1.A Case of Idiopathic CD4 + T Lymphocytopenia Associated with Kaposi's Sarcoma.
Hyun Tae LEE ; Ho Sun JANG ; Kyung Sool KWON ; Tae Ahn CHUNG
Korean Journal of Dermatology 1997;35(1):191-195
Idiopathic CD4+ T lymphocytopenia (ICL) is a new disease entity characterized by depletion of helper T cells apparently without any evidence of HIV infection. We report a case of ICL associated with Kaposis sarcoma (KS) and pneumocystis carinii pneumonia (PCP) in a 34-year old woman. She developed violaceous, protruding masses on scalp, back, both extremities, palms, soles, left. first toe and peritonsillar region for 2 months. These lesions were confirmed as KS by histopathologic findings. Chest X-ray and HRCT findings represented PCP and KS. Absolute deficiency of CD4+ T cell was detected in the count of T cell subsets. Serologic tests for HIV-1, 2 and HTLV I, -II were negative. And she was absent any defined immunodeficiency or therapy associated with decreased levels of CD4+ T cells. By CDC criteria, a diagnosis of ICL was made. Because of aggravation of PCP and lung involuement of KS, she died at 22nd day after admission.
Adult
;
Centers for Disease Control and Prevention (U.S.)
;
Diagnosis
;
Extremities
;
Female
;
HIV Infections
;
HIV-1
;
Humans
;
Lung
;
Lymphopenia*
;
Pneumonia, Pneumocystis
;
Sarcoma, Kaposi*
;
Scalp
;
Serologic Tests
;
T-Lymphocyte Subsets
;
T-Lymphocytes
;
T-Lymphocytes, Helper-Inducer
;
T-Lymphocytopenia, Idiopathic CD4-Positive
;
Thorax
;
Toes
2.A Case of Pedunculated Pigmented Eccrine Poroma Combined with Congenital Melanocytic Nevus on the Scalp.
Kyung Hyung SEO ; Ho Sun JANG ; Kyung Sool KWON ; Tae Ahn CHUNG
Korean Journal of Dermatology 1997;35(1):169-173
It has been generally assum d that eccrine poroma arises from acrosyringium, the epidermal sweat duct unit. Eccrine poroma mainly involves the non hairy surfaces of the skin, but it has also been found on hair-bearing areas. One of the characteristics of this structure is absence of melanocytes and melanin granules arnong its cells. However a complete absence of melanocytes and melanin granules in eccrine poroma is not invariable and a few reports of such an occurrence have been presented. The authors report herein a case of unusual and rare eccrine poroma. The eccrine poroma had melanin pigment and melanocytes, was pedunculated and occurred on the parietal scalp which was the unusual site of involvement. The eccrine poroma was also combined with a pedunculated congenital melanocytic nevus on the supraauricular scalp.
Melanins
;
Melanocytes
;
Nevus, Pigmented*
;
Poroma*
;
Rabeprazole
;
Scalp*
;
Skin
;
Sweat
3.A Case of Congenital Cutaneous Candidiasis with Nail Involvement in A Premature Baby.
Myeong Kyoo LIM ; Kyung Sool KWON ; Ho Sun JANG ; Tae Ahn CHUNG
Annals of Dermatology 1996;8(2):129-134
No abstract available.
Candidiasis, Cutaneous*
4.Two cases of nasopharyngeal carcinoma in children.
Tae Sun HA ; Chul Ho JANG ; Hee Young SHIN ; Hyo Seop AHN
Journal of the Korean Pediatric Society 1991;34(4):587-593
No abstract available.
Child*
;
Drug Therapy
;
Humans
;
Radiotherapy
5.A Case of Generalized Annular Lichen Planus Controlled by Erythromycin.
