No abstract available.
Drug Therapy* ; Lung*

No abstract available.
Adipose Tissue* ; Apoptosis ; Lipodystrophy*

No abstract available.
Arthroplasty, Replacement, Hip* ; Bone Density* ; Hip*

Surgical treatment of congenital scoliosis is often frustrating due to its severity and rigidity. Many surgical methods were provided for these complex deformities and some instruments were used to achieve better correction. However, no surgical treatment was satisfactory to correct the deformities. Recently, pedicle screw fixation, enabling a powerful grip of individual vertebral segment, is becoming a promising method to enhance correction of these tenacious deformities. This study was to compare the correction, loss of correction and complications of the various surgical methods employed for congenital scoliosis in Seoul National University Hospital and to verify the advantages of pedicle screw fixation. Ninety-two congenital scoliosis subjected to surgery and followed up for more than 2 years(range 2-9 years) were analysed. Surgical methods were; anterior uninstrumented fusion, 5; posterior fusion, 50(14 without instrument, 15 with hooks, 21 with screws); combined anterior and posterior fusion, 37(7 without instrument, 11 with posterior hooks, 10 with posterior screws, 9 with anterior VDS and posterior screws). Mean preoperative magnitude of index curve was 58° with no significant difference between the groups except for the anterior VDS and posterior screw group which had a mean magnitude of 93°. Mean flexibility of index curve was 18.7% with no significant difference between groups. The correction of index curves were; anterior uninstrumented fusion, 23%; posterior uninstrumented fusion, 28%; posterior hook, 31%; posterior screw, 46%; combined anterior and posterior uninstrumented, 37%; anterior fusion and posterior hook, 30%; anterior fusion and posterior screw, 47%; anterior VDS and posterior screw, 48%. The correction of pedicle screws were significantly better(p < 0.01) with significantly smaller loss of correction(p < 0.01). Nonunion occurred in 4, 1 in posterior uninstrumented fusion, 2 in posterior hooks and 1 in posterior pedicle screws with concomitant instrument failures. However, there were no neurologic or visceral complications related to screw placement. Pedicle screw fixation offers an enhances correction of congenital scoliosis with low complication rate, and when combined with an anterior procedure, enables control of the most severe and rigid curves.
Congenital Abnormalities ; Hand Strength ; Methods ; Pedicle Screws ; Pliability ; Scoliosis ; Seoul

Identifying specific factors and/or mechanism regulating development of periodontal tissue will provide important information as to which molecules and cells are required for regulation of periodontal tissue lost as a consequence of disease. The origin and location of cementoblast and osteoblast precursor cells in adult periodontal tissues is not definitely known but it has been suggested that tooth related periodontal ligament may be the source of cementoblasts and the bone-related periodontal ligament for osteoblasts. However, little is known of the molecular mechanism controlling PDL function. PDL-specific protein; PDLs22 had been previously identified as a novel protein isolated from cultured human PDL fibroblasts using subtraction hybridization between human gingival fibroblasts and PDL fibroblasts. The aim of this study was to examine the functional characterization of PDLs22 in differentiation of periodontal ligament, alveolar bone and cementum. Human osteocalcin (OC), osteonectin (ON) and PDLs22 mRNA were detected by reverse transcription polymerase chain reaction (RT-PCR) in primary cell cultures of periodontal ligament fibroblast during mineral nodule formation in vitro. And the localization of PDLs22 in rat tissues was detected by polyclonal antibody against PDLs22 by means of immunohistochemical staining. The results were as follows: 1. PDL cells were capable of producing mineral-like nodules in vitro. 2. PDLs22 mRNA was expressed in the initial stages whereas it was not expressed in the calcification stage, during mineral nodule formation of PDL cells in vitro. 3. PDLs22 protein was expressed in external dental epithelium and stellate reticulum during crown formation stage, and was continued in external dental epithelium of Hertwig's epithelial sheath. Also PDLs22 protein was strongly expressed in the bone and cementum-related side of the PDL and weakly expressed in the middle of PDL. In the developing bone, PDLs22 protein is only expressed in preosteoblast not osteocyte and osteoblast. The results suggest PDLs22 is important mediator of epithelial-mesenchymal reaction in development of PDL, alveolar bone and cementum and is related to initial differentiation of cementum and alveolar bone.
Adult ; Animals ; Crowns ; Dental Cementum* ; Epithelium ; Fibroblasts ; Humans ; Osteoblasts ; Osteocalcin ; Osteocytes ; Osteonectin ; Periodontal Ligament* ; Polymerase Chain Reaction ; Primary Cell Culture ; Rats ; Reticulum ; Reverse Transcription ; RNA, Messenger ; Tooth

