No abstract available.
Abdominal Pain*

No abstract available.
Carcinoma in Situ* ; Cervix Uteri* ; Epithelium* ; Female

Most glomerular lesions are associated with qualitative and quantitative alterations of the extracellular matrix components, having relation to progressive glomerular sclerosis. We aimed to investigate the characteristic alteraltions in distribution of extracellular matrix components, such as fibronectin, laminin, collagen type III and IV in human glomerular diseases by immunohistochemical method. The materials included are 3 nephrectomy as normal control, 51 renal biopsies and I autopsy; 3 normal, 5 minimal change disease, 5 minimal change disease with minimal mesangial lgA deposit, 5 benign recurrent hematuria, 10 focal segmental glomerulosclerosis, 15 lgA nephropathy, 10 membranoproliferative glomerulonephritis, 2 diffuse mesangial sclerosis of infancy. Type IV collagen and laminin were present normally in the mesangium, GBM, TBM and interstitial vessels, and were increased at the portion of increased mesangial matrix, of sclerosis and thickened GBM in cases of lgA nephropathy, membranoproliferative glomerulonephritis, focal segmental glomrulosclerosis and diffuse mesangial sclerosis in the proportion to the glomerular damage. Type III collagen was absent in the normal glomeruli, but was detectable focally and segmentally in cases of membranoproliferative glomerulonephritis, IgA nephropathy and focal segmental glomerulosclerosis at the sclerotic portion. Fibronectin was normally detectable mainly in the mesangium, and partly and incompletely in GBM, and was increased at the portion of increased mesangial matrix, sclerosis and thickened GBM in cases of focal segmental glomerulosclerosis, membranoproliferative glomerulonephritis, IgA nephropathy and diffuse mesangial sclerosis, but was diminshed at the old slcerotic portion or global sclerosis. The expression of these antibodies in cases of minimal change disease, minimal change disease with minimal mesangial IgA deposit, benign recurrent hematuria was not different, quantitatively and qualitatively, from that of normal glomeruli. These findings suggest that progressive glomerular sclerosis was due to the increase of extraceuular matrix components such as type IV collagen, laminin, fibronectin and new appearance of type III collagen, and the expression was in proportion to the degree of sclerosis, but had no relation to the disease entity.
Humans ; Biopsy

Recently, the oncogene and tumor suppressor gene have been recognized as important factors that is contribute to conversion and progression from normal cell to cnacer one. In the current study, expression rates of c-erbB-2 and p53 oncoprotein were analysed in biopsy tissues of uterine cervix to learn whether the expression rates of p53 and c-erbB-2 were related with prognostic factors. The c-erbB-2 and p53 expression rates of group with invasive cervical carcinoma versus control group were 53.6% vs 17.7% and 51.4% vs 9.7%, respectively. There was stastically significant elevation of e-erbB-2 and p53 oncogene expression in patients with invasive cervical carcinoma(p < 0.01). In comparison of invasive cervical carcinoma with CIN, there were stastically significant differences in p53 expression rates(51.4% vs 28.9%) and c-erbB-2 expression rates(53.6% vs 20.2%) and co-expression rates(31.1% vs 6.8%)(p < 0.01). Also in CIN patients, CIN III group showed statistically significant elevation than CIN I and CIN II group(p < 0.01). Among histologic cell types, the expression rate of p53 was higher in sqamous cell carcinoma than in adenocarcinoma. Except for the expression rate of p53 according to histologic cell type, no statistical difference in expression rates of c-erbB-2 and p53 were found according to age, clinical stage, lymph node metastasis in invasive cervical carcinoma(p > 0.05). In conlcusion, c-erbB-2 and p53 oncoprotein are thought to be possible factors in the carcinogenesis of cervical carcinoma and correlate with progression of it. But continuous analysis and follow up of 5 year survival are desirable to determine the role as prognostic factor and correlation with prognostic factors.
Adenocarcinoma ; Biopsy ; Carcinogenesis ; Cervical Intraepithelial Neoplasia* ; Cervix Uteri ; Female ; Follow-Up Studies ; Genes, Tumor Suppressor ; Humans ; Lymph Nodes ; Neoplasm Metastasis ; Oncogenes*

The DNA ploidy using fresh tissues from 304 cervial cancer were analyzed by flow cytometry in order to evaluate the correlation between DNA ploidy patterns and prognostic factors of uterine cervical cancer. There were l67 diploid cases(55%) and 137 aneuploid(45%). No significant correlation was noted in stage, age and lymph node metastases between diploid and aneuploid tumor. But S-phase fraction and DNA index were higher slightly in cases of lymph node metastases cornpaired to non-metastases. This results suggest that the DNA ploidy cannot be used as an independent prognostic fac- tor, but further evaluation will be needed in order to conclude definite relationship between prognoseic factor and S-phase fraction or DNA index.
Aneuploidy ; Diploidy ; DNA* ; Flow Cytometry ; Lymph Nodes ; Neoplasm Metastasis ; Ploidies ; Uterine Cervical Neoplasms*

BACKGROUND: Basal cell carcinoma(BCC) is the most common tumor of light-skinned people. Most of them are relatively innocuous, but some may cause extensive tissue destruction, and result in death by local infiltration of vital structure or metastatic disease. The bcl-2 is a protooncogene involved in tumorigenesis by blocking apoptosis or programmed cell death. OBJECTIVE: To investigate whether there was a difference in bcl-2 expression in different histopathological types of BCC. Method: We performed immunohistochemical staining by using a monoclonal mouse anti-human bcl-2 oncoprotein in 28 BCC(nodular: 7 cases, micronodular; 3 cases, adenoid; 1 case, infiltrative; 9 cases, and mixed; 8 cases). Result: All 28 BCC expressed bcl-2, and the degree of staining was different according to histopathological types; poor prognostic micronodular(100%) and infiltrative(73.3%) types were relatively strong, and nodular(66.7% ) and adenoid(75.0%) types were moderate. Conclusion . These results suggest that the degree of bcl-2 expression in BCC seems to be dependent to the histopathological types together with clinical behavior.
Adenoids ; Animals ; Apoptosis ; Carcinogenesis ; Carcinoma, Basal Cell* ; Cell Death ; Mice

No Abstract available.
Cross Infection* ; Internet*

We report a case of a tumor of the follicular infundibulum in a 54-year-old woman who had a papule on the medial side of the right upper eyelid for four months. Histopathologic findings were characterized by proliferation of follicular infundibular epithelium in the form of a thin subepidermal plate and small hair follicles in the tumor plate.
Epithelium ; Eyelids ; Female ; Hair Follicle ; Humans ; Middle Aged ; Pituitary Gland*

Epicanthoplasty was performed in 98 patients with the epicanthal fold. Epicanthal fold was classified into three categories-minimal degree, moderate degree, severe degree-according to its severity. In accurate anatomic dissection in medial canthal area, the pathologic mechanism of the formation of the epicanthal fold, I think, are not only the redundancy of skin, but also the early downward insertion of the preseptal and pretarsal portion of orbicularis oculi muscle. A new surgical technique is described for the correction of the epicanthal fold. The procedure is simple to perform and uniformly gives good results.
Humans ; Skin

No abstract available.
Pregnancy Rate* ; Pregnancy* ; Sterilization*