1.Fresh motherwort capsule treatment of postpartum uterine hemorrhage clinical value analysis
Meiqing ZHANG ; Bingjie XU ; Sukun WANG
Chinese Journal of Biochemical Pharmaceutics 2017;37(5):139-141
Objective To analysis the fresh motherwort capsule treatment of postpartum uterine hemorrhage clinical value.Methods100 cases of postpartum uterine hemorrhage patients of our hospital from January 2016 to December 2016 were selected as the research object, the control treatment, use contractions observed group of using fresh motherwort capsule combined contractions for treatment.Check after drug treatment in patients with uterine instauration and clinical curative effect.ResultsAfter five days, two groups of patients with postpartum uterine instauration is close, there was no statistically significant difference.After 14 days, observation group of patients with uterine instauration was significantly better than the control group, there was statistically significant difference (P< 0.05);Observation group of patients treatment of cure rate (76.0%), and total effective rate (96.0%) were significantly higher than control group (56.0%, 88.0%), statistically significant difference (P< 0.05).ConclusionFresh motherwort capsule in the treatment of postpartum uterine hemorrhage has significant clinical efficacy, can promote the patients with uterine instauration, has significant clinical value, worthy of popularization and application.
2.The correlation study between the level of serum BNP ,sFlt-1 and NO and changes of condition in preeclampsia pregnant women
Wen ZHANG ; Hongjian LIU ; Bao LI ; Xin SONG ; Sukun HAN ; Yuanyuan GAO
International Journal of Laboratory Medicine 2018;39(12):1473-1475,1478
Objective To research the correlation between the level of serum brain natriuretic peptide (BNP) ,soluble vascular endothelial growth factor receptor 1 (sFlt-1) and nitric oxide (NO) and the changes of condition in preeclampsia(PE) patients.Methods Totally 89 patients with PE who had prenatal examina-tion and normal delivery in the hospital from May 2014 to January 2017 were enrolled in this study as the PE group ,and 94 healthy pregnant women who underwent normal delivery during the same period were selected as the NP group.The levels of serum BNP ,sFlt-1 and NO in PE patients with different severity and different onset stages were compared and analyzed.Results The levels of serum BNP and sFlt-1 in the PE group were significantly higher than those in the NP group ,and the level of NO was significantly lower than that in the NP group ,and the differences were statistically significant (P<0.05).The levels of serum BNP and sFlt-1 in the severe PE group were significantly higher than those in the mild PE group ,and the level of NO was signifi-cantly lower than that in the mild PE group ,and the differences were statistically significant (P<0.05).The levels of serum BNP and sFlt-1 in the early and late onset PE groups were significantly higher than those in the early NP group and the late NP group ,while the NO levels were significantly lower than those in the early NP group and the late NP group ,and the differences were statistically significant (P<0.05).Conclusion On the occurrence of PE ,the levels of serum BNP and sFlt-1 in pregnant women elevated abnormally ,and the lev-el of NO decreased.The changes of serum BNP ,sFlt-1 and NO levels are closely related to the development of PE ,and can be used as a reference index to detect the changes of PE.
3.The relationships of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) inhalational dose and oxidative damage in foundry workers
Jintong HE ; Sukun ZHANG ; Ming ZHAO ; Zhuang ZHANG ; Tingming SHI ; Weihong CHEN
Chinese Journal of Industrial Hygiene and Occupational Diseases 2016;34(9):647-652
Objective To investigate the potential dose-response relationship between PCDD/Fs inhalational exposure and oxidative damage to DNA and lipid in foundry workers.Methods The participants were divided into three groups,including exposure group,administrator group and control group.The concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in air environment were determined by isotope dilution high resolution capillary column gas chromatography/high resolution mass spectrometry (HRGC-HRMS).The inhalational dose of PCDD/Fs were evaluated by Houmen's model.Urinary 8OHdG was analyzed by high performance liquid chromatography-electrochemical detector (HPLC-ECD).Urinary 8-iso-PGF2a were determined by ELISA.Results The PCDD/Fs environmental concentrations of three groups (pg· TEQ/m) were 0.21 +0.08,0.03 ±0.01,0.0012 ±0.0007 (P<0.05),respectively.The inhalational dose of exposure group (92.54 (32.90~264.49) fg· TEQ/kg· d) was 5.4 folds higher than the administrator group,and was 201 times more than control group.The levels of urinary 8-OHdG(nmol/L crea) of three groups were 3.25 (1.07~15.36),2.72(0.75~16.07),2.17(0.38~17.07) (P<0.05) and the levels of urinary 8-iso-PGF2n (nmol/L crea)were 19.11(9.33~76.50),20.95(8.40~79.31),11.48(4.85~37.80)(P<0.05),respectively.The multiple linear regression analysis revealed that there were significantly increased trend for levels of urinary 8-OHdG and 8-iso-PGF2a as PCDD/Fs exposure levels increased,after adjustment for age,sex,smoking statue,alcohol use and BMI (P<0.01).Conclusion There was a dose-response relationship between PCDD/Fs inhalational exposure and oxidative damage in foundry workers.
