1.The Current Situation and Countermeasures of Three Key Construction Projects in the Field of Medicine and Health in Shandong Province
Min WU ; Jing LV ; Sujing MA ; Yanling ZHENG ; Jianhua YAN ; Yan LIU
Chinese Journal of Medical Science Research Management 2015;28(6):496-501
Objective To analyze the current situation and existing problems in the construction of key disciplines of medicine and health in 20 years in Shandong province and to explore the development countermeasures.Methods The data of all key disciplines of medicine and health certified by former Shandong Provincial Health Department from 1993 to 2013 were collected and analyzed.Results A total of 99 key professionals,71 key disciplines and 115 key laboratories were constructed in 20 years in the provincial medical and health institutions.The key projects in general hospitals had accounted for 74.38%.The numbers of key projects in Jinan,Qingdao,Weifang City were over the provincial average.Provincial Hospital and Qilu Hospital stayed top with 25 key projects among medical and health institutions.63.16% of the key projects take the three grade discipline name as the standard name.There were ten discipline names emerged in the three key projects conjointly,including the names of 71 items.Conclusions The construction of three key projects of medicine and health in 20 years in Shandong province had gain the marked achievement.However,the problems of regional inequality,the lack of public health discipline,discipline name confusion and other issues still existed.To amendthe management approach,unified specification,strengthening process supervision,balanced development are the countermeasures for the constructions of key projects in Shandong Province.
2.The Research on the Construction of Medical Key Discipline Based on Application/Estimation/ Documents of Constructive Task
Jianhua YAN ; Yanling ZHENG ; Sujing MA ; Jing LV ; Min WU ; Yan LIU
Chinese Journal of Medical Science Research Management 2016;29(1):70-74
Objective To determine key medical disciplines construction elements and specific contents.Methods The information of national and provincial level construction standards in medical key discipline was collected,and the key indexes and specific requirements in the standards were analyzed.Results There were 10 one-class indexes with a frequency of five and plus,including the overall situation,academic leaders,scientific research performance and support conditions which have emerged to 10 times.There are 4 first-class indexes set,4~14 second-class indexes respectively,and the frequencies of the second-class indexes were from 1 ~ 10.Conclusions Research on a number of the construction and evaluation criteria from different levels and regions was the best way to discover and identify priority disciplines and the best way to assess the contents.It is an important guidance for build a scientific,sustainable development key medical disciplines.It had important guiding significance to how to construct and develop the medical key disciplines.
3.Status survey of job satisfaction of nurses at public hospitals and recommendations
Liming CHEN ; Lifang BIAN ; Lifang SHAO ; Ying WANG ; Beilei GAO ; Qi WU ; Sujing WANG ; Wendan SHI
Chinese Journal of Hospital Administration 2018;34(6):500-504
Objective To analyze the status and influencing factors of job satisfaction of nurses at public hospitals, providing references for the teambuilding strategy of nurses. Methods Questionnaire survey method was used, in October 2017, to study job satisfaction of 1,047 nurses at 13 public general hospitals, for a countermeasure study. Results Job satisfaction of the nurses was found at a medium level. Specifically, their overall job satisfaction score was 3. 68, and the satisfaction scores of the following dimensions from high to low were: on-the-job training (3. 91), hierarchical nurse use (3. 79), performance appraisal (3. 68), promotion evaluation (3. 67), and remuneration (3. 62) respectively. Contents of the five dimensions are strongly related to the overall job satisfaction (r>0. 6). Job satisfaction scores of nurses with their differences in positions, annual income, and hospital level were significantly different (P< 0. 05). The three main influencing factors for talent turnover rate are remuneration, workplace pressure and work environment. Conclusions Higher remuneration, improved hierarchical management system, and greater attention to nursing care at secondary hospitals are very important for effectively improving the job satisfaction of nurses and ensuring the health care industry.
