BACKGROUND: Basal cell carcinoma(BCC) is the most common tumor of light-skinned people. Most of them are relatively innocuous, but some may cause extensive tissue destruction, and result in death by local infiltration of vital structure or metastatic disease. The bcl-2 is a protooncogene involved in tumorigenesis by blocking apoptosis or programmed cell death. OBJECTIVE: To investigate whether there was a difference in bcl-2 expression in different histopathological types of BCC. Method: We performed immunohistochemical staining by using a monoclonal mouse anti-human bcl-2 oncoprotein in 28 BCC(nodular: 7 cases, micronodular; 3 cases, adenoid; 1 case, infiltrative; 9 cases, and mixed; 8 cases). Result: All 28 BCC expressed bcl-2, and the degree of staining was different according to histopathological types; poor prognostic micronodular(100%) and infiltrative(73.3%) types were relatively strong, and nodular(66.7% ) and adenoid(75.0%) types were moderate. Conclusion . These results suggest that the degree of bcl-2 expression in BCC seems to be dependent to the histopathological types together with clinical behavior.
Adenoids ; Animals ; Apoptosis ; Carcinogenesis ; Carcinoma, Basal Cell* ; Cell Death ; Mice

No abstract available.
Colorectal Neoplasms*

Transmitral left ventricular diastolic inflow velocities determined by pulsed Doppler in 47 normotensives, 80 hypertensives and 44 age-matched hypertensives were measured to evaluate the effects of age and left ventricular hypertrophy on left ventricular diastolic fuction in normotensives and hypertensives. The results were as follows: 1) The peak E velocity in normotensives(77.82+/-13.53cm/sec) was significantly different from those of hyeprtensives(58.13+/-11.80cm, p<0.01) and age-matched hypertensives(59.31+/-10.94cm/sec, p<0.01). The peak E/A in normotensives(1.31+/-0.45) was significantly different from those of hypertensives(0.83+/-0.21,p<0.01) and age-matched hypertensives(0.83+/-0.20, p<0.01). 2)In normotensives, simple linear regression analysis revealed strong inverse correlations of peak E with age(r=-0.758, p<0.01), peak E/A with age(r=-0.748, p<0.01), but no significant correlation of peak E and peak E/A with LVMI(p>0.05). Stepwise regression analysis revealed that age was the most important correlate of peak E and peak E/A in normotensives(peak E: R
Heart Diseases ; Hypertrophy, Left Ventricular* ; Linear Models

A case of testicular embryonal carcinoma developed in s cryptorchid testis is presented with a review of the literature. According to Campbell's series, the incidence of malignant cryptorchid testis was 11.6%. and his statistical evaluation was similar to Gilbert and Hamilton's series of 7,000 cases of testicular neoplasms where 840 tumors were developed in undescended testes(12%). Both authors agree that the chance of neoplastic development in a cryptorchid testis is approximately 48 times greater then that developing in a normally descended testis. Several cases of testicular tumor were reported sporadically in Korea, but malignant tumors in cryptorchism were rarely seen in the literatures Only two cases of malignant cryptorchid testis were already reported in Korea.
Carcinoma, Embryonal* ; Cryptorchidism ; Incidence ; Korea ; Male ; Testicular Neoplasms ; Testis*

No abstract available.
Panax*

Intraosseous ganglion is a rare disease and identified as a cystic lesion on plain radiograph. One case ofintraosseous ganglion is examined by plain radiography and CT and findings are analyzed.
Bone Cysts ; Ganglion Cysts ; Radiography ; Rare Diseases

