Authors observed many cases of vertical deviation in the patients complaining of marked asthenopia. Of 1275 cases who had refraction, there were 183 cases of vertical deviation (13.54%) in our clinic, during the last 2 years from July 1, 1973 to August 31, 1975. In the series of our observation, the females were much more frequent than the males in numbers, especially after 30 years of age group. The right hyperphoria was more frequent than the left. In the most of the vertical deviation, the degrees of deviation were less than one prism diopter and associated with low grade of refractive errors (less than +/- 0.5 diopter). If the marked refractive error was corrected without correction of vertical deviation, the headache appeared to be increased in the cases of marked refractive error associated with vertical deviation. In the majority of the cases who had vertical deviation, the headache (marked asthenopia) was complained of and in the many cases of them the head was tilted slightly to one shoulder. 1) In the many cases, the headache was occipital in character. 2) The headache seemed to be marked in looking the moving picture or on walking the streets (by the looking of moving objects). 3) The headache started easily by looking out of door in the railway journey or driving. 4) The headache occured usually by the exercise or home work and increased in the afternoon while they were comfortable early in the morning.
Asthenopia ; Female ; Head ; Headache* ; Humans ; Male ; Refractive Errors* ; Shoulder ; Walking

Among 4465 patients visited in the department of ophthalmology of the our hospital from January 1, 1975 to September 30, 1976, 146 patients (under the age of 25 ; 88 patients, over the age of 26 ; 58 patients) was statistically observed for errors of their glasses. 1) The rate of glasses over or under corrected 0.75D or more was 37%, and of this rate, 12% were over corrected. In age group, it was about twice the age of 25 than over the age of 26. 2) The rate of glasses which diopters of cylindrical lens were wrongly corrected 0.50D or more was 65% (of 156 glasses), and of this rate, 40% were glasses which astigmatism was absent but in refraction astigmatism was present more than 0.50D. In age group, it wasabout 2.5 times the rate of it in under the age of 25 than over the age of 26. The rate of glasses which axis of astigmatism was wrongly corrected 100 on more was 65% (of 52 glasses). 3) The rate of glasses which distance between optical centers was short or long more than 3mm was 53%, and of this rate, the rate of long ditstance between optical centers was 3 times than that of short distance. It was also about twice the rate of in under the age of 25 than over the age of 26. 4) The rate of glasses which corrected 1/2 delta or more was 20%, and of this rate glasses which vertical deviation was present but in examination vertical deviation was not present. 5) Among 146 patient, patients which has worn glasses not to belong to above the categories were only 15 patients and rate of it was only 10%.
Astigmatism ; Axis, Cervical Vertebra ; Eyeglasses ; Glass ; Humans ; Ophthalmology

Anti-glomerular basement membrane disease is a rare autoimmune disease characterized by rapidly progressive renal failure and/or pulmonary hemorrhage. The presence of severe crescentic glomerular inflammation with linear deposition of immunoglobulin G along the glomerular basement membrane is pathognomonic. Because renal function is rapidly and often irretrievably destroyed, many patients require hemodialysis all through their lifetime. We report a case of 33 year(s)-old man who was diagnosed as anti-glomerular basement membrane disease without pulmonary hemorrhage. The patient was treated with pulse methylprednisolone and plasmapheresis followed by oral corticosteroid and cyclophosphamide. His renal function was successfully recovered with early diagnosis and aggressive treatment.
Adrenal Cortex Hormones ; Anti-Glomerular Basement Membrane Disease ; Autoimmune Diseases ; Cyclophosphamide ; Early Diagnosis ; Glomerular Basement Membrane ; Hemorrhage ; Humans ; Immunoglobulin G ; Immunosuppression ; Inflammation ; Methylprednisolone ; Plasmapheresis ; Renal Dialysis ; Renal Insufficiency