4.The comparison of bladder neck descent and the hiatus area of levator ani between lithotomy position and separating-legs-holding-knees position
Xiufeng HUANG ; Jian ZHENG ; Qingjuan WANG ; Junyan CAO ; Qian LIANG ; Sujing WU ; Xinling ZHANG
Chinese Journal of Ultrasonography 2020;29(7):618-622
Objective:To investigate whether the bladder neck descent and the area of levator ani hiatus obtained on the maximum Valsalva were consistent at the lithotomy position and separating-legs-holding-knees position.Methods:Forty four subjects who underwent perineal pelvic floor four-dimensional ultrasound at 6-8 weeks postpartum in Third Hospital of Longgang Shenzhen from November 2019 to January 2020 were enrolled in this study. All subjects were able to effectively complete the maximum Valsalva maneuver both at the lithotomy position and the separating-legs-holding-knees position. The bladder neck descent and hiatus area of the levator Ani on the maximum Valsalva at these two positions were measured and compared.Results:The bladder neck descent at the separating-legs-holding-knees position was higher than that at the lithotomy position [(41.06±8.25)mm vs (39.96±8.10)mm; t=-2.965, P=0.005], and the hiatus area of levator Ani at the separating-legs-holding-knees position was larger than that at the lithotomy position[(27.55±4.90)cm 2 vs (26.32±4.76)cm 2; t=-3.820, P<0.001]. Conclusions:The bladder neck descent and the area of levator Ani hiatus on the maximum Valsalva at separating-legs- holding-knees position are larger than those on the maximum Valsalva at the lithotomy position.
5.A Brief Analysis of Equivalence Demonstration Techniques for Clinical Evaluation of Medical Devices.
Huanhuan TIAN ; Sujing WU ; Yu LIANG ; Weili WANG ; Chengxue JI
Chinese Journal of Medical Instrumentation 2023;47(3):328-331
This study overviewed equivalence demonstration, the principles for the selection of comparative devices, the difficulties in equivalence demonstration, and the equivalence demonstration of special medical devices. In addition, the concept of equivalence demonstration was adopted for the products exempted from clinical evaluation, and there were many confusion in actual use. The operation points and difficult points of equivalence demonstration for the products exempted from clinical evaluation were introduced in order to provide reference for medical device colleagues.
6.Combined use of phospholipid complexes and self-emulsifying microemulsions for improving the oral absorption of a BCS class IV compound, baicalin.
Huiyi WU ; Xiaoying LONG ; Fei YUAN ; Li CHEN ; Sujing PAN ; Yunjun LIU ; Yoshiko STOWELL ; Xiaoling LI
Acta Pharmaceutica Sinica B 2014;4(3):217-226
The aim of this study was to develop a formulation to improve the oral absorption of baicalin (BA) by combining a phospholipid complex (PC) and self-emulsifying microemulsion drug delivery system (SMEDDS), termed BA-PC-SMEDDS. BA-PC was prepared by a solvent evaporation method and evaluated by complexation percentage (CP). The physicochemical properties of BA-PC were determined. The synergistic effect of PC and SMEDDS on permeation of BA was studied in vitro with Caco-2 cells and in situ with a single pass intestinal perfusion model. The improved bioavailability of BA in BA-PC-SMEDDS was confirmed in an in vivo rat model. The CP of BA-PC reached 100% when the molar ratio of drug to phospholipid (PP) was ≥1:1. The solubility of BA-PC increased in both water and octanol, and the log P o/w of BA-PC was increased significantly. BA-PC-SMEDDS could be dispersed more evenly in water, compared to BA and BA-PC. Both the Caco-2 cell uptake and single-pass intestinal perfusion models illustrated that transport of BA in BA-PC was lower than that of free BA, while improved significantly in BA-PC-SMEDDS. The relative bioavailability of BA-PC(1:2)-SMEDDS was 220.37%. The combination system of PC and SMEDDS had a synergistic effect on improving the oral absorption of BA.
