2.A Study of Protective Effect of Selenium Against Cytotoxicity of Methylmercury Chloride.
Dai Ha KOH ; Jung Ho YOUM ; Young Sang KOH ; Sun Hwan JOH ; Tak Soon OH
Korean Journal of Occupational and Environmental Medicine 1998;10(3):310-319
The purpose of the present study was to elucidate the cytotoxical influence of mercurial compounds and the protective effect of selenium against mercurial compounds. The effects of mercury compounds and selenium on the syntheses of nitrite(NO2-) and ATP were observed in the cell cultures of EMT-6 cells and peritoneal macrophages from Balb/c mouse. The viabilities of EMT-6 cells and peritoneal macrophages at the end of culture were significantly decreased in dose-dependent manner by methylmercury chloride (CH3HgCl) added into the media. NO2- and ATP syntheses of the cells were dose-dependently inhibited by CH3HgCl. Simultaneous addition of the equimolar dose of selenium completely prevented mercury-induced inhibitions of NO2- and ATP syntheses, which were observed in both of EMT-6 cells and peritoneal macrophages. But these effects of selenium were not appeared in the new medium containing mercurials only which were removed the selenium after the pretreatment of selenium for 6 hours. These results suggest that protective effect of selenium against mercurial compounds was archived by the formation of a complex consisting of Se-Hg or Se-Hg-protein. Though its mechanism was not clear, the protective role of selemium against the mercury toxicity would be exhibited in the immunological system.
Adenosine Triphosphate
;
Animals
;
Cell Culture Techniques
;
Macrophages, Peritoneal
;
Mercury Compounds
;
Mice
;
Nitric Oxide
;
Selenium*
3.Validity of Measles Immunization Certificates and Perception of General Practitioners Concerning Immunization Certificate.
Kun Sei LEE ; Hee Kyung JOH ; Eunyoung SHIN ; Sun Hwan BAE ; Yoon Jeong KIM ; Hyun Kyung OH
Journal of the Korean Academy of Family Medicine 2006;27(12):1005-1012
BACKGROUND: In Korea, the law reguires submission of immunization certificate to elementary school on admission since 2001 in order to prevent measles outbreaks such as those that occurred in the year 2000 and 2001. As a result, the submission rate of immunization certificate has been almost 99%. To that effect it seems to have been a very successful policy. But the validity and accuracy of such certificates have not been guestioned. This study aimed to assess the validity of the measles immunization certificates and general practitioners' perception of the law to submit immunization certificate. METHODS: A postal survey was conducted from April to May 2005 among general practitioners who were pediatricians and family physicians. The main questions were the method to confirm childrens' past vaccination and the proportion of doing booster vaccination, and also their opinions on governments' policy to extend the submission of immunization certificate on school admission. RESULTS: The total study subjects were 840. The proportion of issued immunization certificates based on exact vaccination records or booster vaccination was 98.7%. The opinions concerning the law to submit immunization certificates were: very necessary (88.8%), and should include all children basic immunization (62.8%). On the other hand, the most common reason against the law was that they did not feel the necessity (31.4%). CONCLUSION: The validity of immunization certificates was very high. The opinions concerning the law to submit immunization certificates were favorable in most subjects. And mutual understanding between the general practitioners and the government is in demand before the law to submit immunization certificates becomes effect.
Child
;
Disease Outbreaks
;
General Practitioners*
;
Hand
;
Humans
;
Immunization*
;
Jurisprudence
;
Korea
;
Measles Vaccine
;
Measles*
;
Physicians, Family
;
Vaccination
4.Simultaneous Laparoscopic Cholecystectomy and Endovascular Abdominal Aortic Aneurysm Repair.
Jin Hyun JOH ; Sun Hyung JOO ; Bum Soo KIM ; Kwang Ro JOO ; Deok Ho NAM ; Suk Hwan LEE ; Ho Chul PARK
Journal of the Korean Society for Vascular Surgery 2012;28(3):155-158
Concomitant cholelithiasis and abdominal aortic aneurysm (AAA) is not uncommon. Cholecystectomy at the time of aneurysm repair was delayed in patients with asymptomatic cholelithiasis due to the possibility of the graft infection. If a patient is subjected to a high risk of aneurysmal rupture and symptomatic cholelithiasis, the combined cholecystectomy and aneurysm repair should be performed. With the advent of the minimally invasive surgery, minimal invasive approach is widely adopted in patients with cholelithiasis and AAA. We reported one patient who had symptomatic cholelithiasis and AAA, successfully treated with the laparoscopic cholecystectomy and endovascular AAA repair.
Aneurysm
;
Aortic Aneurysm
;
Aortic Aneurysm, Abdominal
;
Cholecystectomy
;
Cholecystectomy, Laparoscopic
;
Cholelithiasis
;
Endovascular Procedures
;
Humans
;
Rupture
;
Transplants
5.Diagnosis and Treatment of Lower Extremity Deep Vein Thrombosis: Korean Practice Guidelines.
Seung Kee MIN ; Young Hwan KIM ; Jin Hyun JOH ; Jin Mo KANG ; Ui Jun PARK ; Hyung Kee KIM ; Jeong Hwan CHANG ; Sang Jun PARK ; Jang Yong KIM ; Jae Ik BAE ; Sun Young CHOI ; Chang Won KIM ; Sung Il PARK ; Nam Yeol YIM ; Yong Sun JEON ; Hyun Ki YOON ; Ki Hyuk PARK
Vascular Specialist International 2016;32(3):77-104
Lower extremity deep vein thrombosis is a serious medical condition that can result in death or major disability due to pulmonary embolism or post-thrombotic syndrome. Appropriate diagnosis and treatment are required to improve symptoms and salvage the affected limb. Early thrombus clearance rapidly resolves symptoms related to venous obstruction, restores valve function and reduces the incidence of post-thrombotic syndrome. Recently, endovascular treatment has been established as a standard method for early thrombus removal. However, there are a variety of views regarding the indications and procedures among medical institutions and operators. Therefore, we intend to provide evidence-based guidelines for diagnosis and treatment of lower extremity deep vein thrombosis by multidisciplinary consensus. These guidelines are the result of a close collaboration between interventional radiologists and vascular surgeons. The goals of these guidelines are to improve treatment, to serve as a guide to the clinician, and consequently to contribute to public health care.
