1.Ethical issues in clinic application of tumor vaccine
Chinese Medical Ethics 1996;0(01):-
Tumor vaccine is current hotspot of medicine. The article explicates the status quo, merit, side effects of tumor vaccine and brings up the ethic principle we should follow in clinic application.
2.Clinical study of urinary microprotein as predictors of outcome in critically ill patients
Chinese Journal of Nephrology 2005;0(08):-
Objective To evaluate the feacibility of microalbumin(MA),alpha-1 -raicroglobulin (?1-MG) ,N-acetyl-beta-D-glucosaminidase (NAG), retinol-binding protein (RBP)as predictors of outcome in critically ill patients. Methods A prospective study was underwent in 30 critically ill patients.Urinary samples were collected at ICU admission and on the third,seventh ICU day for MA,?1-MG,NAG,RBP measurement.The severity of illness was assessed by APACHE II score calculated on the first ICU day,and the degree of organ dysfunction was assessed using SOFA score calculated on the first,third,seventh ICU day. Results MA,?1-MG,the durations of ICU stay and mechanical ventilation,APACHE II score, SOFA score were relative factors of MODS and death in ICU. There was significant association of APACHE II with MA (r=0.397),?1-MG (r=0.448), and RBP (r= 0.465), respectively. The area under ROC curve of APACHE II score,SOFA score,MA,?1-MG, RBP,NAG to predicate the death in ICU were 0.875 ( P
3.INFLUENCE OF VITAMIN E ON THE NUMBER OF LYMPHOCYTE OF SPLEEN AND THYMUS AND THE BLASTOGENIC RESPONSES OF SPLENO- CYTES OF MICE EXPOSED TO RADIATION
Xuanyue MA ; Zhiren SUI ; Biao FENG
Acta Nutrimenta Sinica 1956;0(04):-
Mice were fed basic diet or basic diet plus vitamin E 50 mg or 500 mg per kg of diet for 4 weeks. The animals were killed at 6 or 14 days after one exposure to 400 rad X-ray whole body radiation and the number of lymphocytes of spleen and thymus and blastogenic responses of splenocytes were tested. The results showed; (1) the number of lymphocytes both in spleen and thymus were significantly decreased in mice fed basic diet in com-parision with that in mice fed with basic diet plus vitamin E (P
5.Correlation between heel vessel and human balance function.
Hui TIAN ; Di BIAN ; Yuejiao SUI ; Lu REN ; Tieming MA
Chinese Acupuncture & Moxibustion 2015;35(4):352-354
The heel vessel belongs to the eight extra meridians in human meridian system, which is closely related to the human motion function. Balance function plays an essential role in successful completion of activities in daily life, so the physiological function and pathology of heel vessel as well as human balance function are analyzed, and from the aspect of running course of heel vessel and syndrome, the correlation between heel vessel and human balance function is explored, and the application status of acupoints related to heel vessel for balance dysfunction is introduced. It is believed that heel vessel is closely related to human balance function, especially the motion regulation mechanisms of balance function, and it is hoped that new ideas and methods can be provided for acupuncture treatment for the balance function disorders.
Acupuncture Points
;
Acupuncture Therapy
;
Humans
;
Meridians
;
Postural Balance
6.Cloning and expression analysis of leucoanthocyanidin reductase gene in Fagopyrum dibotrys.
Jing MA ; Bin WANG ; Yin DAI ; Shunzhao SUI ; Mingyang LI
Acta Pharmaceutica Sinica 2012;47(7):953-61
The leucoanthocyantin reducase (LAR) gene, an important functional gene of catechins biosynthesis pathway, was cloned from Fagopyrum dibotrys (D.Don) Hara by degenerate PCR and rapid amplification of cDNA ends (RACE). The full-length cDNA of FdLAR is 1 581 bp (GenBank accession: JN793953), containing a 1 176 bp ORF encoding a 391 amino acids protein, and its 3'-untranslated region has an obvious polyadenylation signal. The recombinant plasmid containing FdLAR completed ORF was transformed into E. coli BL21 (DE3). The target fusion peptide with molecular weight of 66 kD was expressed under the condition of 16 degrees C and induced by IPTG at final concentration of 1.0 mmol x L(-1). Bioinformation analysis indicated that the amino acid sequence of FdLAR showed great homology to other LAR with the NADB-Rossmann conversed domain in the N-terminus. Real-time quantitative PCR was used to detect the expression levels of FdLAR gene during different development periods. The determination of flavonoids contents in appropriate rhizomes showed that the relationship between FdLAR gene expression and the accumulation of flavonoids displayed different trends during vegetative growth and reproductive growth stages, suggesting that the FdLAR gene may be involved in the pathway of flavonoid metabolisms in Fagopyrum dibotrys.
