When.direct approximation of the ends of the injured nerves is impossible, nerve autografting is widely used in these days. Authors tried to observe nerve regeneration in time sequence of nerve autografting and tried to find out the most optimal time for nerve autografting in experimental study. The Sprague-Dawley mice were used in performing nerve autografting and it performed with the segment of the opposite sciatic nerve as a donor nerve after resection of a sciatic nerve. The results obtained were as follows: 1. The regeneration of axon can be observed well in the first observation of 2 weeks after nerve autografting within 2 days, but active myelination can be observed apparently 4 weeks after grafting. 2. The groups of grafting within 2 days after nerve resection showed more rapid nerve regeneration and less atrophy of the reinnervated skeletal muscle than the groups of grafting over 1 week after nerve resection did. 3. In case which has been grafted at 4 weeks after nerve resection, there was abundant axonal proliferation at 4 weeks after grafting. 4. Changes of the reinnervated skeletal muscle in the groups of grafting within 2 days were subtle, but the groups of grafting after 1 week showed irregular neurogenic atrophy although nerve regeneration has been active at 8 weeks after grafting. 5. Although the functional effect can not be evaluated exactly, the result of autograft showed relatively good evidence of nerve regeneration even after grafting has been performed 16 weeks after the nerve injury.
Animals ; Atrophy ; Autografts ; Axons ; Humans ; Mice ; Muscle, Skeletal ; Myelin Sheath ; Nerve Regeneration ; Rats ; Rats, Sprague-Dawley ; Regeneration ; Sciatic Nerve ; Tissue Donors ; Transplantation, Autologous ; Transplants

Most obviuos will be the several anatomic differences between the proximal femur of the child and the adult. Fractures of the femoral neck in the children are extremely rsre and usually are the result of severe trauma in 80% of the cases. This accounts for the high frequency of serious associated injuries. In this injury the vascular anatomy changing with age, continuing growth potential and the effect of deforming forces play critical roles in high complication rate and these make treatment difficult. But still any secure guidelines for the treatment of this injury are not established and this is a field which requires more active research and further progress in future. 26 cases treated at Paik Hospital from Jan. 1979 to June 1988 were analyzed in clinical and radiological aspect and the following results were obtained. 1. The commonest type was Cervicotrochanteric fracture in 13 cases(50%),displaced one 21 cases. 2. In Transepiphyseal, Transcervical and Cervicotrochanteric fracture by early reduction and internal fixation, and in Intertrochanteric fracture by conservative treatment we gained satisfactory results. 3. We experienced 2 cases of coxa vara in nonthreaded pin used cases, 4 cases of premature epiphseal closure and 4 cases of avascular necrosis in threaded pin used ones. 4. Complications were developed in 13 cases (50%). These were 5 cases of coxa vara(19.2%) 4 cases of premature epiphyseal closure (15.4%) and 4 cases of avascul necrosis (15.4%). 5. Avascykar necrosis was developed in displaced fracture of Transcervical or Cervico- trochanteric fracture beyond postoperative 1 year. So. we recommend periodic long follow up for evaluation of avascular necrosis.
Adult ; Child ; Clinical Study ; Coxa Vara ; Femur ; Femur Neck ; Follow-Up Studies ; Hip ; Humans ; Necrosis

The ankle joint is a modified complex hinge joint which plays an important role in weight bearing, walking and standing. Injuries about the ankle joint cause destruction of not only bony architecture but often also the ligamentous and soft tissue component. So the goal of the treatment of ankle fracture is restoring normal relations of ankle mortise and regaining a smooth articular surface. The author have reviewed 84 cases of ankle fractures which were treated through the admission in the Orthopedic Department, In Je Medical College Pusan Paik Hospital from June 1979 to August 1986. The average duration of the follow-up was one year. The results obtained from this study were as follows : 1. The most common type was Danis-Weber type C. Nexts were B and A in order. According to the classification of Lauge-Hansen, the most common type was Pronation-external rotstion(39.2%). 2. In Danis-Weber type B and C, satisfactory result was obtained by operative treatment. 3. Danis-Weber's classification was very practical criteria for treatment of the ankle fracture.
Ankle Fractures ; Ankle Joint ; Ankle ; Busan ; Classification ; Clinical Study ; Follow-Up Studies ; Joints ; Ligaments ; Orthopedics ; Walking ; Weight-Bearing

No abstract available.
Fetal Development* ; Pregnancy*

Failure of a glaucoma filtering surgery mainly results from scarring at thefiltering wound. Postoperative proliferation of fibroblasts plays an imrortant role in scar tissue formation. Colchicine is a cytoplasmic microtubule inhibitor capable of inhibiting fibroblast proliferation. The effect of colchicine on fibroblast proliferation at the filtering wound after filtering surgery was investigated. Posterior lip sclerectomies were performed in each eye of albino rabbits.Intraocular pressures, conjunctival fibrosis, histologic findings and drug tox-icities were examined postoperatively under the topical or oral administration of colchicine. Reductions of intraocular Pressure and conjunctival fibrosis in colchicinetreated groups after filtering surgory were statistically significant (p< 0.05), and changes in the topical administration group were more significant than in the oral administration group (pl 0.05). Histologicallyr reductions of active fibroblasts and collagen fibers at the filtering wound and the subconjunctival area were seen in colchicine treated eyes.Histologic changes were more prominent in the topical administration group. Signs of orular and systemic toxicity were absent. The above results suggest that administration of colchicine, especially topicaladministration, can increase the success rate of filtering surgery.
Administration, Topical ; Animals ; Colchicine/*pharmacology ; Fibroblasts/*drug effects ; Glaucoma/*surgery ; Rabbits

