and the incidence of stomach and liver cancer in both sexes, and cervical cancer in women have continually declined. Although the number of cancer deaths increased by a factor of 2.7 from 1983 to 2016, the age-standardized mortality associated with cancer has been decreasing by 3% every year. The 5-year relative survival rate (RSR) has also improved over the past several decades, especially for stomach, prostate, and breast cancer, which had 5-year RSRs greater than 90% in the most recent report.
Aging
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Breast
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Breast Neoplasms
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Cause of Death
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Epidemiology*
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Female
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Food Habits
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Humans
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Incidence
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Korea*
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Liver Neoplasms
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Mortality
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Obesity
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Prostate
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Prostatic Neoplasms
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Republic of Korea
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Smoke
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Smoking
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Stomach
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Survival Rate
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Thyroid Gland
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Uterine Cervical Neoplasms
3.Relationship of Average Volume of Alcohol Consumption and Binge Drinking to Arterial Stiffness in Community-Dwelling Healthy Adults.
Sun Seog KWEON ; Young Hoon LEE
Journal of Agricultural Medicine & Community Health 2012;37(1):23-35
OBJECTIVES: The purpose of this study was to investigate the association of the average volume of alcohol consumption and binge drinking with arterial stiffness. METHODS: The study population consisted of 5944 community-dwelling healthy adults aged 50 years and older. Average volume of alcohol consumption was calculated and frequency of binge drinking defined as the consumption of 7 or more drinks for men and 5 or more for women on a single occasion, was assessed using a structured interview. High brachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness, was defined as the highest gender-specific quartile of maximal baPWV distribution in the study population. RESULTS: Compared to never drinkers, the multivariate-adjusted odds ratio (OR) of men who consumed 0.1-10.0, 10.1-20.0, 20.1-40.0, and >40.0 g/day was 0.93, 1.18, 1.38, and 2.36, respectively. The OR was 0.90, 0.97, 1.45, and 1.82 in women consuming 0.1-5.0, 5.1-10.0, 10.1-20.0, and >20.0 g/day, respectively. Binge drinking of <1 day/week (OR=1.66, 95% confidence interval [CI]=1.13-2.42) and > or =1 day/week (OR=1.61, 95% CI=1.04-2.50) were associated with increased risk for high baPWV in men, and binge drinking of > or =1 day/week (OR=3.12, 95% CI=1.16-8.34) was associated with increased risk for high baPWV in women. CONCLUSIONS: A J-shaped relationship between the average volume of alcohol consumption and high baPWV was observed, suggesting the detrimental effects of heavy alcohol drinking on arterial stiffness. Binge drinking was also significant risk factors for increased arterial stiffness, independently of the average volume of alcohol consumption.
Adult
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Aged
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Alcohol Drinking
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Atherosclerosis
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Binge Drinking
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Female
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Humans
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Male
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Odds Ratio
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Peripheral Arterial Disease
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Pulse Wave Analysis
;
Risk Factors
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Vascular Stiffness
4.Epidemiology of liver cancer in Korea
Journal of the Korean Medical Association 2019;62(8):416-423
The incidence rate of primary liver cancer in Korea, the majority of which is hepatocellular carcinoma, has been decreasing steadily since 1999. However, Korea still has one of the highest incidence rates of liver cancer worldwide. Currently, liver cancer is the fifth most common cancer type in men and sixth in women. A total of 15,771 cases (11,774 men and 3,997 women) were identified, with an age-standardized incidence rate of 18.0 persons per 100,000 (29.2 in men and 7.9 in women) in 2016. Mortality from liver cancer has also decreased since 2002 in both sexes, although it is still the second most common cause of cancer deaths with 10,721 deaths (7,982 in men and 2,739 in women) in 2017. The 5-year relative survival rate was 13.2% in those diagnosed in 1996–2000, and it increased to 34.3% in those diagnosed in 2012–2016. Hepatitis B (HBV) and C (HCV) viruses are the most important causes of liver cancer, accounting for approximately 70% and 10% of liver cancer cases, respectively. Recently, the seroprevalence of HBV has markedly decreased to less than 3%, and the HCV antibody positivity rate has been estimated as about 0.7% in a nationwide survey. The participation rate of patients with hepatitis in liver cancer screening, a part of the National Cancer Screening Program, was still low at about 60% in 2018. Recent advances in the treatment of HBV and HCV could further reduce the burden of liver cancer despite its limited accessibility.
