China ; Humans ; Logistic Models ; Non-alcoholic Fatty Liver Disease ; Risk Factors

AIM: To study the anti-inflammatory effect of the Antivirus Oral Liquid(AOL) in experimental rabbit conjunctivitis model. METHODS: Rabbit's staphococcus aureus conjunctivitis models and cantharides tincture conjunctivitis models were made to observe different groups of animals' symptom of eye stimulation,negative rate of bacteria and conjunctiva histopathology.And then AOL compared with the effect of amphemycin gutta or Shumu(gutta.) RESULTS: It showed that AOL possessed significant anti-inflammatory effect on bacterial conjunctivitis.The negative rate of bacteria was more than 90% after being given AOL for 4 days successively.Compared with the models group,the hyperemia and edemda were markedly relieved.The result showed that AOL possessed significant anti-inflammatory effect on irritable conjunctivitis.The hyperemia and edema were markedly relieved at the second day after being given AOL,and the inflammatory symptoms had almost disappeared after being given AOL for 4 days successively. CONCLUSION: AOL has a good effect on the therapy of staphylococcus aureus conjunctivitis and cantharides tincture.

Objective To explore a novel management method of neonatal first dose of vaccination, and aim to promote the vaccination rate and ensure the safety of vaccination. Methods The results of neonatal first dose of Hepatitis B and BCG vaccine of 955 newborns under the novel management method were analyzed from January to April, 2014. Results With the novel management method, 898 newborns were inoculated Hepatitis B vaccine and the vaccination rate reached 94. 03%. 890 newborns were inoculated BCG vaccine and vaccination rate was 93. 19%. The differences were not statistically significant in different months (χ2 =2. 106, 5. 221;P>0. 05). The novel management method helped to promote the vaccination rate and safety rate was 100%. Conclusions The novel management method can promote the vaccination rates and the safety of the neonatal first dose of Hepatitis B and BCG vaccine. This novel method should be expanded to the neonatal vaccination to ensure the vaccination of newborns.

Objective:To investigate the predictive value of different body obesity measures for non-alcoholic fatty liver disease (NAFLD).Methods:It was a cross-sectional study. The present study was a case-control study involving 553 subjects who underwent physical examination from January to April 2022. The subjects were divided into NAFLD group ( n=321 cases) and control group ( n=232 cases) according to abdominal ultrasound imaging parameters. All subjects completed a general information questionnaire, liver ultrasound examination, serum biochemical indices and physical measurements. Logistic regression model was used to analyze the correlation between human obesity measures (neck circumference, triceps skinfold thickness (TSF),body mass index (BMI), waist-to-hip ratio, lipid accumulation index (LAP), visceral fat index (VAI), body roundness index (BRI) and a body shape index (ABSI)) and NAFLD. Receiver operating characteristic (ROC) curve and area under the curve (AUC) were used to evaluate the predictive value of single and combined measures of obesity for NAFLD. Results:The subjects were stratified by gender, and the quartile levels of BMI, neck circumference, TSF, waist-to-hip ratio, LAP, VAI and BRI were all correlated with NAFLD in both male and female (all P<0.05). After further adjustment for confounding factors, compared with those in group Q 1, group Q 4 of the above-mentioned indexes still had higher odds ratios ( P<0.05). The AUC value of LAP in predicting NAFLD was the largest in both men and women, which was 0.836(0.788-0.876) and 0.885(0.839-0.921), and the cut-off value was 41.93 and 33.27, respectively. There was no significant difference in AUC of ROC predicting NAFLD among LAP, BRI and BMI ( P>0.05). The AUC of ABSI in predicting NAFLD was less than 0.7(namely 0.584(0.525-0.641) and 0.679(0.618-0.735) in men and women, respectively), which indicated poor predictive performance for NAFLD. In the pairwise combination index, the AUC of ROC predicting NAFLD with TSF+LAP in male was the largest, which was 0.864(0.819-0.901), and there was statistical significance when compared with BRI (AUC=0.818(0.769-0.860)) and BMI (AUC=0.816(0.767-0.858)) ( P<0.05), but there was no statistical significance when compared with LAP (AUC=0.836(0.788-0.876)) ( P>0.05). The AUC of ROC predicting NAFLD with VAI+LAP in women was the largest, it was 0.894(0.849-0.928), there was statistical significance when compared with BMI (AUC=0.849(0.799-0.890)) ( P<0.05), but there was no statistical significance when compared with LAP (AUC=0.885(0.839-0.921)) and BRI (AUC=0.870(0.822-0.908)) ( P>0.05). Conclusion:BMI, neck circumference, TSF, waist-to-hip ratio, LAP, VAI and BRI all have good predictive value for NAFLD.