1.Bullous Pemphigoid Responding to DDS.
Kwang Soo KIM ; Ji Soo KIM ; Kyung Jin RHIM ; Sook Ja SON ; Chang Woo LEE
Korean Journal of Dermatology 1982;20(6):913-917
Bullous pemphigoid is a chronic and relatively benign subepidermal blistering disease and is generally considered not to be a sulfa-responsive dermatosis. As a rule, bullous dermatosis that excellently responded to sulfapyridine and sulfones was considered by some to be diagnostic of dermstitis herpetiformia. In 1977, Person and Rogers described 6 cases of bullous pemphigoid responded to sulfapyridine and sulfones. These sulfa-responsive cases were younger than ordinary bullous pemphigoid patients and the histopathologic findings showed prevalence of the neutrophilic infiltration. In this report, the patient who diagnosed as bullous pemphigoid by immunofluorescent studies has younger onset (38 years of age) than usual bullous pemphigoid and histopatbologic findings showed dense neutrophilic infiltrations. The patient was treated with 100-200mg of DDS for 2 months and the skin lesions completely disappeared.
Blister
;
Humans
;
Neutrophils
;
Pemphigoid, Bullous*
;
Prevalence
;
Skin
;
Skin Diseases
;
Sulfapyridine
;
Sulfones
2.Juvenile DErmatitis Herpetiformis : Bullous Type: Report of a Case.
Korean Journal of Dermatology 1974;12(3):171-173
Dermatitis Herpetiformis rarely in childhood, and certain features of the disease in children differ from its manifestations in adults. Juvenile dermatitis herpetiformis appears not to be the same disease as the typical dermatitis herpetiformis of adults. Juvenile dermatitis herpetiformis has been described as a predomimantly bullous disease, but rarely papulovesicular eruptions. This bullous eruption in children must be considered in the several entities such as bullous pemphigoid and erythema multiforme. Juvenile bullous dermatitis herpetiformis has not responded routinely to sulfapyridine and sulfone therapy. A 15-month-old child whose skin lesions fulfilled clinical, histologic, and therapeutic criteria for Juvenile dermatitis hepetiformis is reported. The skin lesions showed bullous eruptions and also complained of severe itching sensation different from bullous Juvenile dermatitis herpetiformis.
Adult
;
Child
;
Dermatitis Herpetiformis*
;
Dermatitis*
;
Erythema Multiforme
;
Humans
;
Infant
;
Pemphigoid, Bullous
;
Pruritus
;
Sensation
;
Skin
;
Sulfapyridine
3.A Case of Chronic Bullous Dermatosis of Childhood: Implication for Duration of Dapsone Maintenance Therapy.
Sang Hee YOO ; Young Gull KIM ; Ai Young LEE
Korean Journal of Dermatology 1999;37(11):1664-1666
Chronic bullous dermatosis of childhood(CBDC) is a rare vesicobullous disorder in infancy and early childhood. The direct immunofluorescence(DIF) study is mandatory for diagnosis because its clinical and histological findings may be indistinguishable from those of bullous pemphigoid and dermatitis herpetiformis. The response to sulfonamides such as dapsone and sulfapyridine is usually rapid and complete. After remission of the disease, however, it is difficult to predict the course of the disease and to decide when treatment should be stopped. We report a case of CBDC in a 2-year-old boy. Treatment was started with dapsone and complete resolution of lesions was achieved in 2 weeks. The entire regimen was continued for 6 months and the patient has been clinically free of disease activity after 18 months of follow-up.
Child, Preschool
;
Dapsone*
;
Dermatitis Herpetiformis
;
Diagnosis
;
Follow-Up Studies
;
Humans
;
Male
;
Pemphigoid, Bullous
;
Skin Diseases*
;
Sulfapyridine
;
Sulfonamides
4.A Case of Mesalazine-induced Eosinophilic Pneumonia in a Patient with Ulcerative Colitis.
Ji Young PARK ; Hong Mo KANG ; Su Young KIM ; Yo Seb HAN ; Yong Seon CHO ; Hyo Jong KIM ; Jee Hong YOO
Tuberculosis and Respiratory Diseases 2001;51(5):474-481
Measlazine(5-Aminosalicylic acid, 5-ASA), a component of Sulfasalazine (sulfapyridine bound to 5-ASA), is used to treat inflammatory bowel disease. Most adverse pulmonary effects caused by sulfasalazine have been attributed to sulfapyridine. However, lung toxicity associated with measlazine(5-ASA) is rare. Here we report a case of eosinophilic pneumonia in a 44-year-old woman with ulcerative colitis, who was treated with mesalazine. She developed symptoms of a dry cough, mild night fever, and evertional dyspnea. Bilateral peripheral pulmonary infiltrates, peripheral blood eosinophilia, and histologic features were consistent with eosinophilic pneumonia. The symptoms improved quite rapidly after the discontinuation of mesalazine and initiation of steroid therapy. Therefore, adverse pulmonary reactions to mesalazine must be considered in a differential diagnosis of pulmonary involvement in patients with inflammatory bowel disease who are receiving with measlazine therapy.
Adult
;
Colitis, Ulcerative*
;
Cough
;
Diagnosis, Differential
;
Dyspnea
;
Eosinophilia
;
Eosinophils*
;
Female
;
Fever
;
Humans
;
Inflammatory Bowel Diseases
;
Lung
;
Mesalamine
;
Pulmonary Eosinophilia*
;
Sulfapyridine
;
Sulfasalazine
;
Ulcer*