Although rare spontaneous regression of either primary or metastatic malignant tumor in the absence of inadequate therapy has been well documented. Since the earliest day of this century various malignant tumors havebeen reported to spontaneously disappear or to be arrested of their growth, but the cases of hepatocarcinoma has been very rare. From the literature, we were able to find out 5 previously reported cases of hepatocarcinoma which showed spontaneous regression at the primary site. Recently we have seen a case of multiple pulmonary metastaticnodules of hepatocarcinoma which completely regressed spontaneously and this forms the basis of the present casereport. The patient was 55-year-old male admitted to St. Mary's Hospital, Catholic Medical College because of ahard palpable mass in the epigastrium on April 26, 1978. The adimssion PA chest roentgenogram revealed multiplesmall nodular densities scattered throughout both lung field especially in lower zones and toward the peripheralportion . A hepatoscintigram revealed a large cold area involving the left lobe and inermediate zone of the liver. Alfa-fetoprotein and hepatitis B serum antigen test were positive whereas many other standard liver function teststurned out to be negative. A needle biopsy of the tumor revealed well differentiated hepatocellular carcinoma. The patient was put under chemotherapy which consisted of 5 FU 500 mg intravenously for 6 days form April 28 to May 3,1978. The patient was discharged after this single course of 5 FU treatment and was on a herb medicine, the nature and quantity of which obscure. No other specific treatment was given. The second admission took place on Dec. 3, 1980 because of irregularity in bowel habits and dyspepsia. A follow up PA chest roentgenogram obtained on the second admission revealed disappearance of previously noted multiple pulmonary nodular lesions. Follow up liverscan revealed persistence of the cold area in the left lobe with slight decreased in size. The patient was discharged again without any specific prescription after confirming negative resuls of various clinical studies including upper GI series and colon study. At the time of finishing this paper the patient is doing well without apparent medical problems.
Biopsy, Needle ; Carcinoma, Hepatocellular ; Colon ; Drug Therapy ; Dyspepsia ; Follow-Up Studies ; Hepatitis B ; Humans ; Liver ; Lung ; Male ; Middle Aged ; Prescriptions ; Thorax

No abstract available.
Metallothionein*

Kawasaki disease is an acute vasculitis of infancy and early childhood characterized by high fever, rash, mucositis, lymphadenopathy and coronary artery damage. The failure to indentify a causative organism using convetional culture and serological techniques, and the lack of response to antibiotics indicate that the disorder is probably not due to any known bacterial or viral pathogens. During the acute phase of the disease, the alterations of T and B cell functions, changes of cytokine and immunoglobulin levels have been reported. This study was performed to investigate the changes of immunoglobulins levels in patients with Kawasaki disease. IgG, IgA, IgM and IgG subclasses were measured using immunoprecipitation and EIA in the sera of patients with Kawasaki disease. The results were as follows: 1) Acute phase reactants such as CRP and ESR were significantly increased in Kawasaki patients compared to those in control patients(p<0.01). 2) Serum IgG levels in Kawasaki disease were markedly increased than those in control patients, while serum IgA and IgM levels showed no significant changes (P: No Significance). 3) IgG1 and IgG4 were predominantly increased increased in the sera of Kawasaki patients, while IgG2 and IgG3 were not significantly increased (P: No Significance). With these results, unidentified infectious organism with abnormal immune response could be suggested as an etiologic factor of Kawasaki disease.
Acute-Phase Proteins ; Anti-Bacterial Agents ; Child* ; Coronary Vessels ; Exanthema ; Fever ; Humans ; Immunoglobulin A ; Immunoglobulin G* ; Immunoglobulin M ; Immunoglobulins ; Immunoprecipitation ; Lymphatic Diseases ; Mucocutaneous Lymph Node Syndrome* ; Mucositis ; Vasculitis