4.The relationships of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) inhalational dose and oxidative damage in foundry workers
Jintong HE ; Sukun ZHANG ; Ming ZHAO ; Zhuang ZHANG ; Tingming SHI ; Weihong CHEN
Chinese Journal of Industrial Hygiene and Occupational Diseases 2016;34(9):647-652
Objective To investigate the potential dose-response relationship between PCDD/Fs inhalational exposure and oxidative damage to DNA and lipid in foundry workers.Methods The participants were divided into three groups,including exposure group,administrator group and control group.The concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in air environment were determined by isotope dilution high resolution capillary column gas chromatography/high resolution mass spectrometry (HRGC-HRMS).The inhalational dose of PCDD/Fs were evaluated by Houmen's model.Urinary 8OHdG was analyzed by high performance liquid chromatography-electrochemical detector (HPLC-ECD).Urinary 8-iso-PGF2a were determined by ELISA.Results The PCDD/Fs environmental concentrations of three groups (pg· TEQ/m) were 0.21 +0.08,0.03 ±0.01,0.0012 ±0.0007 (P<0.05),respectively.The inhalational dose of exposure group (92.54 (32.90~264.49) fg· TEQ/kg· d) was 5.4 folds higher than the administrator group,and was 201 times more than control group.The levels of urinary 8-OHdG(nmol/L crea) of three groups were 3.25 (1.07~15.36),2.72(0.75~16.07),2.17(0.38~17.07) (P<0.05) and the levels of urinary 8-iso-PGF2n (nmol/L crea)were 19.11(9.33~76.50),20.95(8.40~79.31),11.48(4.85~37.80)(P<0.05),respectively.The multiple linear regression analysis revealed that there were significantly increased trend for levels of urinary 8-OHdG and 8-iso-PGF2a as PCDD/Fs exposure levels increased,after adjustment for age,sex,smoking statue,alcohol use and BMI (P<0.01).Conclusion There was a dose-response relationship between PCDD/Fs inhalational exposure and oxidative damage in foundry workers.
5.Research progress in ultrasound cycloplasty for the treatment of glaucoma
Sukun MENG ; Ke XU ; Chun ZHANG
Chinese Journal of Experimental Ophthalmology 2022;40(4):357-360
Surgery to destroy the ciliary body is an effective means to reduce the intraocular pressure in glaucoma.Ultrasound cycloplasty (UCP) is a computer-aided automatic operation that produces high-intensity focused ultrasound to induce ciliary body coagulation through miniaturized transducers.UCP reduces intraocular pressure mainly by destroying ciliary process epithelial cells and increasing uveoscleral outflow.With a wide range of indications, UCP is mainly used for refractory glaucoma, including patients with or without history of anti-glaucoma surgery.It can reduce intraocular pressure safely and efficiently with good outcome, and can be used as a reproducible effective alternative to non-invasive glaucoma surgery.The effect of UCP is better in patients with angle-closure glaucoma, high intraocular pressure before operation, application of second-generation probe and long exposure time.In order to provide reference for clinical treatment and research, the indications, surgical procedures, precautions, mechanism of action, effectiveness, safety, factors affecting therapeutic effect and the deficiencies of researches about UCP in the treatment of glaucoma were reviewed in this article.
6.New intraoral digital impression with pneumatic gingival retraction used in the restoration of crown for posterior teeth: a case report
Xinkai XU ; Meizi ZHANG ; Zhongning LIU ; Yuchun SUN ; Hu CHEN ; Weiwei LI ; Xiaoyi ZHAO ; Yongjie JIA ; Shujuan XIAO ; Chao MA ; Xiaojun CHEN ; Tengfei JIANG ; Xiaobo ZHAO ; Sukun TIAN
Chinese Journal of Stomatology 2024;59(10):1044-1048
In fixed prosthodontics, clear exposure of the preparation margin is the prerequisite for obtaining accurate digital impressions and improving the marginal fit of restorations. To resolve the issues associated with the cord retraction technique, such as pain, acute injury, and prolonged procedural time, this study proposes a new technology for intraoral digital impression taking with pneumatic gingival retraction. The new scanning head blows a high-speed airflow that instantaneously separates the free gingiva, locally exposing the subgingival preparation margin. Combined with the farthest point preservation stitching algorithm based on the distance from the normal vector and high-speed laser scanning photography, it achieves global preparation edge data and gingival reconstruction, realizing painless, non-invasive, and efficient precise acquisition of the preparation margin. Using this new technique, a patient with a full porcelain crown restoration on a posterior tooth was treated. The digital impression revealed a clear margin of the preparation, and the crown made from this data has a good marginal fit.