5.The Relationship between 5-year Overall Survival Rate, Socioeconomic Status and SEER Stage for Four Target Cancers of the National Cancer Screening Program in Korea:Results from the Gwangju-Jeonnam Cancer Registry
Jeong-Hee KANG ; Chul-Woung KIM ; Sun-Seog KWEON
Journal of Korean Academy of Community Health Nursing 2022;33(2):237-246
Purpose:
The aim of this study was to investigate the relationship between the 5-year survival rate, socioeconomic status, and SEER (Surveillance Epidemiology and End Results) stage of stomach, colorectal, breast and cervical cancer patients.
Methods:
A total of 11,770 cases of four target cancers, which were diagnosed during 2005-2007, were extracted from the database of Gwangju-Jeonnam Regional Cancer Registry. The subjects of the study were 11,770 including stomach (n=5,479), colorectal (n=3,565), breast (n=1,516) and cervical cancers (n=710). Cox’s proportional hazards model was used to obtain the hazards ratio (HR) according to the SEER stage and socioeconomic status.
Results:
Stomach cancer had a significantly higher HR in the medical aid recipients (HR=1.39), and the group below 20% (HR=1.20) compared to the group with the highest income level. Colorectal cancer had a significantly higher HR in the medical aid recipients (HR=1.26) than in the group with the highest income level. In addition, stomach, colorectal, breast and cervical cancers had a significantly higher HR according to the SEER stage in regional direct (stomach=4.10, colorectal=1.76, breast=12.90, cervical=3.10), regional lymph only(stomach=2.58, colorectal=2.33, breast=4.32, cervical= 4.43), regional both (stomach=6.74 colorectal=3.04, breast=15.57 cervical=6.50), and regional NOS (Not Otherwise Specified)/distant (stomach=17.53, colorectal=11.53, breast=25.34, cervical=26.51) than in situ and localized only.
Conclusion
In order to increase the cancer survival rate, a support system for early detection and early treatment of cancer should be established for groups with low individual income levels, and regular health checkups and management measures should be actively implemented through the National Cancer Screening Program.
6.Non-linear Relationship Between Body Mass Index and Lower Urinary Tract Symptoms in Korean Males
Chang Kyun CHOI ; Sun A KIM ; Ji An JEONG ; Sun Seog KWEON ; Min Ho SHIN
Korean Journal of Preventive Medicine 2019;52(3):147-153
OBJECTIVES: The purpose of this study was to evaluate the association between body mass index (BMI) and severe lower urinary tract symptoms (LUTS) in Korean males. METHODS: This study was conducted on males aged ≥50 years who participated in the 2011 Korean Community Health Survey. LUTS severity was assessed using the Korean version of the International Prostate Symptom Score (IPSS) questionnaire, and was dichotomized as severe (IPSS >19) and non-severe (IPSS ≤19). BMI was divided into 6 categories: <18.5, 18.5-22.9, 23.0-24.9, 25.0-27.4, 27.5-29.9, and ≥30.0 kg/m². To evaluate the relationship between BMI and LUTS, a survey-weighted multivariate Poisson regression analysis was performed to estimate prevalence rate ratios (PRRs). Age, smoking status, alcohol intake, physical activity, educational level, household income, and comorbidities were adjusted for in the multivariate model. RESULTS: A U-shaped relationship was detected between BMI and severe LUTS. Compared with a BMI of 23.0-24.9 kg/m², the PRR for a BMI <18.5 kg/m² was 1.65 (95% confidence interval [CI], 1.35 to 2.02), that for a BMI of 18.5-22.9 kg/m² was 1.25 (95% CI, 1.09 to 1.44), that for a BMI of 25.0-27.4 kg/m² was 1.20 (95% CI, 1.00 to 1.45), that for a BMI of 27.5-29.9 kg/m² was 1.11 (95% CI, 0.83 to 1.47), and that for a BMI ≥30.0 kg/m² was 1.85 (95% CI, 1.18 to 2.88). CONCLUSIONS: This study showed that both high and low BMI were associated with severe LUTS.
