1.peripheral Blood T Lymphocytes in parients with psoriasis.
Won Suk KIM ; Yoo Shin YOO ; Hong Shik KIM ; Yong Woo CINN ; Kyu Joong AHN ; Kee Chan MOON
Korean Journal of Dermatology 1980;18(3):183-188
Recent immunological investigations have demonstrated that the patients with psoriasis have various humoral and cellular immune abnormalities, such as increased serum IgG, IgE and secretory IgA, anti-IgC factor in psoriatic lesions, in peripheral blood lymphocytes and in serum, rhumatoid-like factors in IgA and IgG classes of immunoglobulins, antinuclear antibodies (ANA; reacting with the basal cell nuclei of uninvolved skin., anti-stratum corneum antibody and complements in psoriatic scales, immuoglobulin and complement bearing polymorphonuclear leucocytes in the Muro microabscess. These abnormal findings are enough to suggest an autoimmune mechanism in the pathogenesis of psoriasis. Several investigators have also reported the results of T cell enumeration in the peripheral blood in psoriatic patients. However, the results are not in general agreement,. Thee present study was undertaken to clarify any abnormality in the proportion of T cells in the peripheral blood in psoriatic patients. Forty-one patients with active psoriasis registered at the Department of Dermatology, Seoul National University Hospital entered this study from May, 1979 through April, 1980. Twelve healthy medical and paramedical personel the comprised the control group. Active and total T cells were enumerated by the method of E-rosetting technique, and the results were as follows. 1, in normal controls, the active and total T celIs identified as E rosetteforming cells accounted for 61.6+7.4% and 68.1+8.9% of the total lymphocyte population, respectively. 2. In patients with psoriasis, significant decrease of active T cells (54. 2,+11.0%,p<0.005) and total T cells (62.2+11.2%, p<0.05) was observed. More profound reduction of T cells was noted in patients with wide spread psoriasis than those with limited extent.
Antibodies, Antinuclear
;
Cell Nucleus
;
Complement System Proteins
;
Dermatology
;
Humans
;
Immunoglobulin A
;
Immunoglobulin A, Secretory
;
Immunoglobulin E
;
Immunoglobulin G
;
Immunoglobulins
;
Lymphocytes
;
Psoriasis*
;
Research Personnel
;
Seoul
;
Skin
;
T-Lymphocytes*
;
Weights and Measures
2.The Effect of Nasogastric Tube on Swallowing Function in Stroke Patients with Dysphagia.
Woo Kyoung YOO ; Suk Bong YUN ; Eun Ha SO ; Sung Suk JUNG
Journal of the Korean Academy of Rehabilitation Medicine 2001;25(5):758-765
OBJECTIVE: This study was designed to evaluate the effect of nasogastric tube on swallowing function in stroke patients with dysphagia. METHOD: Twelve stroke patients with dysphagia were included in this study. We evaluated the Functional Dysphagia Scale using videofluoroscopic swallowing study. Swallowing tasks were composed of swallowing 5 cc of thick food and same volume of fluid on nasogastric tube insertion state and then nasogastric tube removal state. RESULTS: As the result of measuring oral phase score before and after removing nasogastric tube, all of 12 patients showed no significant difference. There was statistically significant increase in score of residue in piriform sinuses on thick food swallowing after removing nasogastric tube (p<0.05). After removing nasogastric tube, aspiration was decreased on fluid swallowing in cases of 2 patients, while aspiration on thick food swallowing was increased in cases of 2 patients, compared with nasogastic tube insertion state. CONCLUSION: As the result of this study, the stroke patients with dysphagia on nasogastric tube were increased on fluid aspiration due to rapid descending and inhibition of epiglottic closure compared with the removal state of nasogastric tube. And there was significant increased in scores of residue in piriform sinuses on thick food swallowing and aspiration pneumonia after removing nasogastric tube.
