OBJECTIVE: To explore the characteristics of traditional Chinese medical syndrome (TCM syndrome) of hepatocirrhosis. METHODS: Clinical information from the four diagnosis methods of traditional Chinese medicine (TCM) and related laboratorial indexes were systematically collected from 223 hepatocirrhosis cases, and the multi-statistical methods including systematic cluster analysis, principal component analysis, stepwise discrimination and variance analysis were made with the software SAS 6.11. RESULTS: Multi-analysis showed that there were 3 categories of syndrome characteristics. Type 1 (134 cases): damp heat, blood stasis, deficiency of liver and spleen Qi; Type 2 (62 cases): deficiency of both Qi and Yin with severe deficiency of Qi, heat with severe dampness, blood stasis; Type 3 (27 cases): deficiency of both Qi and Yin with severe deficiency of Yin, stasis and heat or dampness. Analysis of the changes of the related laboratorial indexes among the three types of syndrome showed that Type 1 mainly manifested asthenia syndrome with sthenia syndrome, and its indexes of AST, ALT, GGT levels were markedly higher than those of Type 2 and Type 3, both of which mainly showed sthenia syndrome with asthenia syndrome, and that Type 3 was in active inflammation, deficiency of both Qi and Yin (deficiency of Yin > deficiency of Qi), and its FN, Alb, FV, FVII, PLT, PCT levels were obviously reduced. CONCLUSION: The multi-statistical methods can reveal the characteristics and regularity of TCM syndrome of hepatocirrhosis, and the 3 categories of syndrome characteristics basically conform to clinical manifestations. The result of TCM syndrome distribution and laboratorial indexes infer that damp heat is the pathological basis of hepatocirrhosis, and the degree of liver function disorder and liver damage may be the pathological basis of deficiency of Yin of both liver and kidney.

Objective To systematically evaluate the clinical effect and safety of repaglinide and metformin for treating diabetes mellitus (MD) of secondary failure of sulfonylurea (SFS).Methods The randomized controlled trials (RCT) at home and abroad on the comparison of effect and safety of repaglinide and metformin in treating MD with SFS were retrieved.The modified Jadad scale was employed to evaluate the literature quality.The RevMan5.3.1 software was used for conducting the meta analysis.Results A total of 10 RCT were included.The meta-analysis results showed that compared with metformin for treating MA with SFS,repaglinide decreased the fasting blood glucose effectively (MD=-2.30,95 ％ CI:-2.53--2.06,P＜0.01),increased the fasting C-peptide (MD=0.06,95％CI:0.02-0.11,P=0.01),reduced the postprandial 2 h blood glucose (MD=-2.17,95 ％CI:-2.44-1.89,P＜0.01) and decreased glycosylated hemoglobin (MD=-2.60,95％CI:-3.21--2.00,P＜0.01) as well as the adverse reactions (RR=0.05,95％CI:0.02-0.09,P＜0.01).However,there was no statistical difference in fasting insulin between the repaglinide and metformin groups (MD=0.18,95％CI:-0.18-0.54,P=0.32).Conclusion Currently evidences suggest that repaglinide is superior to metformin for treating MD with SFS.

Endothelialization of artificial vascular graft is considered as one of the most promising methods to improve its antithrombotic ability and long-term patency. Endothelialization of artificial vascular graft includes harvesting endothelial cells, choosing some materials with better compliance and seeding endothelial cells. The methods such as immobilization of extracellular matrix protein and growth factor to substrates, stimulation of chronic in vitro shear stress for endothelial cell retention on artificial vascular graft in bioactor, genetic modificatioin of ECs, and changes of electric charge of ECs are used to increase the adherence ability of endothelial cells. This paper reviews the process of endothelialization of artificial vascular graft and makes brief comments on the methods of endothelialization of artificial vascular graft.
Blood Vessel Prosthesis ; Endothelial Cells ; cytology ; Endothelium, Vascular ; growth & development ; Genetic Therapy ; Humans ; Stress, Mechanical

Objective:To explore the effects of contract-based follow-up management of special diseases on self-perceived burden, self-management behaviors and disease control in patients with diabetic nephropathy (DN) .Methods:Taking the establishment of DN contract-based follow-up management model by the First Affiliated Hospital of Xinjiang Medical University and the community in January 2020 as the dividing line, 50 DN patients who were included in the study and implemented routine follow-up management from the First Affiliated Hospital of Xinjiang Medical University and the community from July 2018 to September 2019 were selected as the control group, and 50 DN patients who were included in the study and implemented contract-based follow-up management of specific diseases from January 2020 to March 2021 were selected as the observation group. All patients were followed up for 3 months. Self-perceived burden [Self-Perceived Burden Scale (SPBS) ] , self-management behaviors [Self-made Self-management Behavior Scale of Patients with DN] , disease status indicators [fasting blood glucose (FBG) , 2 h postprandial blood glucose (PBG) , urine albumin creatine ratio (UACR) ] and nursing satisfaction were compared between the two groups before and after intervention.Results:After 3 months of intervention, the physical burden, economic burden and emotional burden scores on the SPBS scale of patients of the two groups decreased compared to those before intervention, and the physical burden, economic burden and emotional burden scores on the SPBS scale of the observation group were lower than those of the control group after intervention, and the differences were statistically significant ( P<0.05) . After 3 months of intervention, the scores of dietary management, exercise management, blood glucose monitoring, hemodialysis care, and medication compliance in Self-management Behavior Scale of Patients with DN of patients in the two groups increased compared to those before intervention. Moreover, the scores of dietary management, exercise management, blood glucose monitoring, hemodialysis care and medication compliance in Self-management Behavior Scale of Patients with DN of the observation group were higher than those in the control group after intervention, and the differences were statistically significant ( P<0.05) . After 3 months of intervention, the levels of FBG, PBG, and UACR in both groups of patients decreased compared to before intervention. The levels of FBG, PBG, and UACR in the observation group after intervention were lower than those in the control group, and the differences were statistically significant ( P<0.05) . The overall nursing satisfaction of the observation group patients was higher than that of the control group, and the difference was statistically significant ( P<0.05) . Conclusions:The contract-based follow-up management of special diseases can reduce the self-perceived burden of DN patients, improve their self-management behavior and contribute to better disease control.