PURPOSE: The purpose of this study was to investigate the influencing factors on externalized and internalized problem behaviors among high school students. METHODS: The subjects for this study were 707 students in two high schools in K province. The data were collected during the period from October to November, 2014 by use of questionnaires. The instruments used were the Korean Youth Self-report, Daily Hassles Questionnaire, State-Trait Anger Expression Inventory, and Ego Resiliency Scale. The data were analyzed using SPSS. RESULTS: Significant predictors to explain externalized problem behaviors comprised anger-out, anger-in, anger-control, relation with parents, daily stress, and religion. It was found that these factors explained 46% of externalized problem behavior. Ego resiliency, anger-in, daily stress, gender, relation with parent, and anger-out were significant predictors to explain internalized problem behaviors. It was found that these factors explained 45% of internalized problem behaviors. CONCLUSION: This study suggests that the influencing factors on problem behaviors differ from externalized and internalized problem behaviors. So these findings will provide the basic data to develop a program that is differentiated by problem behavior type.
Adolescent* ; Anger ; Ego ; Humans ; Parents ; Problem Behavior* ; Stress, Psychological

PURPOSE: This study was conducted to examine the mediating effect of meaning in life on the relationship between social connectedness and depression among middle-aged women.METHODS: A descriptive correlational design was employed. One hundred and forty-two middle-aged women who visited welfare centers or churches in Seoul and Gyeonggi Province participated in the study. The data were collected from May to June, 2019 and analyzed using descriptive statistics, Pearson's correlation coefficients, and multiple linear regression analyses based on Baron and Kenny criteria.RESULTS: Social connectedness was significantly positively correlated with meaning in life (r=.52, p < .001) and negatively with depression (r=−.53, p < .001). Meaning in life was also significantly negatively correlated with depression (r=−.50, p < .001). Furthermore, meaning in life had a significant mediating effect on the relationship between social connectedness and depression (β=−.31, p < .001).CONCLUSION: Our study findings suggest that meaning in life plays an important role in maintaining mental health and well-being for middle-aged women. Therefore, it is necessary to develop a nursing intervention program that can enhance the meaning in life to promote mental health and well-being.
Depression ; Female ; Gyeonggi-do ; Humans ; Linear Models ; Mental Health ; Negotiating ; Nursing ; Seoul

No abstract available.
Empyema, Subdural* ; Haemophilus influenzae* ; Haemophilus* ; Meningitis*

Purpose: To assess the effectiveness of an automated screening program that diagnoses horizontal strabismus using machine learning based on ocular deviation data captured by the wearable eyetracker, Tobii pro glasses 2 (TPG2). Methods: The TPG2 which locates the pupil center to measure ocular movement was used. In normal adults wearing TPG2, horizontal ocular deviation was induced by covering the left eye and applying prisms of varying strengths (2, 3, 4, 5, 6, 8, 10, 12, 15, 20, 25, 30, 35, and 40 PD base-in and out) to the right eye. TPG2 automatically recorded ocular deviation before and after prism induction generating 28 types of ocular deviation sets. From each set, 20 X-axis values before and after ocular deviation were randomly extracted using an oversampling technique creating a total of 61,600 ocular deviation sets. For training, 56,000 sets were used and 5,600 were evaluated for sensitivity, specificity, and area under the curve (AUC). Results: Eleven normal adults (5 males) participated with a mean age of 34.8 ± 7.37 years. Based on an 8 PD threshold, deviations of 8 PD or less demonstrated a sensitivity of 1.0, a specificity of 0.95, and an AUC of 0.97. When categorized into three groups based on 8 PD and 20 PD thresholds, the results were: sensitivity of 0.90 and specificity of 0.95 for ≤ 8 PD; sensitivity of 0.60 and specificity of 1.00 for 8-20 PD; sensitivity of 1.00 and specificity of 0.88 for > 20 PD. Conclusions The machine learning program developed using induced ocular deviations measured with prisms and TPG2 shows promise for use in future strabismus screening tests.