Macrodactyly is one of the most difficult congenital anomalies to treat. Treatment of macrodactyly requires surgical intervention because it gives rise to esthetic, social, and functional disability including difficulty in wearing shoes. A myriad of surgical techniques has been introduced to reduce the size of macrodactyly. However, treatment of toe macrodactyly has not been spotlighted due to less significant functional and social issues compared with finger macrodactyly. We treated two patients with toe macrodactyly by single stage reduction operation.
Fingers ; Humans ; Shoes ; Toes*

No abstract available.
Survival Rate* ; Wilms Tumor*

No abstract available.
Survival Rate* ; Wilms Tumor*

PURPOSE: To investigate the ocular findings, risk factors, and clinical outcomes in juvenile rheumatoid arthritis (JRA) patients. METHODS: JRA patients were classified to polyarticular, pauciarticular and systemic-onset type. We retrospectively analyzed the incidence of uveitis, cataract, elevation of intraocular pressure, and compared them to the type of JRA, gender, the presence of HLA B27 and antinuclear antibody. RESULTS: Acute uveitis in 14 patients (23.7%) of 59 patients manifested 20~37.5% evenly in JRA type except polyarticular rheumatoid factor positive type and systemic-onset type. Chronic uveitis occurred only in 2 pauciarticular type patients. In female, antinuclear antibody positive, HLA B27 positive and pauciarticular type the uveitis was more frequently occured. Cataract was occured in 7 patients (11 eyes, 10.2%), preceded by uveitis in 3 patients (3 eyes) and no history of uveitis in the others (8 eyes). The cataract surgery was performed in 3 patients (4 eyes) due to visual disturbance and then corrected visual acuities were more than 0.7 except one eye with band keratopathy. CONCLUSIONS: This study suggests that the ocular examinations are regularly required in cases of female, the presence of antinuclear antibody and pauciarticular type of JRA patients. Cataract surgery combined with posterior chamber intraocular lens implantation can be done with a good visual results in cases of poor vision.
Antibodies, Antinuclear ; Arthritis, Juvenile* ; Cataract ; Child* ; Female ; Humans ; Incidence ; Intraocular Pressure ; Lens Implantation, Intraocular ; Retrospective Studies ; Rheumatoid Factor ; Risk Factors ; Uveitis ; Visual Acuity

PURPOSE: To determine whether primary snoring could be distinguished from obstructive sleep apnea syndrome (OSAS) by clinical evaluation and symptom scores. METHODS: 56 snoring and 20 asymptomatic subjects were recruited and polysomnography was used to confirm that there were 39 OSAS, 17 primary snoring, and 20 control subjects. We evaluated the size of the childrens adenoids and tonsils. Parents completed sleep disordered breathing scale (SDBS) and obstructive sleep apnea 18 (OSA-18) questionnaires for use as symptom scores, as well as an attention deficit hyperactivity disorder rating scale-IV (ADHD RS-IV). RESULTS: There were no differences between primary snoring and OSAS in terms of tonsil and adenoid size, SDBS (9.4+/-4.6 vs 10.8+/-4.5), and OSA-18 score (61.1+/-25.1 vs 71.2+/-8.4). The patients with OSAS (15.8+/-7.9) and PS (22.2+/-9.4) had a higher ADHD RS-IV score than the control subjects (2.9+/-3.3). There was no difference in the ADHD RS-IV scores of patients with primary snoring and OSAS. CONCLUSION: We confirmed that clinical evaluation could not distinguish OSAS and primary snoring. In addition, our study suggests that primary snoring as well as OSAS is associated with attention deficit hyperactivity disorder.
Adenoids ; Attention Deficit Disorder with Hyperactivity ; Child ; Discrimination (Psychology) ; Humans ; Palatine Tonsil ; Parents ; Polysomnography ; Surveys and Questionnaires ; Sleep Apnea Syndromes ; Sleep Apnea, Obstructive ; Snoring