PURPOSE: Cerebral small vessel disease (SVD) is known to be associated with ischemic stroke, intracerebral hemorrhage (ICH), and cognitive impairment. In this retrospective observational study, we explored SVD markers on MRI relevant to spontaneous ICH. MATERIALS AND METHODS: The ICH group consisted of 150 consecutive patients with a first primary parenchymal ICH, and the control group consisted of 271 age- and sex-matched individuals who underwent brain MRI in a health care center. We compared cerebral microbleeds (CMBs), white matter hyperintensities (WMHs), enlarged perivascular space (EPVS), and lacunae in the ICH and control groups. RESULTS: A total of 1278 CMB lesions were identified in 121 of the 150 patients in the ICH group (80.6%), while 77 CMB lesions were found in 32 of the 271 individuals in the control group (11.8%). WMH and EPVS were more severe and lacunae were more frequent in the ICH patients than in the control group. When receiver operating characteristic (ROC) curves were plotted, number of CMBs most significantly predicted ICH. All imaging markers were significantly associated with ICH in every age group. The location of CMBs coincided with the location of ICH, and ICH volume correlated with CMB count. CONCLUSION: All MRI markers for SVD were worse in ICH patients than in healthy controls, and these markers were prominent even in young ICH patients. Lacunae, WMH, EPVS, and CMB should be considered as factors related with spontaneous ICH.
Brain ; Cerebral Amyloid Angiopathy ; Cerebral Hemorrhage ; Cerebral Small Vessel Diseases ; Cognition Disorders ; Delivery of Health Care ; Humans ; Hypertension ; Intracranial Hemorrhages ; Magnetic Resonance Imaging ; Observational Study ; Retrospective Studies ; ROC Curve ; Stroke ; White Matter

This study was done to examine consciousness and preventive strategies of adolescent drug abuse. This study design was descriptive survey. The data were collected from 1,830 students from 32 middle and high schools from November 11 to December 20, 1997, using questionnaires. The data were analyzed using SAS computer programs. The study results are as follows : Most of adolescent get the information on narcotics and drug abuse from TV, newspaper, magazine and advertisement. Some of them(48.8%) have received education on drug prevention. However, respondents(49.3%) answered unsatisfactory on preventive education. 69.2% of respondents do not know the legal regulation on alcohol and cigarette. The survey on the degree of cognition on drug abuse shows the serious results : cigarette(79.1%), alcohol(74.1%), bonds(55.1%), gas(49.8%), excitants(48.5%), narcotics(29%), marihwana(27.8%) and, diuretics(21.9%). The situation of adolescent drug abuse is also serious in the order of alcohol 38.2%, cigarette 14.3%, marihwana 9.4%.
Adolescent* ; Cognition ; Consciousness* ; Surveys and Questionnaires ; Education ; Humans ; Narcotics ; Periodicals ; Periodicals as Topic ; Substance-Related Disorders* ; Tobacco Products

MR imaging of the brain in 34 patients were reviewed to characterize the MR findings of brain damage due to perinatal hypoxic insult All the patients had a history of perinatal hypoxia and showed abnormal brain MR findings. Out of 34, eight infants were born premature and twenty-six were born at term or post-term. MR findings were analysed for the extent and location of abnormalities of the white matter, cortical abnormality. Corpus callosum atrophy, and abnormal progression of myelination. The major abnormalities were abnormal signal lesions or atrophy of the cerebral white matter and gyral atrophy of the cerebral cortex. The distribution of white matter lesions well correlated with maturity of the brain at the time of hypoxic insult. Periventricular and deep white matter lesions predominated in the premature-born patients. Corpus callosum atrophy was frequently seen. Reflecting the location of white matter injury. Delay in myelination was present in 55%. MR is a very useful diagnostic imaging modality and guide for the prediction of prognosis by accurate depiction of the location and extent of brain damage due to perinatal hypoxic insult.
Anoxia* ; Atrophy ; Brain* ; Cerebral Cortex ; Corpus Callosum ; Diagnostic Imaging ; Humans ; Infant ; Magnetic Resonance Imaging ; Myelin Sheath ; Prognosis ; White Matter

