1.The effects of continuous and intermittent compressive pressure on alkaline phosphatase activity of periodontal ligament cells.
Suk Yee KWON ; Seong Min BAE ; Hee Moon KYUNG ; Jae Hyun SUNG
Korean Journal of Orthodontics 1997;27(4):599-605
The propose of this study was to evaluate the effect of cellular activity of PDL cells dependent on intermittent and continuous compressive force by determining the alkaline phosphatase activity. An intermittent and continuous compressive forces were applied on PDL cells at the confluent stage. The alkaline phosphatase activity was measured on control and experimental groups every 24, 48, 72hours. The experimental group were consist of continous and intermittent compressive group which were compressed by 300g/cm2 of diaphragm pump. The intermittent compressive group was connected by timer which was worked on 10 minutes and off 10minutes. The results were as follow; 1. The alkaline phosphatase activity of intermittent compressive group was lower than control group at 24 hours(P<0.05). 2. The alkaline phosphatase activity between each groups showed no significant difference at 48hours. 3. The alkaline phosphatase activity of continuous compressive group was significantly higher than control group at 72 hours(P<0.01).
Alkaline Phosphatase*
;
Diaphragm
;
Periodontal Ligament*
2.Clinical Study of Gastrointestinal Carcinoid Tumors.
Moon Gi CHUNG ; Dong Hoon KANG ; Eun Soo KIM ; Dong Kyun PARK ; Oh Sang KWON ; Sun Suk KIM ; Yang Suh KOO ; Yu Kyung KIM ; Duck Joo CHOI ; Hyun Chul PARK ; Ju Hyun KIM ; Hyun Yee CHO
Korean Journal of Gastrointestinal Endoscopy 2002;24(3):135-142
BACKGROUND/AIMS: Carcinoid tumors are often indolent asymptomatic tumors, however significant proportions are malignant. The patients with these tumors have usually been treated by radical excision. Recently, small gastrointestinal carcinoid tumors can be easily be detected with increasing use of endoscopy and surgical treatment has been questioned. We evaluate clinical characteristics of gastrointestinal carcinoid tumors and clinical usefulness of endoscopic resection in treatment of gastrointestinal carcinoid tumors. METHODS: We reviewed the medical records of 37 cases of gastrointestinal carcinoid tumors over the past three years in our instituide. RESULTS: The peak incidence was in the 5th decade and slight male predominance. The most comgastrointestinal carcinoid tumors were diagnosed by endoscopy with biopsy. Twenty-six cases of carcinoid tumors of size less than 15 mm have been safely treated with endoscopic resection. All of the patients are alive and clinically free of disease during 23 months after endoscopic resection. CONCLUSIONS: Recently, the detection of small carcinoid tumors in gastrointestinal tract, especially in rectum, is increasing with frequent use of endoscopy. Endoscopic resection was found to be useful and safe for treatment of small gastrointestinal carcinoid tumors.
Biopsy
;
Carcinoid Tumor*
;
Endoscopy
;
Gastrointestinal Tract
;
Humans
;
Incidence
;
Male
;
Medical Records
;
Rectum
3.The Effect of Intraperitoneal Hyperthermic Perfusion on the Postoperative Liver Function in Cancer Patient.
Keon Hee RYU ; Dong Eon MOON ; Jong Ho CHOI ; Yee Suk KIM ; Jae Yong SHIM ; Oh Kyung KWON ; Cheol Joo PARK ; Sung Nyeon KIM
Korean Journal of Anesthesiology 1998;34(5):1014-1020
BACKGROUND: Intraperitoneal hyperthermic perfusion (IPHP) has been introduced in clinical practice to improve the survival of cancer patients. But despite of this advantage, postoperative hepatic dysfunction may occur more severely after IPHP than general anesthesia. The protective mechanism of liver is destroyed by hyperthermia as the result. The purpose of this study is to evaluate the effect of intraperitoneal hyperthermic perfusion on the postoperative liver function in cancer patients. METHODS: Sixty patients with ovarian cancer were divided into two groups; 30 patients undergone only radical hysterectomy (control group), and 30 patients undergone radical hysterectomy combined with IPHP (IPHP group). Anesthesia was performed with enflurane-N2O-O2 in both groups. Serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT) and albumin levels were evaluated before anesthesia, 1, 3, 5, 7, 10 and 14th days after surgery on both groups. RESULTS: Postoperative SGOT levels were increased on 1, 3, 5, 7, 10 and 14th days in both groups, and on 1, 3 and 5 days postoperatively were increased more significantly in IPHP group than control group, but there were no significant difference between both groups after post-operative 7 days. SGPT levels were increased more significantly on 1, 3 and 5 days postoperatively in IPHP group than control group. Albumin levels were decreased more significantly on 1 and 3 days postoperatively in IPHP group than control group. CONCLUSION: We consider that postoperative liver function in cancer patients is influenced by the intraperitoneal hyperthermic perfusion.
