Herpes zoster is a localized vesicular eruption limited to the dermatome of a singl spinal or cranial sensory nerve. It is thought that the varicella-zoster virus enters the sensory nerve ending during the course of chickenpox and spreads up to theganglion and remains there in a latent state. If immunity is impaired, the virus replicates and migrates along sensory nerves to the skin or eye causing the lesins of zoster. The ophthalmic branch of the trigeminal nerve can be affected in the zoster patients. If ocular involvement occurs in association with a varicella-zoster infection of the ophthalmic branch of the trigeminal nerve, a number of clinical changes may take place in the eye and adnexa. Therefore, authors analyzed 320 cases of the herpes zoster patients who had visited Chon Buk National University Hospital from 1981 to 1986. The results were as follows: 1. The sex distribution was 149(46.6%) male patients and 171(54.4%) females. 2. The peak incidence was in the 6th decades. 3. Thoracic nerve was involved in 134(41.9%) patients, lumbosacral in 65(20.3%), ophthalmic division of the trigeminal nerve in 59(18.4%), other trigeminal nerve, in 59(18.4%), and cervical in 28(8.8%). 4. 36 patients were associated with systemic diseases: tuberculosis in 12, diabetis mellitus in 8, steroid therapy for arthritis in 6, hepatitis in 5, malignancy in 4, physical trauma in 2, CO poisoning in 1, and chronic renal failure in 1. 5. Zoster ophthalmicus patients were 32 among 59 involved in ophthalmic division of the trigeminal nerve. 6. The ocular leions were conjunctivities in 27(84.4%), keratitis in 13(40.6%), iritis in 10(31.3%), scleritis and episc1eritis in 9(28.1%), ptosis in 9(28.1%), and pupil distortion in 5(15.6%). 7. Complications and sequelae ensued in 23 patients: corneal opacity in 8, lid scar with retraction in 7, chronic ptosis in 3, post-herpetic neuralgia in 2, iris atrophy in 2, and chronic glauooma in 1.
Arthritis ; Atrophy ; Chickenpox ; Cicatrix ; Corneal Opacity ; Diagnosis* ; Female ; Hepatitis ; Herpes Zoster* ; Herpesvirus 3, Human ; Humans ; Incidence ; Iris ; Iritis ; Keratitis ; Kidney Failure, Chronic ; Male ; Neuralgia ; Poisoning ; Pupil ; Scleritis ; Sensory Receptor Cells ; Sex Distribution ; Skin ; Strabismus* ; Thoracic Nerves ; Trigeminal Nerve ; Tuberculosis

Signs and Symptoms consistent with the irritation of the cauda equina developed during epidural morphine therapy for the relief of pain from osteosarcoma in a 10-year-old female patient. This was considered to be due to a subarachnoid diffusion of the epidurally administrated morphine through the dural opening formed by a previous inadvertent dural puncture. The subarachnoid diffusion of the drug was confirmed by fluoroscopy following injection of the contrast media through the indwelling epidural catheter. The chemical inflammation of the cauda equina might be due to substances formed by chemical reactions with a certain preservative vehicle rather than the morphine itself. Spinal steroid therapy may be effective for the suppression of a chemical inflammatory reaction.
Catheters ; Cauda Equina ; Child ; Contrast Media ; Diffusion ; Female ; Fluoroscopy ; Humans ; Inflammation ; Morphine* ; Osteosarcoma ; Punctures*

Type 2 diabetes mellitus (T2DM) is a multifactorial disease with a complex and progressive pathogenesis. The two primary mechanisms of T2DM pathogenesis are pancreatic β-cell dysfunction and insulin resistance. Pancreatic β-cell dysfunction is recognized to be a prerequisite for the development of T2DM. Therapeutic modalities that improve β-cell function are considered critical to T2DM management; however, blood glucose control remains a challenge for many patients due to suboptimal treatment efficacy and the progressive nature of T2DM. Incretin-based therapies are now the most frequently prescribed antidiabetic drugs in Korea. Incretin-based therapies are a favorable class of drugs due to their ability to reduce blood glucose by targeting the incretin hormone system and, most notably, their potential to improve pancreatic β-cell function. This review outlines the current understanding of the incretin hormone system in T2DM and summarizes recent updates on the effect of incretin-based therapies on β-cell function and β-cell mass in animals and humans.
Animals ; Blood Glucose ; Diabetes Mellitus ; Diabetes Mellitus, Type 2 ; Humans ; Hypoglycemic Agents ; Incretins ; Insulin Resistance ; Korea ; Treatment Outcome

The relationship between the Ledig cell of testis and the tropic hormones of the anterior pituitary gland has been ineddquately expiored in man because of methodological difficulties levels in human serum. As testosterone in one of the most important anabolie hormones, it would therefore serve as an index to hormanal response to stress in man. This study was performed to inveatigate the effect of thalamonal-N2O-O2 anesthesia and surgery on human sex hormone by radioimmunoassay method. Measured serum testosterone lexels in the preanesthetic period, 60 minutes after anesthesia and surgery, and at full rectxary from anesthesia were 5.64ng/ml 4.40ng/ml and 5.02ng/ml, respectively.
Anesthesia* ; Humans ; Methods ; Pituitary Gland, Anterior ; Radioimmunoassay ; Testis ; Testosterone*