Purpose: To evaluate the short-term efficacy and safety of latanoprostene bunod 0.024% in patients with primary open-angle glaucoma. Methods: A retrospective study was conducted from September 2022 to September 2023, involving 29 eyes from patients diagnosed with primary open-angle glaucoma. The study analyzed the intraocular pressure (IOP)-lowering effects of latanoprostene bunod 0.024% at 1 and 3 months after administration. Additionally, adverse events reported by patients at each visit were documented. Results: The mean age of patients at the start of treatment was 64.46 years. The baseline IOP was 17.46 ± 4.03 mmHg, which significantly decreased to 15.07 ± 4.23 mmHg (p = 0.002) at 1 month (29 eyes) and 14.93 ± 3.86 mmHg (p = 0.002) at 3 months (28 eyes) after latanoprostene bunod administration. After 1 month, 9 patients reported adverse events, including conjunctival hyperemia (1 eye, 3.5%), itching (2 eyes, 6.9%), foreign body sensation (2 eyes, 6.9%), stinging (2 eyes, 6.9%), ocular pain (2 eyes, 6.9%), and deepening of the upper eyelid sulcus (1 eye, 3.5%). The patient who experienced deepening of the upper eyelid sulcus discontinued treatment. After 3 months, 2 eyes with itching discontinued treatment due to conjunctival allergy. Conclusions Latanoprostene bunod 0.024% demonstrated short-term efficacy in reducing IOP and a manageable safety profile in patients with primary open-angle glaucoma.

Purpose: To evaluate the short-term efficacy and safety of latanoprostene bunod 0.024% in patients with primary open-angle glaucoma. Methods: A retrospective study was conducted from September 2022 to September 2023, involving 29 eyes from patients diagnosed with primary open-angle glaucoma. The study analyzed the intraocular pressure (IOP)-lowering effects of latanoprostene bunod 0.024% at 1 and 3 months after administration. Additionally, adverse events reported by patients at each visit were documented. Results: The mean age of patients at the start of treatment was 64.46 years. The baseline IOP was 17.46 ± 4.03 mmHg, which significantly decreased to 15.07 ± 4.23 mmHg (p = 0.002) at 1 month (29 eyes) and 14.93 ± 3.86 mmHg (p = 0.002) at 3 months (28 eyes) after latanoprostene bunod administration. After 1 month, 9 patients reported adverse events, including conjunctival hyperemia (1 eye, 3.5%), itching (2 eyes, 6.9%), foreign body sensation (2 eyes, 6.9%), stinging (2 eyes, 6.9%), ocular pain (2 eyes, 6.9%), and deepening of the upper eyelid sulcus (1 eye, 3.5%). The patient who experienced deepening of the upper eyelid sulcus discontinued treatment. After 3 months, 2 eyes with itching discontinued treatment due to conjunctival allergy. Conclusions Latanoprostene bunod 0.024% demonstrated short-term efficacy in reducing IOP and a manageable safety profile in patients with primary open-angle glaucoma.

Purpose: To evaluate the short-term efficacy and safety of latanoprostene bunod 0.024% in patients with primary open-angle glaucoma. Methods: A retrospective study was conducted from September 2022 to September 2023, involving 29 eyes from patients diagnosed with primary open-angle glaucoma. The study analyzed the intraocular pressure (IOP)-lowering effects of latanoprostene bunod 0.024% at 1 and 3 months after administration. Additionally, adverse events reported by patients at each visit were documented. Results: The mean age of patients at the start of treatment was 64.46 years. The baseline IOP was 17.46 ± 4.03 mmHg, which significantly decreased to 15.07 ± 4.23 mmHg (p = 0.002) at 1 month (29 eyes) and 14.93 ± 3.86 mmHg (p = 0.002) at 3 months (28 eyes) after latanoprostene bunod administration. After 1 month, 9 patients reported adverse events, including conjunctival hyperemia (1 eye, 3.5%), itching (2 eyes, 6.9%), foreign body sensation (2 eyes, 6.9%), stinging (2 eyes, 6.9%), ocular pain (2 eyes, 6.9%), and deepening of the upper eyelid sulcus (1 eye, 3.5%). The patient who experienced deepening of the upper eyelid sulcus discontinued treatment. After 3 months, 2 eyes with itching discontinued treatment due to conjunctival allergy. Conclusions Latanoprostene bunod 0.024% demonstrated short-term efficacy in reducing IOP and a manageable safety profile in patients with primary open-angle glaucoma.

