1.Expression of Epstein-Barr Virus Gene Products, Bcl-2 and p53 Proteins in Nasopharyngeal Carcinomas.
Sun Hee YOON ; Kang Suek SUH ; Chang Hun LEE
Korean Journal of Pathology 1997;31(8):723-734
The authors studied EBV genome expression in 40 conventionally processed samples of nasopharyngeal carcinomas (NPC), using in situ hybridization for EBERs and immunohistochemistry for LMP, Bcl-2 and p53 proteins. The NPCs consisted of 6 keratinizing squamous cell carcinomas (KSCs), 13 nonkeratinizing carcinomas (NKCs) and 21 undifferentiated carcinomas (UCs). The results were summarized as follows: 1) EBERs were expressed in 80.0% of all the NPCs (32/40). As for the subtypes, they were detected in 92.3% of NKCs (12/13), in 90.5% of the UCs (19/21), and in 16.7% of the KSCs (1/6). In positive cases, the nuclei of tumor cells displayed uniformly strong staining. 2) LMP was expressed in 10.0% of all the NPCs (4/40), all of which were UC. The LMP expression in the UCs was not correlated to the expression of EBERs, Bcl-2 and p53 proteins. 3) Bcl-2 protein was detected in 85.0% of all the NPCs (34/40). As for the subtypes, they were detected in 92.3% of the NKCs (12/13), in 90.5% of the UCs (19/21), and in 50.0% of the KSCs (3/6). 4) p53 protein was detected in 75.0% of all the NPCs (30/40). As for the subtypes, they were detected in 81.0% of the UCs (17/21), in 69.2% of the NKCs (9/13), and in 66.7% of the KSCs (4/6). 5) In the NPCs the expression of EBER showed a significantly positive correlation with that of p53 or Bcl-2 protein. The above results indicate that the association of EBV with NPC is chiefly with poorly differentiated and undifferentiated carcinomas. Additionally, carcinomas commonly display widespread, strong immunoreactivity of Bcl-2 and p53 proteins over tumor cells. In conclusion, these observations indicate that the EBV-association in NPC appears to contribute to the overexpression of tumor-related genes during carcinogenesis.
Carcinogenesis
;
Carcinoma
;
Carcinoma, Squamous Cell
;
Genome
;
Herpesvirus 4, Human*
;
Immunohistochemistry
;
In Situ Hybridization
2.Methodological Review on Cardiovascular Disease Clinical Trials in Korea.
Il SUH ; Sun Ha JEE ; Hee Jung BACK
Korean Circulation Journal 1995;25(6):1077-1083
BACKGROUND: Cardiovascular disease is the major cause of death in industrialized countries including Korea. METHODS: The methodology of cardiovascular disease clinical trials, published in 'The Korean Circulation Journal(KCJ)' and in 'The Korean Journal of Internal Medicine (KJIM)' from 1971 to 1993 were reviewed. For the study period, a total of 169 research papers in this field, includion 155 papers in the KCJ and 14 in the KJIM, were reviewed. To review the methodology behind the cardiovascular disease clinical trials, presence of a control group, set up a primary end point, determined sample size and the statistical method to be used, report on the side effects, and consent of patients were checked. In cases involving clinical trials using control groups, rendomization and blinding were also analysed. RESULTS: Among clinical trials reviewed only 6 (4.0%) of the 169 papers were used a control group, and 46.7% were set up with a primary end point. There was no clinical trial which used statitical methods to estimate the sample size. Clinical trials which reported results with statistical methods were 107 to 169 papers;most of these used the student's paired t-test. The number reporting the side effects of intervention was 143(88.7%) and papers reporting with the consent of patients was 15(8.8%). CONCLUSION: Most of clinical trials reviewed did not use appropriate method for clinical trials. Methodologically well-designed clinical trials in cardiovascular disease should be performed to guarantee the validity of study result.
Cardiovascular Diseases*
;
Cause of Death
;
Developed Countries
;
Humans
;
Internal Medicine
;
Korea*
;
Sample Size
3.A usefulness of BACTEC 460 on the identification and srug suscepti-bility test on mycobacterium.
Jin Tae SUH ; Woo In LEE ; Sun Hee KIM
Korean Journal of Clinical Pathology 1991;11(3):633-641
No abstract available.
Mycobacterium*
4.A case of Prune Belly syndrome.
Hee Suk JUNG ; Hong Kuk KIM ; Sun Kyung LEE ; Byung Hee SUH ; Jae Hyun LEE
Korean Journal of Obstetrics and Gynecology 1991;34(3):432-436
No abstract available.
Prune Belly Syndrome*
5.A case of sirenomelia.
Hong Kuk KIM ; Hee Sook JUNG ; Sun Kyung LEE ; Byung Hee SUH ; Jae Hyun LEE
Korean Journal of Obstetrics and Gynecology 1992;35(5):774-777
No abstract available.
Ectromelia*
6.Cholera in Korea, 1991: models of transmission.
Han Joong KIM ; Il SUH ; Hee Choul OH ; Kyoo Sang KIM ; Sun Ha JEE ; Soon Young LEE ; Sun Hee LEE
Korean Journal of Epidemiology 1991;13(2):123-139
7.Myelodysplastic syndrome Transformed into Erythroleukemia.
Sun Hee KIM ; Don Hee AHN ; Keun Chan SOHN ; Jung Il SUH ; Jung Hee UM ; Hea Ran PARK
Journal of the Korean Pediatric Society 1985;28(12):1231-1237
No abstract available.
Leukemia, Erythroblastic, Acute*
;
Myelodysplastic Syndromes*
8.Mediastinal Hemangioma: Report of a case.
Jong Ok KIM ; Bum Kyeong KIM ; Kyoung Hee KIM ; Dae Young KANG ; Kwang Sun SUH
Korean Journal of Pathology 1997;31(9):891-894
Benign hemangioma of the mediastinum is rare. This slowly growing tumor is described as well circumscribed, cystic, hemorrhagic tumor. Histologically it can be differentiated into capillary or cavernous form. We present a case of mediastinal hemangioma. A 20-year-old-man was presented with a slowly growing posterior mediastinal mass of 6 years duration, 8x6 cm in size. The mass was relatively well defined but focally invasive. Microscopically, it was differentiated into vessels of capillary, cavernous, and venous patterns. A solid cellular proliferation with inconspicuous capillary lumens was focally seen. The stroma between variable-sized vessels showed marked myxoid change associated with some smooth muscle bundles and adipose tissue. Ultrastructurally, areas of solid cellular proliferation showed formation of lumens. These lumens were lined by active endothelial cells showing plasmalemmal vesicles and Weibel-Palade bodies on the abluminal surface.
Adipose Tissue
;
Capillaries
;
Cell Proliferation
;
Endothelial Cells
;
Hemangioma*
;
Mediastinum
;
Muscle, Smooth
;
Weibel-Palade Bodies
9.The clinical value of the ultrasonography in the diagnosis of the malignant ovarian ca.
Kwang Hwi PARK ; Sun Kyung LEE ; Byung Hee SUH ; Jae Hyun LEE ; Jung Eun MOK
Korean Journal of Obstetrics and Gynecology 1993;36(4):543-552
No abstract available.
Diagnosis*
;
Ultrasonography*
10.The clinical value of the ultrasonography in the diagnosis of the malignant ovarian ca.
Kwang Hwi PARK ; Sun Kyung LEE ; Byung Hee SUH ; Jae Hyun LEE ; Jung Eun MOK
Korean Journal of Obstetrics and Gynecology 1993;36(4):543-552
No abstract available.
Diagnosis*
;
Ultrasonography*