Nalbuphine HCl, a new narcotic agonist/antagonist was given for the control of post-operative pain to 120 patients who underwent various operative procedures. The patients were divided into three (3) groups of equal number. Each group received one intravenous dose of 0.10, 0.15 or 0.20 mg/kg b.w., respectively. When anesthesia wore off and the patients complained of unbearable pain, Nalbuphine was given intravenously. The onset, the quality and the duration of pain relief were studied. All patients who received the three (3) different dosages experienced pain relief within 5 minutes. Patients who received 0.15 and 0.20 mg/kg of Nalbuphine experienced relief lasting longer than 6 hours. The majority of those who received 0.10 mg/kg experienced pain relief for 4 hours or more; only one third experienced pain relief for less than 4 hours. Side effects were minimal. Only one patient (0.8 percent) experienced dizziness, sweating, nausea and vomiting.
Human ; Male ; Female ; Adult ; NALBUPHINE ; ANESTHESIA, INTRAVENOUS ; NOCICEPTIVE PAIN ; PAIN, POSTOPERATIVE