Deglutition Disorders*
;
Deglutition*
;
Humans
;
Pneumonia, Aspiration
;
Pyriform Sinus
;
Stroke*
3.The Extensor Plus Finger: A case Report
Soo Yong KANG ; Eun Woo LEE ; Young Chull CHUNG ; Young Suk YOO
The Journal of the Korean Orthopaedic Association 1981;16(2):489-492
The extensor plus finger is a rare condition, in which there is such tension of the extensor hood mechanism that simultaneous, complete flexion of the metacarpophalangeal joint and the interphalngeal joint is impossible. Full flexion of the metacarpophalngeal joint compels the interphalngeal joints to extend and vise versa. This condition is a severe handicap to grasp. The extensor plus state is produced by any condition which shortens the excursion of the extensor hood mechanism over the metacarpophalngeal joint and proximal phalanx. When the extensor hood (central extrinsic extensor and sagittal band) is the villain of the extenaor plus state, stretching out the hood by tenotomies of the central extrinsic extensor restored normsl function immediately. We experienced four cases of the extensor plus finger of a patient with severe crushing open forearm bone fracture, and treated the cases by staggered tenotomies or complete tenotomies of the central extrinsic extensor and division of the sagittal band, and obtained a satisfactory result.
Fingers
;
Forearm
;
Fractures, Bone
;
Hand Strength
;
Humans
;
Joints
;
Metacarpophalangeal Joint
;
Tenotomy
4.Discrepant results by High Protein Anti-D and Low Protein Anti-D in a D Negative Newborn.
Jin Woo YOO ; Suk Woo CHOI ; Seongsoo JANG ; Nak Eun CHUNG
Korean Journal of Clinical Pathology 2001;21(3):221-224
High-protein anti-D reagents prepared from pools of human serum have been used for routine RhD typing but, low-protein, saline reactive anti-D reagents formulated predominantly with monoclonal antibodies are in current use. Because some of the high-protein reagents contain macromolecular additives that may cause red cells coated with immunoglobulin to aggregate spontaneously, antisera with these additives may produce a false-positive reaction. A four-day old male was admitted due to severe jaundice. Initially, the RhD type of the newborn using a high-protein reagent was D-positive and then, using two low-protein reagents, it was D-negative. The blood type of the mother was B, CDe, and that of the newborn was B, CcdEe. The direct antiglobulin test on the newborn's RBC was positive. Anti-E and anti-c were identified in the mother's serum and anti-E only was identified in the newborn's serum. The newborn was treated with phototherapy for 10 days and discharged as recovered. We present a case of hemolytic disease of the D negative newborn, which showed a discrepancy between high protein anti-D and low protein anti-D. With a review of literature, the newborn was possibly misinterpreted as D positive.
Antibodies, Monoclonal
;
Coombs Test
;
Humans
;
Immune Sera
;
Immunoglobulins
;
Indicators and Reagents
;
Infant, Newborn*
;
Jaundice
;
Male
;
Mothers
;
Phototherapy
5.Two cases of tuberculosis spinal arachnoiditis diagnosed by MRI.
Yong Joo KIM ; Suk Hyun KIM ; Chul Woo YANG ; Soon Jib YOO ; Je Yung WOO ; Suk Yung KIM ; Eui Jin CHOI ; Moon Won KANG ; Byung Ki BANG
Korean Journal of Infectious Diseases 1993;25(3):265-269
No abstract available.
Arachnoid*
;
Arachnoiditis*
;
Magnetic Resonance Imaging*
;
Tuberculosis*
6.Two cases of tuberculosis spinal arachnoiditis diagnosed by MRI.
Yong Joo KIM ; Suk Hyun KIM ; Chul Woo YANG ; Soon Jib YOO ; Je Yung WOO ; Suk Yung KIM ; Eui Jin CHOI ; Moon Won KANG ; Byung Ki BANG
Korean Journal of Infectious Diseases 1993;25(3):265-269
No abstract available.
Arachnoid*
;
Arachnoiditis*
;
Magnetic Resonance Imaging*
;
Tuberculosis*
7.Objective Non-invasive Assessment of Irritant Patch-test Reactions with Laser Doppler Perfusion Imaging (LDPI).
Chan Woo JEONG ; Suk Jin CHOI ; Jae Hak YOO ; Joo Heung LEE ; Jun Mo YANG ; Eil Soo LEE
Annals of Dermatology 2001;13(4):222-227
BACKGROUND: Traditional visual reading of patch-test reactions is a rather subjective method, lacking the sensitivity and reproducibility needed in experimental studies. Recently the laser Doppler perfusion imaging (LDPI) has been used to measure objectively the increase in superficial blood flow which results in the appearance of erythema. OBJECTIVE: We designed this study to examine the relationship between the LDPI measurement and visual reading after patch test to several different irritants. METHODS: In this study, reading of erythema in experimentally-induced irritant contact dermatitis was performed visually and by laser Doppler perfusion imaging (LDPI). In addition, we investigated whether the LDPI measurement was appropriate in the routine patch test clinic. RESULTS: A close correlation was shown between the 2 methods (r=0.9046, p<0.001) and the LDPI producing mean adjusted perfusion values (APVs) was able to discriminate between the different visual grades. CONCLUSION: LDPI is a valuable instrument to objectively assess intensity of irritant patch-test reaction, and is indeed one of the few methods which overcomes the inter-individual variations in visual reading, but this instrument is not appropriate to use routinely in patch test clinic because of unacceptably long measurement time.