Jae Bong LEE ; Hang Gye SHIN ; Ho Sun JANG ; Kyung Sool KOWN ; Tae Ahn CHUNG
Korean Journal of Dermatology 1997;35(2):307-311
A 69-year-old man presented with annular lichen planus involving both forearms, hand dorsa, wrists, inner sides of the thighs, knees and ankles. He was treated initially with systemic corticosteroids and etretinate, but rernission and recurr ence of the skin lesions were observed. During the follow-up, we found erythrasma on all his toewebs and both soles. After administration of erythromycin for the treatment of erythrasma, lesions of the lichen planus rapidly improved. Five months later, some lesions of lihen planus and erythrasma had recurred. After administration of erythromycin, the lesions of lichen planus improved again. No recurrence was observed for the following 8 months. We suspect that eradication of the chronic focus of infection and the anti-inflammatory effect, of erythromycin may lead to supression of abnormal immunological reactions and resolution of lichen planus.
Acitretin
;
Adrenal Cortex Hormones
;
Aged
;
Ankle
;
Erythrasma
;
Erythromycin*
;
Etretinate
;
Follow-Up Studies
;
Forearm
;
Hand
;
Humans
;
Knee
;
Lichen Planus*
;
Lichens*
;
Recurrence
;
Skin
;
Thigh
;
Wrist
6.Determination of antigenic domain in GST fused major surface protein (Nc-p43) of Neospora caninum.
Eui Sun SON ; Hye Jin AHN ; Jae Hoon KIM ; Dae Yong KIM ; Ho Woo NAM
The Korean Journal of Parasitology 2001;39(3):241-246
The antigenic domain of the major surface protein (Nc-p43) of Neospora caninum was examined by polymerase chain reaction of its gene fragments and recombinant expression as GST fusion proteins. The fragments of Nc-p43 were as follow: a total open reading frame (OFR), T; OFR without signal sequence and C-terminal hydrophobic sequence, S; N-terminal 2/3 parts of S, A; C-terminal 2/3 parts, P; N-terminal 1/3 part, X; middle 1/3 part, Y; and C-terminal 1/3 part, Z, respectively. The DNA fragments were cloned into pGEX-4T vector. Recombinant plasmids transformed into Escherichia coli of BL21 pLysS (DE3) strain were induced to express GST or GST fused fragments of Nc-p43 such as 69 kDa protein for T, 66 kDa for S, 52 kDa for A, 53 kDa for P, and 40 kDa proteins for X, Y, and Z, respectively in SDS-PAGE. The Nc-p43 fragments of T, S, and P reacted with a bovine serum of neosporosis while those of A, X, Y, and Z together with GST did not in the western blot. These findings suggest that the antigenic domain of Nc-p43 of N. caninum may be localized in the C-terminal 2/3 parts. Together with A19 clone in SAG1 of Toxoplasma gondii (Nam et al., 1996), the P fragment of Nc-p43 could be used as efficient antigens to diagnose and differentiate those infections with both species.
Amino Acid Sequence
;
Animals
;
Base Sequence
;
Biological Markers/analysis
;
Blotting, Western
;
Cells, Cultured
;
Cercopithecus aethiops
;
Coccidiosis/diagnosis
;
Neospora/*immunology
;
Protozoan Proteins/*analysis/genetics/immunology
;
Reverse Transcriptase Polymerase Chain Reaction
;
Support, Non-U.S. Gov't
;
Vero Cells/parasitology
7.A Case of Hypergammaglobulinemic Purpura of Waldenstrom.
Myeong Kyoo LIM ; Ho Sun JANG ; Kyung Sool KWON ; Tae Ahn CHUNG
Korean Journal of Dermatology 1995;33(4):789-793
Hypergammaglobulinemic purpura of Waldenstrom is characterized by recurrent episodes of petechiae, hypergammaglobulinemia, an elevated erythrocyte sedimentation rate, and the presence of rheumatoid factor, and leukocytoclastic vasculitis or mild lymphocytic perivasculitis. There is a primary type and a secondary type which is associated with other autoimmune diseases. We present a csae of a 48 year-old female with hypergammaglobulinemic purpura of Waldenstrom. She showed characteristic clinical, histopathological and laboratory findings consistent with hypergammaglobulinema purpura of Waldenstrom. Although there was a decrease in the Schimer test, we couldt den ostrate an association with Sjogrens syndrome. We think that this case may be a secondary type and needs a follow-up study.
