1.Proliferating cell nuclear antigen in squamous cell carcinoma of the uterine cervix.
Journal of the Korean Cancer Association 1991;23(4):755-768
No abstract available.
Carcinoma, Squamous Cell*
;
Cervix Uteri*
;
Female
;
Proliferating Cell Nuclear Antigen*
2.The study on the nucleolar organizer regions in squamous cell carcinoma of the uterine cervix.
Korean Journal of Obstetrics and Gynecology 1991;34(9):1268-1278
No abstract available.
Carcinoma, Squamous Cell*
;
Cervix Uteri*
;
Female
;
Nucleolus Organizer Region*
3.A clinical study of thyroid nodules.
Journal of the Korean Surgical Society 1993;44(6):954-960
No abstract available.
Thyroid Gland*
;
Thyroid Nodule*
4.Agents increasing intracellular calcium levels ameliorate the antodepressant-induced reduction of submandibular salivation in cast.
Jae Hyun YOUN ; Won Jae KIM ; Sun Youl RYU
Journal of the Korean Association of Oral and Maxillofacial Surgeons 1997;23(1):17-26
Tri- and tetra-cyclic antidepressants are known to cause dry mouth among other several major complications. The present study was designed to compare the degree of reduced salivation due to antidepressants and to explore whether intracellular calcium-increasing agents ameliorate the salivation. Effects of antidepressants and agents increasing intracellular calcium on the cholinergic submandibular secretion and blood flow induced by the chorda stimulation or intra-arterial acetylcholine were observed in anesthetized cats. Effects of antidepressants and calcium-mobilizing agents on K+ efflux were also observed in excised gland slices. The results obtained were as follows: 1. Salivary secretion in response to the chorda stimulation (3 V, 20 Hz, 1 msec) was significantly attenuated by antidepressants in a dose-dependent manner, whereas the blood flow was not affected. 2. Salivary secretion and increased blood flow evoked by intra-arterial acetylcholine (20 microgram/kg) were markedly diminished by antidepressants, the magnitude of which was amitryptyline>imipramine >mianserin in order. 3. Cholinergic salivation was significantly decrease by cyclopiazonic acid, a calcium pump inhibitor of the endoplasmic reticulum, or by BAPTA/AM, a specific intracellular calcium chelator. 4. Caffeine and ryanodine potentiated the cholinergic salivation and ameliorated the depressed salivary secreation due to antidepressants. 5. Calcium ionophore A 23187 ameliorated the depressed salivation due to antidepressants. 6. Antidepressants inhibited the K+ efflux, which were restored by caffeine or A 23187. These results suggest that the depressed salivary secreation due to antidepressants is ameliorated by increasing intracellular calcium levels.
Acetylcholine
;
Animals
;
Antidepressive Agents
;
Caffeine
;
Calcimycin
;
Calcium*
;
Cats
;
Endoplasmic Reticulum
;
Mouth
;
Ryanodine
;
Salivation*
5.Recurrent Guillain-Barr'e Syndrome.
Kyo Sun KIM ; Jae Song KIM ; Pyung Kil KIM
Journal of the Korean Pediatric Society 1981;24(4):367-450
No abstract available.
6.A comparative study of DNA ploidy pattern by flow cytometry and AG-NORs in colon adenocarcinoma.
Jae Man KIM ; Han Sun KIM ; Sae Min KIM
Journal of the Korean Society of Coloproctology 1993;9(4):339-351
No abstract available.
Adenocarcinoma*
;
Colon*
;
DNA*
;
Flow Cytometry*
;
Ploidies*
7.A clinical study on acute appendicitis in children.
Eun Sub PARK ; Jae Man KIM ; Han Sun KIM
Journal of the Korean Society of Coloproctology 1993;9(1):57-65
No abstract available.
Appendicitis*
;
Child*
;
Humans
8.The Prevalence of Epstein-Barr Virus in Uterine Cervical Cancer: Detection by PCR and In Situ PCR Methods.
In Sun KIM ; Jae Seong KANG ; An Na CHOI ; Young Sik KIM
Korean Journal of Obstetrics and Gynecology 2000;43(2):184-191
OBJECTIVE: Uterine cervical cancer is the most common malignant tumor in Korean women. Human papillomaviruses are associated in 85-90% of the cases. However, other cofactors are considered to be important in carcinogenesis. There is an evidence that the uterine cervix is the site of shedding of the Epstein-Barr viruses(EBV). Furthermore the virus has been detected in cervical intraepithelial neoplasia and invasive carcinoma of the uterine cervix. We studied to evaluate the role of EBV in cervical carcinogenesis. METHODS: Non-neoplastic cervices(12), carcinoma in situ(32), microinvasive squamous cell carcinomas(9), invasive squamous cell carcinomas(37) and adenocarcinomas and adenosquamous carcinomas(14) were studied for EBV infection. PCR and in situ PCR for EBNA-1 were done and subtyping was done using PCR for EBNA 3C. RESULTS: In non-neoplastic cervix, EBV was detected in 16.7% by PCR and found in normal epithelial cells and lymphocytes in in situ PCR. By PCR technique, EBV was detected in 65.6% of CIS, 66.3% and 51.4% of microinvasive and invasive squamous cell carcinomas, 57.1% of adenocarcinomas and adenosquamous carcinomas. EBV subtyping was done in EBV positive cases by PCR and all showed type 1. CONCLUSION: EBV was detected in higher frequency in cervical cancer than in non-neoplastic cervix. However the frequency was not correlated to the invasion depth and histologic types of cervical carcinomas. EBV was detected in tumor cells as well as normal epithelial cells and lymphocytes also. It was suggested that EBV may play a role in cervical cancers but the mechanism in carcinogenesis remains to be solved.
Adenocarcinoma
;
Carcinogenesis
;
Carcinoma, Adenosquamous
;
Carcinoma, Squamous Cell
;
Cervical Intraepithelial Neoplasia
;
Cervix Uteri
;
Epithelial Cells
;
Epstein-Barr Virus Infections
;
Female
;
Herpesvirus 4, Human*
;
Humans
;
Lymphocytes
;
Polymerase Chain Reaction*
;
Prevalence*
;
Uterine Cervical Neoplasms*
9.A clinical study of traumatic hemoperitoneum.
Seung Kyun PARK ; Jae Man KIM ; Han Sun KIM
Journal of the Korean Surgical Society 1993;45(4):517-526
No abstract available.
Hemoperitoneum*
10.Transfer of Drugs Resistancy in Staphylococci.
Jae Kyu CHUNG ; Sung Kwang KIM ; Hee Sun KIM
Yeungnam University Journal of Medicine 1987;4(2):15-21
No abstract available.