1.A study on evaluation of isolated rabbit kidney function withcomputed 99mTc-DTPA scintigraphy.
Korean Journal of Nuclear Medicine 1991;25(1):95-100
No abstract available.
Kidney*
;
Radionuclide Imaging*
2.A study on evaluation of isolated rabbit kidney function withcomputed 99mTc-DTPA scintigraphy.
Korean Journal of Nuclear Medicine 1991;25(1):95-100
No abstract available.
Kidney*
;
Radionuclide Imaging*
3.Rectal prolapse in Korean.
Doo Sun CHUNG ; Il Woo WHANG ; Soo Han JUN
Journal of the Korean Society of Coloproctology 1992;8(1):9-14
No abstract available.
Rectal Prolapse*
4.Cloning and characterization of Giardia intestinalis cyclophilin.
Hak Sun YU ; Hyun Hee KONG ; Dong Il CHUNG
The Korean Journal of Parasitology 2002;40(3):131-138
The cyclophilins (Cyps) are family members of proteins that exhibit peptidylprolyl cis-trans isomerase (PPIase, EC 5.2.1.8) activity and bind the immunosuppressive agent cyclosprin A (CsA) in varying degrees. During the process of random sequencing of a cDNA library made from Giardia intestinalis WB strain, the cyclophilin gene (gicyp 1) was isolated. An open reading frame of gicyp 1 gene was 576 nucleotides, which corresponded to a translation product of 176 amino acids (Gicyp 1). The identity with other Cyps was about 58-71%. The 13 residues that constituted the CsA binding site of human cyclophilin were also detected in the amino acid sequence of Gicyp 1, including tryptophan residue essential for the drug binding. The single copy of the gicyp 1 gene was detected in the G. intestinalis chromosome by southern hybridization analysis. Recombinant Gicyp 1 protein clearly accelerated the rate of cis--
5.Renal cell carcinomas first detected by Tc-MDP bone scan.
Seoung Oh YANG ; Sun Seob CHOI ; Yung Il LEE ; Duck Hwan CHUNG
Korean Journal of Nuclear Medicine 1993;27(1):148-149
No abstract available.
Carcinoma, Renal Cell*
6.A clinical study on patients with porencephaly.
Sung Yoon CHO ; Jai Yoon KIM ; Kwang Sun HAN ; Sa Jun CHUNG ; Chang Il AHN
Journal of the Korean Pediatric Society 1993;36(7):975-981
Porencephaly is relatively rare condition defined by an defect or a defect or cavity in the cerebrum owing to a developmental malformation or to a destructive lesion. Fory-five porencephaly patients diagnosed by Brain CT were clinically analyzed and the following results were obtained. 1) By the age group presenting initial symptoms, the peak incidence was from 1 month to below 3 years old. 2) In initial symptoms, seizure, spastic weakness, headache were showed in order of frequency. But 7 cases (15.5%) were asymptomatic. 3) The latency of diagnosis after presenting initial symptoms from the symptom onset time to 10 years. 4) The subsequent symptoms were as follows: spastic weakness, speech disturbance, gait disturbance, mental retardation, sensory loss and seizure showed independently or combined. 5) As etiologic factor, 21 cases (46.7%) were congenital, 16 cases (35.5%) were post-traumatic or post-operative and 8 cases (17.8%) were perinatal. 6) The prognosis was seen various from mild to severe. Out of 45 cases, 29 cases (64.4%) were no complications. But the prognosis in patients with post-traumatic or postoperative etiological factors was poor. With the advent of brain CT and the resultant capability of detecting structural defect and cerebral lesions responsible for epilepsy or focal neurologic signs, porencephaly was seen to be readily recongizable by CT examination. Since porencephaly is a significant contributor to the spectrum of CNS lesion and benign condition, ist recognition is important in determining prognosis and therapy.
Brain
;
Cerebrum
;
Child, Preschool
;
Diagnosis
;
Epilepsy
;
Gait
;
Headache
;
Humans
;
Incidence
;
Intellectual Disability
;
Muscle Spasticity
;
Neurologic Manifestations
;
Prognosis
;
Seizures
7.Sebaceous Trichofolliculoma: A case report.
Jeana KIM ; Seong Beom LEE ; Seok Jin KANG ; Soo Il CHUNG ; Sun Moo KIM
Korean Journal of Pathology 1995;29(6):794-796
Sebaceous trichofolliculoma is a variant of trichofolliculoma which occurs in the sebaceous areas rich in follicles and is a relatively rare skin tumor. This tumor is a clinically and histologically easy tumor to recognize that is well differentiated. We examined a case of a consists of a 21-year-old female who had a pedunculated nodule on her scalp. Microscopically, the tumor was large, had a centrally located cavity lined by squamous epithelium and radially arranged sebaceous follicles connected to the cavity. No cytological atypia or recurrence after excision was found.
Female
;
Humans
8.Expression of Neuroendocrine Cells in Benign Prostatic Hyperplasia and the Effect of Dihydrotestosterone .