Strumal carcinoma of the ovary is rare tumor of germ cell origin characterized by intimate mixture of thyroid tissue and carcinoid. We report a strumal carcinoid tumor associated with ipsilateral follicular cyst and contralateral mature cystic teratoma of the ovary in a 47-year-old woman. Histologically it was composed largely of trabeculae partly of insular carcinoid and focally of individual thyroid follicles. Many cells in the carcinoid areas and even some follicular areas contained abundant argyrophile granules, and they also, in the corresponding areas, demonstrated thyroglobulin. Electron microscopic findings revealed abundant neurosecretory granules and colloid material in the same cell. We agree that this tumor is derived from hybrid showing thyroid and neuroendocrine differenciation.
Female ; Humans ; Cysts

No abstract available.
Adult* ; Constriction, Pathologic* ; Humans ; Ventriculostomy*

Orbital fractures with conspicious enophthalmos or continuous diplopia should be repaired surgically. From June 1984 to March 1991, 22 patients with orbital fracture were repaired with silastic sheets. Of the 22 patients, there were 12 cases of inferior wall fracture, 4 cases of medial wall fracture, 5 cases of inferior and medial wall fracture, and 1 case of lateral wall fracture. The age ranged from 7 to 41 years (average 20 years). Seventeen were males and five were females. The duration from receving trauma to operation was from one day to six months (average 37 days). After the follow'up period of 6 to 74 months (average 18.8 months), most of the patients showed improvement of diplopia and decreased enophthalmos (average 1.4mm) with good cosmesis, except in the 2 severe fracture cases of the posterior portion of the orbital floor without serious complications.
Diplopia ; Enophthalmos ; Female ; Humans ; Male ; Orbit* ; Orbital Fractures*

Electrical burn is thought to be similar to crushing injury in that it usually involves skin, muscle and neurovascular structure simultaneously. Especially in extremity, there are many occasions that amputations are inevitable. Since the demarcation between viable and non-viable tissue tends to be obscure, electrical burn greatly differs from other types of injury in detailed methods of treatment, such as the level, the timing and the technique of amputation. During the past 10 years from January, 1978 to December, 1987, authors experienced 285 amputations in 181 cases of electrical burn at Orthopedic Department of Hanil Hospital. The clinical data of our experience were reviewed and analysed. The results were as follows ;l. Amputation rate in electrical burn was 22.4%. 2. Out of total 285 amputations, the number of upper extremity was 187 (65.6%) and it was 1.9 times more than that of lower extremity. Right forearm was 1.8 times more than left forearm. 3. Multiple limbs amputation were performed in 83 cases (45.9%). 4. Among 285 stumps, more than one operation were done in 74 stumps because of infection (50%), necrosis of stump end (35.1%), bony overgrowth at stump end (8.1%) and neuroma(6.8%).
Amputation ; Amputees ; Burns ; Extremities ; Forearm ; Humans ; Lower Extremity ; Necrosis ; Orthopedics ; Skin ; Upper Extremity

No abstract available.
Constriction, Pathologic* ; Decompression* ; Laminectomy*

No abstract available.
Osteotomy*

Orchiopexy is the generally recommended procedure to treat and to prevent intravaginal testicular torsion. But recurrent torsion of the previously fixed testis has been reported infrequently. Failure of orchiopexy leading to recurrent torsion has been attributed by some to use of absorbable suture material and as a result nonabsorbable sutures often has been recommended. To determine whether there were differences between absorbable and nonabsorbable sutures, and also to study various surgical and chemical methods to produce fixation between the testis and scrotal wall, we used rats as an experimental model of orchiopexy. Eversion of the tunica vaginalis with absorbable and nonabsorbable suture to dartos muscle produced excellent scarification. Eversion of the tunica vaginalis without suture also produced good scarification but less than above method. Absorbable and nonabsorbable sutures between tunica albuginea and tunica vaginalis produced only minor degree of inflammation. Tetracycline instillation similarly failed to produce a significant inflammation. Histopathologic changes of testis after orchiopexy were also studied. The main histopathologic changes were inflammatory reaction, interference of local blood flow and obstruction of seminiferous tubules. So it can be suggested that testicular injury after orchiopexy can be developed.
Animals ; Inflammation ; Models, Theoretical ; Orchiopexy ; Rats* ; Seminiferous Tubules ; Spermatic Cord Torsion ; Sutures ; Testis* ; Tetracycline