PURPOSE: The purpose of this study was to examine the effects of the mental health promotion program based on Positive Psychology for adolescents with problem behavior. METHODS: The study used a nonequivalent control group pretest-posttest design. Eligible participants were first grade students in two high schools in K Province. The inclusion criteria for the study were those with scores in the upper 15% on the Korean Youth Self-Report. A total of 74 participants were assigned to an 8-session program (n=38) or to a control (n=36) group. The outcome variables were psychological well-being, depression, and self-esteem. RESULTS: There were no statistically significant differences in demographic variables or outcome variables, except self-esteem, between the two groups at the baseline. The experimental group had higher mean scores on psychological well-being and self-esteem and a lower mean score on depression. There were significant differences in psychological well-being (t=3.45, p=.001), self-esteem (F=5.45, p=.022), and depression (t=-2.80, p=.007) between the two groups. CONCLUSION: The mental health promotion program based on Positive Psychology was effective in decreasing depression as well as improving psychological well-being and self-esteem for adolescents with problem behavior. This study contributes to suggesting a framework for promoting mental health for high school students with problem behavior.
Adaptation, Psychological ; Adolescent* ; Depression ; Humans ; Mental Health* ; Problem Behavior* ; Program Evaluation ; Psychology* ; Self Concept

BACKGROUND: Calcium antagonists are highly effective agents for lowering high blood pressure and play a very important role in the treatment of Patient with ischemic heart disease and various other cardiovascular disorder. Manidipine, a dihydropyridine-type ccalcium channel blocker, is a potent relaxant of the arteriolar smooth muscle. We studied ths new calcium channel blocker to evaluated the efficacy and safety in patients with essectial hypertension. METHODS: Twenty patients(ten women and ten men;range of age, 30-66 years old)with mild-to-moderate essential hypertension were enrolled in this study. After a placebo run-in phase of two weeks duration, 5mg-20mg manidipine once daily orally was administered for eight weeks. RESULTS: 1) At the end of 8 weeks of manidipine therapy, systolic and diastolic blood pressure were significantly reduced from 160.1+/-11.8/105.5+/-5.1mmHG in sitting, 160.1+/-12.1/104.5+/-5.4mmHG in supine, 157.1+/-17.0/104.1+/-5.3mmHg in standing to 128.4+/-10.1/85.2+/-5.7mmHg in sitting, 129.1+/-10.2/84.2+/-5.9mmHg in supine, 128.1+/-12.8/86.7+/-5.9mmHg in standing(p<0.01). 2) The pulse rate did dnot change significantly. 3) The reduction of mean systolic and diastolic blood pressur at the end of 8 weeks were 31.5+/-14.5/20.3+/-7.4mmHg in sitting. 4) There was no serious side effect except mild symptom, mild headache(6 casem 30%) and facial flushing(1 case, 5%). CONCLUSION: These results indicate that manidipine is an effective and safe antihypertensive agent in the treatment of mild and moderate essential hypertension.
Blood Pressure ; Calcium ; Calcium Channels ; Female ; Heart Rate ; Humans ; Hypertension* ; Muscle, Smooth ; Myocardial Ischemia

Neurofibromatosis type 1 (NF1) is an autosomal dominant disease, characterized by cafe-au-lait spot, axillary and inguinal freckle, peripheral neurofibroma and pigmented iris hamartoma. The various cancer incidences are increased in the NF1. But NF1 with breast cancer is rare. In this report we present a case of a 46-year-old NF1 female with a bilateral metachronous breast cancer. The patient has no BRCA2 mutation, but there are two unclassified variants in the exon 11 of BRCA1. The possibility of LOH of BRCA1 gene in the cancer tissue cannot be excluded.
Breast ; Breast Neoplasms ; Cafe-au-Lait Spots ; Exons ; Female ; Genes, BRCA1 ; Hamartoma ; Humans ; Incidence ; Iris ; Melanosis ; Middle Aged ; Neurofibroma ; Neurofibromatoses ; Neurofibromatosis 1