Sung Joon HONG ; Soo Mee KWON ; Sun Il KIM ; Hea Young OH ; Bong Chul CHUNG
Korean Journal of Urology 2003;44(3):267-271
PURPOSE: Neuroendocrine (NE) cells of the prostate are considered to be involved in the pathogenesis of benign prostate hyperplasia (BPH). By a comparative analysis of NE cell density in BPH tissue of men who were either exposed to or not exposed to 5alpha-reductase inhibitor, we investigated the relationship between NE cells and BPH, and the effect of androgen deprivation on NE cells. MATERIALS AND METHODS: Prostate tissue specimens, obtained from 30 men by transurethral resection of the prostate or radical cystoprostatectomy, were used. Of the 30 patients, 10 had a prostate smaller than 25 ml (normal control), the other 20 had a prostate larger than 40ml, 10 of who had taken 5alpha-reductase inhibitor (finasteride) for 3 months before surgery (androgen blockade group), and 10 who had not (BPH group). The distribution of NE cells in the prostate was examined using the anti-chromogranin A (CgA) antibody, and the density of the CgA-positive cells was compared by an optical dissector method. Immunoblotting was performed using the neuron specific enolase (NSE) antibody. A Mann-Whitney U test was used in a statistical analysis. RESULTS: Most of the CgA-positive NE cells were localized between the acinar epithelial cells. The mean numbers of CgA-positive NE cells per acinus in the normal controls and the BPH groups were 1.67+/-0.78 and 4.45+/-2.54, respectively, and the difference was statistically significant (p<0.05). However, the mean number of CgA-positive NE cells in the androgen blockade group, was 4.93+/-2.17, which was similar to the BPH group. In a NSE immunoblotting study, a distinct band was observed in the BPH and androgen blockade groups, but the density of the band was higher in the androgen blockade group. CONCLUSIONS: Our results suggest that NE cells may be involved in the hyperplastic process of BPH. Inhibition of dihydrotestosterone, caused by the oral administration of the 5alpha-reductase inhibitor, failed to induce any significant change in the NE cells, probably due to the incomplete androgen blockade.
Administration, Oral
;
Cell Count
;
Dihydrotestosterone*
;
Epithelial Cells
;
Humans
;
Hyperplasia
;
Immunoblotting
;
Male
;
Neuroendocrine Cells*
;
Phosphopyruvate Hydratase
;
Prostate
;
Prostatic Hyperplasia*
9.Purification and characterization of a 33 kDa serine protease from Acanthamoeba lugdunensis KA/E2 isolated from a Korean keratitis patient.
Hyo Kyung KIM ; Young Ran HA ; Hak Sun YU ; Hyun Hee KONG ; Dong Il CHUNG
The Korean Journal of Parasitology 2003;41(4):189-196
In order to evaluate the possible roles of secretory proteases in the pathogenesis of amoebic keratitis, we purified and characterized a serine protease secreted by Acanthamoeba lugdunensis KA/E2, isolated from a Korean keratitis patient. The ammonium sulfate-precipitated culture supernatant of the isolate was purified by sequential chromatography on CM-Sepharose, Sephacryl S-200, and mono Q-anion exchange column. The purified 33 kDa protease had a pH optimum of 8.5 and a temperature optimum of 55 degrees C. Phenylmethylsulfonylfluoride and 4- (2- Aminoethyl) -benzenesulfonyl-fluoride, both serine protease specific inhibitors, inhibited almost completely the activity of the 33 kDa protease whereas other classes of inhibitors did not affect its activity. The 33 kDa enzyme degraded various extracellular matrix proteins and serum proteins. Our results strongly suggest that the 33 kDa serine protease secreted from this keratopathogenic Acanthamoeba play important roles in the pathogenesis of amoebic keratitis, such as in corneal tissue invasion, immune evasion and nutrient uptake.
Acanthamoeba/*enzymology/isolation & purification/pathogenicity
;
Acanthamoeba Keratitis/*parasitology
;
Animals
;
Cornea/parasitology
;
Humans
;
Hydrogen-Ion Concentration
;
Korea
;
Serine Endopeptidases/chemistry/*isolation & purification/*metabolism
;
Substrate Specificity
;
Temperature
;
Virulence Factors
10.A Comparison on General Education Curriculum of 4-year and 3-year Nursing Schools in Korea.
Sook Young KIM ; Sun Ei JOUNG ; Chung Il HWANG
Journal of Korean Academy of Nursing 2011;41(1):101-109
PURPOSE: This study was done to comparatively analyze the general education curriculum of 4-yr and 3-yr nursing schools in Korea. METHODS: Ten university 4-yr nursing schools were selected based on universities in Korean Accreditation Board of Nursing 2010 or "2009 Korea's Best Universities-Top 10" published by Joong-Ang Daily. Ten college 3-yr nursing schools were selected based on colleges in Korean Accreditation Board of Nursing 2010. RESULTS: 1) Generally 4-yr nursing schools maintained the relationships between organizational philosophy/purposes and subjects in the general education curriculum. But 3-yr nursing schools did not. 2) In 4-yr nursing schools there was a relatively higher credits ratio of general education curriculum and selective courses than in 3-yr nursing schools. 3) In 4-yr nursing schools variety of courses was relatively higher than 3-yr nursing schools. 4) In 4-yr nursing schools, operating conditions were relatively better (number of tenure professors, ratio of professors to students, Identification of exclusive organization in charge of the general education curriculum) for the general education curriculum than 3-yr nursing schools. CONCLUSION: The results identify significant differences in the general education curriculum of 4-yr and 3-yr nursing schools in Korea, indicating that 3-yr nursing schools should make efforts to improve the good quality of general education curriculum.
*Curriculum
;
Education, Nursing, Baccalaureate/*standards/trends
;
Education, Nursing, Diploma Programs/*standards/trends
;
Humanities/*education
;
Humans
;
Nursing Education Research
;
Republic of Korea