Tumor hypoxia contributes to the progression of a malignant phenotype and resistance to ionizing radiation and anticancer drug therapy. Many of these effects in hypoxic tumor cells are mediated by expression of specific set of genes whose relation to therapy resistance is poorly understood. In this study, we revealed that DNA-dependent protein kinase (DNA-PK), which plays a crucial role in DNA double strand break repair, would be involved in regulation of hypoxia inducible factor-1 (HIF-1). HIF-1beta-deficient cells showed constitutively reduced expression and DNA-binding activity of Ku, the regulatory subunit of DNA-PK. Under hypoxic condition, the expression and activity of DNA- PK were markedly induced with a concurrent increase in HIF-1alpha expression. Our result also demonstrated that DNA-PK could directly interact with HIF- and especially DNA-PKcs, the catalytic subunit of DNA-PK, could be involved in phosphorylation of HIF-1alpha, suggesting the possibility that the enhanced expression of DNA- PK under hypoxic condition might attribute to modulate HIF-1alpha stabilization. Thus, the correlated regulation of DNA-PK with HIF-1 could contribute to therapy resistance in hypoxic tumor cells, and it provides new evidence for developing therapeutic strategies enhancing the efficacy of cancer therapy in hypoxic tumor cells.
Antibodies/immunology ; Cell Hypoxia ; Cell Line, Tumor ; DNA Helicases/immunology/metabolism ; DNA-Binding Proteins/genetics/*metabolism/*physiology ; Deferoxamine/pharmacology ; Drug Resistance, Neoplasm/*physiology ; Humans ; Immunoprecipitation ; Neoplasms/enzymology/*metabolism ; Nuclear Proteins/genetics/*metabolism/physiology ; Phosphorylation ; Protein-Serine-Threonine Kinases/metabolism/*physiology ; Research Support, Non-U.S. Gov't ; Transcription Factors/genetics/*metabolism/physiology ; Up-Regulation

Here we determined which radiation-responsive genes were altered in radioresistant CEM/IR and FM3A/IR variants, which showed higher resistance to irradiation than parental human leukemia CEM and mouse mammary carcinoma FM3A cells, respectively and studied if radioresistance observed after radiotherapy could be restored by inhibition of protein kinase A. The expressions of DNA-PKcs, Ku70/80, Rad51 and Rad54 genes that related to DNA damage repair, and Bcl-2 and NF-kappaB genes that related to antiapoptosis, were up-regulated, but the expression of proapototic Bax gene was down-regulated in the radioresistant cells as compared to each parental counterpart. We also revealed that the combined treatment of radiation and the inhibitor of protein kinase A (PKA) to these radioresistant cells resulted in synergistic inhibition of DNA-PK, Rad51 and Bcl-2 expressions of the cells, and consequently restored radiosensitivity of the cells. Our results propose that combined treatment with radiotherapy and PKA inhibitor can be a novel therapeutic strategy to radioresistant cancers.
Animals ; Apoptosis/drug effects ; Cell Line, Tumor ; Cyclic AMP-Dependent Protein Kinases/*antagonists & inhibitors/metabolism ; DNA Damage/drug effects ; DNA Repair/drug effects ; Gamma Rays ; Gene Expression Regulation, Neoplastic/radiation effects ; Genes, bcl-2 ; Humans ; Mice ; Neoplasm Proteins/genetics/metabolism ; Neoplasms/enzymology/*genetics ; Radiation Tolerance/*genetics ; Research Support, Non-U.S. Gov't

Extravaginal testicular torsion is known to be the predominant mechanism of the torsion in fetuses and neonates. In this torsion, twisting of the spermatic cord occurs outside the sac of the tunica vaginalis in the scrotum. Herein, we describe the sonographic findings of an extravaginal testicular torsion in a newborn baby who presented with a hard scrotal mass. Gray-scale ultrasound (US) showed hypoechoic linear striations in the testis with a thick hyperechoic peritesticular rim. Surgical exploration revealed an extravaginally twisted testis.
Fetus ; Humans ; Infant, Newborn ; Scrotum ; Spermatic Cord ; Spermatic Cord Torsion ; Testis