No abstract available.
Diabetes Mellitus*

The relationship between the Leydig cell of testis and the tropic hormones of the anterior pituitary gland has been inadequately explored in man because of methodological difficulties. A report has appeared on the effect of anesthesia per se on sex hormone levels in human serum. As testosterone is one of the most important anabolic hormones, it would therefore serve as an index to hormonal response to stress in man. Tcsticular blood level of testcsterone in man was increased by ether anesthesia but plasma testcsterone one in man was decreased by halothane anesthesia. Plasma testostercne levels were measured by others. by a competitive protein binding method. This study was performed to investigate the effect of methoxyflurane anesthesia and surgery on human sex hormone by a radioimmunoassay method. Serum testosterone levels measured in the pre-anesthetic period, (60 minutes after anesthesia and surgery, and at full recovery from. anesthesia were 3.80+/-1. 75 ng/ml, 0. 58+/-1. 22 ng/ml and 3. 55+/-1. 85 ng/ml, respectively. No statistical significance was observed. The obtained value of testostercne was the lowest when compared with the values reported by others.
Anesthesia* ; Ether ; Halothane ; Humans ; Methods ; Methoxyflurane* ; Pituitary Gland, Anterior ; Plasma ; Protein Binding ; Radioimmunoassay ; Testis ; Testosterone*

The relationship between the Leydig cell of testis and the tropic hormones of the anterior pituitary gland has been inadequately explored in man because of methodological difficulties. Ether anesthesia has been shown to increase testicular blood level of testosterone in man. Some report has appeared on the effect of anesthesia person sex hormone levels in human serum. As testosterone is one of the most important anabolic hormones, it would therefore serve as an index to hormonal response to stress in man. Testosterone levels were measured by Oyama et al by competitive protein binding method. This study was done to investigate the effect of halothane anesthesia and surgery on human sex hormone by radioimmunoassay method. Serum testosterone levels measured at preanesthetic period, 60 minutes after anesthesia and surgery, and full recovery from anesthesia were 4. 18+/-l. 64 ng/ml, 4. 19+/-1.40 ng/ml and 3. 74+/-1. 65 ng/ml, respectively. No statistical significance was noticed each other. The obtained value of testosterone was the lowest compared with the values reported by other authors.
Anesthesia* ; Ether ; Halothane* ; Humans ; Methods ; Pituitary Gland, Anterior ; Protein Binding ; Radioimmunoassay ; Testis ; Testosterone*

No abstract available.
Colon* ; Colonic Neoplasms* ; Humans ; Vaccination*

A postanesthetic recovery score to provide objective information on the phsical condition of patients arriving in the recovery room after anesthesia. The status of the patients was judged after arriving in the recovery room and every 30minutes thereafter, until their discharge to the ward or Intensive Care Unit. To study this method, 324 patients were selected at random to include as many variants of anesthesia as possible. The patients were transported to the recovery room within 10 minutes of the completion of the anesthesia; Once there, the first score was made by the anesthesiologist. Thereafter, the evaluation was made by the same anesthesiologist. Depending on the length of stay in recovery room, this evaluation was repeated 30, 60, and 90 minutes after the patients arrival. The various signs were evaluated. The independent variables such as age, sex, physical status, anesthetic agents or technics, type of surgery, use of muscle relaxants, duration of anesthesia were correlated with the proportional number of patients receiving top or safe score 10, 9 or 8, and those given 7 or less, which were considered low or dangerous.
Anesthesia ; Anesthetics ; Humans ; Intensive Care Units ; Length of Stay ; Recovery Room*

Peripheral arterial disease is an arteriosclerotic disease that can affect the arteries of the whole body except the coronary arteries and the aorta. In general, disease of the descending aorta, iliac artery, and lower limb arteries below the renal artery is referred to as peripheral artery disease (PAD) or lower extremity artery disease. PAD is highly associated with ischemic heart disease, cerebrovascular disease, and mortality. Diabetes mellitus (DM) is a major risk factor for a variety of cardiovascular diseases, especially PAD. Recent studies have shown that PAD patients with DM have a significantly higher rate of major adverse cardiovascular events, all-cause mortality, and limb amputation compared with patients with PAD alone. To prevent and manage various complications of patients with DM, aggressive diagnosis and management and treatment of PAD play an important role in prevention of complications threatening quality of life such as cardiovascular disease and limb amputation.
Amputation ; Aorta ; Aorta, Thoracic ; Arteries ; Cardiovascular Diseases ; Cerebrovascular Disorders ; Coronary Vessels ; Diabetes Mellitus ; Diagnosis ; Extremities ; Humans ; Iliac Artery ; Lower Extremity ; Mortality ; Myocardial Ischemia ; Peripheral Arterial Disease ; Quality of Life ; Renal Artery ; Risk Factors