BACKGROUND: Intramuscular stimulation (IMS) shows good results in the treatment of chronic pain patients who did not respond to other treatments such as oral analgesics, trigger point injection, nerve block and epidural steroid injection. Fluoroscopy Guided Interventional Musculoskeletal Adhesiolysis and Nerve Stimulation (FIMS) was used to stimulate the correct anatomic point using fluoroscopy. We present the results of FIMS in spinal stenosis. METHODS: 106 patients with ages ranging from 39 to 87 years were enrolled in this study. All the patients were postoperatively evaluated for the clinical outcomes such as numeric rating scale (NRS) for pain at 1 month, reduction in the analgesics dose, and the overall satisfaction rate. The patients considered to have received clinical benefit from FIMS were evaluated for the recurrence of pain by either a follow-up or telephone interview. RESULTS: FIMS reduced the level of pain compared with the pretreatment (P < 0.001). In addition, 61% of patients reported that they were satisfied. There were no procedural related serious complications. Three months after FIMS, there was continuing pain relief in 50% of the patients treated successfully. CONCLUSIONS: FIMS is a safe and effective treatment modality for spinal stenosis.
Analgesics ; Chronic Pain ; Fluoroscopy* ; Follow-Up Studies ; Humans ; Interviews as Topic ; Nerve Block ; Recurrence ; Spinal Stenosis* ; Trigger Points

Cryptococcosis is a disease caused by the Cryptococcus neoformans, occcuring most frequently in immunocompromised hosts. Cutaneous involvement is seen in 10-15 % of disseminated cases and its manifestation is variable. A 52 year old man presented with a subcutaneous neck mass and severe headache which had lasted for 2 months and 1 month respectively. Initially cutaneous involvement was monomorphic and localized and a CSF study failed to reveal any organisms. After several weeks of herb medication, however, multiple skin lesions occurred with varied morphology and a CSF study confirmed cryptococcosis by culture. The Urine cortisol was markedly elevated, suggesting an exogenous intake of steroid.
Cryptococcosis* ; Cryptococcus neoformans ; Headache ; Humans ; Hydrocortisone ; Immunocompromised Host ; Middle Aged ; Neck ; Skin

Purpose: The treatment of fractures has shown excellent safety enabling solid fixation and early exercise treatment with the development of internal metal fixtures and fixation techniques. On the other hand, complications remain, such as secondary surgery for implant removal and, discomfort caused by internally fixed metal materials. Recently, a bioabsorbable magnesium implant with relatively high strength and low decomposition, manufactured using only body components, was developed in the form of screws and K-wire for use in orthopedic surgery. This study aimed to apply bioabsorbable magnesium screws and K-wires to upper extremity fracture surgery and investigate the results. Materials and Methods: From May 2019 to September 2019, 46 cases (clavicle 11, humerus 4, olecranon 2, radial head 4, coronoid process 3, radius 4, ulna 1, phalanx 8, metacarpals 8, and hamate 1) in 44 patients who agreed to use a bioabsorbable magnesium implant among patients requiring internal fixation using screws and K-wires for upper extremity fractures at the author’s orthopedic surgery department were enrolled. The U&I Corporation commissioned this study, and a prospective study was conducted. The radiological findings and The Disabilities of the Arm, Shoulder, and Hand (DASH) score, hydrogen gas generation, and complications were evaluated. In comminuted fractures, the magnesium screws and K-wires were used for additional interfragmentary fixation with a conventional metal plate and screws in 22 cases. There were 24 cases of exclusive usage. The most common surgical method was intramedullary fixation of bioabsorbable magnesium K-wires in 10 cases. Results: In all cases, bone union was achieved on average 16 weeks (4–28 weeks) after surgery, and the mean DASH score at the last follow-up was 45.0 (30–116). A hydrogen gas cavity produced around the absorbable magnesium implant was observed at an average of two weeks and six days, and the largest was noted at an average of 12 weeks. There were no interactive reactions with drugs, infection, osteolysis, tendon rupture and swelling with hydrogen gas. There were two cases of the loss of reduction, one case of implant breakage, two cases of urticaria. Conclusion Bioabsorbable magnesium screws and K-wires can be applied for upper extremity fractures, but caution is required.

No abstract available.