Objective To investigate the relationship between self management behavior,life style and blood pressure control in patients with high blood pressure complicated with cerebral infarction,and discuss its nursing countermeasures.Methods 268 patients with high blood pressure complicated with cerebral infarction were recruited by stratified sampling and were investigated with a self-designed questionnaire about self management behavior,life style,and we analyzed the above influencing factors on the blood pressure control and the nursing countermeasures.Results Younger age,higher education degree,high standard of living,stronger self management ability,enough vegetables intake,low consumption of salt,alcohol and tobacco,and moderate physical exercises could control blood pressure better,older age,poorer self management ability,too much salt intake were detrimental to the control of blood pressure.Conclusions Effective self management and good life style can control high blood pressure well in patients with high blood pressure complicated with cerebral infarction,and improve the prognosis and the quality of life.

[Objective] To investigate of application value and nursing strategy during continuous infusion of enteral nutrition liquid for elderly stroke patients with long-term tracheostomy.[Methods] 100 elderly stroke patients underwent tracheostomy were randomly divided into the treatment group and the control group with 50 patients in each group.The treatment group received enteral nutrition by continuous infusion of enteral nutrition liquid.While the control group was given eateral nutrition by routine nasal feeding.The nutritional status and incidence of adverse reactions were compared between two groups.[Results] The albumin level in the treatment group at the second and third weeks was significantly higher than the control group,the difference was statistically significant.The incidence rate of gastroesophageal reflux,choking,aspiration,stomach retention,diarrhea,abdominal distension,stress ulcer was higher in the treatment group than that in the control group,the difference was statistically significant.[Conclusions] Continuous infusion of enteral nutrition liquid in elderly stroke patients with long-term tracheotomy can reduce complications caused by traditional nasal feeding,which is worthy of clinical application.

Therapeutic hypothermia is believed to improve neurodevelopment outcome of infants with moderate-to-severe hypoxic-ischemic encephalopathy(HIE),however,the severe brain injury and neurologic sequelae still can be observed in some infants received therapeutic hypothermia.Optimal monitor and management of systematic complications presented by infants during cooling treatment are necessary for improvement of overall outcome.Therefore,it is essential to understand the functional change of each system of the whole body,to adapt adequate diagnostic methods and to train multidisciplinary staffs to monitor and manage moderate-to-severe HIE infants during therapeutic cooling.With the development of therapeutic hypothermia,it is currently considered as a standard of care for infants with moderate-to-severe HIE.It is recommended that any neonatal intensive care unit(NICU) using routinely therapeutic hypothermia to reference the national or international benchmarking protocols in order to improve the medical quality and prognosis of infants.

Objective To evaluate the effects of therapeutic touch on the pain in patients being undergoing percutaneous laser disk decompression. Methods Ninety-one patients undergoing pereutaneous laser disk decompression were randomly as-signed to therapeutic touch group and routine care group. The intraoperative pain was assessed at the end of operation. Result There was significant difference in the level of pain between the two groups(P<0.05). Conclusion Therapeutie touch can alleviate intraoperative pain in patients undergoing percutuneous laser disk decompression.

Objective To investigate the clinical value of laparoscopically assisted vaginal hysterectomy(LAVH).Methods A total of 125 cases of benign uterine diseases were freely divided into two groups: 65 cases was given LAVH(LAVH Group) and 60 cases was given traditional total abdominal hysterectomy(TAH Group).Results The operation time was 127?4.1 min in the LAVH Group and 70?1.7 min in the TAH Group(t=99.669,P=0.000).The blood loss was 80?23.1 ml in the LAVH Group and 190.8?53 ml in the TAH Group(t=-15.339,P=0.000).The incidence of postoperative complications was 30.8%(20/65) in the LAVH Group and 58.3%(35/60) in the TAH Group,with significant difference between the two groups(?~2=9.621,P=0.002).Conclusions LAVH has advantages of micro-invasion,little blood loss,and quick recovery,being an ideal procedure.

Objective To observe the effect of ginkolide B derivative(XQ) on animal thrombosis.Methods SD male rats were randomized into the model group,troxerutin(48 mg?kg-1?d-1) group,ginkolide B(7.8 mg?kg-1?d-1) group,and low-,middle-and high-dose XQ(in the dose of 3.9,7.8 and 15.6 mg?kg-1?d-1 respectively) groups.The anti-thrombotic effect of XQ was observed on rats mixed thrombosis model induced by arterio-venous shunt method and electrical stimulation.Meanwhile,ICR male mice were randomized into the model group,troxerutin(96 mg?kg-1?d-1) group,ginkolide B(15.6 mg?kg-1?d-1) group,and low-,middle-and high-dose XQ(in the dose of 7.8,15.6 and 31.2 mg?kg-1?d-1 respectively) groups.The anti-thrombotic effect of XQ was also observed on mice acute pulmonary embolism model induced by adenosine diphosphate(ADP).Results XQ at the dose of 7.8 and 15.6 mg?kg-1?d-1 decreased the dry and wet weight of the thrombosis,and obviously prolonged the formation time of rats carotid artery thrombosis as compared to the model group(P