Alanine Transaminase
;
Anesthesia
;
Anesthesia, General
;
Aspartate Aminotransferases
;
Fever
;
Humans
;
Hysterectomy
;
Liver*
;
Ovarian Neoplasms
;
Perfusion*
4.The Collaborative Clinical Analysis of 985 Cases of Rheumatic Fever and Rheumatic Carditis in Children for 10 Years(1978~1987) in Korea.
Sung Ho CHA ; Sang Young JEONG ; Du Bong LEE ; Kyong Su LEE ; Sang Bum LEE ; Tae Chan KWON ; Young Chang TOCKGO ; Chang Sung SOHN ; Keun Chan SOHN ; Young Kin HONG ; Chan Young KIM ; Chang Yee HONG ; Yong Soo YUN ; Hong Yun CHOI ; Chang Hwi KIM ; Chul Ho KIM ; Tae Ju HWANG ; Jae Suk MA ; Chan Uhul JOO ; Kyoo Hwan RHEE ; Hahng LEE
Journal of the Korean Pediatric Society 1989;32(12):1621-1631
No abstract available.
Child*
;
Humans
;
Korea*
;
Myocarditis*
;
Rheumatic Fever*
5.Clinical Outcome of Rituximab-Based Therapy (RCHOP) in Diffuse Large B-Cell Lymphoma Patients with Bone Marrow Involvement.
Byung Woog KANG ; Joon Ho MOON ; Yee Soo CHAE ; Soo Jung LEE ; Jong Gwang KIM ; Yeo Kyeoung KIM ; Je Jung LEE ; Deok Hwan YANG ; Hyeoung Joon KIM ; Jin Young KIM ; Young Rok DO ; Keon Uk PARK ; Hong Suk SONG ; Ki Young KWON ; Min Kyung KIM ; Kyung Hee LEE ; Myung Soo HYUN ; Hun Mo RYOO ; Sung Hwa BAE ; Hwak KIM ; Sang Kyun SOHN
Cancer Research and Treatment 2013;45(2):112-117
PURPOSE: We investigated the clinical outcome of bone marrow (BM) involvement in patients with diffuse large B-cell lymphoma (DLBCL) who received rituximab-based therapy. MATERIALS AND METHODS: A total of 567 consecutive patients with newly diagnosed DLBCL treated with rituximab-CHOP (RCHOP) between November 2001 and March 2010 were included in the current study. All of the patients underwent a BM study at the initial staging and the clinical characteristics and prognosis of these patients with or without BM involvement were analyzed retrospectively. RESULTS: The total cohort included 567 patients. The overall incidence of BM involvement was 8.5%. With a median follow-up duration of 33.2 months (range, 0.1 to 80.7 months) for patients who were alive at the last follow-up, the five-year overall survival (OS) and event-free survival (EFS) rate in patients without BM involvement (76.3% and 67.5%, p<0.001) was statistically higher than that in patients with BM involvement (44.3% and 40.1%, p<0.001). In multivariate analysis, among total patients, BM involvement showed a significant association with OS and EFS. In univariate and multivariate analyses, even among stage IV patients, a significant association with worse EFS was observed in the BM involvement group. CONCLUSION: BM involvement at diagnosis affected the survival of patients with DLBCL who received RCHOP. Although use of RCHOP can result in significant improvement of the therapeutic effect of DLBCL, BM involvement is still a negative prognostic factor of DLBCL patients in the era of rituximab.
Antibodies, Monoclonal, Murine-Derived
;
B-Lymphocytes
;
Bone Marrow
;
Cohort Studies
;
Disease-Free Survival
;
Follow-Up Studies
;
Humans
;
Incidence
;
Lymphoma, B-Cell
;
Multivariate Analysis
;
Prognosis
;
Rituximab