OBJECTIVE: The accuracy of analytical results of blood and urine heavy metals came out to the main issue on occupational health from late eighties. The discrepancy of the results for same samples from different laboratories made the diagnosis for occupational diseases be unreliable. Therefore, a quality control program for analysis of samples taken from workplace had been introduced in Korea since 1992. This study aims to show the quality control program f'or analysis of blood and urine samples and its proficient rates from 1992 to 1999 and to know how they have been being used in occupational health. METHODS: The quality control program runs twice a year with mandatory items of blood lead and urine hippuvic acid and voluntary items of blood cadmium and manganese and urine mandellic acid and methyl hippuric acid. Participant laboratories are receiving three levels for each items and two out of three samples have to be qualified for being a proficient laboratory for the item. The acceptable range of blood lead and urine hippuric acid is +/-15% and that of the others is within 3 SD(standard deviation) from the reference values. RESULTS: The proficient rates of blood lead and urine hippuric acid was 89%, 90%, repectively, however those of the other voluntary items have been from 51% to 62%. The proficient rates of urine mercury and urine N-methylformamide(NMF), which are introduced since 1999, were very poor. Urine hippuric acid and blood lead were analyzed frequently for the purpose of biological monitoring conducting by special health examination organizations. Urine and blood manganese and urine metabolites of trichloroethylene, urine phenol, methylhippuric acid and cadmium were followed. CONCLUSIONS: In conclusion, the quality control program for biological monitoring has dramatically improve the ability of analysing blood and urine samples and eventually contributes to diagnose occupational diseases and to prevent occupational poisoning. However, some biological monitoring data, such as urine manganese, mercury and NMF, have been still reported from laboratories that were not accepted as a proficient laboratory.
Cadmium ; Diagnosis ; Environmental Monitoring ; Korea ; Manganese ; Metals, Heavy ; Occupational Diseases ; Occupational Health ; Phenol ; Poisoning ; Quality Control ; Reference Values ; Trichloroethylene

No abstract available.
Mass Screening*

Chordoma arising from the notochordal remnants is a rare primary bone tumor in the cervicosacral region and is even more unusual in the thoracic region. The authors experienced a case of thoracic chordoma and report its CT and MR findings.
Chordoma* ; Notochord

Chordoma arising from the notochordal remnants is a rare primary bone tumor in the cervicosacral region and is even more unusual in the thoracic region. The authors experienced a case of thoracic chordoma and report its CT and MR findings.
Chordoma* ; Notochord

This study was done to examine consciousness and preventive strategies of adolescent drug abuse. This study design was descriptive survey. The data were collected from 1,830 students from 32 middle and high schools from November 11 to December 20, 1997, using questionnaires. The data were analyzed using SAS computer programs. The study results are as follows : Most of adolescent get the information on narcotics and drug abuse from TV, newspaper, magazine and advertisement. Some of them(48.8%) have received education on drug prevention. However, respondents(49.3%) answered unsatisfactory on preventive education. 69.2% of respondents do not know the legal regulation on alcohol and cigarette. The survey on the degree of cognition on drug abuse shows the serious results : cigarette(79.1%), alcohol(74.1%), bonds(55.1%), gas(49.8%), excitants(48.5%), narcotics(29%), marihwana(27.8%) and, diuretics(21.9%). The situation of adolescent drug abuse is also serious in the order of alcohol 38.2%, cigarette 14.3%, marihwana 9.4%.
Adolescent* ; Cognition ; Consciousness* ; Surveys and Questionnaires ; Education ; Humans ; Narcotics ; Periodicals ; Periodicals as Topic ; Substance-Related Disorders* ; Tobacco Products

No abstract available.
Apgar Score* ; Depression* ; Humans ; Psychology*

No abstract available.
Apgar Score* ; Depression* ; Humans ; Psychology*