Consensus
;
Cooperative Behavior
;
Diagnosis*
;
Extremities
;
Incidence
;
Lower Extremity*
;
Methods
;
Public Health
;
Pulmonary Embolism
;
Surgeons
;
Thrombosis
;
Venous Thrombosis*
6.Correlation between Pneumonia Severity and Pulmonary Complications in Middle East Respiratory Syndrome.
Wan Beom PARK ; Kang Il JUN ; Gayeon KIM ; Jae Phil CHOI ; Ji Young RHEE ; Shinhyea CHEON ; Chang Hyun LEE ; Jun Sun PARK ; Yeonjae KIM ; Joon Sung JOH ; Bum Sik CHIN ; Pyeong Gyun CHOE ; Ji Hwan BANG ; Sang Won PARK ; Nam Joong KIM ; Dong Gyun LIM ; Yeon Sook KIM ; Myoung don OH ; Hyoung Shik SHIN
Journal of Korean Medical Science 2018;33(24):e169-
This nationwide, prospective cohort study evaluated pulmonary function and radiological sequelae according to infection severity in 73 survivors from the 2015 Middle East respiratory syndrome (MERS) outbreak in Korea. Patients with severe pneumonia in MERS-coronavirus infection had more impaired pulmonary function than those with no or mild pneumonia at the 1-year follow-up, which was compatible with the radiological sequelae. Severe pneumonia significantly impairs pulmonary function and makes long radiological sequelae in MERS.
Cohort Studies
;
Coronavirus
;
Coronavirus Infections*
;
Follow-Up Studies
;
Humans
;
Korea
;
Middle East*
;
Pneumonia*
;
Prospective Studies
;
Survivors
7.Clinical Presentation and Outcomes of Middle East Respiratory Syndrome in the Republic of Korea.
Won Suk CHOI ; Cheol In KANG ; Yonjae KIM ; Jae Phil CHOI ; Joon Sung JOH ; Hyoung Shik SHIN ; Gayeon KIM ; Kyong Ran PECK ; Doo Ryeon CHUNG ; Hye Ok KIM ; Sook Hee SONG ; Yang Ree KIM ; Kyung Mok SOHN ; Younghee JUNG ; Ji Hwan BANG ; Nam Joong KIM ; Kkot Sil LEE ; Hye Won JEONG ; Ji Young RHEE ; Eu Suk KIM ; Heungjeong WOO ; Won Sup OH ; Kyungmin HUH ; Young Hyun LEE ; Joon Young SONG ; Jacob LEE ; Chang Seop LEE ; Baek Nam KIM ; Young Hwa CHOI ; Su Jin JEONG ; Jin Soo LEE ; Ji Hyun YOON ; Yu Mi WI ; Mi Kyong JOUNG ; Seong Yeon PARK ; Sun Hee LEE ; Sook In JUNG ; Shin Woo KIM ; Jae Hoon LEE ; Hyuck LEE ; Hyun Kyun KI ; Yeon Sook KIM
Infection and Chemotherapy 2016;48(2):118-126
BACKGROUND: From May to July 2015, the Republic of Korea experienced the largest outbreak of Middle East respiratory syndrome (MERS) outside the Arabian Peninsula. A total of 186 patients, including 36 deaths, had been diagnosed with MERS-coronavirus (MERS-CoV) infection as of September 30th, 2015. MATERIALS AND METHODS: We obtained information of patients who were confirmed to have MERS-CoV infection. MERS-CoV infection was diagnosed using real-time reverse-transcriptase polymerase chain reaction assay. RESULTS: The median age of the patients was 55 years (range, 16 to 86). A total of 55.4% of the patients had one or more coexisting medical conditions. The most common symptom was fever (95.2%). At admission, leukopenia (42.6%), thrombocytopenia (46.6%), and elevation of aspartate aminotransferase (42.7%) were observed. Pneumonia was detected in 68.3% of patients at admission and developed in 80.8% during the disease course. Antiviral agents were used for 74.7% of patients. Mechanical ventilation, extracorporeal membrane oxygenation, and convalescent serum were employed for 24.5%, 7.1%, and 3.8% of patients, respectively. Older age, presence of coexisting medical conditions including diabetes or chronic lung disease, presence of dyspnea, hypotension, and leukocytosis at admission, and the use of mechanical ventilation were revealed to be independent predictors of death. CONCLUSION: The clinical features of MERS-CoV infection in the Republic of Korea were similar to those of previous outbreaks in the Middle East. However, the overall mortality rate (20.4%) was lower than that in previous reports. Enhanced surveillance and active management of patients during the outbreak may have resulted in improved outcomes.
Antiviral Agents
;
Aspartate Aminotransferases
;
Coronavirus Infections*
;
Disease Outbreaks
;
Dyspnea
;
Extracorporeal Membrane Oxygenation
;
Fever
;
Humans
;
Hypotension
;
Leukocytosis
;
Leukopenia
;
Lung Diseases
;
Middle East Respiratory Syndrome Coronavirus
;
Middle East*
;
Mortality
;
Pneumonia
;
Polymerase Chain Reaction
;
Republic of Korea*
;
Respiration, Artificial
;
Thrombocytopenia