Autoimmune Diseases
;
Blood Sedimentation
;
Female
;
Follow-Up Studies
;
Humans
;
Hypergammaglobulinemia
;
Middle Aged
;
Purpura
;
Purpura, Hyperglobulinemic*
;
Rheumatoid Factor
;
Sjogren's Syndrome
;
Vasculitis
8.A Case of Captopril-induced Pemphigus Foliaceus.
Ho Sun JANG ; Doo Chan MOON ; Kyung Sool KWON ; Tae Ahn CHUNG
Annals of Dermatology 1990;2(1):63-67
A 65-year-old male received captoPnl therapy (25mg three times a day, for the treatment of congestive heart failure. Seven months after starting the captopril therapy he developed flaccid vesiculobullae and erythematous patches with oozing, crusted surfaces on his trunk and the proximal portion of his extremities. The mucous membranes were not involved. The mucous membranes were not involved.) The histopathologic findings showed subcorneal bulla containing a few acantholytic cells and direct immunofluorescent studies revealed intercellular deposition of IgG and C3 throughout entire epidermis, consistent with pemphigus foliaceus. After captopril therapy was discontinued, the skin lesions gradually improved within 1 month. Pemphigus foliaceus; is a rare complication of captopril therapy and this is, to our knowledge, the first case report in Korea.
Aged
;
Captopril
;
Epidermis
;
Extremities
;
Heart Failure
;
Humans
;
Immunoglobulin G
;
Korea
;
Male
;
Mucous Membrane
;
Pemphigus*
;
Skin
9.A Case of Granuloma Pyogenicum-like Cutaneous Metastasis to the Fingertip in Papillary Thyroid Carcinoma.
Sung Kwi PARK ; Ho Sun JANG ; Kyung Sool KWON ; Tae Ahn CHUNG
Annals of Dermatology 1995;7(4):350-353
Cutaneous metastasis of the papillary thyroid carcinoma(PTC) is very rare. We report a case of PTC that metastasized to the left fourth fingertip. Its cutaneous appearance was similar to granuloma pyogenicum. A 65-year-old woman who has PTC with regional lymph nodes involvement and pulmonary metastasis complained of a protruding hemorrhagic subungual mass on the left fourth finger for two months. The histopathologic findings showed papillary projections of the tumor cells surrounding the axial fibrovascular stroma and mitotic cells. The tumor cells showed a positive reaction with antithyroglobulin antibody in immunoperoxidase stain. To the best of our knowledge, this is the first case report of PTC that metastasized to the fingertip, and that showed granuloma pyogenicum-like cutaneous lesion at the metastatic site.
Aged
;
Female
;
Fingers
;
Granuloma*
;
Granuloma, Pyogenic
;
Humans
;
Lymph Nodes
;
Neoplasm Metastasis*
;
Thyroid Gland*
;
Thyroid Neoplasms*
10.A Case of Rhinocerebral Mucormycosis in a Diabetic Woman.
Ho Sun JANG ; Doo Chan MOON ; Kyung Sool KWON ; Tae Ahn CHUNG
Annals of Dermatology 1991;3(2):145-152
We report a case of rhinocerebral mucormycosis in a 63-year-old female with a 1-year history of poorly controlled diabetes mellitus. She had black necrotic ulcers on the hard palate, bloody nasal discharge, swelling of the left side of her face, left blepharoptosis, proptosis, and conjunctival injection. Histopathological examination of the palatal lesion showed large, nonseptate, right-angled branching fungal hyphae in the dermis, and Rhizopus species was isolated on Sabouraud's agar media. The patient was treated with a combination of amphotericin B and surgical debridements but died of asphyxia one month after admission. This is a relatively uncommon, opportunistic infection occurring in a diabetic woman, and only several cases are reported in the Korean literature up to date.
Agar
;
Amphotericin B
;
Asphyxia
;
Blepharoptosis
;
Debridement
;
Dermis
;
Diabetes Mellitus
;
Exophthalmos
;
Female
;
Humans
;
Hyphae
;
Middle Aged
;
Mucormycosis*
;
Opportunistic Infections
;
Palate, Hard
;
Rhizopus
;
Ulcer