Objective To discuss and study the ethics related issues of xenocorneal transplantation.Methods The ethics related issues of xenocorneal transplantation were discussed through analysis of the cornea characteristics and present situation of corneal transplantation.Results The ethical problems faced by corneal transplantation mainly consisted of technical barriers social problems:immune rejection after corneal transplantation; species chosen whether or not to meet the ethical requirements,whether to violate the ethics; animal rights issues; whether can cause characteristics change of xenocorneal transplantation person; whether xenocorneal transplantation will lead to the spread of deadly diseases,and endanger public safety.Conclusions Xenocorneal transplantation can help patients regain their sight,its success requires not only the innovation breakthrough of science and technology,but also the attention of people on ethical issues of xenocorneal transplantation.

[Objective]To observe the effect of electroacupuncture at Baliao on a chronic pelvic pain syndrome. [Method] Choice in March 2014 to January 2016 in our hospital clinic of 103 patients with chronic pelvic pain syndrome, according to the order of the patient, with reference to random number table, divided the patients into the treatment group and control group, the treatment group patients with 50 cases, control group 53 cases. Treatment group patients given cuppingBaliaopoint treatment, control group patients give Tensorosin hydrochloride sustained-release capsules, one time a day, 0.2 mg each time, after meals, a total of two groups of patients in the treatment of 4 weeks, observe two groups of patients with prostatic inflammation at the end of the treatment of NIH-CPSI score, clinical curative effect and clinical relapse over 3 months of treatment. [Results] (1)After the treatment, two groups of patients with pain or discomfort, micturition abnormal, the quality of life score and NIH-CPSI total score were improved significantly, the difference was statistically significant;Comparison between the two ways, found that the treatment group patients in pain or discomfort, the quality of life, and the NIH-CPSI total integral comparison, obviously improved compared with control group, difference had statistical significance( P<0.05), but the two groups of patients with abnormal micturition, had no statistically significant difference(P>0.05); (2) the treatment group patients clinical total effective rate was 85.4%, the control group was 74.5%, two groups of clinical curative effect comparison, had no statistically significant difference( P>0.05); (3) 3 months after treatment, the treatment group patients there were 7 cases of recurrence of patients with recurrence(17.1%), the control group 14 cases of recurrence of patients with recurrence(36.8%), compared two groups of clinical relapse rate, difference had statistical significance( P<0.05), recurrence of clinical treatment group was obviously less than the control group. [Conclusion] Take electroacupuncture at Baliao point can obviously improve clinical symptoms in patients with the disease, improve patient's quality of life and reduce recurrence forward, but in the future it's a worthy research to adopt a more scientific research design, including evaluationBaliaopoint for the clinical curative effect of treatment of the disease.

Hypoxia-inducible factor (HIF) is an important transcriptional factor,which plays crucial role in response to hypoxia.HIF is highly expressed in many human cancers,and it is closely related to tumor angiogenesis.HIF promotes tumor growth,invasion and metastasis via up-regulating vascular endothelial growth factor gene and starting associated angiogenesis.With the in-depth study of HIF regulation of tumor angiogenesis mechanism,HIF is expected to become an important target for anti-angiogenesis therapy.

Gastric cancer can spread to the liver through hematogenous metastasis,lymphatic metastasis and serosal invasion of primary tumor.The occurrence of gastric cancer with liver metastasis is only second to the occurrence of peritoneal metastasis.Liver metastasis is one of the main distant metastasis of gastric cancer,and is a major cause of cancer-related death.The treatment of gastric cancer with liver metastasis still remains controversial.The optimal treatment strategies should be based on the clinicopathological characteristics of each patients and evidence-based medicine,and the individualized plan should be set through multidisciplinary team discussions.Before the more results of prospective studies released,multidisciplinary treatment is the main method,and the appropriate patients should be cautiously choosed for surgery.

Objective To observe HAMD,SDS scores and plasma 5-tT content with Depressive Patients treated by Turtle-Dragon decoction combined with acupuncture.Methods 70 patients were randomly divided into the treatment group and the control group,the treatment group treated with the turtle dragon decoction combined with acupuncture,the control group treated with fluoxetine hydrochloride,all patients before treatment and after treated 8 weeks were measured by HAMD,SDS and detected by plasma 5-HT content.Results Two groups of patients after 8 weeks of treatment,the total effective rate was 80％ in the treatment group,the total effective rate was 85.71％ in the control group,two groups showed no significant difference (x2=0.40,P＞0.05).HAMD and SDS[the treatment group were(9.31 ± 2.10) points,(55.91± 4.13) points,the control group were(9.36±2.28)points,(56.70±3.77)points] scores were significantly lower(P＜0.01) than before treatment[the treatment group were(12.79±2.50)points,(61.54±3.26)points,the control group were(11.89±2.73)points,(62.09±3.24)points] in all the patients,Plasma 5-HT content[the treatment group were (118.62 ± 29.74) ng/ml,the control group were (121.10 ± 30.56) ng/ml] has been significantly improved (P＜0.01) after treatment[the treatment group were(65.97±23.35)ng/ml,the control group were(63.40±21.24) ng/ml] in all the patients.Between the two groups of patients after treatment,the comparison of the HAMD,SDS scores and Plasma 5-HT content was no significant difference (P ＞ 0.05).Conclusion Turtle-Dragon decoction combined with acupuncture can obviously improve the HAMD,SDS scores and plasma 5-HT content with Depressive Patients.Also treatments between two groups have equivalent effects.

