1.Computed tomography of body trauma
Dong Jin LEE ; Suk Yl LEE ; Hae Won PARK ; Won Hyung WOO
Journal of the Korean Radiological Society 1986;22(5):858-865
CT findings of seventy seven cases in sixty six patients were compared with the conventional radiographicfindings to evaluate the utility and the merits of the high resolusin CT in trauma, The resuls were as follows: 1.CT was helpful in the management in 50 cases(64%) of total 77 cases. 2. CT was useful in detection and evaluationof traumatic lesion in shoulder, wrist and ankle as well as spine, pelvis, hip and knee. 3. In difficultdiagnostic dilemas in trauma of the bones and the joints with the complex anatomy, CT should be consideredroutinely when appropriate.
Ankle
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Hip
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Humans
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Joints
;
Knee
;
Pelvis
;
Shoulder
;
Spine
;
Wrist
2.CT of lumbar disc herniation : correlation with surgical findings
Suk Yl LEE ; Dong Jin LEE ; Kyu Bo SUNG ; Won Hyung WOO
Journal of the Korean Radiological Society 1986;22(5):715-721
CT from fortynine patients with 53 surgical disc explorations were reviewed and correlated with surgicalfindings. The results were as follows: 1. Frequent locations of HNP were in L4–5 (65%) and L5-S1(31%). The mostcommon type of HNP was paramedian type (71%). 2. Focal protrusion of the posterior margin of disc and obliterationof epidural fat pad were observed in all of cases (100%) and other common findings were indentation of epiduralsac in 46 cases(96%) and compression of nerve root sleeve in 33 cases(69%). 3. Cephalad and caudad extension ofproturded soft tissue density in the spinal canal was observed in 15 cases (31%) with variable degree. And morethan 6mm extension were provided to be extruded disc in 9 cases. 4. Vacuum phenomenon was demonstrated in 5cases(10%) and was accompained with bulging annulus. 5. Forty eight herniated nucleus(HNP) were confirmedsurgically in 44 patients. Misinterpretations were made in 4 instances(4 patients); 1 because of lumbar scoliosis,1 because of spondylolisthesis, and the other 2 because of calcified posterior longitudinal ligament and bulgingannulus. One case of true negative examination was central and foraminal stenosis in spinal CT. Thus, sensitivity,specificity and overall accuracy of lumbar spine CT in HNP were 92%, 100% and 92%, respectively.
Adipose Tissue
;
Constriction, Pathologic
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Humans
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Longitudinal Ligaments
;
Spinal Canal
;
Spine
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Spondylolisthesis
;
Vacuum
3.Randomized, Multi-center Phase II Trial of Docetaxel Plus Cisplatin Versus Etoposide Plus Cisplatin as the First-line Therapy for Patients with Advanced Non-Small Cell Lung Cancer.
Nam Su LEE ; Hee Sook PARK ; Jong Ho WON ; Dae Sik HONG ; Su Taek UH ; Sang Jae LEE ; Joo Hang KIM ; Se Kyu KIM ; Myung Ju AHN ; Jung Hye CHOI ; Suk Chul YANG ; Jung Ae LEE ; Keun Seok LEE ; Chang Yeol YIM ; Yong Chul LEE ; Chul Soo KIM ; Moon Hee LEE ; Kab Do JUNG ; Hanlim MOON ; Yl Sub LEE
Cancer Research and Treatment 2005;37(6):332-338
PURPOSE: We prospectively conducted a multi-center, open-label, randomized phase II trial to compare the efficacy and safety of docetaxel plus cisplatin (DC) and etoposide plus cisplatin (EC) for treating advanced stage non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: Seventy-eight previously untreated patients with locally advanced, recurrent or metastatic NSCLC were enrolled in this study. The patients received cisplatin 75 mg/m2 on day 1 and either docetaxel 75 mg/m2 on day 1 or etoposide 100 mg/m2 on days 1 to 3 in the DC or EC arm, respectively, every 3 weeks. RESULTS: The objective response rate was 39.4% (15/38) and 18.4% (7/38) (p=0.023) in the DC and EC arms, respectively. The median time to progression (TTP) was 5.9 and 2.7 months (p=0.119), and the overall survival was 12.1 and 8.7 months (p=0.168) in the DC and EC arms, respectively. The prognostic factors for longer survival were an earlier disease stage (stage III, p=0.0095), the responders to DC (p=0.0174) and the adenocarcinoma histology (p=0.0454). The grades 3 and 4 toxicities were similar in both arms, with more febrile neutropenia (7.9% vs. 0%) and fatigue (7.9% vs. 0%) being noted in the DC arm. CONCLUSION: DC offered a superior overall response rate than does EC, along with tolerable toxicity profiles, although the DC drug combination did not show significantly improved survival and TTP.
Adenocarcinoma
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Arm
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Carcinoma, Non-Small-Cell Lung*
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Cisplatin*
;
Etoposide*
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Fatigue
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Febrile Neutropenia
;
Humans
;
Prospective Studies