Body Mass Index
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Comorbidity
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Cross-Sectional Studies
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Family Characteristics
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Health Surveys
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Humans
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Lower Urinary Tract Symptoms
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Male
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Motor Activity
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Prevalence
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Prostate
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Smoke
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Smoking
7.The Relationship between Socioeconomic Status and Gastric Cancer Screening in the Population of a Metropolitan Area.
Hyun Suk OH ; Sun A KIM ; Sun Seog KWEON ; Jung Ae RHEE ; So Yeon RYU ; Min Ho SHIN
Journal of Agricultural Medicine & Community Health 2013;38(3):174-181
OBJECTIVES: Socioeconomic status plays an important role in health care and disease prevention. This study aimed to examine the association between socioeconomic status, measured by education levels and household income, and gastric cancer screening. METHODS: A total of 21,220 community-dwelling adults aged 40 to 69 years within a defined geographic area participated in a community health survey in 2009 and 2010. The survey was conducted using a structured questionnaire by trained investigators who visited the subjects' households directly. Logistic regression analysis was used to determine the relationship between self-reported participation in gastric cancer screening and socioeconomic variables (education and household income). RESULTS: The gastric cancer screening rate was 52.1% for subjects in their forties, 63.7% for those in their fifties, and 67.3% for those in their sixties. In multivariate analysis, higher education and income levels were associated with higher rates of gastric cancer screening (high school vs. elementary school: odds ratio [OR] 1.41, 95 % confidence interval [CI] 1.26-1.58; highest income quartile vs. lowest income quartile: OR 1.62, 95% CI 1.44-1.84). The gradient between income and screening rate was more pronounced in the population aged 40 to 49 years than in the other age groups. CONCLUSIONS: This study demonstrates that lower socioeconomic status is associated with decreased participation in gastric cancer screening. Our findings suggest that the screening program should be focused on low-income and less-educated populations, especially among younger adults, to reduce health disparities.
Adult
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Delivery of Health Care
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Education
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Family Characteristics
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Health Surveys
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Humans
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Logistic Models
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Mass Screening*
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Multivariate Analysis
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Odds Ratio
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Research Personnel
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Social Class*
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Stomach Neoplasms*
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Surveys and Questionnaires
8.Non-linear Relationship Between Body Mass Index and Lower Urinary Tract Symptoms in Korean Males
Chang Kyun CHOI ; Sun A KIM ; Ji An JEONG ; Sun Seog KWEON ; Min Ho SHIN
Journal of Preventive Medicine and Public Health 2019;52(3):147-153
OBJECTIVES:
The purpose of this study was to evaluate the association between body mass index (BMI) and severe lower urinary tract symptoms (LUTS) in Korean males.
METHODS:
This study was conducted on males aged ≥50 years who participated in the 2011 Korean Community Health Survey. LUTS severity was assessed using the Korean version of the International Prostate Symptom Score (IPSS) questionnaire, and was dichotomized as severe (IPSS >19) and non-severe (IPSS ≤19). BMI was divided into 6 categories: <18.5, 18.5-22.9, 23.0-24.9, 25.0-27.4, 27.5-29.9, and ≥30.0 kg/m². To evaluate the relationship between BMI and LUTS, a survey-weighted multivariate Poisson regression analysis was performed to estimate prevalence rate ratios (PRRs). Age, smoking status, alcohol intake, physical activity, educational level, household income, and comorbidities were adjusted for in the multivariate model.
RESULTS:
A U-shaped relationship was detected between BMI and severe LUTS. Compared with a BMI of 23.0-24.9 kg/m², the PRR for a BMI <18.5 kg/m² was 1.65 (95% confidence interval [CI], 1.35 to 2.02), that for a BMI of 18.5-22.9 kg/m² was 1.25 (95% CI, 1.09 to 1.44), that for a BMI of 25.0-27.4 kg/m² was 1.20 (95% CI, 1.00 to 1.45), that for a BMI of 27.5-29.9 kg/m² was 1.11 (95% CI, 0.83 to 1.47), and that for a BMI ≥30.0 kg/m² was 1.85 (95% CI, 1.18 to 2.88).