No abstract available.
Endometrial Neoplasms* ; Female ; Ovary*

Urinary tract infections constitute a large clinical problems that particularly affect catheter indwelling patients, causing morbidity and mortality. To investigate 1) the rate of infection by duration of catheter indwelling in patients of several kinds of disease, 2) the kinds of colonized bacteria and the similarity or difference of the bacterial species cultured in the urine and catheter of same patient, and 3) the comparison of sensitivity to antibiotics of cultured bacteria of both material, bacterial culture and antibiotic sensitivity test were done from urine and proximal tip of catheters in 31 catheter indwelling patients who had been administered, sometimes intermittently, various antibiotics. The rate of bacterial infection increased markedly with the lengthening of catheter indwelling period in urine and catheter cultures, 22.2% and 33.3% at 1 week, both 50% at 2-3 weeks, 78.6% and 85.7% at 4 weeks respectively The results of bacterial culture from both material were same in 27 (87.1%) patients. The gram negative bacteria composed of 41 (89.1%) species in cultured bacteria. The three frequent species were 16 (34.8%) Escherichia coli, 9 (19.6%) Klebsiella pneumonia, and 6 (13.0%) Morganella morgagni. The overall sensitivity of urine cultured bacteria to tested antibiotics showed minor difference from that of catheter, susceptible in 70.4%, and 73.8%, resistant in 28. 6%, and 24.6%, respectively. Almost all of the patients indwelling catheter longer than 4 weeks had bacterial infection or colonization in urine and proximal catheter-tip in spite of preventive administration of antibiotics. The urine culture only may be enough instead of culturing both the urine and proximal catheter-tip in long-term catheterized patients. Routine antibacterial drug administration should be taken into consideration not to be overused in long-term catheter indwelling patients.
Anti-Bacterial Agents ; Bacteria ; Bacterial Infections ; Catheters* ; Catheters, Indwelling ; Colon ; Escherichia coli ; Gram-Negative Bacteria ; Humans ; Klebsiella ; Morganella ; Mortality ; Pneumonia ; Urinary Tract Infections

Diffuse interstitial lung disease(DILD) is a large group of heterogeneous diseases that diffusely involve the pulmonary connective tissues, principally subpleural, interlobular and alveolar wall portions. Terminology and classification of these diseases are not uniform, and the cause and the pathogenesis are unknown in many entities. It is generally accepted that the response to therapy is related to the relative degree of cellularity and fibrosis present, therefore a histologic evaluation of the relative extent and severity of these changes is required. We reviewed 52 cases of DILD from January 1990 to May 1995 diagnosed by open lung biopsy to reappraise classification and quantitative assessment of the histopathologic features. Differential histopathologic features between usual interstitial pneumonia(UIP) and nonspecific interstitial pneumonia(NIP) were examined with a correlation of HRCT findings and clinical findings. Among 52 cases of DILD, 18 cases(34.6%) were UIP, 6 cases(11.5%) were hypersensitivity pneumonia was NIP was 5 cases(9.6%), interstitial lung diseases associated with the connective tissue diseases were 5 cases(9.6%), inorganic dusts were 4 cases(7.7%), infections were 4 cases(7.7%), durgs were 2 cases(3.8%), acute interstitial pneumonia was 1 case(1.9%), sarcoidosis was 1 case(1.9%) in order of frequency plus 6 other cases(11.5%). UIP was the most frequent DILD in this study which seemed to be a criteria bias of patient selection on open lung biopsy. Quantitative assessment of histopathologic features was useful in the differential diagnosis of DILD and differentiation of UIP from NIP was possible based on histopathologic features and supported by HRCT. UIP disclosed a significantly high score of fibrotic changes, especially in the interstitial fibrosis, smooth muscle proliferation and honeycombing, otherwise NIP appeared relatively high score in inflammatory changes. Correlation between histopathologic scores and the clinical outcome after steroid therapy or no therapy in UIP was not evident.
Diagnosis, Differential ; Biopsy

No abstract available.
Humans* ; Papilloma* ; Polymerase Chain Reaction* ; Uterine Cervical Neoplasms*

Cardiac lymphangioma is one of the rarest, primary, benign tumor of the heart. We report a case of cardiac lymphangioma, which was diagnosed with CT and MRI in a 50 years old female. Plain chest film showed minimal enlargement and globular shape of the heart. On CT scan, abnormal fluid density mass lesion was noted within pericardial sac. The signal intensity was lower on T1-weighted image and hgher on T2-weighted image than that of the myocardium and located along the left atrioventricuar groove. Several small low signal spots representing hemorrhage were seen within this lesion.
Female ; Heart ; Hemorrhage ; Humans ; Lymphangioma* ; Magnetic Resonance Imaging ; Myocardium ; Thorax ; Tomography, X-Ray Computed