Objective To investigate clinical characteristics and risk factors in early and advanced menopausal women with coronary heart disease (CHD).Methods A total of 259 menopausal women with CHD confirmed by coronary angiography in our hospital were selected as research objects,among whom 102 cases were in menopause≤ 10 years group,and 157 cases in menopause ＞ 10 years group.The clinical characteristics and risk factors of two groups were compared.Results The menopause ≤ 10 years group had higher incidence rate of hypertension and estrogen levels(P ＜ 0.05),but there was no significant difference in HLD-C,and TC levels,and carotid intima-media thickness (IMT) reached the degree of atherosclerosis.Menopause ＞ 10 years group showed a significantly higher incidence of diabetes,but LDL-C level and estrogen levels was significantly lower (P ＜ 0.05).The coronary artery disease in the menopause≤ 10 years group mainly occurred in single lesion,while the menopause ＞ 10 years group in double or multi-vessel lesion (P ＜0.05).Multivariate analysis showed that hypertension,diabetes,triglycerides,low-density lipoprotein cholesterol were risk factors for coronary heart disease,while estradiol was a protective factor.Conclusion Hypertension,diabetes,triglycerides,and low-density lipoprotein cholesterol and decreased estrogen are risk factors for women with coronary heart disease.Conditions of vascular endothelium and atherosclerosis of early postmenopausal women are better than the advanced postmenopausal women,and estrogen alternative is favorable for the patients.

Objective To investigate clinical characteristics and risk factors in early and advanced menopausal women with coronary heart disease (CHD).Methods A total of 259 menopausal women with CHD confirmed by coronary angiography in our hospital were selected as research objects,among whom 102 cases were in menopause≤ 10 years group,and 157 cases in menopause ＞ 10 years group.The clinical characteristics and risk factors of two groups were compared.Results The menopause ≤ 10 years group had higher incidence rate of hypertension and estrogen levels(P ＜ 0.05),but there was no significant difference in HLD-C,and TC levels,and carotid intima-media thickness (IMT) reached the degree of atherosclerosis.Menopause ＞ 10 years group showed a significantly higher incidence of diabetes,but LDL-C level and estrogen levels was significantly lower (P ＜ 0.05).The coronary artery disease in the menopause≤ 10 years group mainly occurred in single lesion,while the menopause ＞ 10 years group in double or multi-vessel lesion (P ＜0.05).Multivariate analysis showed that hypertension,diabetes,triglycerides,low-density lipoprotein cholesterol were risk factors for coronary heart disease,while estradiol was a protective factor.Conclusion Hypertension,diabetes,triglycerides,and low-density lipoprotein cholesterol and decreased estrogen are risk factors for women with coronary heart disease.Conditions of vascular endothelium and atherosclerosis of early postmenopausal women are better than the advanced postmenopausal women,and estrogen alternative is favorable for the patients.

Objective :To explore influence of acupuncture combined butylphthalide soft capsule on cognitive function and head MRI imaging in patients with vascular dementia (VD).Methods : A total of 94 VD patients treated in our hospital were randomly and equally divided into butylphthalide group (received butylphthalide soft capsules ) and combined treatment group (received acupuncture pericardial acupoint treatment based on butylphthalide group ) ,both groups received controls of blood pressure and blood lipids ,anti—infection intervention ,and continuously treated for eight weeks .Mini—mental state ex—amination (MMSE) and clinical dementia rating scale (CDR) were used to assess cognitive function ,related head MRI in—dexes ,plasma levels of somatostatin (SS) and arginine vasopressin (AVP ) were measured.Results : Compared with bu—tylphthalide group after treatment ,there was significant rise in total effective rate (78.72% vs.93.62%) , P＝0.036 ;sig—nificant rise in MMSE score [ (19.18 ± 3.24) scores vs.(21.15 ± 4.11) scores] and significant reduction in CDR score [ (1.51 ± 0.26) scores vs.(1.37 ± 0.28) scores] , P＜0.05 both ;MRI indexes :significant reduction in width of three brain ventricles [(1.12 ± 0.13) cm vs.(1.03 ± 0.19) cm] ,and significant rise in anterior angle index [ (3.08 ± 0.96) vs. (3.54 ± 0.85)] and lateral brain ventricle body width index [ (3.19 ± 0.18) vs.(3.32 ± 0.21)] ,P＜0.05 or ＜0.01 ;sig—nificant rise in plasma levels of SS [ (133.59 ± 10.11) pg／ml vs.(139.14 ± 10.56) pg／ml] and AVP [ (35.37 ± 9.12) pg／ml vs.(40.25 ± 8.08) pg／ml] in combined treatment group , P＜0.05 or ＜0.01. There were no severe adverse reactions in either group .Conclusion : Acupuncture combined butylphthalide soft capsule can significantly improve cognitive function , plasma SS and AVP levels ,inhibit brain ventricle dilation ,promote brain function recovery in patients with vascular de—mentia ,and safety is high .