CONCLUSIONS
This study showed that both high and low BMI were associated with severe LUTS.
9.The Morbidity and Mortality of the Patients with Hansen's Disease in a Leprosarium.
Hyung Cheol PARK ; Gyong Deok LEE ; Min Ho SHIN ; Mi Ja CHOI ; Sun Seog KWEON
Korean Leprosy Bulletin 2009;42(1):67-80
ansen's disease, death certificates of the inpatients of Sorokdo National Hospital between 2001 and 2008 and died during the same time period were used to analyze the causes of their death, and the morbidity patterns of those patients who are hospitalized in the same hospital as of 2008 were analyzed. The results are as follows: The average number of diseases per inpatient was 3.4 with the maximum being 10. The distribution of morbidity was 67.2% for circulatory diseases, 58.4% for musculoskeletal diseases, and 36.3% for infectious diseases and skin diseases respectively. The morbidity rank of all patients was 50.1% for primary hypertension, 34.4% for chronic viral hepatitis, 27.4% for arthritis, 27.2% for skin diseases, and 23.7% for cataracts. The age-standardized death rate of males per 100,000 was 557.6 for heart diseases, 500.2 for liver diseases, 460.5 for respiratory diseases, and 459.8 for cancers. The age-standardized death rate of females was 266.3 for sepsis, 232.6 for liver diseases, 212.0 for cancers, 208.8 for pneumonia and 206.9 for respiratory diseases. The standardized death rate for all patients was 456.6 for heart diseases, 414.7 for liver diseases, 393.8 for respiratory diseases, and 383.0 for malignant neoplasms. In conclusion, the patterns of morbidity and mortality of patients with Hansen's disease was different than those of the general population. Additional public health approaches will be needed to improve the health status and quality of life of these patients, and additional studies on related factors will also be in order.
Arthritis
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Cataract
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Communicable Diseases
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Death Certificates
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Female
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Heart Diseases
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Hepatitis
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Humans
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Hypertension
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Inpatients
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Leprosy
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Liver Diseases
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Male
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Musculoskeletal Diseases
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Pneumonia
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Public Health
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Quality of Life
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Sepsis
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Skin Diseases
10.Does Waist Indicate Dyslipidemia better than BMI in Korean Adult Population?.
Seul Ki JEONG ; Man Wook SEO ; Young Hyun KIM ; Sun Seog KWEON ; Hae Sung NAM
Journal of Korean Medical Science 2005;20(1):7-12
Obesity is an independent and modifiable risk factor for cardiovascular disease, and known as a core of the metabolic syndrome. Obesity has been largely diagnosed based upon anthrompometric measurements like waist circumference (WC) and body mass index (BMI). We sought to determine associations between anthropometric measurements and dyslipidemia in a community adult sample composed of 1,032 community residents (356 men, 676 women) aged 50 yr and over in Namwon, Korea. Blood tests for lipid profiles, including total cholesterol (TC) and HDL cholesterol (HDL) were performed, and dyslipidemia was defined as TC/HDL greater than 4. Anthropometric measurements included WC, waist-to-height ratio (WHtR), waist-to-hip ratio, and BMI. All anthropometric measures were categorized into quartiles and evaluated for associations with dyslipidemia. TC/HDL showed the significant associations with the anthropometric measures, independently of potential confounders. In women, increases of obesity indexes by quartile analyses showed linear increases of odds ratios for dyslipidemia (p values <0.01 by trend test). In men, except BMI, same patterns of association were noted. WC and WHtR were significantly associated with dyslipidemia in Korean adult population. As a simple and non-invasive method for a detection of obesity and dyslipidemia, anthropometric measurements could be efficiently used in clinical and epidemiologic fields.
Adult
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Age Factors
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Aged
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Body Composition
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Body Mass Index
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Body Size
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Cardiovascular Diseases/pathology
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Cholesterol/metabolism
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Female
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Humans
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Hyperlipidemia/*pathology
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Korea
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Lipids/metabolism
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Lipoproteins, HDL Cholesterol/metabolism
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Male
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Middle Aged
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Obesity
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Odds Ratio
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Research Support, Non-U.S. Gov't
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Risk Factors
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Waist-Hip Ratio