Cerebral Infarction ; diagnosis ; Child ; Humans ; Male ; Purpura, Schoenlein-Henoch ; pathology

Objective To evaluate the early diagnostic value of cerebrospinal fluids (CSF) procalcitonin(PCT) for the post-neurosurgery bacterial meningitis (PNBM).Methods Conduct a prospective study in 34 patients who suspected PNBM in ICU of Kowloon Hospital of Suzhou.On the first day, all the patient blood samples were obtained for detection of routine blood count, C-reactive protein, PCT.Also, all the patient CSF samples were obtained for detection of routine CSF count, biochemical tests, PCT and for CSF culture.The patients were divided into PNBM group and non-PNBM group according to PNBM diagnostic criteria.Results Fifteen cases(44.12％) patients were diagnosed as PNBM,the other 19 cases were non infection group.Levels of CSF procalcitonin PCT 0.50 μg/L were significantly higher in patients with PNBM than those non-PNBM 0.29 μg/L on the first day(P＜0.01).The ROC curues indicated that the area under the curve (AUC) for CSF PCT was 0.846, it was significantly higher than the other traditional indicators' area.The cut off points of CSF procalcitonin was set to be 0.415 μg/L for patients with proven PNBM.The corresponding sensitivity, sepecificity were 80.0％ and 73.7％.Conclusion The level of the CSF procalcitonin may be valuable early diagnostic parameter for PNBM.Sensitivity and specificity of the CSF procalcitonin was higher than the other traditional indicators.

Objective To analyse the causes of non-union and delayed union in distal femur and assess the clinical outcomes of retrograde intramedullary interlocking nail(RIIN). Methods Between June 1995 and December 1998, 15 cases of non-union and delayed union of distal femur were treated with RIIN. There were 9 males and 6 females, the average age of the patients was 34.5 years(range 23 to 46 years). At surgery, the failed implants were removed in all 15 cases, bone graft was performed in 10 cases, closed reaming was done in 5 cases. 11 patients also received knee adhesion release operation. The X-ray examination and KSS knee functional score were used to evaluate the results. Results The average duration of follow-up was 14.5 months. All patients achieved solid bone union at an average of 6.4 months. There were no malunion, infection and refracture in this series. According to the KSS rating system, the average range of motion(ROM) was 93.5 degrees, increased by 28 degrees(42.7％ ) compared with the preoperation ROM. The average knee score was 96 points. The excellent result was obtained in 13 cases, good in 2 cases. The average knee function score was 90.5 points. Conclusion The main reasons for non-union and delayed union were improper selection of the indications and use of implants. Retrograde intramedullary interlocking nail is one of the effective alteratives for treatment of distal femur non-union and delayed union. It can provide a stable and reliable fixation which is of benefit for early functional exercise. Bone grafting, closed reaming technique and knee joint adhesion release should be considered in order to enhance the bone healing and the improvement of knee ROM and function.

Objective To evaluate effects of different types of gingival flap suture on the quality of life in patients after removal of mandibular third molar. Methods A randomized, controlled clinical trial design was adopted. Sixty-two patients in oral surgery department, Stomatology Hospital of Tianjin Medical University were selected. Patients were required removal of bilateral symmetry impacted mandibular third molars, and enclosed suture (primary suture) was used in one side, open drainage suture (secondary suture) was used in the other side. The postoperative symptom severity scale (PoSSe scale) was used to evaluate the quality of life in patients after removal of mandibular third molar. The evaluation was completed 7 days after surgery, and the scale was compared between two groups. Results A total of 57 cases of clinical data were enrolled in the final analysis. The operative time for primary suture group was (17.7±4.6) min, and the operative time for secondary su?ture group was (16.3 ± 5.1) min, the difference was not statistically significant (t=1.539, P>0.05). The PoSSe score was sig?nificantly higher in primary suture group (26.348 ± 12.414) than that of secondary suture group (21.633 ± 11.382, P<0.05). Conclusion Secondary suture reduces the influence of teeth removal on quality of life in patients through relieving pain and swelling, and which is suitable for clinical application.

Objective To investigate the influence of tooth preparation surface roughness and different dental ce-ments on adhesive strength, and provide some reference information on the selection of dental rotary instruments and dental cements. Methods Sixty dentin samples were prepared and randomly divided into 3 groups. Samples from group A, B and C were grinded by diamond burs with grit-sizes of 125μm, 60μm and 28μm respectively. Two samples selected randomly from each group were observed under scanning electron microscope (SEM) for the surface microprofile. The remaining 18 samples from each group were evenly divided into 3 subgroups. Each subgroup was teamed with one of 3 dental cements:zinc polycarboxylate cement (ZP), glass ionomer cement (GI) and resin-modified glass ionomer cement (RMGI). Co-Cr alloy casts were cemented onto the dentin samples, and the adhesive strength was tested. Meanwhile, the types of failure were re-corded for each sample. Results The surface roughness of tooth preparation samples showed a downward trend in group A, group B and group C. Among the involved 3 dental cements, RMGI exhibited the highest adhesive strength, and there was no significant difference in the adhesive strength between ZP and GI. Among different combination subgroups, A-RMGI had the highest adhesive strength, B-RMGI run the second place, while C-ZP and C-GI were proved the lowest. However, there was no interaction between the two factors. Furthermore, group A mainly showed failure typesⅠandⅡ, group B evenly showed all the failure types and group C mainly showed failure typesⅡandⅢ. Conclusion The adhesive strength is related to the surface roughness. RMGI exhibits the highest adhesive efficiency. There is no obvious compatibility in particular surface roughness and dental cements.