7.Effect of ropivacaine combined with dexamethasone sprayed intratracheally in patients with resistant tubes and postoperative sore throat
Yingxin ZHANG ; Guanhua LI ; Bo SUI ; Wei WANG ; Tao MA
Chinese Journal of Postgraduates of Medicine 2014;37(6):26-29
Objective To investigate the effect of ropivacaine combined with dexanmethasone sprayed intratracheally in patients with resistant tubes and postoperative sore throat.Methods Eighty patients ASA Ⅰ-Ⅱ grade undergoing laparoscopic cholecystectomy were randomly divided into four groups by random digits tabel method,20 patients in each.2 ml of 0.75% ropivacaine combined with 1 ml dexamethasone (group A) ; 2 ml of 0.75% ropivacaine combined with 1 ml 0.9% sodium (group B) ; 3 ml of 1% tetracaine (group C); 3 ml of 0.9% sodium (group D) were immediately intratracheal sprayed before intubation.The resistant tubes and degree of postoperative 24 h sore throat [by visual analog scale (VAS) scores],comfort [by Bruggrmann comfort scale (BCS) scores] and the incidence of sore throat were recorded.Results The resistant tubes appraised rate in group A,B and C was higher than that in group D [65.0% (13/20),60.0% (12/20),70.0% (14/20) vs.5.0% (1/20)] (P < 0.05),but there was no significant difference among group A,B and C (P> 0.05).The incidence of sore throat at 24 h after surgery in group A,B and C was lower than that in group D [20.0%(4/20),25.0% (5/20),25.0% (5/20) vs.90.0% (18/20)] (P < 0.05),but there was no significant difference among group A,B and C (P> 0.05).The VAS and BCS scores in group A were better than those in group B,C and D [(0.52 ± 1.14) scores vs.(1.68 ± 1.42),(1.59 ± 1.33),(4.22 ± 1.95) scores,(2.80 ± 1.54) scores vs.(1.60 ± 1.19),(1.80 ± 1.20) and (0.45 ± 0.81) scores] (P < 0.05),but there were no significant differences between group B and group C (P > 0.05).Conclusion Ropivacaine combined with dexamethasone sprayedintratracheally can significantly increase the degree of postoperative resistant tubes,decrease the rate of sore throat after general anesthesia,and increase patient' s comfort.
8.Livin gene-new target for cancer therapy
Haojie WEN ; Jing MA ; Jun SUI ; Xiaojiang LI
International Journal of Surgery 2010;37(11):774-777
Livin is a new and important member of the inhibitor of apoptosis protein(IAPs)family.Livin is high expressed in most human tumor cells, involved in apoptosis inhibition and closely related with tumor development and progression.Studies found that through the down-regulation or inhibition of Livin expression and the induction specific antibodies of Livin could inhibi and kill tumor cells, which provided a new method for tumors'diagnosis, cell and gene targeted therapy.
9.The application of facial liposuction and fat grafting in the remodeling of facial contour.
Huicai WEN ; Li MA ; Ynnpeng SUI ; Xueping JIAN
Chinese Journal of Plastic Surgery 2015;31(2):89-92
OBJECTIVETo investigate the application of facial liposuction and fat grafting in the remodeling of facial contour.
METHODSFrom Nov. 2008 to Mar. 2014, 49 cases received facial liposuction and fat grafting to improve facial contours. Subcutaneous facial liposuction with tumescent technique and chin fat grafting were performed in all the cases, buccal fat pad excision of fat in 7 cases, the masseter injection of botulinum toxin type A in 9 cases, temporal fat grafting in 25 cases, forehead fat grafting in 15 cases.
RESULTSMarked improvement was achieved in all the patients with stable results during the follow-up period of 6 - 24 months. Complications, such as asymmetric, unsmooth and sagging were retreated with acceptance results.
CONCLUSIONCombination application of liposuction and fat grafting can effectively and easily improve the facial contour with low risk.
Adipose Tissue ; transplantation ; Botulinum Toxins, Type A ; administration & dosage ; Chin ; Face ; surgery ; Forehead ; Humans ; Injections, Intramuscular ; Lipectomy ; adverse effects ; methods ; Masseter Muscle ; Neuromuscular Agents ; administration & dosage
10.INFLUENCE OF VITAMIN E ON THE BLASTOGENIC RESPONSE OF SPLENOCYTES AND LIPID PEROXIDES IN LIVERS OF AGED MICE
Xuanyue MA ; Zhiren SUI ; Tianwei LI ; Wen XUONG
Acta Nutrimenta Sinica 1956;0(02):-
Semi-purified diets containing 30 ppm or 500 ppm dl-?-tocopherol (VE) were fed for 8 weeks to young (3 months) and old (18 months) Swiss mice. The blastogenic response of splenocytes as well as serum VE and lipid peroxides (LPO) in livers were measued. The results showed that the old mice fed 500 ppm VE had a significantly higher serum VE level and blastogenic response of splenocytes to Con A and LPS than those fed 30 ppm VE (p