Dermatitis, Contact
;
Erythema
;
Irritants
;
Methods
;
Patch Tests
;
Perfusion Imaging*
;
Perfusion*
8.Clinical efficacy of fluconazole in oropharyngeal and asophageal candidiasis.
Jong Dae JI ; Chul Won CHOI ; Goo LEE ; Jae Myung YOO ; Woo Joo KIM ; Jun Suk KIM ; Sung Shull PARK
Korean Journal of Infectious Diseases 1992;24(4):303-307
No abstract available.
Candidiasis*
;
Fluconazole*
9.Clear Cell Sarcoma of the Kidney: A case in 39 year old man.
Hyun Ju YOO ; Yun Kyung KANG ; Mee JOO ; Hye Kyung LEE ; Dae Woo KIM ; Suk San PARK
Korean Journal of Pathology 1996;30(12):1138-1143
Clear cell sarcoma of kidney(CCSK) is a rare pediatric neoplasm characterized by a predominating component of clear cells, a predilection for metastases to bone, and a poor prognosis. The incidence of CCSK peaks during the 2nd year of life and adult cases are very rare. We report a case of CCSK encountered in the right kidney of a 39-year-old man. Grossly, it was a lobulated mass showing infiltrative margin, measured 7x5.5x5cm and had a homogeneous gray-tan color with a soft, fish-flesh consistency. Microscopically, about half of the tumor revealed the classic pattern of CCSK, having tumor cell cords or nests separated by the characteristic alveolar capillary networks. The tumor cells had clear pale cytoplasm, bland looking round nuclei and inconspicuous nucleoli. The other half showed the epithelioid-trabecular pattern forming pseudorosette or cord-like structures. Immunohistochemically, there was only a focal positive reaction to vimentin. Ultrastructurally, the tumor cells showed the primitive nephrogenic mesenchymal differentiation such as electron lucent cytoplasm, a small amount of organelles, scanty heterochromatin, inconspicuous nucleoli, and a lack of flocculant basal lamina material around the cytoplasmic membrane. We consider that this is a case of CCSK occuring in the oldest patient ever reported, confirmed by both immunohistochemistry and electron microscopy.
Adult
;
Male
;
Female
;
Humans
;
Incidence
;
Neoplasm Metastasis
10.A Clinical Study of Ribavirin (Virazole) in Herpes Zoster.
Kyung Jeh SUNG ; Kwang Joong KIM ; Yong Woo CINN ; Won Suk KIM ; Hong Sik KIM ; Yoo Shin LEE
Korean Journal of Dermatology 1980;18(6):573-577
Ribavirin(l-b-D-ribofuranosyl-l, 2, 4-triazole-3-carboximide, Virazole) is a. synthetic nucleoside derivative with reported broad spectrum activity in vitro and in vivo against a wide variety of DNA and RNA viruses. This drug works by selective inhibition of viral protein in the early stage of viral replication, but does not influence on host cell protein. The present study was undertaken to evaluate the therapeutic effect of Ribavirin in patients with herpes zoster. A total of 15 patients entered this study at the Department of Dermatology, Seoul National University Hospital during 5 months' period, from May, 1980 to September, 1980, Ribavirin(10mg/kg/d) was given to 10 patients. After initiation of therapy, we observed duration of pain and vesicles and onset of crust formation in each patient clinically. The results observed in the 15 patients were as follows. 1. The average duration of pain was 6.0 days in Ribavirin group and 8.6 days in. control group (p<0. 05). 2. Postherpetic neuralgia was not found in any patients treated with Ribavirin. 3. The average duzation of all vesicles and onset of crust formation were 7.0 days and 3.8 days in Ribavirin group and 7.2 days and 4.2 days in control group respectively. 4. No side effects were observed during the course of Ribavirin treatment.
Dermatology
;
DNA
;
Herpes Zoster*
;
Humans
;
Neuralgia, Postherpetic
;
Ribavirin*
;
RNA Viruses
;
Seoul