Objective To compare the success rate, the one-time success rate, the average required time and the incidence of complications of two methods in oronasal conversion of nose biliary duct in naso-biliary drainage. Methods 60 cases of patients with ENBD in the ERCP in our department from March,2008 to March, 2010 were divided into the study group and the control group by random. The patients with sleeving the gastric tube by the guidewire during oronasal conversion of nose biliary duct were considered as the study group, and the patients using the traditional method were considered as the control group. The success rate of sleeving gastric tube, the one-time success rate of grasping, the average required time and the adverse reactions of the two groups were compared. Results The success rate of the study group was 100%, and the control group was 90%, there was no statistical significance. The one-time success rate of the study group was 76.7%, higher than 46.7% of the control group. The average required time of the study group were (1.3±0.3) min, shorter than (5.1±0.7) min of the control group. The incidence of complications in the study group were 13.3%, lower than 93.3% of the control group. Conclusions To sleeve the gastric tube by the guidewire can increase the one-time success rate of grasping the gastric tube, shorten time of grasping the gastric tube and significantly reduce discomfort of patients.