7.Efficacy and safety of cryoablation combined with Camrelizumab monoclonal antibody in treatment of hepatocellular carcinoma
Changwang ZHANG ; Ninghan WU ; Cong WANG ; Zheng ZHENG ; Siming GAO ; Changpeng ZOU ; Sujing ZHANG ; Na LI
Journal of Clinical Hepatology 2024;40(6):1169-1174
ObjectiveTo investigate the efficacy and safety of cryoablation combined with Camrelizumab monoclonal antibody in the treatment of hepatocellular carcinoma (HCC). MethodsA total of 103 HCC patients who were admitted to our hospital from June 2020 to June 2023 were enrolled and randomly divided into combined treatment group with 53 patients and control group with 50 patients. The patients in the control group received percutaneous argon-helium cryoablation, and those in the combined treatment group received percutaneous argon-helium cryoablation combined with Camrelizumab monoclonal antibody. The two groups were compared in terms of short-term response, changes in T lymphocyte subsets after treatment, changes in liver function and alpha-fetoprotein (AFP) after treatment, and progression-free survival and overall survival during follow-up. The t-test was used for comparison of normally distributed continuous data between groups, and the chi-square test was used for comparison of categorical data between groups. The Kaplan-Meier method was used to plot survival curves, and the log-rank test was used for comparison of survival time between the two groups. ResultsThe combined treatment group had significantly higher overall response rate and disease control rate than the control group (χ2=4.156 and 4.348, P=0.042 and 0.037). After treatment, the combined treatment group had significant increases in the percentages of CD3+ and CD4+ T lymphocytes and CD4+/CD8+ ratio (P<0.05) and a significant reduction in the percentage of CD8+ T lymphocytes (P<0.05), while the control group had no significant changes in T lymphocyte subsets after treatment (P>0.05), and compared with the control group after treatment, the combined treatment group had significantly higher percentages of CD3+ and CD4+ T lymphocytes and CD4+/CD8+ ratio (all P<0.05) and a significantly lower percentage of CD8+ T lymphocytes (P<0.05). After treatment, both groups had significant reductions in the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and AFP (all P<0.05) and a significant increase in the level of albumin (Alb) (P>0.05), and compared with the control group after treatment, the combined treatment group had significantly lower levels of ALT, AST, and AFP (all P<0.05) and a significantly higher level of Alb (P<0.05). There were no significant differences in the incidence rates of grade Ⅲ—Ⅳ (moderate to severe) adverse reactions between the two groups (P>0.05). Compared with the control group, the combined treatment group had significantly better median progression-free survival (21.32 months vs 15.31 months, χ2=4.689, P=0.030) and median overall survival (28.36 months vs 20.75 months, χ2=5.030, P=0.025). ConclusionArgon-helium cryoablation combined with Camrelizumab monoclonal antibody can effectively improve short-term response, enhance immune function, and prolong survival time, with a favorable safety profile.
8. Impact of hypertensive disorder complicating pregnancy on neonatal mortality and major complications in preterm infants
Meiyu WANG ; Xiangyong KONG ; Zhichun FENG ; Fengdan XU ; Hongyan LYU ; Lihong YANG ; Sujing WU ; Rong JU ; Jin WANG ; Li PENG ; Zhankui LI ; Xiaolin ZHAO ; Shujuan ZENG ; Huixian QIU ; Weixi WEN ; Hui WU ; Ying LI ; Nan LI ; Xuefeng ZHANG ; Wenzheng JIA ; Guo GUO ; Weipeng LIU ; Feng WANG ; Gaimei LI ; Fang LIU ; Wei LI ; Xiao-ying ZHAO ; Hongbin CHENG ; Yunbo XU ; Wenchao CHEN ; Huan YIN ; Yanjie DING ; Xiaoliang WANG ; Ruiyan SHAN ; Ping XU ; Meiying HAN ; Chunyan YANG ; Tieqiang CHEN ; Xiaomei TONG ; Shaojun LIU ; Ziyuan LIU
Chinese Journal of Applied Clinical Pediatrics 2018;33(14):1065-1070
Objective:
To investigate the effect of hypertensive disorder complicating pregnancy (HDCP) on the mortality and early complications of premature infants.
Methods:
The general clinical data of preterm infants with gestational age 24-36+ 6 weeks were collected from the cooperative units in the task group from January 1, 2013 to December 31, 2014.According to the severity of HDCP, the infants were divided into 4 groups: HDCP group, preeclampsia group, eclampsia group and non HDCP group, the mortality and major complications of preterm infants were compared, and the influencing factors were analyzed.
Results:
The mortality rate of preterm in the HDCP group was significantly higher than that of non HDCP group, and there was statistical significance (