Objective:The fingerprint chromatograms were established for quality evaluation of Sedum aizoon L.collected from different habitats by HPLC.Methods:The analysis was performed on a Diamonsil C18 column(4.6mm? 250mm,5?m)with acetonitrile-water(acidified to 0.5%with phosphoric acid)as mobile phase in a gradient mode at a flow rate of 1.0 mL/min,and at a column temperature of 25℃.The detection of wavelength was at 254 nm.Results:2lpeaks were selected as the common fingerprint peaks.The relative standard deviations for relative retention values and relative peak areas were less than 3%in the precision and repeated test.The similarity of l0 batches of samples were no less than 0.9.Conclusion:The method was reliable and can be helpful on the quality control of Sedum aizoon L.

AIM: To investigate the inhibiting effect and mechanism of dimethylaminoethyl ginkgolide B mesylate on platelet aggregation and release function.METHODS: The effect of dimethylaminoethyl ginkgolide B mesylate on inhibiting PAF-induced platelet aggregation was measured by turbidimetry method through giving rabbits dimethylaminoethyl ginkgolide B mesylate at different final concentration via i.v.for 5 days.The release of Ca2 + from PAF-induced platelet in rabbits was assayed with fluorospectrophotometry and the contents of TXA2 and PGI2 were measured by radio-immunity method.RESULTS: Three groups of dimethylaminoethyl ginkgolide B mesylate (1.95,3.90,7.80 mg/kg) had significant effect on inhibiting PAF-induced platelet aggregation in rabbits (compared to normal,P

ObjectiveTo clarify the clinicopathological features of renal amyloidosis in order to achieve early diagnosis and treatment.MethodsClinicopathological data of 26 biopsyproven renal amyloidosis cases in Department of Nephrology,Zhongshan Hospital,Fudan University between2006and2010wereanalyzedretrospectively.Immunohistochemistryand immunofluorescence of amyloid A protein,immunoglobulin light chains such as K、λ were performed on renal specimens for further classification.ResultsAge of 26 patients ranged from 40 to 77 years old,average(58.54±10.07) years.Twenty-two out of 26 patients(84.62％) were treated in local hospital before admitted to our department,and 21 patients(95.45％) were misdiagnosed as chronic primary glomerulonephritis.The prominent clinical manifestations of renal amyloidosis were nephrotic syndrome(17 cases,65.38％),decreased blood pressure(16 cases,61.53％),organ enlargement (8 cases,30.77％) and bodyweight loss (6 cases,23.08％).Fourteen out of 25 patients (56.00％) were found to have monoclonal light chains in serum by immunofixation electrophoresis.Three patients with mild pathological changes who had no confirmable Congo red stain were conffimed by electron microscopy. Twenty-three(88.46％) patients werediagnosed as AL amyloidosis,one(3.85％) as AA amyloidosis,one was strongly suspected of hereditary amyloidosis,and one was undetermined.ConclusionsRenal amyloidosis is frequently misdiagnosed.Middleaged and old nephrotic patients with decreased blood presure,organ enlargement and bodyweight loss may be the most helpful clues of the disease.Most patients have monoclonal light chains in serum or urine.Renal biopsy,especially electronic microscopy plays a crucial role in the early diagnosis of renal amyloidosis.Immunohistochemistry is important for patients with renal amyloidosis in pathological classification and treatment.

Objective To explore the role of brief ischemia pretreatment in the induction of renal ischemic tolerance,and investigate its effects on tubular cell necrosis,apoptosis and proliferation. Methods Male Sprague-Dawley rats were randomly divided into three groups,including sham-operated group (Sham),ischemia/reperfusion injured group subjected to theocclusion of both renal pedicles for 40 min followed by reperfusion(I/R),and preconditioned group with 20-min ischemia pretreatment induced 4 days before I/R(IPC).Histological changes were evaluated by PAS staining.The ultra-structure of tubular cells was observed by transmission electron microscopy(TEM).Apoptosis was confirmed by terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL).The proliferation of tubular cells was evaluated with proliferating cell nuclear antigen(PCNA). Results Twenty-minites ischemia pretreatment offered both promising functional and histological protection against 40-min ischemia/reperfusion injury (P<0.01).The mortality rate wag reduced from 33%in I/R group to 0 in IPC group.The renopmtection offered by 20-min ischemia pretreatment was accompanied with reduced postischemic tubular cell apoptosis and necrosis (P<0.05), and increased cell proliferation (PCNA positive) (P< 0.01). Conclusions Brief and sublethal prior ischemia can render the kidney more tolerant to subsequent prolonged I/R injury. Its ability to tilt the balance of tubular cell fate toward survival, reducing postischemic cell death and enhancing cell proliferation, may play an important role in renal protection of ischemic preconditioning.