Objective To analyze and evaluate the 48 selected highly polymorphic SNP loci in Chinese Han population on genetic and forensic aspects.Methods Samples from 200 unrelated Han individuals in East China were collected.48 X-SNP polymorphic genetic markers were selected according to the information providedby NCBI and HapMap,and then were typed by SNPlex~(TM) System for establishing genetic data.Results The 48 X-SNP loci were highly polymorphic markers in East China Han population except rs6527549,and their polymorphism information contents(PIC)were all above 0.32,the discrimination power(DP)in females and males were above 0.56 and 0.40 respectively,the probability of exclusion(PE)in duos and trios were above 0.20 and 0.32 respectively.In addition,linkage disequilibriums were observed among some loci.Conclusion The 48 X-SNP loci union is suitable for developing high-throughout automated research and also useful for special parentage testing.

Attention deficit hyperactivity disorder (ADHD) is a common, highly heritable psychiatric disorder characterized by hyperactivity, inattention and increased impulsivity. In recent years, a large number of genetic studies for ADHD have been published and related genetic data has been accumulated dramatically. To provide researchers a comprehensive ADHD genetic resource, we previously developed the first genetic database for ADHD (ADHDgene). The abundant genetic data provides novel candidates for further study. Meanwhile, it also brings new challenge for selecting promising candidate genes for replication and verification research. In this study, we surveyed the computational tools for candidate gene prioritization and selected five tools, which integrate multiple data sources for gene prioritization, to prioritize ADHD candidate genes in ADHDgene. The prioritization analysis resulted in 16 prioritized candidate genes, which are mainly involved in several major neurotransmitter systems or in nervous system development pathways. Among these genes, nervous system development related genes, especially SNAP25, STX1A and the gene-gene interactions related with each of them deserve further investigations. Our results may provide new insight for further verification study and facilitate the exploration of pathogenesis mechanism of ADHD.
Attention Deficit Disorder with Hyperactivity ; genetics ; Computer Simulation ; Databases, Genetic ; Gene Regulatory Networks ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Models, Genetic ; Software ; Synaptosomal-Associated Protein 25 ; genetics ; Syntaxin 1 ; genetics

Algorithms ; Case-Control Studies ; Genome-Wide Association Study ; Humans ; Internet ; Phenotype ; Polymorphism, Single Nucleotide ; genetics ; Schizophrenia ; genetics ; Signal Transduction ; Software ; User-Computer Interface

Bipolar Disorder ; genetics ; Genome-Wide Association Study ; Genomics ; methods ; Humans

Objective:To provide reference for domestic colleagues by introducing the contents of the discipline construction of the National Clinical Research Center for mental disorders.Methods:By reviewing the original intention of the construction of the National Clinical Research Centers initiated by many ministries and departments, taking into account of the actual construction practice at hospital level in the field of mental disorders, this paper discusses the discipline construction of the National Clinical Research Center.Results:From the aspects of construction goals, purposes, overall operation modes, construction of collaborative innovation research network, the paper clarifies the concrete measures of the construction of the center.Conclusions:Through the evaluation of the current situation, the National Clinical Research Center for mental disorders has defined the focus of the construction: to build a management platform and two professional platforms, in order to provide support for the development of high-quality and high-level clinical research, and provide support for the transformation of clinical medicine.